专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4167570A 2-Methyl-6-alkyl-11-aminoalkyl-6,11-dihydro-5H-pyrido(2,3-B)(1,5)benzodia zepin-5-ones and salts thereof 失效
标题翻译： 2-甲基-6-烷基-11-氨基烷基-6,11-二氢-5H-吡啶并（2,3-B）（1,5）苯并二氮杂-5-酮及其盐
公开(公告)号：US4167570A
公开(公告)日：1979-09-11
申请号：US837578
申请日：1977-09-28
申请人： Gunther Schmidt , Sigfrid Puschmann , Gunther Engelhardt
发明人： Gunther Schmidt , Sigfrid Puschmann , Gunther Engelhardt
IPC分类号： A61K31/55 , A61K31/551 , A61P11/08 , A61P11/10 , C07D213/80 , C07D471/04
CPC分类号： C07D213/80 , C07D471/04 , Y10S514/826 , Y10S514/959 , Y10S514/962 , Y10S514/966
摘要： Compounds of the formula ##STR1## wherein R.sub.1 --is hydrogen, alkyl of 1 to 6 carbon atoms or benzyl;R.sub.2 --is alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 7 carbon atoms or, together with R.sub.1 and the adjacent nitrogen atom, pyrrolidino, piperidino, hexamethyleneimino, morpholino or N'-methyl-piperazino, where each of the heterocycles may have one or two alkyl of 1 to 3 carbon atoms or one or two methoxy substituents attached thereto;R.sub.3,--r.sub.4 and R.sub.5 are each hydrogen or methyl;R.sub.6 --is alkyl of 1 to 4 carbon atoms; andA--is alkylene of 2 to 4 carbon atoms;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as bronchospasmolytics and bronchosecretolytics.
摘要翻译：其中R 1是氢，1至6个碳原子的烷基或苄基的式IMAMA的化合物; R 2 - 为1至6个碳原子的烷基，5至7个碳原子的环烷基，或与R 1和相邻氮原子一起为吡咯烷子基，哌啶子基，六亚甲基亚氨基，吗啉代或N'-甲基哌嗪子基，其中每个杂环可以具有一个或两个具有1至3个碳原子的烷基或与其连接的一个或两个甲氧基取代基; R3，-R4和R5各自为氢或甲基; R6是1-4个碳原子的烷基; 且A为2至4个碳原子的亚烷基; 和非毒性，药理学上可接受的酸添加量; 化合物作为其生物利用作为BRONCHOSPASMOLYTICS和BRONCHOSECRETOLYTICS有用。

2. 发明授权

US4021557A 11-Aminoalkyl-pyridobenzodiazepinones and salts thereof 失效
标题翻译： 11-氨基烷基 - 吡啶并二氮杂酮及其盐
公开(公告)号：US4021557A
公开(公告)日：1977-05-03
申请号：US570805
申请日：1975-04-23
申请人： Gunther Schmidt , Gunther Engelhardt , Sigfrid Puschmann
发明人： Gunther Schmidt , Gunther Engelhardt , Sigfrid Puschmann
IPC分类号： C07D243/38 , A61K31/00 , A61P11/08 , A61P11/10 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, straight or branched alkyl of 1 to 3 carbon atoms or benzyl,R.sub.2 is straight or branched alkyl of 1 to 3 carbon atoms, orR.sub.1 and R.sub.2, together with each other and the nitrogen atom to which they are attached, are pyrrolidino, piperidino or hexamethyleneimino,A and B are each nitrogen or methylidenyl (=CH-), but other than both nitrogen or methylidenyl at the same time, andn is 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as bronchospasmolytics.
摘要翻译：其中R 1为氢，1至3个碳原子的直链或支链烷基或苄基，R2为具有1至3个碳原子的直链或支链烷基，或R 1和R 2，彼此和氮它们所连接的原子是吡咯烷子基，哌啶子基或六亚甲基亚氨基，A和B各自同时为氮或亚甲基（= CH-），但不包括氮或亚甲基，N和N为2或3，毒性，药理学上可接受的酸添加量; 化合物作为BRONCHOSPASMOLYTICS有用的销售。

