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1. 发明授权

US07893064B2 Hydrazone derivatives as kinase inhibitors 有权
标题翻译：腙衍生物作为激酶抑制剂
公开(公告)号：US07893064B2
公开(公告)日：2011-02-22
申请号：US11871472
申请日：2007-10-12
申请人： Guozhang Xu , Lily Lee Searle , Shenlin Huang
发明人： Guozhang Xu , Lily Lee Searle , Shenlin Huang
IPC分类号： C07D403/12 , A61K31/506
CPC分类号： C07D403/12
摘要： The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof as inhibitors of ATP-protein kinase interactions, wherein substituents on each side of the iminomethyl double bond in Formula (I) may be in the E or Z configuration; and wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译：本发明涉及式（I）的新型双环嘧啶化合物或其形式或组成作为ATP-蛋白激酶相互作用的抑制剂，其中式（I）中亚氨基甲基双键各侧的取代基可以在E 或Z配置; 并且其中R 1，R 2，R 3和R 4如本文所定义。

2. 发明申请

US20110237625A1 SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-á MODULATORS 有权
标题翻译：作为雌激素相关受体 - 阿尔法调节剂的取代的苯氧基噻唑烷二酮
公开(公告)号：US20110237625A1
公开(公告)日：2011-09-29
申请号：US12899812
申请日：2010-10-07
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/454 , C07D277/34 , A61K31/426 , C07D263/44 , A61K31/421 , A61P19/00 , A61P11/00 , A61P35/00 , A61P3/00 , A61P9/12
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

3. 发明授权

US07846953B2 Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators 有权
标题翻译：取代苯氧基噻唑烷二酮类作为雌激素相关受体α调节剂
公开(公告)号：US07846953B2
公开(公告)日：2010-12-07
申请号：US12043269
申请日：2008-03-06
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/426 , C07D277/04
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

4. 发明申请

US20090111855A1 SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-alpha MODULATORS 有权
标题翻译：作为雌激素相关受体-α调节剂的取代的苯氧基噻唑烷
公开(公告)号：US20090111855A1
公开(公告)日：2009-04-30
申请号：US12043269
申请日：2008-03-06
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/454 , C07D277/34 , A61K31/426 , A61K31/421 , C07D263/44 , A61P3/04
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

5. 发明授权

US08344009B2 Substituted phenoxy thiazolidinediones as estrogen related receptor-á modulators 有权
标题翻译：取代苯氧基噻唑烷二酮作为雌激素相关受体α调节剂
公开(公告)号：US08344009B2
公开(公告)日：2013-01-01
申请号：US12899812
申请日：2010-10-07
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/426 , C07D277/04
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

6. 发明申请

US20070254896A1 SUBSTITUTED PYRIMIDINE KINASE INHIBITORS 有权
标题翻译：取代的吡咯嗪激酶抑制剂
公开(公告)号：US20070254896A1
公开(公告)日：2007-11-01
申请号：US11690305
申请日：2007-03-23
申请人： Jeannene Butler , Peter Connolly , Angel Fuentes-Pesquera , Lee Greenberger , Shenlin Huang , Kenneth LaMontagne , Ronghua Li , Guozhang Xu
发明人： Jeannene Butler , Peter Connolly , Angel Fuentes-Pesquera , Lee Greenberger , Shenlin Huang , Kenneth LaMontagne , Ronghua Li , Guozhang Xu
IPC分类号： A61K31/505 , A61P25/00 , A61P35/00 , C07D239/30 , C07D239/34
CPC分类号： C07D401/12 , C07D239/47 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/14 , C07D417/12
摘要： The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.
摘要翻译：本发明涉及式（I）的取代嘧啶化合物及其形式，其用于治疗慢性或急性蛋白激酶介导的疾病，病症或病症的合成和用途。

7. 发明申请

US20080114004A1 HYDRAZONE DERIVATIVES AS KINASE INHIBITORS 有权
标题翻译：氢化衍生物作为激酶抑制剂
公开(公告)号：US20080114004A1
公开(公告)日：2008-05-15
申请号：US11871472
申请日：2007-10-12
申请人： Guozhang Xu , Lily Searle , Shenlin Huang
发明人： Guozhang Xu , Lily Searle , Shenlin Huang
IPC分类号： A61K31/497 , C07D401/12 , A61P35/00 , A61P17/06 , A61P17/00 , A61P19/02 , A61P25/00
CPC分类号： C07D403/12
摘要： The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof as inhibitors of ATP-protein kinase interactions, wherein substituents on each side of the iminomethyl double bond in Formula (I) may be in the E or Z configuration; and wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译：本发明涉及式（I）的新型双环嘧啶化合物或其形式或组成作为ATP-蛋白激酶相互作用的抑制剂，其中式（I）中亚氨基甲基双键各侧的取代基可以在E 或Z配置; 并且其中R 1，R 2，R 3和R 4都如本文所定义。

8. 发明授权

US08013153B2 Substituted pyrimidine kinase inhibitors 有权
标题翻译：取代的嘧啶激酶抑制剂
公开(公告)号：US08013153B2
公开(公告)日：2011-09-06
申请号：US11690305
申请日：2007-03-23
申请人： Jeannene Butler , Peter J. Connolly , Angel R. Fuentes-Pesquera , Lee M. Greenberger , Shenlin Huang , Kenneth R. LaMontagne, Jr. , Ronghua Li , Guozhang Xu
发明人： Jeannene Butler , Peter J. Connolly , Angel R. Fuentes-Pesquera , Lee M. Greenberger , Shenlin Huang , Kenneth R. LaMontagne, Jr. , Ronghua Li , Guozhang Xu
IPC分类号： C07D403/12 , C07D403/14 , A61K31/506 , A61P19/02
CPC分类号： C07D401/12 , C07D239/47 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/14 , C07D417/12
摘要： The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.
摘要翻译：本发明涉及式（I）的取代嘧啶化合物及其形式，它们用于治疗慢性或急性蛋白激酶介导的疾病，病症或病症的合成和用途。

9. 发明授权

US09045389B2 Biphenyl derivatives useful as glucagon receptor antagonists 有权
标题翻译：可用作胰高血糖素受体拮抗剂的联苯衍生物
公开(公告)号：US09045389B2
公开(公告)日：2015-06-02
申请号：US13478568
申请日：2012-05-23
申请人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
发明人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC分类号： A61K31/166 , C07C229/52 , C07C237/36
CPC分类号： C07C237/36
摘要： The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。

10. 发明申请

US20110200587A1 AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS 有权
公开(公告)号：US20110200587A1
公开(公告)日：2011-08-18
申请号：US13028284
申请日：2011-02-16
申请人： Gilles Bignan , Micheal Gaul , Guozhang Xu , Bao-Ping Zhao
发明人： Gilles Bignan , Micheal Gaul , Guozhang Xu , Bao-Ping Zhao
IPC分类号： A61K39/395 , C07D417/10 , C07D417/14 , C07D453/02 , A61K31/4985 , A61K31/427 , A61K31/5377 , A61K31/496 , A61K31/4439 , A61K31/454 , A61K31/439 , A61K31/506 , A61P19/08 , A61P19/06 , A61P19/10 , A61P35/04 , A61P35/00 , A61P19/02 , A61P17/06 , A61P1/02 , A61P29/00 , A61P11/00 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P7/02
CPC分类号： C07D417/06 , C07D417/14
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

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