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1. 发明授权

US07863047B2 Intracorporeal medicaments for photodynamic treatment of disease 有权
标题翻译：用于光动力治疗疾病的体内药物
公开(公告)号：US07863047B2
公开(公告)日：2011-01-04
申请号：US12150330
申请日：2008-04-25
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K51/00 , A61K49/00 , A61M36/14 , G01N23/00
CPC分类号： A61K31/352 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K41/0038 , A61K41/0057 , A61K41/0071 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/153333 , Y10T436/19 , Y10T436/193333
摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的体内光动力学药物和用于治疗人或动物组织中的这种光动力药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤代呫吨衍生物。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道和相关器官，循环系统内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个优选的实施方案中，这些药物以包括液体，半固体，固体或气溶胶递送载体的各种制剂生产。

2. 发明申请

US20080207746A1 Intracorporeal medicaments for photodynamic treatment of disease 有权
公开(公告)号：US20080207746A1
公开(公告)日：2008-08-28
申请号：US12150330
申请日：2008-04-25
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K31/352 , A61P1/00 , A61P11/00 , A61P13/00 , A61P15/00 , A61P9/00 , A61P17/00 , A61P5/00 , A61P31/00 , A61P41/00
CPC分类号： A61K31/352 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K41/0038 , A61K41/0057 , A61K41/0071 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/153333 , Y10T436/19 , Y10T436/193333
摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

3. 发明授权

US07390668B2 Intracorporeal medicaments for photodynamic treatment of disease 有权
公开(公告)号：US07390668B2
公开(公告)日：2008-06-24
申请号：US09799785
申请日：2001-03-06
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： G01N33/00
CPC分类号： A61K31/352 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K41/0038 , A61K41/0057 , A61K41/0071 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/153333 , Y10T436/19 , Y10T436/193333
摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

4. 发明申请

US20100076246A1 Intracorporeal Medicaments for High Energy Phototherapeutic Treatment of Disease 审中-公开
标题翻译：体内高能量光疗治疗疾病的药物
公开(公告)号：US20100076246A1
公开(公告)日：2010-03-25
申请号：US12543653
申请日：2009-08-19
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61N5/10 , A61K31/352 , A61P35/04
CPC分类号： A61K31/352 , A61B2017/22062 , A61B2017/22087 , A61K9/0019 , A61K41/0038 , A61N5/0601 , A61N5/062 , A61N5/10 , A61N2005/1098 , C07D311/82
摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的体内放射碘化物药物和用于治疗人或动物组织的这种高能光疗药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤化呫吨衍生物。卤化呫吨构成了一种有效的放射增敏剂，其在用电离辐射照射治疗部位时变得光活化。在本发明的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官的各种病症，循环系统和相关器官，头颈部，内分泌和淋巴系统及相关器官，各种其他组织，例如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个实施方案中，这些药物是以包括液体，半固体，固体或气溶胶输送载体在内的各种制剂生产的。

5. 发明授权

US07402299B2 Intracorporeal medicaments for photodynamic treatment of disease 有权
标题翻译：用于光动力治疗疾病的体内药物
公开(公告)号：US07402299B2
公开(公告)日：2008-07-22
申请号：US10999313
申请日：2004-11-30
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61B5/55
CPC分类号： A61K31/352 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K41/0038 , A61K41/0057 , A61K41/0071 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/153333 , Y10T436/19 , Y10T436/193333
摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的体内光动力学药物和用于治疗人或动物组织中的这种光动力药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤代呫吨衍生物。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个优选的实施方案中，这些药物以包括液体，半固体，固体或气溶胶递送载体的各种制剂生产。

