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1. 发明申请

US20100130740A1 PROCESS FOR PREPARATION OF RISPERIDONE 审中-公开
标题翻译：雷帕酮的制备方法
公开(公告)号：US20100130740A1
公开(公告)日：2010-05-27
申请号：US12452874
申请日：2008-07-25
申请人： Guiling Zhang , Yidong Zhu , Chuanwen Fan , Minghui Zhang , Jingyi Wang
发明人： Guiling Zhang , Yidong Zhu , Chuanwen Fan , Minghui Zhang , Jingyi Wang
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention provides a more handy and environment friendly process for preparing risperidone, which comprises reacting 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride with 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one in a basic aqueous solution or suspension. The concentration of alkaline metal carbonates in the basic aqueous solution or suspension is ranged from 15% to 40%. The reaction is carried out at a temperature range of 101-140° C. and the reaction is completed within 10 minutes to 2 hours.
摘要翻译：本发明提供了一种更方便和环境友好的制备利培酮的方法，其包括使6-氟-3-（4-哌啶基）-1,2-苯并异恶唑盐酸盐与3-（2-氯乙基）-2-甲基-6- 7,8,9-四氢-4H-吡啶并[1,2-a]嘧啶-4-酮在碱性水溶液或悬浮液中的溶液。碱性水溶液或悬浮液中碱金属碳酸盐的浓度范围为15％至40％。反应在101-140℃的温度范围内进行，反应在10分钟至2小时内完成。

2. 发明授权

US08637681B2 Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof 失效
标题翻译：吡咯基取代的二氢吲哚-2-酮衍生物，其制备方法和用途
公开(公告)号：US08637681B2
公开(公告)日：2014-01-28
申请号：US13702956
申请日：2011-03-31
申请人： Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
发明人： Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D411/06 , A61K31/403 , A61K31/497 , A61K31/535
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D413/14
摘要： Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).
摘要翻译：提供由式（I）表示的吡咯基取代的二氢吲哚-2-酮衍生物，所述衍生物的药学上可接受的盐或溶剂合物，或所述盐的溶剂化物，其是有效的酪氨酸激酶抑制剂。还提供了上述化合物的制备方法，含有这些化合物的药物组合物，以及这些化合物在制备可用于治疗或辅助治疗由酪氨酸激酶药物或由酪氨酸激酶驱动的肿瘤细胞的增殖或迁移的药物中的用途在哺乳动物（包括人）。

3. 发明授权

US08916574B2 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors 有权
标题翻译：用作酪氨酸激酶抑制剂的4-（取代的苯胺基） - 喹唑啉衍生物
公开(公告)号：US08916574B2
公开(公告)日：2014-12-23
申请号：US13498547
申请日：2010-09-20
申请人： Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
发明人： Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D405/04
摘要： The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.
摘要翻译：本发明涉及作为酪氨酸激酶抑制剂的4-（取代的苯胺基） - 喹唑啉衍生物。具体地，公开了式I化合物或其药学上可接受的盐或溶剂合物，其中式I中的每个取代基在说明书中定义。还公开了式I化合物的制备方法，药物组合物及其药物用途。式I化合物是有效的酪氨酸激酶抑制剂。

4. 发明申请

US20130158030A1 PYRROLYL SUBSTITUTED DIHYDROINDOL-2-ONE DERIVATIVES, PREPARATION METHODS AND USES THEREOF 失效
标题翻译：吡咯基取代的二氢吲哚-2-酮衍生物，其制备方法及其用途
公开(公告)号：US20130158030A1
公开(公告)日：2013-06-20
申请号：US13702956
申请日：2011-03-31
申请人： Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
发明人： Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
IPC分类号： C07D403/06
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D413/14
摘要： Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).
摘要翻译：提供由式（I）表示的吡咯基取代的二氢吲哚-2-酮衍生物，所述衍生物的药学上可接受的盐或溶剂合物，或所述盐的溶剂化物，其是有效的酪氨酸激酶抑制剂。还提供了上述化合物的制备方法，含有这些化合物的药物组合物，以及这些化合物在制备可用于治疗或辅助治疗由酪氨酸激酶药物或由酪氨酸激酶驱动的肿瘤细胞的增殖或迁移的药物中的用途在哺乳动物（包括人）。