3. 发明授权

US4292319A Antiphlogistic pharmaceutical compositions and method of use 失效
标题翻译：消炎药组合物及其使用方法
公开(公告)号：US4292319A
公开(公告)日：1981-09-29
申请号：US168608
申请日：1980-07-14
申请人： Oswald Tauber , Gunther Engelhardt , Matyas Leitold , Gunther Schmidt
发明人： Oswald Tauber , Gunther Engelhardt , Matyas Leitold , Gunther Schmidt
IPC分类号： A61K31/045 , A61K31/19 , A61K31/195 , A61K31/22 , A61K31/405 , A61K31/415 , A61K31/55 , A61K45/00 , A61P29/00 , C07D471/04 , A61K31/40 , A61K31/445 , A61K31/495
CPC分类号： A61K31/55 , A61K31/60 , Y10S514/825 , Y10S514/974
摘要： Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.
摘要翻译：含有非甾体抗炎化合物和5,11-二氢-11 - [（4-甲基-1-哌嗪基） - 乙酰基] -6H-吡啶并[2,3-b] - [1,4] 苯并二氮杂-6-酮或其无毒酸加成盐，以及其用作消炎剂的方法; 吡啶并苯并二氮杂酮成分有效地抑制了抗炎成分的胃肠副作用。

4. 发明授权

US4154833A Antiphlogistic pharmaceutical composition and method of use 失效
标题翻译：消炎药组合物及其使用方法
公开(公告)号：US4154833A
公开(公告)日：1979-05-15
申请号：US878904
申请日：1978-02-17
申请人： Oswald Tauber , Gunther Engelhardt , Matyas Leitold , Gunther Schmidt
发明人： Oswald Tauber , Gunther Engelhardt , Matyas Leitold , Gunther Schmidt
IPC分类号： A61K31/045 , A61K31/19 , A61K31/195 , A61K31/22 , A61K31/405 , A61K31/415 , A61K31/55 , A61K45/00 , A61P29/00 , C07D471/04 , A61K31/40 , A61K31/495
CPC分类号： A61K31/55 , A61K31/60 , Y10S514/825 , Y10S514/974
摘要： Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.
摘要翻译：含有非甾体抗炎化合物和5,11-二氢-11 - [（4-甲基-1-哌嗪基） - 乙酰基] -6H-吡啶并[2,3-b] - [1,4] 苯并二氮杂-6-酮或其无毒酸加成盐，以及其用作消炎剂的方法; 吡啶并苯并二氮杂酮成分有效地抑制了抗炎成分的胃肠副作用。

5. 发明授权

US4328235A Suppressing pain with benzothiazol-2(3H)-ones 失效
标题翻译：用苯并噻唑-2（3H）酮抑制疼痛
公开(公告)号：US4328235A
公开(公告)日：1982-05-04
申请号：US163965
申请日：1980-06-30
申请人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
发明人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/425 , A61K31/428 , A61P25/04 , A61P29/00 , C07D277/68
CPC分类号： C07D277/68 , A61K31/425
摘要： There are described pharmaceutical compositions containing as active substances benzothiazol-2(3H)-ones of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl, methoxy, or ethoxy group. The pharmaceutical compositions serve as analgesics and antipyretics and possess little or no methemoglobin-forming activity.
摘要翻译：描述了含有作为活性物质的通式为“IMAGE”的苯并噻唑-2（3H） - 酮的药物组合物，其中R表示氢原子或甲基，甲氧基或乙氧基。药物组合物用作止痛剂和解热药，并且几乎没有或没有高铁血红蛋白形成活性。

6. 发明授权

US4256747A Antiphlogistic pharmaceutical compositions and method of use 失效
公开(公告)号：US4256747A
公开(公告)日：1981-03-17
申请号：US25718
申请日：1979-03-30
申请人： Oswald Tauber , Gunther Engelhardt , Matyas Leitold , Gunther Schmidt
发明人： Oswald Tauber , Gunther Engelhardt , Matyas Leitold , Gunther Schmidt
IPC分类号： A61K31/045 , A61K31/19 , A61K31/195 , A61K31/22 , A61K31/405 , A61K31/415 , A61K31/55 , A61K45/00 , A61P29/00 , C07D471/04 , A61K31/495
CPC分类号： A61K31/55 , A61K31/60 , Y10S514/825 , Y10S514/974
摘要： Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.

