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1. 发明授权

US06905471B2 Method and device for training pelvic floor muscles 失效
标题翻译：训练盆底肌肉的方法和装置
公开(公告)号：US06905471B2
公开(公告)日：2005-06-14
申请号：US10153692
申请日：2002-05-24
申请人： Gunnar Leivseth , Ole Olsen
发明人： Gunnar Leivseth , Ole Olsen
IPC分类号： A61B5/22 , A61H1/00 , A61H19/00 , A61H21/00 , A61H23/02 , A63B23/20 , A61B5/103 , A61B5/117
CPC分类号： A61H19/40 , A61B5/227 , A61B5/4519 , A61B2562/0247 , A61H19/44 , A61H23/0254 , A61H2201/0157 , A61H2201/5071 , A61H2205/085 , A61H2205/086 , A61H2205/087 , A63B23/20 , A63B2213/00 , A63B2230/60
摘要： A method and device for training pelvic floor muscles in order to treat or prevent urinary or fecal incontinence. The device comprises a probe having a pressure sensor and a vibrator, and a microprocessor connected with the sensor and the vibrator. Initially, the probe is inserted into a person's vagina or rectum and the highest force that can be applied by the person contracting the pelvic muscles is ascertained and registered. The contraction of the pelvic floor muscles is repeated at intervals, and the force applied by pelvic floor muscles at each contraction is ascertained and compared with the registered highest value. The vibrator is activated at each contraction of the floor muscles only if the force has a predetermined relationship to the registered value, and only for a predetermined period as long as the predetermined relationship is maintained.
摘要翻译：用于训练盆底肌肉以治疗或预防尿失禁或大便失禁的方法和装置。该装置包括具有压力传感器和振动器的探头以及与传感器和振动器连接的微处理器。最初，将探针插入人的阴道或直肠，确定并注册由承包骨盆肌的人施加的最高的力。每隔一段时间重复骨盆底肌肉的收缩，确定每次收缩时骨盆底肌肉施加的力，并将其与登记的最高值进行比较。仅当力与注册值具有预定的关系时，振动器才能在地板肌肉的每次收缩时被激活，并且只要保持预定关系即可达预定时间。

2. 发明授权

US06923773B2 Device for vibratory stimulation on the human body 失效
标题翻译：用于人体振动刺激的装置
公开(公告)号：US06923773B2
公开(公告)日：2005-08-02
申请号：US10465392
申请日：2003-06-20
申请人： Gunnar Leivseth , Ole Olsen
发明人： Gunnar Leivseth , Ole Olsen
IPC分类号： A61H1/00 , A61H23/02
CPC分类号： A61H1/005 , A61H1/001 , A61H1/006 , A61H23/0263 , A61H2203/0406
摘要： A device for vibratory stimulation on the human body comprises a support platform, a panel supported by the platform and forming a standing surface for a person using the device, and a vibrator for imparting to the panel a vibratory movement. Two standards are mounted to the platform at opposite sides of the panel, forming handles for the person standing on the standing surface between the standards to hold on. A sensor is provided for sensing the load on the panel or on the standards exerted by the person standing on the standing surface. A control unit is connected with the sensor and the vibrator for controlling the operation of the vibrator in dependence on the load sensed by the sensor.
摘要翻译：用于在人体上进行振动刺激的装置包括支撑平台，由平台支撑的面板，并且使用该装置形成人的站立面，以及用于向面板施加振动运动的振动器。两个标准安装在面板对面的平台上，形成了站在站立表面上的人员握持标准之间的手柄。提供传感器用于感测面板上的负载或者站在站立面上的人施加的标准。控制单元与传感器和振动器连接，用于根据传感器感测到的负载来控制振动器的操作。

3. 发明授权

US6059740A Method for diagnosing and testing/training pelvic floor musculature 失效
标题翻译：诊断和测试/训练盆底肌肉组织的方法
公开(公告)号：US6059740A
公开(公告)日：2000-05-09
申请号：US78106
申请日：1998-05-13
申请人： Gunnar Leivseth , Ole Olsen
发明人： Gunnar Leivseth , Ole Olsen
IPC分类号： A61B5/22 , A63B23/20 , A63B24/00 , A61B5/103
CPC分类号： A63B23/20 , A61B5/227 , A63B2220/51
摘要： A measurement and training apparatus to be inserted in the vagina or rectum for diagnostic and pelvic musculature training purposes, comprises, two axially split halves of a substantially cylindrical body, kept at an adjustable distance from each other. A strain gauge measures a force perpendicular to the axis of the apparatus. The measurement is executed in a flexural mode where a forward end of one of the halves is bent toward the other half with a small deflection.
摘要翻译：插入阴道或直肠以进行诊断和骨盆肌肉训练目的的测量和训练装置包括保持彼此可调节距离的基本圆柱形主体的两个轴向分开的两半。应变计测量垂直于设备轴线的力。测量以弯曲模式执行，其中一个半部的前端以小的偏转向另一半弯曲。