5. 发明申请

US20120208833A1 4-(Substituted Anilino)-Quinazoline Derivatives Useful as Tyrosine Kinase Inhibitors 有权
标题翻译： 4-（取代的苯胺基） - 喹唑啉衍生物，可用作酪氨酸激酶抑制剂
公开(公告)号：US20120208833A1
公开(公告)日：2012-08-16
申请号：US13498547
申请日：2010-09-20
申请人： Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
发明人： Jingyi Wang , Chuanwen Fan , Long Zhang , Zhongru Guo , Ying Li , Shaobo Yang , Shousheng Yan , Jianrong Zhu , Qingmin Yang , Minghui Zhang
IPC分类号： A61K31/517 , A61P35/04 , A61P35/02 , C07D405/10 , A61P35/00
CPC分类号： C07D405/04
摘要： The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.
摘要翻译：本发明涉及作为酪氨酸激酶抑制剂的4-（取代的苯胺基） - 喹唑啉衍生物。具体地，公开了式I化合物或其药学上可接受的盐或溶剂合物，其中式I中的每个取代基在说明书中定义。还公开了式I化合物的制备方法，药物组合物及其药物用途。式I化合物是有效的酪氨酸激酶抑制剂。

6. 发明申请

US20150302000A1 A METHOD AND A TECHNICAL EQUIPMENT FOR ANALYSING MESSAGE CONTENT 审中-公开
标题翻译：一种用于分析消息内容的方法和技术设备
公开(公告)号：US20150302000A1
公开(公告)日：2015-10-22
申请号：US14443831
申请日：2012-11-30
申请人： Hongrui SHEN , Naichen CUI , Lu LIU , Minghui ZHANG
发明人： Hongrui Shen , Naichen Cui , Lu Liu , Minghui Zhang
IPC分类号： G06F17/27 , H04L12/58
CPC分类号： G06F17/2765 , G06F16/94 , G06Q10/107 , H04L51/34 , H04W4/14
摘要： The present embodiments relate to a method and a technical equipment for implementing the method. The method comprises receiving a message; identifying an action request from the message; determining a keyword from the message; monitoring the requested action, and detecting a data item relating to the action; and associating the keyword with the detected data item.
摘要翻译：本实施例涉及实现该方法的方法和技术设备。该方法包括接收消息; 从消息中识别动作请求; 从消息中确定关键字; 监视所请求的动作，以及检测与动作相关的数据项; 并将关键字与检测到的数据项相关联。

7. 发明申请

US20130222931A1 PRISM SHEET AND DISPLAY DEVICE 有权
标题翻译： PRISM表和显示设备
公开(公告)号：US20130222931A1
公开(公告)日：2013-08-29
申请号：US13701644
申请日：2012-07-20
申请人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
发明人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
IPC分类号： G02B5/04
CPC分类号： G02B5/04 , G02B5/0231 , G02B5/0268 , G02B5/0278
摘要： The present invention discloses a prism sheet and a display device comprising the prism sheet for improving performances of a backlight module in a liquid crystal display device. The prism sheet comprises a first substrate and a second substrate, wherein the first substrate comprises a first surface and a second surface opposite to the first surface, and the second surface comprises a plurality of first protrusions arranged in parallel along a first direction; the second substrate comprises a third surface and a fourth surface opposite to the third surface, the third surface comprises a plurality of second protrusions arranged in parallel along the first direction, and the fourth surface comprises a plurality of third protrusions arranged in parallel along a second direction; and the second surface and the third surface are joined by meshing of the first protrusions with the second protrusions.
摘要翻译：本发明公开了一种棱镜片和显示装置，包括用于提高液晶显示装置中的背光模块的性能的棱镜片。所述棱镜片包括第一基板和第二基板，其中所述第一基板包括与所述第一表面相对的第一表面和第二表面，并且所述第二表面包括沿着第一方向平行布置的多个第一突起; 所述第二基板包括与所述第三表面相对的第三表面和第四表面，所述第三表面包括沿所述第一方向平行布置的多个第二突起，并且所述第四表面包括沿着第二表面平行设置的多个第三突起方向; 并且第二表面和第三表面通过第一突起与第二突起的啮合而接合。