6. 发明申请

US20080118578A1 Topical Medicaments and Methods for Photodynamic Treatment of Disease 有权
标题翻译：光动力治疗疾病的专题药物和方法
公开(公告)号：US20080118578A1
公开(公告)日：2008-05-22
申请号：US11936963
申请日：2007-11-08
申请人： H. Craig Dees , Timothy C. Scott , John Smolik , Eric A. Wachter , Walter G. Fisher
发明人： H. Craig Dees , Timothy C. Scott , John Smolik , Eric A. Wachter , Walter G. Fisher
IPC分类号： A61K33/14 , A61P43/00
CPC分类号： A61K31/352 , A61K33/14 , A61K41/00 , A61K2300/00
摘要： New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.
摘要翻译：描述了用于治疗人或动物组织的新的光动力学，局部适用药物和这种光动力药物的某些医学用途，其中这种药物的主要活性成分是卤代呫吨。卤化呫吨构成了一系列有效的光敏剂，在用可见光波长照射治疗部位时变得光活化。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官的各种病症; 口腔和消化道及相关器官; 泌尿生殖道及相关器官; 呼吸道及相关器官; 各种其他内部或外部组织表面，例如在手术期间暴露的组织表面; 并用于治疗与微生物或寄生虫感染有关的各种病症。在另一个优选的实施方案中，这种药物是以包括液体，半固体或气溶胶递送载体在内的各种制剂生产的。

7. 发明授权

US06991776B2 Intracorporeal medicaments for high energy phototherapeutic treatment of disease 有权
公开(公告)号：US06991776B2
公开(公告)日：2006-01-31
申请号：US10331854
申请日：2002-12-30
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K51/00
CPC分类号： A61K41/0038 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K31/352 , A61K41/0057 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y10S436/813 , Y10S436/819
摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

8. 发明授权

US08974363B2 Topical medicaments and methods for photodynamic treatment of disease 有权
标题翻译：疾病光动力治疗的专题药物和方法
公开(公告)号：US08974363B2
公开(公告)日：2015-03-10
申请号：US11936963
申请日：2007-11-08
申请人： H. Craig Dees , Timothy C. Scott , John Smolik , Eric A. Wachter , Walter G. Fisher
发明人： H. Craig Dees , Timothy C. Scott , John Smolik , Eric A. Wachter , Walter G. Fisher
IPC分类号： A61K31/352 , A61K33/14 , A61K41/00
CPC分类号： A61K31/352 , A61K33/14 , A61K41/00 , A61K2300/00
摘要： New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.
摘要翻译：描述了用于治疗人或动物组织的新的光动力学，局部适用药物和这种光动力药物的某些医学用途，其中这种药物的主要活性成分是卤代呫吨。卤化呫吨构成了一系列有效的光敏剂，在用可见光波长照射治疗部位时变得光活化。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官的各种病症; 口腔和消化道及相关器官; 泌尿生殖道及相关器官; 呼吸道及相关器官; 各种其他内部或外部组织表面，例如在手术期间暴露的组织表面; 并用于治疗与微生物或寄生虫感染有关的各种病症。在另一个优选的实施方案中，这种药物是以包括液体，半固体或气溶胶递送载体在内的各种制剂生产的。

9. 发明授权

US08470296B2 Intracorporeal medicaments for high energy phototherapeutic treatment of disease 有权
公开(公告)号：US08470296B2
公开(公告)日：2013-06-25
申请号：US11715780
申请日：2007-03-08
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K51/00
CPC分类号： A61K31/352
摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

10. 发明申请

US20110097280A1 Intracorporeal Medicaments for Photodynamic Treatment of Disease 审中-公开
标题翻译：体内光动力治疗疾病的体内药物
公开(公告)号：US20110097280A1
公开(公告)日：2011-04-28
申请号：US12981977
申请日：2010-12-30
申请人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K9/12 , A61K31/352 , A61P35/00 , A61P1/04 , A61P31/04 , A61P31/10 , A61P17/00 , A61P31/12
CPC分类号： A61K31/352 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K41/0038 , A61K41/0057 , A61K41/0071 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/153333 , Y10T436/19 , Y10T436/193333
摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的体内光动力学药物和用于治疗人或动物组织中的这种光动力药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤代呫吨衍生物。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个优选的实施方案中，这些药物以包括液体，半固体，固体或气溶胶递送载体的各种制剂生产。

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