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1. 发明授权

US07816544B2 Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species 有权
标题翻译：通过光化学生成氧化吡啶类物质合成罗卡酰胺天然产物
公开(公告)号：US07816544B2
公开(公告)日：2010-10-19
申请号：US10593502
申请日：2005-03-23
申请人： Guilford Jones, II , Baudouin Gerard , John A. Porco, Jr.
发明人： Guilford Jones, II , Baudouin Gerard , John A. Porco, Jr.
IPC分类号： C07D313/00 , C07D307/93 , C07D311/00
CPC分类号： C07D307/93 , C07D311/30 , C07D313/08 , C07D493/08
摘要： The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.
摘要翻译：本发明提供了合成罗卡酰胺家族化合物和相关天然产物的新策略。特别地，新的仿生合成方法包括从3-羟基色酮衍生物光化学生成氧化吡啶鎓物质，随后将氧化吡啶类物质偶氮环加成到偶极子体。该方法可用于形成含有阿格林核心结构的加合物。还提供了将阿格林核心结构转化为阿格林，罗卡酰胺和巴格林环系统的方法。本发明还涉及用于制造用于治疗癌症或癌症病症的药物，与细胞过度增殖相关的疾病或NF-和B受体依赖性病症的药物的罗卡酰胺/阿格林/用于囊霉素衍生物的用途。

2. 发明申请

US20110065786A1 SYNTHESIS OF ROCAGLAMIDE NATURAL PRODUCTS VIA PHOTOCHEMICAL GENERATION OF OXIDOPYRYLIUM SPECIES 审中-公开
标题翻译：通过氧化亚光谱物种的光化学生成合成山梨酰胺天然产物
公开(公告)号：US20110065786A1
公开(公告)日：2011-03-17
申请号：US12900874
申请日：2010-10-08
申请人： John A. Porco, JR. , Baudouin Gerard , Guilford Jones, II
发明人： John A. Porco, JR. , Baudouin Gerard , Guilford Jones, II
IPC分类号： A61K31/343 , C07D307/77 , A61P35/00
CPC分类号： C07D307/93 , C07D311/30 , C07D313/08 , C07D493/08
摘要： The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.
摘要翻译：本发明提供了合成罗卡酰胺家族化合物和相关天然产物的新策略。特别地，新的仿生合成方法包括从3-羟基色酮衍生物光化学生成氧化吡啶鎓物质，随后将氧化吡啶类物质偶氮环加成到偶极子体。该方法可用于形成含有阿格林核心结构的加合物。还提供了将阿格林核心结构转化为阿格林，罗卡酰胺和巴格林环系统的方法。本发明还涉及用于制造用于治疗癌症或癌性病症的药物，与细胞过度增殖相关的病症或NF-和B受体依赖性病症的药物的罗卡酰胺/阿格林/用于囊霉素衍生物的用途。

3. 发明授权

US06402986B1 Compositions and methods for luminescence lifetime comparison 失效
标题翻译：发光寿命比较的组成和方法
公开(公告)号：US06402986B1
公开(公告)日：2002-06-11
申请号：US09354891
申请日：1999-07-16
申请人： Guilford Jones, II , Dingxue Yan
发明人： Guilford Jones, II , Dingxue Yan
IPC分类号： C09K1106
CPC分类号： G01N21/6408 , C09D11/50
摘要： This patent disclosure describes novel compositions and methods used in the verification of products or documents based on the reading of emitted light from luminescent compositions that can be incorporated or applied to a wide variety of materials. Specifically, the compositions are uniquely luminescent at various wavelengths, displaying qualities of image, wavelength, and time scale for the measure of luminesce decay. The light emitted from the composition, and specifically, the measure of the variable and adjustable luminescence lifetimes provides a multi-parameter signature for purposes of comparative light decay analysis of verification marks or features.
摘要翻译：该专利公开描述了基于从可以掺入或应用于各种各样的材料的发光组合物的发射光的读取中用于验证产品或文献的新型组合物和方法。具体地，组合物在各种波长下是唯一发光的，显示用于测量发光衰变的图像质量，波长和时间尺度。从组合物发射的光，具体地，可变和可调节的发光寿命的测量提供了用于验证标记或特征的比较光衰减分析的多参数签名。

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