4. 发明授权

US09587210B2 Energy saving brewing method 有权
标题翻译：节能酿造方法
公开(公告)号：US09587210B2
公开(公告)日：2017-03-07
申请号：US13701604
申请日：2011-05-31
申请人： Søren Knudsen , Preben Riis , Birgitte Skadhauge , Lene Mølskov Bech , Ole Olsen
发明人： Søren Knudsen , Preben Riis , Birgitte Skadhauge , Lene Mølskov Bech , Ole Olsen
IPC分类号： C12C1/00 , C12C7/00 , A01H5/00 , C12C1/073 , C12C7/20 , C12C1/18 , C12C7/22
CPC分类号： C12C7/22 , C12C1/073 , C12C1/18 , C12C7/20
摘要： Barley based beverages are produced in large quantities, employing highly energy consuming methods, for example in the malting and brewhouse facilities for kiln drying and wort boiling operations, respectively. The present invention relates to energy saving methods for preparing barley based beverages, as well as to barley plants useful in such methods. In particular, the invention describes barley plants with combined traits of null-lipoxygenase-1 (null-LOX-1), null-lipoxygenase-2 (null-LOX-2) and null-S-adenosylmethionine:methionine S-methyltransferase in one plant, which is particularly useful for energy saving methods to prepare barley based beverages, such as beer.
摘要翻译：大麦生产的大麦饮料分别采用高耗能的方法，例如用于窑干和麦汁煮沸操作的麦芽酿造设施。本发明涉及制备大麦饮料的节能方法以及用于这种方法的大麦植物。特别地，本发明描述了一种具有零脂肪氧合酶-1（无效LOX-1），无效脂氧合酶-2（无效LOX-2）和无效S-腺苷甲硫氨酸：甲硫氨酸S-甲基转移酶的组合性状的大麦植物植物，其对于制备基于大麦的饮料（例如啤酒）的节能方法特别有用。

5. 发明授权

US09363959B2 Barley with reduced lipoxygenase activity and beverage prepared therefrom 有权
标题翻译：具有降低的脂氧合酶活性的大麦和由其制备的饮料
公开(公告)号：US09363959B2
公开(公告)日：2016-06-14
申请号：US13141579
申请日：2009-12-28
申请人： Birgitte Skadhauge , Finn Lok , Klaus Breddam , Ole Olsen , Lette Mølskov Bech , Søren Knudsen
发明人： Birgitte Skadhauge , Finn Lok , Klaus Breddam , Ole Olsen , Lette Mølskov Bech , Søren Knudsen
IPC分类号： A01H5/10 , C12C1/18 , C12C12/00
CPC分类号： A01H5/10 , C12C1/18 , C12C12/00 , C12C2200/01
摘要： According to the invention, there is provided barley with total loss of functional lipoxygenase (LOX)-1 and LOX-2 enzymes, and plant products produced thereof, such as malt manufactured by using barley kernels defective in the synthesis of the fatty acid-dioxygenating enzymes LOX-1 and LOX-2. Said enzymes account for the principal activities related to dioxygenation of linoleic acid into 9- and 13-hydroperoxy octadecadienoic acid, respectively. 9-Hydroperoxy octadecadienoic acid represents a LOX pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal (T2N). The invention enables brewers to produce a beer having insignificant levels of stale, T2N-specific off-flavors, even after prolonged storage of the beverage.
摘要翻译：根据本发明，提供了具有功能性脂氧合酶（LOX）-1和LOX-2酶的总损失的大麦及其生产的植物产品，例如通过使用在合成脂肪酸 - 双氧合中缺陷的大麦仁制备的麦芽酶LOX-1和LOX-2。所述酶分别涉及与亚油酸双加氧相关的9-和13-氢过氧十八碳二烯酸的主要活性。 9-氢过氧十八碳二烯酸代表LOX途径代谢物，通过进一步的酶促或自发反应，可能导致反式-2-壬醛（T2N）的出现。本发明使酿造商能够生产具有不明显水平的陈年T2N特异性异味的啤酒，即使在饮料长期储存之后。