7. 发明授权

US4381303A 1,4,9,10-Tetrahydro-pyrazolo [4,3-]pyrido[-3,2-b][1,4]diazepin-10-ones 失效
标题翻译： 1,4,9,10-四氢 - 吡唑并[4,3]吡啶并[-3,2-b] [1,4]二氮杂-10-酮
公开(公告)号：US4381303A
公开(公告)日：1983-04-26
申请号：US377911
申请日：1982-05-13
申请人： Gunther Schmidt , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gunther Engelhardt
发明人： Gunther Schmidt , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gunther Engelhardt
IPC分类号： A61K31/55 , A61K31/5517 , A61P25/04 , A61P29/00 , C07D231/16 , C07D471/14
CPC分类号： C07D471/14 , C07D231/16
摘要： This invention is directed to the compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or an alkyl of from 1 to 6 carbon atoms;R.sub.2 is an alkyl of from 1 to 3 carbon atoms;R.sub.3 is hydrogen or an alkyl of from 1 to 3 carbon atoms; andR.sub.4 is hydrogen or an alkyl of from 1 to 4 carbon atoms.These compounds are useful in pharmaceutical compositions which serve as analgesics, antiphlogistics and antipyretics.
摘要翻译：本发明涉及式（I）的化合物，其中R 1是氢或1至6个碳原子的烷基; R2是1至3个碳原子的烷基; R3是氢或1至3个碳原子的烷基; 且R 4为氢或1至4个碳原子的烷基。这些化合物可用作用作镇痛药，消炎药和解热药的药物组合物。

8. 发明授权

US4353919A Analgesic and antipyretic pharmaceutical compositions containing a benzothiazol-2(3H)-one 失效
标题翻译：含有苯并噻唑-2（3H） - 酮的镇痛药和解热药物组合物
公开(公告)号：US4353919A
公开(公告)日：1982-10-12
申请号：US254539
申请日：1981-04-15
申请人： Wolfhard Engel , Gunter Trummlitz , Wolfgang Eberlein , Gunther Schmidt , Gunther Engelhardt , Rainer Zimmermann
发明人： Wolfhard Engel , Gunter Trummlitz , Wolfgang Eberlein , Gunther Schmidt , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/425 , C07D277/68
CPC分类号： C07D277/68 , A61K31/425 , Y10S514/916
摘要： Analgesic and antipyretic pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.5 is methyl or methoxy, and R.sub.4, R.sub.6 and R.sub.7 are hydrogen; orR.sub.6 is fluorine or chlorine, and R.sub.4, R.sub.5 and R.sub.7 are hydrogen; orR.sub.7 is chlorine, and R.sub.4, R.sub.5 and R.sub.6 are hydrogen; orR.sub.5 and R.sub.6 are methoxy, and R.sub.4 and R.sub.7 are hydrogen; orR.sub.4 is methyl or chlorine, and R.sub.5, R.sub.6 and R.sub.7 are hydrogen;and methods of using said compounds as analgesics and antipyretics.
摘要翻译：镇痛药和解热药物单位组合物，其含有下式的化合物作为活性成分：其中R5是甲基或甲氧基，R4，R6和R7是氢; 或R6是氟或氯，R4，R5和R7是氢; 或R 7为氯，R 4，R 5和R 6为氢; 或R5和R6是甲氧基，R4和R7是氢; 或R4是甲基或氯，R5，R6和R7是氢; 以及使用所述化合物作为止痛剂和解热剂的方法。

