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    • 2. 发明授权
    • Integrated lung therapy method
    • 综合肺部治疗方法
    • US06308705B1
    • 2001-10-30
    • US09467881
    • 1999-12-21
    • Thomas RupprechtRainer Kuth
    • Thomas RupprechtRainer Kuth
    • A61M1600
    • A61M16/10A61B5/055A61M2202/02A61M2230/205
    • In a lung therapy method, hyperpolarized gas is administered for one breath to a subject, and a magnetic resonance scan of at least one lung of the subject is conducted. The data obtained from the scan are evaluated, specifically to determine the extent and distribution of infusion of hyperpolarized gas in the lung, as an indication of the alveolae in the lung which are open. Based on the evaluation of the data obtained in the magnetic resonance scan, a determination is made as to whether administration of a surfactant is necessary in order to improve opening of the lung. If a surfactant is administered, the procedure can be repeated to obtain an updated dataset, which can be evaluated to determine whether the administered surfactant has been effective.
    • 在肺部治疗方法中,对受试者进行一次呼吸的超极化气体,并进行受试者的至少一个肺的磁共振扫描。 评估从扫描获得的数据,特别是确定肺中超极化气体输注的程度和分布,作为开放的肺中的肺泡的指示。 基于对磁共振扫描中获得的数据的评估,确定为了改善肺的开放是否需要施用表面活性剂。 如果施用表面活性剂,则可以重复该过程以获得更新的数据集,其可以被评估以确定所施用的表面活性剂是否有效。
    • 9. 发明授权
    • Asthma analysis method employing hyperpolarized gas and magnetic resonance imaging
    • 哮喘分析方法采用超极化气体和磁共振成像
    • US06338836B1
    • 2002-01-15
    • US09406372
    • 1999-09-28
    • Rainer KuthThomas Rupprecht
    • Rainer KuthThomas Rupprecht
    • A61K4900
    • A61K49/1815A61K49/0004Y10T436/24
    • In an integrated asthma analysis and therapy determination method, a patient is administered hyperpolarized gas and an magnetic resonance (MR) scan is conducted to obtain a first MR image set, and the patient is then administered an allergen provoker and is again administered hyperpolarized gas and another MR scan is conducted, to obtain a second MR image set. This is followed by administering asthma therapeutics and again administering hyperpolarized gas to the subject, and another MR scan is conducted to obtain a third image data set. The first, second and third image data sets are compared among each other in order to determine the effect of the allergen provoker and the effect of the asthma therapeutics, in order to determine an appropriate medication dosage for the subject.
    • 在综合哮喘分析和治疗测定方法中,给予患者超极化气体并进行磁共振(MR)扫描以获得第一MR图像组,然后向患者施用过敏原检疫者,并再次施用超极化气体和 进行另一MR扫描,以获得第二MR图像集。 随后施用哮喘治疗剂并再次对受试者施用超极化气体,并进行另一MR扫描以获得第三图像数据集。 将第一,第二和第三图像数据集彼此进行比较,以便确定过敏原检疫者的效果和哮喘治疗剂的作用,以确定受试者的适当药物剂量。
    • 10. 发明授权
    • Method for monitoring growth disorder therapy
    • 监测生长障碍治疗的方法
    • US06334066B1
    • 2001-12-25
    • US09467884
    • 1999-12-21
    • Thomas RupprechtRainer Kuth
    • Thomas RupprechtRainer Kuth
    • A61B5055
    • G06F19/3481G06F19/00
    • In a method for monitoring growth disorder therapy, a magnetic resonance image of a skeletal body portion, such as a hand, of a candidate for growth disorder therapy is obtained using an open magnetic resonance scanner and using an imaging sequence to produce a tomogram having a slice thickness which approximates the thickness of the hand. The number of visible wrist bones and the width of epiphysis joints in the magnetic resonance image is evaluated to obtain osteo age data, and the osteo age data, in conjunction with an atlas of compiled osteo age data, are used to determine the osteo age of the candidate for growth disorder therapy. The relationship between the osteo age of the candidate and the chronological age of the candidate is used to determine whether growth disorder therapy is required. If growth disorder therapy is administered, such as by administering a hormone, the above procedure is repeated after a predetermined time, and the status of the therapy is again evaluated.
    • 在用于监测生长障碍治疗的方法中,使用开放磁共振扫描仪获得用于生长障碍治疗的候选者的诸如手的骨骼体部分的磁共振图像,并且使用成像序列产生具有 切片厚度近似于手的厚度。 评估磁共振图像中可见腕骨的数量和骨ysis关节的宽度,以获得骨龄数据,并将骨龄数据与编制骨龄数据的图集一起用于确定骨形态 生长障碍治疗的候选人。 候选人的骨龄与候选人的年龄之间的关系用于确定是否需要生长障碍治疗。 如果施用生长障碍治疗,例如通过施用激素,则在预定时间后重复上述过程,并再次评估治疗的状态。