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1. 发明申请

US20070225778A1 PDT apparatus with an addressable LED array for therapy and aiming 审中-公开
标题翻译：具有可寻址LED阵列的PDT设备，用于治疗和瞄准
公开(公告)号：US20070225778A1
公开(公告)日：2007-09-27
申请号：US11387995
申请日：2006-03-23
申请人： Gregory Heacock , William Barnard , Wes Williams , Wayde Watters
发明人： Gregory Heacock , William Barnard , Wes Williams , Wayde Watters
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61F9/0079 , A61F9/008 , A61F2009/00863 , A61N2005/0652 , A61N2005/0659
摘要： An apparatus for directing light to an eye for exciting a photosensitizer includes an addressable LED array so that the size and shape of the LED light used for aiming or therapy is selectable so as to match the size and shape of targeted tissue. The LED array has a configuration that provides increased LED density, increased current spreading with minimal light blocking and a simplified addressing connection sheme.
摘要翻译：用于将光引导到眼睛以激发光敏剂的装置包括可寻址的LED阵列，使得用于瞄准或治疗的LED灯的尺寸和形状是可选择的，以便与目标组织的尺寸和形状相匹配。 LED阵列具有提供增加的LED密度，增加的电流扩展和最小的光阻和简化的寻址连接方式的配置。

2. 发明授权

US08603014B2 Hands-free operator-independent transcranial ultrasound apparatus and methods 有权
标题翻译：免提操作者独立经颅超声仪和方法
公开(公告)号：US08603014B2
公开(公告)日：2013-12-10
申请号：US13209408
申请日：2011-08-14
申请人： Anthony John Alleman , William Barnard , Randal Lee Radford
发明人： Anthony John Alleman , William Barnard , Randal Lee Radford
IPC分类号： A61H1/00
CPC分类号： A61N7/00 , A61B8/4427 , A61B2017/00734 , A61N2007/0078 , A61N2007/0095
摘要： Disclosed is a “hands-free”, autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.
摘要翻译：公开了一种“免提”自主操作的电池供电装置，其具有用于非侵入性超声治疗缺血性卒中的电子可编程驱动电路，脑血管系统的微动脉，颅内高压和其他脑血管病变，例如与偏头痛相关的灌注不足。该装置设置有对准构件，以便于相对于目标颅内解剖结构将耳机的立体定向放置在头骨上。一旦安装在颅骨上的位置并被激活，该装置在手术期间不需要临床干预; 不需要熟练的技术调整波形图案; 并实现功耗小于400 mAmp-hr的治疗效果，从而延长便携操作而无需外部电源，无需辅助冷却。使用本发明的装置，经颅超声可以是自我施用的。该装置可用于治疗方法，例如治疗中风或偏头痛的方法，用于非侵入性增加药物作用，以及释放或分散内源性神经血管介质。

3. 发明授权

US07331925B2 System for remote evaluation of ultrasound information obtained by a programmed application-specific data collection device 有权
标题翻译：用于远程评估由编程的应用专用数据采集设备获得的超声信息的系统
公开(公告)号：US07331925B2
公开(公告)日：2008-02-19
申请号：US11216244
申请日：2005-08-30
申请人： Gerald J. McMorrow , William Barnard , Stephen Dudycha , Timothy Shelton , Vikram Chalana
发明人： Gerald J. McMorrow , William Barnard , Stephen Dudycha , Timothy Shelton , Vikram Chalana
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B8/56 , A61B8/565 , G06F19/00 , G06F19/3418
摘要： A system which includes at least one ultrasound data collection device which is programmable to carry out a specific ultrasound procedure on a selected part of a human body of a patient. The resulting ultrasound data is transmitted via a local server at the site of the data collection device to the internet and from there to a web database server which processes the raw ultrasound data to produce medical result information, including ultrasound images, which is then sent to a skilled technician, who accepts the results, rejects or edits them. Accepted medical results are transmitted back to the medical practitioner, while edited medical results are reprocessed, the results of which are transmitted to the medical practitioner.
摘要翻译：一种系统，其包括至少一个超声数据收集装置，其可编程以在患者的人体的所选部分上执行特定的超声程序。所得到的超声数据经由本地服务器在数据收集装置的位置被传输到因特网，并从那里传送到网络数据库服务器，该数据库服务器处理原始超声数据以产生医疗结果信息，包括超声图像，然后发送到技术熟练的技术人员接受结果，拒绝或编辑结果。接受的医疗结果被传回医生，而编辑的医疗结果被重新处理，其结果被传送给医师。

