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1. 发明授权

US06839585B2 Preloaded sensor holder 有权
标题翻译：预装传感器支架
公开(公告)号：US06839585B2
公开(公告)日：2005-01-04
申请号：US10370119
申请日：2003-02-19
申请人： Guy Russell Lowery , Asaf Danzinger , Yoram Wasserman , Yitzhak Mendelson , Charles Edward Beuchat
发明人： Guy Russell Lowery , Asaf Danzinger , Yoram Wasserman , Yitzhak Mendelson , Charles Edward Beuchat
IPC分类号： A61B5/00
CPC分类号： A61B5/6833 , A61B5/14552 , A61B5/1464
摘要： A holder for a sensor includes a body having a top wall and a side portion extending away from the top wall. The sensor is adapted to sense a parameter of an item. The top wall and the side portion of the body form an interior cavity. A flange is coupled to and extends away from an edge of the side portion. A pressure application portion is coupled to a surface of the interior cavity of the body and is adapted to apply force to the sensor when the holder is coupled to the surface of the item.
摘要翻译：用于传感器的保持器包括具有顶壁和远离顶壁延伸的侧部的主体。传感器适于感测物品的参数。主体的顶壁和侧部形成内部空腔。凸缘联接到侧部的边缘并且远离侧部的边缘延伸。压力施加部分联接到主体的内部空腔的表面，并且适于在保持器联接到物品的表面时向传感器施加力。

2. 发明授权

US5372135A Blood constituent determination based on differential spectral analysis 失效
标题翻译：基于差分光谱分析的血液成分测定
公开(公告)号：US5372135A
公开(公告)日：1994-12-13
申请号：US216083
申请日：1994-03-21
申请人： Yitzhak Mendelson , Hannu Harjunmaa , Yi Wang , Brian D. Gross
发明人： Yitzhak Mendelson , Hannu Harjunmaa , Yi Wang , Brian D. Gross
IPC分类号： G06F15/18 , A61B5/00 , G01N21/31 , G06K9/62 , G06K9/66 , G06N99/00
CPC分类号： A61B5/1455 , A61B5/14532 , G01N21/314
摘要： The present invention relates to the determination of an analyte or multiple analytes in blood using information derived from the differential optical absorption spectra of blood. Specifically, the information is derived from the differential spectra of tissue before and immediately after the volume of blood in the tissue has been changed.
摘要翻译：本发明涉及使用从血液的差分光吸收光谱得到的信息来确定血液中的分析物或多个分析物。具体地，该信息是从组织中的血液体积变化之前和之后的组织的差分光谱导出的。

3. 发明申请

US20200375513A1 PULSE OXIMETER SENSORS WITH REDUCED SENSITIVITY TO MOTION ARTIFACTS 审中-公开
公开(公告)号：US20200375513A1
公开(公告)日：2020-12-03
申请号：US16362084
申请日：2019-06-03
申请人： Rajesh S. Kasbekar , Yitzhak Mendelson
发明人： Rajesh S. Kasbekar , Yitzhak Mendelson
IPC分类号： A61B5/1455 , A61B5/00
摘要： A reflective PPG sensor, in which motion artifacts have a reduced effect, is configured to be placed on one of a forehead, a finger or a wrist of a subject on a location selected according to a predetermined range of a signal quality index and has a force per unit area between 0.3 N/cm2 and 1.5 N/cm2, and a bonding pressure, for sensor to skin adhesion, between 10 N/cm2 and 20 N/cm2. In one instance, the reflective PPG sensor of these teachings also has a weight between 6 g and 12 g.