9. 发明授权

US5061098A Printer station with output discharging device for individual sheets 失效
标题翻译：带单张纸的出纸装置的打印机
公开(公告)号：US5061098A
公开(公告)日：1991-10-29
申请号：US384736
申请日：1989-07-21
申请人： Gunther Engelhardt , Gerhard Lohrmann , Helmut Riesenegger
发明人： Gunther Engelhardt , Gerhard Lohrmann , Helmut Riesenegger
IPC分类号： B41J13/10
CPC分类号： B41J13/106
摘要： A printer station (1) with output discharging device (3) for individual sheets (6) is in particular used for laser page printers. An outwardly directed output discharging device (3) follows to output roller pairs (5), as seen in transport direction (7) of the printed individual sheets (6). In order to dispose the output discharging device (3) in a space-saving fashion, and in order to create the possibility for the operator to adjust the output discharging device (3) to the local special situation, the output discharging device (3) is tiltably supported at the printer frame (4) of the printer station (1), where the output discharging device (3) is furnished with drivable friction roller pairs (13), disposed behind the output roller pairs (5), as seen in transport direction (7). The shafts (14, 15) of the friction roller pairs (13) are in each case rotatably supported at the side walls (8,9) of the tiltable output discharging device (3).
摘要翻译：具有用于单张纸（6）的输出排出装置（3）的打印机站（1）特别用于激光打印机。如印刷的单张纸（6）的输送方向（7）所见，输出辊对（5）的向外指示的输出排出装置（3）。为了以节省空间的方式配置输出排出装置（3），为了使操作者将输出排出装置（3）调整到本地特殊情况的可能性，输出排出装置（3）被可倾斜地支撑在打印机站（1）的打印机框架（4）处，其中输出排放装置（3）配备有设置在输出辊对（5）后面的可驱动的摩擦辊对（13），如运输方向（7）。摩擦辊对（13）的轴（14,15）各自可旋转地支撑在可倾斜输出排放装置（3）的侧壁（8,9）处。

10. 发明授权

US4244967A Antiphlogistic pharmaceutical compositions containing a phenylethanolamine and methods of use 失效
标题翻译：含有苯乙醇胺的消炎药物组合物及其使用方法
公开(公告)号：US4244967A
公开(公告)日：1981-01-13
申请号：US72553
申请日：1979-09-04
申请人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus Noll , Helmut Pieper , Rainer Zimmermann
发明人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus Noll , Helmut Pieper , Rainer Zimmermann
IPC分类号： A61K31/135 , A61K31/17 , A61K31/275 , A61K31/325 , A61P29/00 , A61P43/00 , A61K31/27
CPC分类号： A61K31/135 , A61K31/17 , A61K31/275 , A61K31/325
摘要： The method of using compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, cyano, trifluoromethyl, nitro or alkyl of 1 to 4 carbon atoms,R.sub.3 is cycloalkyl or alkyl, each of 3 to 5 carbon atoms, andR.sub.4 is hydrogen or --CO--R.sub.5, whereR.sub.5 is alkoxy of 1 to 5 carbon atoms, alkenyloxy of 2 to 5 carbon atoms, aryloxy of 6 to 10 carbon atoms, aralkoxy of 7 to 11 carbon atoms, or amino which may be mono- or di-substituted by alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, aryl of 6 to 10 carbon atoms and/or aralkyl of 7 to 11 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof as antirheumatics and antiphlogistics.
摘要翻译：使用下式化合物的方法其中R1是氢，氟，氯，溴，碘或氰基，R2是氟，氰基，三氟甲基，硝基或1-4个碳原子的烷基，R3是环烷基或烷基， 3〜5个碳原子，R4为氢或-CO-R5，R5为1〜5个碳原子的烷氧基，2〜5个碳原子的烯氧基，6〜10个碳原子的芳氧基，7〜11个芳氧基碳原子或可以被1至5个碳原子的烷基，2至5个碳原子的烯基，6至10个碳原子的芳基和/或7至11个碳原子的芳烷基单取代或二取代的氨基，以及无毒，药理学上可接受的酸加成盐作为抗风湿剂和消炎药。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式