4. 发明授权

US08613714B2 Non-invasive transcranial ultrasound apparatus 有权
标题翻译：非侵入性经颅超声仪
公开(公告)号：US08613714B2
公开(公告)日：2013-12-24
申请号：US13209385
申请日：2011-08-13
申请人： Anthony J. Alleman , Randal L. Radford , William Barnard
发明人： Anthony J. Alleman , Randal L. Radford , William Barnard
IPC分类号： A61H1/00
CPC分类号： A61B8/546 , A61B8/4427 , A61B8/582 , A61B8/585 , A61B2017/00734 , A61B2090/502 , A61N7/00 , A61N2007/0078 , A61N2007/0095
摘要： Disclosed is an autonomically functioning, battery-powered apparatus for non-invasive delivery of transcranial ultrasound. Insonation is directed by electronic circuitry and programmable instructions in memory and is modulated to achieve stereotemporal modulation of insonation so as to eliminate the need for assisted cooling. The apparatus is provided with registration members to facilitate stereotactic placement of transducer arrays and does not require diagnostic imaging guidance during setup and operation. Insonation is directed by electronic circuitry and programmable instructions in memory and is modulated to achieve stereotemporal modulation of insonation so as to eliminate the need for assisted cooling.
摘要翻译：公开了一种用于非侵入性递送经颅超声的自动功能的电池供电设备。绝缘由电子电路和可编程指令引导到存储器中，并进行调制，以实现立体时空调制，从而消除对辅助冷却的需要。该装置设置有配准构件以促进换能器阵列的立体定位放置，并且在设置和操作期间不需要诊断成像引导。绝缘由电子电路和可编程指令引导到存储器中，并进行调制，以实现立体时空调制，从而消除对辅助冷却的需要。

5. 发明申请

US20120083718A1 Hands-Free Operator-Independent Transcranial Ultrasound Apparatus and Methods 有权
标题翻译：免提操作者独立经颅超声设备和方法
公开(公告)号：US20120083718A1
公开(公告)日：2012-04-05
申请号：US13209408
申请日：2011-08-14
申请人： Anthony J. Alleman , William Barnard , Randal Lee Radford
发明人： Anthony J. Alleman , William Barnard , Randal Lee Radford
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/4427 , A61B2017/00734 , A61N2007/0078 , A61N2007/0095
摘要： Disclosed is a “hands-free”, autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.
摘要翻译：公开了一种“免提”自主操作的电池供电装置，其具有用于非侵入性超声治疗缺血性卒中的电子可编程驱动电路，脑血管系统的微动脉，颅内高压和其他脑血管病变，例如与偏头痛相关的灌注不足。该装置设置有对准构件，以有助于相对于目标颅内解剖结构将耳机的立体定位放置在头骨上。一旦安装在颅骨上的位置并被激活，该装置在手术期间不需要临床干预; 不需要熟练的技术调整波形图案; 并实现功耗小于400 mAmp-hr的治疗效果，从而延长便携操作而无需外部电源，无需辅助冷却。使用本发明的装置，经颅超声可以是自我施用的。该装置可用于治疗方法，例如治疗中风或偏头痛的方法，用于非侵入性增加药物作用，以及释放或分散内源性神经血管介质。

