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1. 发明授权

US08026231B2 Aminothiolester compounds, pharmaceutical and cosmetic compositions containing same and uses thereof 有权
标题翻译：氨基硫酯化合物，含有它们的药物和化妆品组合物及其用途
公开(公告)号：US08026231B2
公开(公告)日：2011-09-27
申请号：US11390480
申请日：2006-03-28
申请人： Guy Fournet , Gerard Anthony Quash , Jacques Gore
发明人： Guy Fournet , Gerard Anthony Quash , Jacques Gore
IPC分类号： A61K31/33 , A61K31/535 , A01N37/00 , C07D279/10 , C07D265/30 , C07D295/00 , C07C327/00
CPC分类号： C07D295/145 , C07C327/22
摘要： The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (cancers and precancers, dermatological, rheumatic and ophthalmological complaints in particular) or in cosmetic compositions. The invention also relates to a pharmaceutical or cosmetic composition, characterized in that it comprises, as active agent, a compound of general formula (I) in combination with a pharmaceutically or cosmetically acceptable support.
摘要翻译：本发明涉及具有通式（I）的新型氨基硫醇酯化合物：以及用于制备它们的方法及其在药物组合物中的用途，其用于人或兽医学（癌症和预防剂，皮肤病学，风湿性和眼科学中的投诉）特别）或在化妆品组合物中。本发明还涉及一种药物或化妆品组合物，其特征在于其包含作为活性剂的通式（I）的化合物与药学上或化学上可接受的载体的组合。

2. 发明授权

US07078402B2 Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof 有权
标题翻译：氨基硫醇酯化合物，含有其的药物和化妆品组合物及其用途
公开(公告)号：US07078402B2
公开(公告)日：2006-07-18
申请号：US10296927
申请日：2001-05-31
申请人： Guy Fournet , Gerard Anthony Quash , Jacques Gore
发明人： Guy Fournet , Gerard Anthony Quash , Jacques Gore
IPC分类号： A61K31/535 , A61K31/40 , A61K31/305 , A01N43/36 , A01N43/26
CPC分类号： C07D295/145 , C07C327/22
摘要： The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (cancers and precancers, dermatological, rheumatic and ophthalmological complaints in particular) or in cosmetic compositions. The invention also relates to a pharmaceutical or cosmetic composition, characterized in that it comprises, as active agent, a compound of general formula (I) in combination with a pharmaceutically or cosmetically acceptable support.
摘要翻译：本发明涉及具有通式（I）的新型氨基硫醇酯化合物：以及用于制备它们的方法及其在药物组合物中的用途，其用于人或兽医学（癌症和预防剂，皮肤病学，风湿性和眼科学中的投诉）特别）或在化妆品组合物中。本发明还涉及一种药物或化妆品组合物，其特征在于其包含作为活性剂的通式（I）的化合物与药学上或化学上可接受的载体的组合。

3. 发明授权

US6117902A 6,8-dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical and pharmaceutical compositions intended for the treatment of cancerous tumors 失效
标题翻译：在6-S和/或8-S位置用（3-甲硫基丙酰基）基取代的6,8-二巯基辛酸衍生物和用于治疗癌性肿瘤的药物组合物
公开(公告)号：US6117902A
公开(公告)日：2000-09-12
申请号：US281654
申请日：1999-03-30
申请人： Gerard Anthony Quash , Jacques Gore , Guy Fournet
发明人： Gerard Anthony Quash , Jacques Gore , Guy Fournet
IPC分类号： C07D295/18 , A61K31/00 , A61K31/20 , A61K31/23 , A61K31/495 , A61P35/00 , A61P43/00 , C07C327/32 , C07D295/185 , A61K31/225 , C07C327/04 , C07C327/18
CPC分类号： C07D295/185 , C07C327/32
摘要： The present invention provides 6,8-Dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical, wherein they correspond to the following formula (I): ##STR1## in which: R represents OR.sub.3 or ##STR2## R.sub.3 representing a hydrogen atom, a linear or branched alkyl radical, or a radical of the formula ##STR3## n being an integer from 1 to 10 and r' and r", which are identical or different, representing a hydrogen atom, a linear or branched alkyl radical or, taken together, form with the nitrogen atom, a nitrogen-containing heterocycle optionally substituted with an optionally substituted oxygen or nitrogen atom,R.sub.5 and R.sub.4, identical or different, represent a hydrogen atom or a linear or branched alkyl radical,R.sub.1 and R.sub.2, which are identical or different, represent a hydrogen atom, a radical --COCH.sub.3 or a radical of formula:--CO(CH.sub.2).sub.2 SCH.sub.3 (II)with the proviso that at least one of the radicals R.sub.1 or R.sub.2 represents a radical of formula (II) and the R and S enantiomers and their racemate as well as the salts of the said compounds of formula (I). The present invention also provides pharmaceutical compositions, and method of treatment and prevention of cancerous tumours.
摘要翻译：本发明提供在6-S和/或8-S位置与（3-甲硫基丙酰基）基取代的6,8-二巯基辛酸衍生物，其中它们对应于下式（I）：其中：R表示OR 3 或R3表示氢原子，直链或支链烷基或式n的基团为1至10的整数，r'和r“可相同或不同，表示氢原子，直链或支链烷基支链烷基或与氮原子一起形成，任选被任选取代的氧或氮原子取代的含氮杂环，相同或不同的R 5和R 4表示氢原子或直链或支链烷基， R 1和R 2相同或不同，表示氢原子，基团-COCH 3或式-CO-CH（CH 2）2 SCH 3（II）的基团，条件是基团R 1或R 2中的至少一个表示基团的式（II）和R和S对映异构体和它们的外消旋物以及所述式（I）化合物的盐。本发明还提供药物组合物以及治疗和预防癌性肿瘤的方法。

4. 发明授权

US5744499A Apoptosis-modulating factors influencing the intracellular concentration of methional/malondialdehyde 失效
标题翻译：细胞凋亡调节因子影响细胞内甲基丙二醛浓度
公开(公告)号：US5744499A
公开(公告)日：1998-04-28
申请号：US579244
申请日：1995-12-28
申请人： Gerard Anthony Quash , Alain Doutheau
发明人： Gerard Anthony Quash , Alain Doutheau
IPC分类号： A61K8/30 , A61K8/00 , A61K8/35 , A61K8/36 , A61K8/37 , A61K8/44 , A61K8/49 , A61K8/66 , A61K8/98 , A61K31/11 , A61K31/19 , A61K31/44 , A61K45/00 , A61P17/00 , A61P35/00 , A61P43/00 , A61Q5/02 , A61Q19/00 , A61Q19/08 , A61K31/15
CPC分类号： A61K31/11 , A61K31/44
摘要： Apoptosis (programmed cell death) in mammalian organisms is modulated, whether initiated or suppressed, for example for preventing and/or combating photoinduced or chronologic aging of the skin or for treating a wide variety of human afflictions, by administering thereto, for such prolonged period of time as is required to elicit the desired response, an effective apoptosis-modulating amount of at least one active species selected from among methional, malondialdehyde, or factor influencing the intracellular concentration of methional or malondialdehyde.
摘要翻译：哺乳动物生物体中的细胞凋亡（程序性细胞死亡）被调节，无论是起始的还是抑制的，例如用于预防和/或防治皮肤的光诱导或延缓衰老或治疗各种各样的人类疾病，的时间，以引起所需的反应，有效的凋亡调节量的至少一种选自甲硫氨酸，丙二醛或影响细胞内或丙二醛浓度的因子。

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