8. 发明申请

US20060074205A1 Production of broad molecular weight polyethylene 有权
公开(公告)号：US20060074205A1
公开(公告)日：2006-04-06
申请号：US11202311
申请日：2005-08-11
申请人： Kevin Cann , Minghui Zhang , Jose Cevallos-Candau , John Moorhouse , Mark Goode , Daniel Zilker , Maria Apecetche
发明人： Kevin Cann , Minghui Zhang , Jose Cevallos-Candau , John Moorhouse , Mark Goode , Daniel Zilker , Maria Apecetche
IPC分类号： C08F4/06
CPC分类号： C08F10/00 , B01J21/08 , B01J31/0212 , B01J31/122 , B01J31/128 , B01J31/143 , B01J31/34 , B01J35/1019 , B01J35/1023 , B01J35/1047 , C08F110/02 , C08F210/16 , Y02P20/52 , Y10S526/901 , C08F4/69 , C08F2500/12 , C08F2500/18 , C08F2500/04 , C08F2500/10 , C08F210/14 , C08F4/025
摘要： The present invention is directed to the use of aluminum alkyl activators and co-catalysts to improve the performance of chromium-based catalysts. The aluminum alkyls allow for the variable control of polymer molecular weight, control of side branching while possessing desirable productivities, and may be applied to the catalyst directly or separately to the reactor. Adding the alkyl aluminum compound directly to the reactor (in-situ) eliminates induction times.

9. 发明申请

US20050037917A1 Production of broad molecular weight polyethylene 有权
标题翻译：生产宽分子量聚乙烯
公开(公告)号：US20050037917A1
公开(公告)日：2005-02-17
申请号：US10716291
申请日：2003-11-18
申请人： Kevin Cann , Minghui Zhang , Jose Cevallos-Candau , John Moorhouse , Mark Goode , Daniel Zilker , Maria Apecetche
发明人： Kevin Cann , Minghui Zhang , Jose Cevallos-Candau , John Moorhouse , Mark Goode , Daniel Zilker , Maria Apecetche
IPC分类号： B01J21/08 , B01J23/26 , B01J31/12 , B01J35/10 , C08F2/00 , C08F10/00 , C08F110/02 , C08F210/16 , B01J31/00
CPC分类号： C08F10/00 , B01J21/08 , B01J31/0212 , B01J31/122 , B01J31/128 , B01J31/143 , B01J31/34 , B01J35/1019 , B01J35/1023 , B01J35/1047 , C08F110/02 , C08F210/16 , Y02P20/52 , Y10S526/901 , C08F4/69 , C08F2500/12 , C08F2500/18 , C08F2500/04 , C08F2500/10 , C08F210/14 , C08F4/025
摘要： The present invention is directed to the use of aluminum alkyl activators and co-catalysts to improve the performance of chromium-based catalysts. The aluminum alkyls allow for the variable control of polymer molecular weight, control of side branching while possessing desirable productivities, and may be applied to the catalyst directly or separately to the reactor. Adding the alkyl aluminum compound directly to the reactor (in-situ) eliminates induction times.
摘要翻译：本发明涉及使用烷基铝活化剂和助催化剂来改进铬基催化剂的性能。烷基铝允许聚合物分子量的可变控制，侧分枝的控制，同时具有所需的生产率，并且可以直接或分别地施加到催化剂到反应器。将烷基铝化合物直接加入反应器（原位）消除了诱导时间。

10. 发明授权

US08964318B2 Prism sheet and display device 有权
标题翻译：棱镜片和显示装置
公开(公告)号：US08964318B2
公开(公告)日：2015-02-24
申请号：US13701644
申请日：2012-07-20
申请人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
发明人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
IPC分类号： G02B5/04 , G02B5/02
CPC分类号： G02B5/04 , G02B5/0231 , G02B5/0268 , G02B5/0278
摘要： The present invention discloses a prism sheet and a display device comprising the prism sheet for improving performances of a backlight module in a liquid crystal display device. The prism sheet comprises a first substrate and a second substrate, wherein the first substrate comprises a first surface and a second surface opposite to the first surface, and the second surface comprises a plurality of first protrusions arranged in parallel along a first direction; the second substrate comprises a third surface and a fourth surface opposite to the third surface, the third surface comprises a plurality of second protrusions arranged in parallel along the first direction, and the fourth surface comprises a plurality of third protrusions arranged in parallel along a second direction; and the second surface and the third surface are joined by meshing of the first protrusions with the second protrusions.
摘要翻译：本发明公开了一种棱镜片和显示装置，包括用于提高液晶显示装置中的背光模块的性能的棱镜片。所述棱镜片包括第一基板和第二基板，其中所述第一基板包括与所述第一表面相对的第一表面和第二表面，并且所述第二表面包括沿着第一方向平行布置的多个第一突起; 所述第二基板包括与所述第三表面相对的第三表面和第四表面，所述第三表面包括沿所述第一方向平行布置的多个第二突起，并且所述第四表面包括沿着第二表面平行设置的多个第三突起方向; 并且第二表面和第三表面通过第一突起与第二突起的啮合而接合。

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