6. 发明申请

US20110224551A1 Ultrasound Imaging Probe and Method 有权
标题翻译：超声成像探头和方法
公开(公告)号：US20110224551A1
公开(公告)日：2011-09-15
申请号：US12948622
申请日：2010-11-17
申请人： William Barnard , David Bartholomew Shine
发明人： William Barnard , David Bartholomew Shine
IPC分类号： A61B8/14 , A61B8/00
CPC分类号： A61B8/4455 , A61B5/204 , A61B8/08 , A61B8/4281 , A61B8/4461 , A61B8/4472 , A61B8/461 , A61B8/483 , A61B8/56
摘要： An ultrasound probe is provided having an ultrasound module received in a housing thereof, the ultrasound module including a plurality of transducers longitudinally spaced apart within the housing and a control and processing system electrically coupled to the transducers for collecting ultrasonic data representative of a target biological tissue when the ultrasound probe is in operation. A motor is likewise received in the housing to rotate, oscillate and/or translate the ultrasound module in a data collection mode. Coupling fluid is received in the housing to at least partially surround the ultrasound module and the motor. A method of obtaining ultrasonic data representative of a target biological tissue, such as a bladder, for diagnostic purposes is also provided.
摘要翻译：提供超声波探头，其具有容纳在其外壳中的超声模块，所述超声波模块包括在所述壳体内纵向间隔开的多个换能器以及电耦合到所述换能器的控制和处理系统，用于收集代表靶生物组织的超声数据当超声波探头工作时。电机同样被接收在壳体中以在数据收集模式下旋转，振荡和/或平移超声模块。耦合流体被容纳在壳体中以至少部分地围绕超声模块和电动机。还提供了用于诊断目的的获得表示目标生物组织如膀胱的超声波数据的方法。

7. 发明申请

US20120083717A1 Non-Invasive Transcranial Ultrasound Apparatus 有权
标题翻译：非侵入性经颅超声仪
公开(公告)号：US20120083717A1
公开(公告)日：2012-04-05
申请号：US13209385
申请日：2011-08-13
申请人： Anthony J. Alleman , Randal L. Radford , William Barnard
发明人： Anthony J. Alleman , Randal L. Radford , William Barnard
IPC分类号： A61N7/00
CPC分类号： A61B8/546 , A61B8/4427 , A61B8/582 , A61B8/585 , A61B2017/00734 , A61B2090/502 , A61N7/00 , A61N2007/0078 , A61N2007/0095
摘要： Disclosed is an autonomically functioning, battery-powered apparatus for non-invasive delivery of transcranial ultrasound. Insonation is directed by electronic circuitry and programmable instructions in memory and is modulated to achieve stereotemporal modulation of insonation so as to eliminate the need for assisted cooling. The apparatus is provided with registration members to facilitate stereotactic placement of transducer arrays and does not require diagnostic imaging guidance during setup and operation. Insonation is directed by electronic circuitry and programmable instructions in memory and is modulated to achieve stereotemporal modulation of insonation so as to eliminate the need for assisted cooling.
摘要翻译：公开了一种用于非侵入性递送经颅超声的自动功能的电池供电设备。绝缘由电子电路和可编程指令引导到存储器中，并进行调制，以实现立体时空调制，从而消除对辅助冷却的需要。该装置设置有配准构件以促进换能器阵列的立体定位放置，并且在设置和操作期间不需要诊断成像引导。绝缘由电子电路和可编程指令引导到存储器中，并进行调制，以实现立体时空调制，从而消除对辅助冷却的需要。

