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1. 发明申请

US20080132800A1 NOVEL MEDICAL METHODS AND SYSTEMS INCORPORATING WIRELESS MONITORING 有权
标题翻译：新型医疗方法与系统无线监控
公开(公告)号：US20080132800A1
公开(公告)日：2008-06-05
申请号：US11565283
申请日：2006-11-30
申请人： Douglas A. Hettrick , Kenneth C. Gardeski , H. Toby Markowitz , Sameh Sowelam
发明人： Douglas A. Hettrick , Kenneth C. Gardeski , H. Toby Markowitz , Sameh Sowelam
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法包括至少两个植入标记的监测，每个植入标记适于响应于无线发送的激励信号无线地发送信号; 响应信号被转换成两个标记的位置信息。所述系统和方法还包括植入的感测构件和/或植入的治疗递送装置中的一个或其中之一。从感测构件接收到的信号可以与位置信息进行整理。可以根据位置信息调整从治疗输送装置输送的治疗。

2. 发明申请

US20080183083A1 SYSTEMS AND METHODS FOR MONITORING EFFECTIVENESS OF CONGESTIVE HEART FAILURE THERAPY 审中-公开
标题翻译：用于监测心脏失效治疗有效性的系统和方法
公开(公告)号：US20080183083A1
公开(公告)日：2008-07-31
申请号：US11669396
申请日：2007-01-31
申请人： H. Toby Markowitz , Sameh Sowelam
发明人： H. Toby Markowitz , Sameh Sowelam
IPC分类号： A61B5/0205 , A61N1/36
CPC分类号： A61B5/6826 , A61B5/0285 , A61B5/042 , A61B5/053 , A61B5/08 , A61B5/14551 , A61B5/4818 , A61B5/6838
摘要： A method for monitoring a patient includes measuring a series of consecutive pulse transit times (PTT's) of the patient, and processing the resulting PTT signal to detect a presence or absence of central sleep apnea (CSA). The method further includes determining an effectiveness of congestive heart failure therapy, which is being provided to the patient, based on the detected presence or absence of CSA. A system incorporating the method includes an electrode of an implantable medical device, which is adapted to pick up the patient's ventricular depolarization signals, a sensor, which is adapted to pick up peripheral arterial pulse signals of the patient, and a signal processor, which is adapted to receive the two types of signals and to process the signals according to the method. The system may provide the therapy via cardiac resynchronization pacing and, upon detection of CSA, the system may adjust at least one pacing parameter.
摘要翻译：用于监测患者的方法包括测量患者的一系列连续脉冲传递时间（PTT），并且处理所得到的PTT信号以检测中枢性睡眠呼吸暂停（CSA）的存在或不存在。该方法还包括基于检测到的CSA的存在或不存在来确定正在提供给患者的充血性心力衰竭治疗的有效性。包括该方法的系统包括可植入医疗装置的电极，其适于拾取患者的心室去极化信号，适于拾取患者的外周动脉脉冲信号的传感器，以及信号处理器，其是适于接收两种类型的信号并根据该方法处理信号。系统可以通过心脏再同步起搏提供治疗，并且在检测到CSA时，系统可以调整至少一个起搏参数。

3. 发明授权

US07896813B2 System and method for monitoring periodic breathing associated with heart failure 有权
标题翻译：用于监测与心力衰竭相关的周期性呼吸的系统和方法
公开(公告)号：US07896813B2
公开(公告)日：2011-03-01
申请号：US11278187
申请日：2006-03-31
申请人： Sameh Sowelam , H. Toby Markowitz , Mark K. Erickson , Ioana Nicolaescu
发明人： Sameh Sowelam , H. Toby Markowitz , Mark K. Erickson , Ioana Nicolaescu
IPC分类号： A61B5/08
CPC分类号： A61B5/08 , A61B5/021 , A61B5/087 , A61B5/1135 , A61B5/1455 , A61B5/4818 , A61B7/003
摘要： A system and method for monitoring in a patient includes producing sensor signals representative of a physiologic parameter associated with respiration. A periodic breathing cycle is detected based on the sensor signals. An output is produced as a function of the cycle length.
摘要翻译：用于在患者中监测的系统和方法包括产生代表与呼吸相关的生理参数的传感器信号。基于传感器信号检测周期性呼吸周期。作为循环长度的函数产生输出。

4. 发明授权

US07315759B2 Implantable medical device with circulation delay measurement and therapy control 有权
标题翻译：具有循环延迟测量和治疗控制的植入式医疗设备
公开(公告)号：US07315759B2
公开(公告)日：2008-01-01
申请号：US10945639
申请日：2004-09-21
申请人： H. Toby Markowitz , Pooja Mehta , Chad T. Giese , Mark K. Erickson , Yong K. Cho , Marina Jovanovic , Sameh Sowelam
发明人： H. Toby Markowitz , Pooja Mehta , Chad T. Giese , Mark K. Erickson , Yong K. Cho , Marina Jovanovic , Sameh Sowelam
IPC分类号： A61N1/08
CPC分类号： A61N1/3601 , A61N1/36557 , A61N1/3962
摘要： Oxygen saturation data is monitored during a predefined window to obtain a measurement of circulation delay. The measured circulation delay is used as a basis for determining therapies, including overdrive pacing. In some embodiments, circulation delay is used to identify patients that will benefit from overdrive pacing as a therapy for sleep disordered breathing.
摘要翻译：在预定窗口期间监测氧饱和度数据，以获得循环延迟的测量。测量的循环延迟被用作确定治疗的基础，包括超速起搏。在一些实施例中，循环延迟用于识别将受益于过度起搏起搏作为睡眠无序呼吸治疗的患者。

