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    • 7. 发明授权
    • MRI contrast agent having gadolinium complex
    • 具有钆络合物的MRI造影剂
    • US08901294B2
    • 2014-12-02
    • US13876904
    • 2010-12-21
    • Tae-Jeong KimYong Min ChangHee-Kyung KimSung-Wook Gu
    • Tae-Jeong KimYong Min ChangHee-Kyung KimSung-Wook Gu
    • C07D257/02C07F5/00A61K49/10
    • C07F5/00A61K49/106C07D257/02
    • The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1. A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect. Accordingly, since the MRI contrast agent including the gadolinium complex according to the present invention satisfies the key properties required for a contrast agent for MRI, it can be widely used as an MRI contrast agent and can provide enhanced contrasting effect as compared to the existing contrast agent.
    • 本发明涉及包含钆络合物的磁共振成像(MRI)造影剂,更具体地涉及由化学式1表示的DO3A-氨甲环酸或其酯化合物。DO3A-氨甲环酸或其酯化合物 可以根据本发明制备,并且可以使用该化合物制备钆络合物。 包含根据本发明制备的钆络合物作为活性成分的MRI造影剂与目前市售的造影剂相比具有更高的松弛度。 此外,根据本发明的MRI造影剂具有肝特异性和血池对比效果的双功能性。 因此,由于包含本发明的钆配合物的MRI造影剂满足MRI造影剂所需的关键性质,因此可以广泛用作MRI造影剂,与现有的对比度相比可以提供增强的对比效果 代理商
    • 9. 发明申请
    • Organic light emitting display (OLED) and its method of manufacture
    • 有机发光显示器(OLED)及其制造方法
    • US20080074038A1
    • 2008-03-27
    • US11819139
    • 2007-06-25
    • Hee-Kyung KimShinichiro TamuraDas Rupasree RaginiYoung-Hun ByunO-Hyun KwonChe-Un YangYoung-Mok Son
    • Hee-Kyung KimShinichiro TamuraDas Rupasree RaginiYoung-Hun ByunO-Hyun KwonChe-Un YangYoung-Mok Son
    • H01J1/62H01J9/02H01L51/54H01L51/56
    • H01L51/5048H01L51/5012H01L2251/5384H01L2251/552
    • An Organic Light Emitting Display (OLED) and a method of manufacturing the OLED includes: a first electrode arranged on a substrate; a Hole Transporting Layer (HTL) arranged on the first electrode; a light Emitting Layer (EL) arranged on the HTL; an Electron Transporting Layer (ETL) arranged on the light EL; and a second electrode arranged on the ETL; the light EL includes a soluble hole transporting host, a soluble electron transporting host, and a soluble light emitting dopant; a difference of a Highest Occupied Molecular Orbital (HOMO) level between the HTL and the hole transporting host respectively and the light emitting dopant is 1 eV or less; a difference of a HOMO level between the HTL and the hole transporting host respectively and the electron transporting host is 0.5eV or more; a difference of a Lowest Unoccupied Molecular Orbital (LUMO) level between the ETL and the electron transporting host respectively and the light emitting dopant is 1 eV or less; and a difference of a LUMO level between the ETL and the electron transporting host respectively and the hole transporting host is 0.5 eV or more.
    • 有机发光显示器(OLED)和制造OLED的方法包括:布置在基板上的第一电极; 布置在第一电极上的空穴传输层(HTL); 布置在HTL上的发光层(EL); 布置在光EL上的电子传输层(ETL); 和布置在ETL上的第二电极; 光EL包括可溶性空穴传输基质,可溶性电子传递宿主和可溶性发光掺杂剂; HTL和空穴传输主体之间的最高占据分子轨道(HOMO)水平和发光掺杂剂的差异为1eV或更小; HTL和空穴传输宿主和电子传输宿主之间的HOMO能级的差异为0.5eV以上; ETL和电子传输性宿主和发光掺杂剂之间的最低未占分子轨道(LUMO)水平的差异为1eV以下; 并且ETL和电子传输性宿主之间的LUMO能级和空穴传输性主体的差为0.5eV以上。