4. 发明授权

US6084661A Optical method and apparatus for measuring carbon monoxide in non-hemolyzed blood 失效
标题翻译：用于测量非溶血血中一氧化碳的光学方法和装置
公开(公告)号：US6084661A
公开(公告)日：2000-07-04
申请号：US74186
申请日：1998-05-07
申请人： Yitzhak Mendelson , Karen Mendelson
发明人： Yitzhak Mendelson , Karen Mendelson
IPC分类号： G01N21/31 , G01N33/49 , G01N33/48
CPC分类号： G01N21/314 , G01N33/4925 , G01N2021/3148
摘要： Carbon Monoxide (CO) is a colorless, tasteless, and odorless gas which causes asphyxiation by combining with a strong affinity to blood hemoglobin. Unless a patient is quickly identified as having CO poisoning, the patient could face severe medical consequences including death.This patent describes a reagentless optical method for measuring carboxyhemoglobin (HbCO) in a whole undiluted blood sample that can be obtained from a fingerstick. A battery-operated triple wavelength device measures light transmission at frequencies of 548 nm, 810 nm and 950 nm through a 40 .mu.L sample of undiluted whole blood placed in standard disposable glass capillary tube. Having a portable point-of-care device, for uses by paramedics during an emergency situation, in the emergency room, or in a physician's office, can provide accurate immediate confirmation of CO poisoning.
摘要翻译：一氧化碳（CO）是一种无色，无味，无味的气体，通过结合对血液血红蛋白的强亲和力引起窒息。除非患者被快速识别为患有CO中毒，否则患者可能会面临严重的医疗后果，包括死亡。该专利描述了可以从指纹获得的全部未稀释血液样品中的测量碳氧血红蛋白（HbCO）的无试剂光学方法。电池供电的三重波长装置通过放置在标准一次性玻璃毛细管中的40μL未稀释全血样品测量548nm，810nm和950nm频率的光透射。在紧急情况下，在急诊室或医生办公室内设有便携式点护理装置，由医护人员使用，可以准确地立即确认CO中毒。

5. 发明授权

US5183042A Electromagnetic method and apparatus to measure constituents of human or animal tissue 失效
标题翻译：电磁方法和测量人体或动物组织成分的装置
公开(公告)号：US5183042A
公开(公告)日：1993-02-02
申请号：US725502
申请日：1991-07-03
申请人： Hannu Harjunmaa , Yitzhak Mendelson , Yi Wang
发明人： Hannu Harjunmaa , Yitzhak Mendelson , Yi Wang
IPC分类号： A61B5/00 , G01N21/31 , G01N21/35
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/6843 , G01N21/314 , G01N21/35 , G01N21/359
摘要： To deterine glucose or other constituents of the human or animal body, near-infrared radiation containing two alternating wavelengths that have equal extinction coefficients in the tissue is directed onto a sample area of the body. The intensity relation of the two different wavelengths is adjusted so as to balance the two wavelength detected signals. The extracellular-to-intracellular fluid ratio of the tissue is changed or is allowed to change, and the alternating component of the transmitted beam power is measured. The amplitude of the alternating-current (AC) signal given by the detector represents glucose concentration or the difference from a preset reference concentration.
摘要翻译：为了确定人体或动物身体的葡萄糖或其他成分，包含在组织中具有相同消光系数的两个交替波长的近红外辐射被引导到身体的样品区域上。调整两个不同波长的强度关系，以平衡两个波长检测信号。组织的细胞外 - 细胞内液体比例发生变化或被允许改变，并且测量透射光束功率的交替分量。由检测器给出的交流（AC）信号的幅度表示葡萄糖浓度或与预设参考浓度的差。

6. 发明授权

US5137023A Method and apparatus for monitoring blood analytes noninvasively by pulsatile photoplethysmography 失效
标题翻译：通过脉搏光谱法检测血液分析的方法和装置
公开(公告)号：US5137023A
公开(公告)日：1992-08-11
申请号：US511229
申请日：1990-04-19
申请人： Yitzhak Mendelson , Robert A. Peura , Hannu Harjunmaa
发明人： Yitzhak Mendelson , Robert A. Peura , Hannu Harjunmaa
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A non-invasive system for measuring the concentration of an analyte, such as glucose, in an absorbing matrix is described. The system directs beams of light at the matrix using an analyte sensitive wavelength and an analyte insensitive wavelength. The principles of photoplethysmography are applied to measure the change in light intensity caused by matrix absorption before and after the blood volume change caused by the systolic phase of the cardiac cycle. The change in light intensity is converted to an electrical signal which is used to adjust the light intensity and as a measure of analyte concentration.
摘要翻译：描述了用于测量吸收基质中分析物（例如葡萄糖）浓度的非侵入性系统。该系统使用分析物敏感波长和分析物不敏感波长将光束引导到基质。应用光电体积描描述的原理来测量由心脏周期的收缩期引起的血容量变化之前和之后基质吸收引起的光强变化。光强度的变化被转换为用于调节光强度和作为分析物浓度测量的电信号。