5. 发明授权

US07941213B2 System and method to evaluate electrode position and spacing 有权
标题翻译：评估电极位置和间距的系统和方法
公开(公告)号：US07941213B2
公开(公告)日：2011-05-10
申请号：US12183796
申请日：2008-07-31
申请人： H. Toby Markowitz , Phillip Falkner , Douglas A. Hettrick , Sameh Sowelam
发明人： H. Toby Markowitz , Phillip Falkner , Douglas A. Hettrick , Sameh Sowelam
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/3706
摘要： An IMD can be implanted into a patient to address various conditions. The IMD case and leads can have various electrodes and other portions to measure various physiological conditions. For example, a selected current can be generated between two electrodes, either external or internal in the patient, and a voltage can be measured by one or more electrodes of the IMD. A voltage can be measured at two or more locations to determine a relative motion of different electrodes. If the electrodes are in different portions of the heart, a determination can be made of a relative motion or position of the heart or portions of the heart.
摘要翻译：可以将IMD植入患者中以解决各种情况。 IMD外壳和引线可以具有各种电极和其他部分来测量各种生理条件。例如，可以在患者的外部或内部的两个电极之间产生所选择的电流，并且可以通过IMD的一个或多个电极来测量电压。可以在两个或更多个位置处测量电压以确定不同电极的相对运动。如果电极位于心脏的不同部分，则可以确定心脏或心脏部分的相对运动或位置。

6. 发明申请

US20090093857A1 SYSTEM AND METHOD TO EVALUATE ELECTRODE POSITION AND SPACING 有权
标题翻译：用于评估电极位置和间隔的系统和方法
公开(公告)号：US20090093857A1
公开(公告)日：2009-04-09
申请号：US12183796
申请日：2008-07-31
申请人： H. Toby Markowitz , Phillip Falkner , Douglas A. Hettrick , Sameh Sowelam
发明人： H. Toby Markowitz , Phillip Falkner , Douglas A. Hettrick , Sameh Sowelam
IPC分类号： A61N1/368
CPC分类号： A61N1/05 , A61N1/3706
摘要： An IMD can be implanted into a patient to address various conditions. The IMD case and leads can have various electrodes and other portions to measure various physiological conditions. For example, a selected current can be generated between two electrodes, either external or internal in the patient, and a voltage can be measured by one or more electrodes of the IMD. A voltage can be measured at two or more locations to determine a relative motion of different electrodes. If the electrodes are in different portions of the heart, a determination can be made of a relative motion or position of the heart or portions of the heart.
摘要翻译：可以将IMD植入患者中以解决各种情况。 IMD外壳和引线可以具有各种电极和其他部分来测量各种生理条件。例如，可以在患者的外部或内部的两个电极之间产生所选择的电流，并且可以通过IMD的一个或多个电极来测量电压。可以在两个或更多个位置处测量电压以确定不同电极的相对运动。如果电极位于心脏的不同部分，则可以确定心脏或心脏部分的相对运动或位置。

7. 发明授权

US07676268B2 Medical methods and systems incorporating wireless monitoring 有权
标题翻译：医疗方法和系统结合无线监控
公开(公告)号：US07676268B2
公开(公告)日：2010-03-09
申请号：US11565283
申请日：2006-11-30
申请人： Douglas A. Hettrick , Kenneth C. Gardeski , H. Toby Markowitz , Sameh Sowelam
发明人： Douglas A. Hettrick , Kenneth C. Gardeski , H. Toby Markowitz , Sameh Sowelam
IPC分类号： A61N1/00
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法包括至少两个植入标记的监测，每个植入标记适于响应于无线发送的激励信号无线地发送信号; 响应信号被转换成两个标记的位置信息。所述系统和方法还包括植入的感测构件和/或植入的治疗递送装置中的一个或其中之一。从感测构件接收到的信号可以与位置信息进行整理。可以根据位置信息调整从治疗输送装置输送的治疗。

8. 发明授权

US10568546B2 Devices and methods for sizing valve apertures and luminal organs 有权
公开(公告)号：US10568546B2
公开(公告)日：2020-02-25
申请号：US14742025
申请日：2015-06-17
申请人： 3DT Holdings, LLC , H. Toby Markowitz
发明人： Ghassan S. Kassab , H. Toby Markowitz
IPC分类号： A61B5/107 , A61B5/00 , A61B5/053 , A61B5/02
摘要： Devices and methods for sizing valve apertures and luminal organs. In at least one embodiment of a device for obtaining measurements within a luminal organ of the present disclosure, the device comprises an elongated body, and at least one sizing finger positioned at a distal end of the elongated body, the at least one sizing finger configured to move from a first position to a second position by way of adjustment of at least one movable device coupled thereto, wherein a dimensional measurement within the luminal organ can be determined based upon the first position and the second position.

9. 发明授权

US09179860B2 Determining a location of a member 有权
标题翻译：确定会员的位置
公开(公告)号：US09179860B2
公开(公告)日：2015-11-10
申请号：US12423466
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/05 , A61B5/06 , A61B5/0432 , A61B5/044 , A61B5/042 , A61B5/053 , A61B19/00 , A61B5/0428 , A61B8/06 , A61B8/00 , A61B17/00 , A61B17/22
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者的体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

10. 发明授权

US08831701B2 Uni-polar and bi-polar switchable tracking system between 有权
标题翻译：单极和双极可切换跟踪系统之间
公开(公告)号：US08831701B2
公开(公告)日：2014-09-09
申请号：US12423521
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04 , A61B5/06 , A61B5/0428
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

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