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    • 4. 发明申请
    • DEVICES, SYSTEMS, AND METHODS FOR AIDING IN THE DETECTION OF A PHYSIOLOGICAL ABNORMALITY
    • 用于检测生理异常的装置,系统和方法
    • US20110009764A1
    • 2011-01-13
    • US12835548
    • 2010-07-13
    • Gregory R. LanierDerek Kane
    • Gregory R. LanierDerek Kane
    • A61B5/08
    • A61B5/0836A61B5/0833A61B5/087A61B5/097A61B5/411A61B5/417A61B5/743A61B5/7435A61B2560/0252A61B2560/0431A61B2560/0462
    • The present invention comprises a method for excluding the presence of a pulmonary embolism using a combination of a blood test for D-dimer and a carboximetry test measuring the ratio of exhaled CO2 to O2. If the measured D-Dimer value is at or above a threshold indicative of concern and the carboximetry value is equal to or greater than a pre-determined carboximetry ratio threshold, a clinically significant pulmonary embolism, or a pulmonary thrombus above a certain effective size, is unlikely to be present. If the measured D-Dimer value is at or above a threshold indicative of concern and the respiratory analysis yields a carboximetry ratio less than the carboximetry ratio threshold, test results are inconclusive and additional testing may be required to determine whether a clinically significant pulmonary embolism, or a pulmonary thrombus above a specified size is present. The present invention also comprises a method for diagnosing or excluding the presence of respiratory dysfunction in an individual by using carboximetry values corresponding to an end-tidal volume of an exhaled breath that is a pre-determined multiple of the individual's estimated pulmonary dead space. In one aspect, a linear regression function is used to represent the CO2/O2 ratio derived from the measured CO2 and O2 values in an exhaled breath, and the function is used to determine the CO2/O2 ratio corresponding to the pre-determined end-tidal volume.
    • 本发明包括使用D-二聚体的血液检验和测量呼出的二氧化碳与O 2的比例的氧化测定法的组合来排除肺栓塞的存在的方法。 如果所测量的D-二聚体值等于或高于指示关注的阈值,并且所述碳氧比值等于或大于预定的氧化比例阈值,临床显着的肺栓塞或高于某一有效大小的肺血栓, 不太可能存在。 如果测量的D-二聚体值等于或高于表示关注的阈值,并且呼吸分析产生小于碳氧比例阈值的碳水化合物比例,则测试结果是不确定的,并且可能需要额外的测试来确定是否临床上显着的肺栓塞, 或者存在高于规定尺寸的肺血栓。 本发明还包括通过使用对应于作为个体估计的肺静脉空间的预定倍数的呼气呼吸的终止潮气量的氧化值来诊断或排除个体中呼吸功能障碍的存在的方法。 在一个方面,使用线性回归函数来表示从呼出气体中测量的CO 2和O 2值得到的CO 2 / O 2比例,并且该功能用于确定对应于预定终端的CO 2 / 潮量。