7. 发明授权

US5277181A Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis 失效
标题翻译：通过差分光学分析无创测量血细胞比容和血红蛋白含量
公开(公告)号：US5277181A
公开(公告)日：1994-01-11
申请号：US806144
申请日：1991-12-12
申请人： Yitzhak Mendelson , Yi Wang , Brian D. Gross
发明人： Yitzhak Mendelson , Yi Wang , Brian D. Gross
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/14551
摘要： The present invention relates to the noninvasive measurement of blood hematocrit and hemoglobin content using differential optical absorption of two or more wavelengths of light during blood volume changes. The method is also useful for noninvasive measurements of other blood analytes, such as glucose, where variations in hematocrit or blood hemoglobin concentration cause errors in the measurement.
摘要翻译：本发明涉及使用血液体积变化期间的两个或更多个波长的光的差分光吸收来进行血液血细胞比容和血红蛋白含量的无创测量。该方法还可用于其他血液分析物（如葡萄糖）的非侵入性测量，其中血细胞比容或血红蛋白浓度的变化导致测量误差。

8. 发明授权

US5112124A Method and apparatus for measuring the concentration of absorbing substances 失效
标题翻译：测量吸收物质浓度的方法和装置
公开(公告)号：US5112124A
公开(公告)日：1992-05-12
申请号：US511341
申请日：1990-04-19
申请人： Hannu Harjunmaa , Robert A. Peura , Yitzhak Mendelson
发明人： Hannu Harjunmaa , Robert A. Peura , Yitzhak Mendelson
IPC分类号： A61B10/00 , A61B5/00 , G01N21/27 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A non-invasive system for measuring the concentration of an analyte in an absorbing matrix is described. The system directs a beam of radiation at the matrix. The beam consists of a series of successive alternate pulses of electro-magnetic radiation, one of which is highly absorbed by the analyte and the other of which is non-absorbed. The transmitted or reflected beam is optically detected and an electrical signal proportional to beam intensity is used to adjust the beam intensity and as a measure of analyte concentration.
摘要翻译：描述了用于测量吸收基质中分析物浓度的非侵入性系统。系统将辐射束引导到矩阵。光束由一系列连续的电磁辐射交替脉冲组成，其中之一被分析物高度吸收，另一个不被吸收。透射或反射的光束被光学检测，并且使用与光束强度成比例的电信号来调节光束强度和作为分析物浓度的量度。

9. 发明申请

US20160367198A1 APPARATUS AND METHOD FOR DETECTING AND REMOVING ARTIFACTS IN OPTICALLY ACQUIRED BIOLOGICAL SIGNALS 审中-公开
标题翻译：在光学获取的生物信号中检测和去除人造物的装置和方法
公开(公告)号：US20160367198A1
公开(公告)日：2016-12-22
申请号：US15121277
申请日：2015-02-26
申请人： Ki H. Chon , Jo Woon Chong , Yitzhak Mendelson , S.M.A. Salehizadeh , Duy K. Dao
发明人： Ki H. Chon , Jo Woon Chong , Yitzhak Mendelson , S.M.A. Salehizadeh , Duy K. Dao
IPC分类号： A61B5/00 , A61B5/024
CPC分类号： A61B5/7267 , A61B5/02416 , A61B5/7207 , A61B5/7221
摘要： Systems and methods that can distinguish clean from corrupted PPG signals under various types of motions and reconstruct the MNA contaminated data segments, such that biological parameters, e.g., heart rates and SpO2 values, can be accurately estimated, are disclosed.
摘要翻译：公开了可以精确地估计生物学参数，例如心率和SpO2值的系统和方法，其可以区分各种运动下的干扰和损坏的PPG信号并重构MNA污染的数据段。

10. 发明授权

US06801799B2 Pulse oximeter and method of operation 有权
标题翻译：脉搏血氧仪及操作方法
公开(公告)号：US06801799B2
公开(公告)日：2004-10-05
申请号：US10360666
申请日：2003-02-06
申请人： Yitzhak Mendelson
发明人： Yitzhak Mendelson
IPC分类号： A61B500
CPC分类号： A61B5/14552 , A61B5/1455
摘要： A sensor for use in an optical measurement device and a method for non-invasive measurement of a blood parameter. The sensor includes sensor housing, a source of radiation coupled to the housing, and a detector assembly coupled to the housing. The source of radiation is adapted to emit radiation at predetermined frequencies. The detector assembly is adapted to detect reflected radiation at least one predetermined frequency and to generate respective signals. The signals are used to determine the parameter of the blood.
摘要翻译：用于光学测量装置的传感器和用于非侵入式测量血液参数的方法。传感器包括传感器外壳，耦合到壳体的辐射源，以及耦合到壳体的检测器组件。辐射源适于以预定频率发射辐射。检测器组件适于检测至少一个预定频率的反射辐射并产生相应的信号。这些信号用于确定血液的参数。

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