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1. 发明申请

US20050247565A1 Portable bioagent concentrator 失效
标题翻译：便携式生物聚焦器
公开(公告)号：US20050247565A1
公开(公告)日：2005-11-10
申请号：US10838937
申请日：2004-05-04
申请人： H. Hsieh , Meng Lean , Bryan Preas , Armin Volkel
发明人： H. Hsieh , Meng Lean , Bryan Preas , Armin Volkel
IPC分类号： G01N27/27 , G01N27/453
CPC分类号： G01N27/453
摘要： A portable apparatus for extracting and concentrating bioagents within a fluid medium includes a container with sample solution inlet port and traveling wave grids patterned on surfaces of the container. The traveling wave grids cause bioagents to migrate to a specified surface within the container and then to an extraction port. The traveling wave grids include a substrate, across which extend a collection of closely spaced and parallel electrically conductive electrodes, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids.
摘要翻译：用于在流体介质中提取和浓缩生物体的便携式设备包括具有样品溶液入口的容器和在容器表面上图案化的行波网格。行波网格使生物体迁移到容器内的指定表面，然后迁移到提取口。行波网格包括基板，跨越其延伸紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。电压控制器提供多相电信号，用于收集行波网格的总线和电极。

2. 发明申请

US20050247564A1 Continuous flow particle concentrator 有权
标题翻译：连续流粒子集中器
公开(公告)号：US20050247564A1
公开(公告)日：2005-11-10
申请号：US10838570
申请日：2004-05-04
申请人： Armin Volkel , Meng Lean , H. Hsieh , Jurgen Daniel
发明人： Armin Volkel , Meng Lean , H. Hsieh , Jurgen Daniel
IPC分类号： B03C5/02 , G01N27/27 , G01N27/453 , G01N30/00 , G01N33/487
CPC分类号： B03C5/028 , G01N2030/0035
摘要： An apparatus for extracting and concentrating bioagents within a continuously flowing fluid medium includes a flow channel fluid inlet, in which bioagents are concentrated from three dimensions to a two-dimensional transport layer in a preconcentration area. Traveling wave grids cause the preconcentrated bioagents to migrate to one side of the flow channel and then to an extraction port. Each of the traveling wave grids includes a substrate, a collection of closely spaced and parallel electrically conductive electrodes extending across said substrate, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids. Fluid exits through an outlet port.
摘要翻译：用于在连续流动的流体介质中提取和浓缩生物体的装置包括流动通道流体入口，其中生物体从三维集中到预浓缩区域中的二维输送层。旅行波谷使预浓缩的生物标签迁移到流动通道的一侧，然后迁移到提取口。每个行波波谷包括基板，跨越所述基板的紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。电压控制器提供多相电信号，用于收集行波网格的总线和电极。流体通过出口排出。

3. 发明申请

US20060121555A1 Bio-enrichment device to enhance sample collection and detection 有权
标题翻译：生物富集装置，增强样品收集和检测
公开(公告)号：US20060121555A1
公开(公告)日：2006-06-08
申请号：US11007121
申请日：2004-12-08
申请人： Meng Lean , Armin Volkel , Peter Kiesel , Oliver Schmidt , Noble Johnson , H. Hsieh
发明人： Meng Lean , Armin Volkel , Peter Kiesel , Oliver Schmidt , Noble Johnson , H. Hsieh
IPC分类号： C12M1/34 , C12Q1/24
CPC分类号： G01N30/0005 , B03C5/028 , G01N30/08
摘要： A flow cell is disclosed for collecting and concentrating a sample dispersed in a flowing medium. The collected sample can be selectively manipulated within the cell by the use of one or more traveling wave grids. The cells are particularly useful as bio-enrichment devices and can be utilized upstream of conventional analytical or detection instruments.
摘要翻译：公开了用于收集和浓缩分散在流动介质中的样品的流动池。收集的样品可以通过使用一个或多个行波网格在单元内选择性地操纵。细胞特别可用作生物富集装置，并可用于常规分析或检测仪器的上游。

4. 发明申请

US20060046312A1 Biosensor using microdisk laser 有权
标题翻译：生物传感器使用微盘激光
公开(公告)号：US20060046312A1
公开(公告)日：2006-03-02
申请号：US10930758
申请日：2004-09-01
申请人： Peter Kiesel , Noble Johnson , Meng Lean , H. Hsieh , Michael Kneissl
发明人： Peter Kiesel , Noble Johnson , Meng Lean , H. Hsieh , Michael Kneissl
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： B82Y20/00 , G01N33/54373 , H01S5/041 , H01S5/0607 , H01S5/1075 , H01S5/34333 , H01S5/4025
摘要： A compact sensor for detecting the presence of biological or chemical species includes a microdisk laser and a wavelength shift detector. The microdisk laser is coated with a biological or chemical recognition element, which binds preferentially with a target analyte. Because the recognition element and the target analyte adhere to the sidewall surface of the microdisk laser, they increase the effective diameter of the laser, which shifts the output wavelength by a detectable amount. The presence of a wavelength shift indicates the presence of the target analyte, and the magnitude of the wavelength shift corresponds to the mass load of the target analyte on the sidewall surface of the microdisk laser.
摘要翻译：用于检测生物或化学物质存在的紧凑型传感器包括微盘激光器和波长偏移检测器。微型体激光器涂覆有与目标分析物优先结合的生物或化学识别元件。因为识别元件和目标分析物粘附到微盘激光器的侧壁表面，所以它们增加了激光器的有效直径，这将输出波长移动了可检测的量。波长偏移的存在表示目标分析物的存在，并且波长漂移的大小对应于微盘激光器的侧壁表面上的目标分析物的质量负载。

5. 发明申请

US20060092413A1 Anti-resonant waveguide sensors 有权
标题翻译：反谐振波导传感器
公开(公告)号：US20060092413A1
公开(公告)日：2006-05-04
申请号：US10976434
申请日：2004-10-29
申请人： Peter Kiesel , Oliver Wolst , Michael Kneissl , H. Hsieh
发明人： Peter Kiesel , Oliver Wolst , Michael Kneissl , H. Hsieh
IPC分类号： G01J3/44 , G01J3/30
CPC分类号： G02B6/10 , G01N21/03 , G01N21/0303 , G01N21/33 , G01N21/35 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/651 , G02B6/032 , G02B6/34
摘要： An improved method of analyzing target analytes in a sample is described. The method is based on anti-resonant guided optical waveguides which enables a strongly improved light-target interaction since the light can be guided within the target-containing medium. The light-target interaction can be monitored by many different means to determine characteristics of the target analyte. The anti-resonant waveguide concept is suitable for a large variety of characterization methods and combinations of them, since it is relatively unaffected by changes to both wavelength and film thickness.
摘要翻译：描述了一种分析样品中目标分析物的改进方法。该方法基于反谐振导向光波导，其能够实现强烈改善的光 - 目标相互作用，因为可以在含靶介质的介质内引导光。光靶相互作用可以通过许多不同的手段来监测，以确定目标分析物的特征。反谐振波导概念适用于各种表征方法及其组合，因为它相对不受波长和膜厚度变化的影响。

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