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1. 发明申请

US20060034871A1 Immunogenic compositions for Chlamydia trachomatis 审中-公开
标题翻译：沙眼衣原体的免疫原性组合物
公开(公告)号：US20060034871A1
公开(公告)日：2006-02-16
申请号：US11018868
申请日：2004-12-22
申请人： Guido Grandi , Guilio Ratti , Alessandra Bonci , Oretta Finco
发明人： Guido Grandi , Guilio Ratti , Alessandra Bonci , Oretta Finco
IPC分类号： A61K39/118 , C12N1/20
CPC分类号： A61K39/118 , A61K39/00 , A61K39/02 , A61K2039/505 , A61K2039/55505 , A61K2039/55561 , C07K14/195
摘要： The invention relates to immunogenic compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. The composition may comprise at least two components, one component of which comprises Chlamydia trachomatis antigens for eliciting a Chlamydia trachomatis specific TH1 immune response and another component of which comprises antigens for eliciting a Chlamydia trachomatis specific TH2 immune response. The invention further relates to an immunogenic composition comprising a Chlamydia trachomatis Type III secretion system (TTSS) regulatory protein and a Chlamydia trachomatis Type III secretion system (TTSS) secreted protein or a fragment thereof. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif. The invention further provides a combination of Chlamydia trachomatis antigens comprising a Chlamydia trachomatis antigen that is conserved over at least two serovars.
摘要翻译：本发明涉及包含沙眼衣原体抗原及其在疫苗中的应用的组合的免疫原性组合物。组合物可以包含至少两种组分，其一种组分包含沙眼衣原体抗原，其用于引发沙眼衣原体特异性TH1免疫应答，其另一种成分包含用于引发沙眼衣原体特异性TH2免疫应答的抗原。本发明还涉及包含沙眼衣原体III型分泌系统（TTSS）调节蛋白和沙眼衣原体III型分泌系统（TTSS）分泌蛋白或其片段的免疫原性组合物。本发明还涉及佐剂组合用于与性传播疾病如沙眼衣原体抗原相关的抗原的用途。优选的佐剂组合包括无机盐，例如铝盐和包含CpG基序的寡核苷酸。本发明还提供沙眼衣原体抗原的组合，其包含在至少两种血清型中保守的沙眼衣原体抗原。

2. 发明授权

US08734812B1 Neisserial antigenic peptides 有权
标题翻译： Neisserial抗原肽
公开(公告)号：US08734812B1
公开(公告)日：2014-05-27
申请号：US10111983
申请日：2000-10-30
申请人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： A61K39/095 , A61K39/02 , A61K39/00 , A61K38/00
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto (e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译：本发明尤其提供衍生自脑膜炎奈瑟氏球菌B的细菌的蛋白质，多肽和其片段。还提供了编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸（例如，，反义核酸）。另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。还提供了用组合物制备组合物和处理方法的方法。本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

3. 发明授权

US08394390B2 Neisserial antigenic peptides 有权
公开(公告)号：US08394390B2
公开(公告)日：2013-03-12
申请号：US13405162
申请日：2012-02-24
申请人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： A61K39/095 , A61K39/02 , A61K39/38 , A61K38/00 , C07K1/00
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

4. 发明授权

US09067987B2 Neisserial antigenic peptides 有权
标题翻译： Neisserial抗原肽
公开(公告)号：US09067987B2
公开(公告)日：2015-06-30
申请号：US13405213
申请日：2012-02-24
申请人： Cesira Galeotti , Guido Grandi , Vega Masignani , Marirosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira Galeotti , Guido Grandi , Vega Masignani , Marirosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： C07K14/22 , A61K39/095 , A61K39/00 , A61K48/00
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译：本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如，反义核酸）。另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。还提供了用组合物制备组合物和处理方法的方法。本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

5. 发明申请

US20120276129A1 NEISSERIAL ANTIGENIC PEPTIDES 有权
标题翻译： NEISSERIAL抗原肽
公开(公告)号：US20120276129A1
公开(公告)日：2012-11-01
申请号：US13405213
申请日：2012-02-24
申请人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： A61K39/095 , A61P37/04 , C07K14/22
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译：本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如，反义核酸）。另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。还提供了用组合物制备组合物和处理方法的方法。本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

6. 发明申请

US20120219578A1 NEISSERIAL ANTIGENIC PEPTIDES 有权
公开(公告)号：US20120219578A1
公开(公告)日：2012-08-30
申请号：US13405162
申请日：2012-02-24
申请人： Cesira GALEOTTI , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira GALEOTTI , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

7. 发明申请

US20070116726A1 Immunisation against Chlamydia pneumoniae 审中-公开
标题翻译：免疫肺炎衣原体
公开(公告)号：US20070116726A1
公开(公告)日：2007-05-24
申请号：US11414403
申请日：2006-05-01
申请人： Guilio Ratti , Guido Grandi
发明人： Guilio Ratti , Guido Grandi
IPC分类号： A61K39/118 , C07H21/04 , C12N15/74 , C12N1/21 , C07K14/295
CPC分类号： C07K14/295 , A61K39/00 , A61K2039/53
摘要： The published genomic sequence of Chlamydia pneumoniae reveals over 1000 putative encoded proteins but does not itself indicate which of these might be useful antigens for immunisation and vaccination or for diagnosis. This difficulty is addressed by the invention, which provides a number of C. pneumoniae protein sequences suitable for vaccine production and development and/or for diagnostic purposes.
摘要翻译：公布的肺炎衣原体的基因组序列揭示超过1000个推定编码的蛋白质，但本身并不表明其中哪些可能是免疫接种或疫苗接种或诊断的有用抗原。本发明解决了这个困难，本发明提供了许多适用于疫苗生产和开发和/或用于诊断目的的肺炎衣原体蛋白序列。

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