6. 发明授权

US08852594B2 Compositions and methods for the therapy and diagnosis of cytomegalovirus infections 有权
标题翻译：用于治疗和诊断巨细胞病毒感染的组合物和方法
公开(公告)号：US08852594B2
公开(公告)日：2014-10-07
申请号：US13486569
申请日：2012-06-01
申请人： Ole Olsen
发明人： Ole Olsen
IPC分类号： A61K39/42
CPC分类号： C07K16/088 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56994 , G01N2333/045
摘要： The present invention provides anti-cytomegalovirus antibodies and related compositions and methods. These antibodies may be used in the diagnosis, prevention, and treatment of cytomegalovirus infection.
摘要翻译：本发明提供抗巨细胞病毒抗体及相关组合物和方法。这些抗体可用于巨细胞病毒感染的诊断，预防和治疗。

7. 发明申请

US20130280375A1 BREWING METHOD 审中-公开
标题翻译： BREWING方法
公开(公告)号：US20130280375A1
公开(公告)日：2013-10-24
申请号：US13817573
申请日：2011-08-16
申请人： Stefan Kreisz , Lone Baekgaard , Anne Mette Bhatia Frederiksen , Tine Hoff , Peter Rahbek Oestergaard , Ole Olsen , Ulf Olsson
发明人： Stefan Kreisz , Lone Baekgaard , Anne Mette Bhatia Frederiksen , Tine Hoff , Peter Rahbek Oestergaard , Ole Olsen , Ulf Olsson
IPC分类号： C12C5/00
CPC分类号： C12C5/004 , C12C7/00 , C12N9/52
摘要： A method of improving colloidal stability in beer comprising contacting a mash and/or a wort with a snapalysin during the production of beer. In this process, the foam stability is not affected.
摘要翻译：一种提高啤酒中胶体稳定性的方法，包括在生产啤酒期间使醪液和/或麦汁与snap comprising草接触。在此过程中，泡沫稳定性不受影响。

8. 发明申请

US20120171218A1 Compositions And Methods For The Therapy And Diagnosis Of Influenza 有权
标题翻译：流感的治疗和诊断的组成和方法
公开(公告)号：US20120171218A1
公开(公告)日：2012-07-05
申请号：US13215841
申请日：2011-08-23
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
IPC分类号： A61K39/42 , A61P31/16 , G01N33/577 , C07K16/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译：本发明提供新的人类抗流感抗体及相关组合物和方法。这些抗体用于流感感染的诊断和治疗。

9. 发明申请

US20120121603A1 Compositions And Methods For The Therapy And Diagnosis Of Influenza 有权
公开(公告)号：US20120121603A1
公开(公告)日：2012-05-17
申请号：US13321460
申请日：2010-05-20
申请人： Andres G. Grandea, III , Gordon King , Thomas c. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
发明人： Andres G. Grandea, III , Gordon King , Thomas c. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
IPC分类号： A61K39/42 , C12Q1/70 , A61P37/04 , C07K16/10 , A61P31/16
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.

10. 发明申请

US20110293779A1 BARLEY AND MALT-DERIVED BEVERAGES WITH LOW DMS LEVEL 有权
标题翻译： BARLEY和MALT衍生的饮料低DMS水平
公开(公告)号：US20110293779A1
公开(公告)日：2011-12-01
申请号：US13132765
申请日：2009-12-01
申请人： Søren Knudsen , Gustav Hambraeus , Lene Molskov Bech , Steen Bech Sorensen , Birgitte Skadhauge , Klaus Breddam , Ole Olsen
发明人： Søren Knudsen , Gustav Hambraeus , Lene Molskov Bech , Steen Bech Sorensen , Birgitte Skadhauge , Klaus Breddam , Ole Olsen
IPC分类号： A01H5/00 , C12C1/18 , C12C7/01 , A01H1/06 , C12C1/027
CPC分类号： C12N9/1007 , C12C1/18 , C12C12/00 , C12C2200/01 , C12N15/8243
摘要： According to the invention, there is provided barley-derived beverages characterized by notably reduced levels of both dimethyl sulfide (DMS) and/or its precursor S-methyl-L-methionine (SMM), or lacking said compounds. In addition, the invention relates to methods for producing the above-mentioned beverages—and also to barley plants useful in the preparation of such beverages, as well as other plant products prepared from said plants. Utilization of the invention clears the way for making improved production procedures of beverages with improved taste profiles, and promises also for notable reductions in the thermal energy input for production of beer.
摘要翻译：根据本发明，提供了大麦衍生的饮料，其特征在于二甲硫醚（DMS）和/或其前体S-甲基-L-甲硫氨酸（SMM）的水平显着降低，或缺乏所述化合物。此外，本发明涉及用于制备上述饮料的方法以及用于制备这种饮料的大麦植物以及从所述植物制备的其它植物产品。本发明的利用清除了具有改进的味道特征的饮料改进生产程序的方法，并且还有助于显着降低生产啤酒的热能输入。

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