8. 发明申请

US20070142880A1 Light delivery apparatus 审中-公开
标题翻译：发光装置
公开(公告)号：US20070142880A1
公开(公告)日：2007-06-21
申请号：US11594570
申请日：2006-11-07
申请人： William Barnard , Phillip Burwell , James Chen , Julene Christophersen , William Gembala , David Shine
发明人： William Barnard , Phillip Burwell , James Chen , Julene Christophersen , William Gembala , David Shine
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61N5/0601 , A61N5/062
摘要： A light delivery apparatus to provide light treatment to a patient includes a catheter assembly having a light source that transmit light towards a target site within a patient. A balloon surrounds the light source and has a plurality of tissue engaging elements movable between first positions and second positions. In one embodiment, each element extends radially inward in the first position and radially outward in the second position. An insertion tool is used to deliver the light delivery apparatus. During use, the light delivery apparatus is rotationally locked with the insertion tool for improved steering, navigation, and aiming of emitted light.
摘要翻译：为患者提供光治疗的光输送装置包括导管组件，所述导管组件具有将光发射到患者内的目标部位的光源。气囊围绕光源并且具有可在第一位置和第二位置之间移动的多个组织接合元件。在一个实施例中，每个元件在第一位置处径向向内延伸并且在第二位置中径向向外延伸。插入工具用于输送光输送装置。在使用期间，光输送装置与插入工具旋转地锁定，以改善对发射光的转向，导航和瞄准。

9. 发明授权

US06884217B2 System for aiming ultrasonic bladder instruments 有权
标题翻译：瞄准超声波膀胱器械的系统
公开(公告)号：US06884217B2
公开(公告)日：2005-04-26
申请号：US10607919
申请日：2003-06-27
申请人： Gerald J. McMorrow , William Barnard
发明人： Gerald J. McMorrow , William Barnard
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B5/204 , A61B8/08 , A61B8/483
摘要： The system includes a function for generating a plurality of ultrasound scan planes, each separated by a selected angle, to produce a scan cone having an ultrasound scan cone boundary for scanning the bladder, or other organ. The amount, if any, of the scanned bladder which extends beyond the ultrasound scan cone boundary is then determined, as well as the percentage of the bladder within an inner cone boundary relative to that within the ultrasound cone boundary. A signal is provided, specifically illumination of one of four orthogonal arrows in a display, indicating the direction that the transducer should be moved in order to more accurately center the bladder within the ultrasound scan cone boundary. Re-aiming of the transducer is considered necessary when the ratio of the percentages is less than 70%, while if the percentage ratio is greater than 70%, aiming is optional.
摘要翻译：该系统包括用于产生多个超声扫描平面的功能，每个超声扫描平面以选定角度分隔，以产生具有用于扫描膀胱或其他器官的超声波扫描锥边界的扫描锥体。然后确定延伸超出超声波扫描锥边界的扫描囊的量（如果有的话）以及相对于超声波锥边界内的内锥边界内的膀胱的百分比。提供信号，特别是在显示器中的四个正交箭头之一的照明，指示换能器应该被移动的方向，以更准确地将膀胱居中在超声扫描锥边界内。当百分比的比例小于70％时，传感器的重新瞄准被认为是必要的，而如果百分比率大于70％，瞄准是可选的。

10. 发明授权

US08206307B2 Ultrasound imaging probe and method 有权
标题翻译：超声成像探头和方法
公开(公告)号：US08206307B2
公开(公告)日：2012-06-26
申请号：US12948622
申请日：2010-11-17
申请人： William Barnard , David Bartholomew Shine
发明人： William Barnard , David Bartholomew Shine
IPC分类号： A61B8/14
CPC分类号： A61B8/4455 , A61B5/204 , A61B8/08 , A61B8/4281 , A61B8/4461 , A61B8/4472 , A61B8/461 , A61B8/483 , A61B8/56
摘要： An ultrasound probe is provided having an ultrasound module received in a housing thereof, the ultrasound module including a plurality of transducers longitudinally spaced apart within the housing and a control and processing system electrically coupled to the transducers for collecting ultrasonic data representative of a target biological tissue when the ultrasound probe is in operation. A motor is likewise received in the housing to rotate, oscillate and/or translate the ultrasound module in a data collection mode. Coupling fluid is received in the housing to at least partially surround the ultrasound module and the motor. A method of obtaining ultrasonic data representative of a target biological tissue, such as a bladder, for diagnostic purposes is also provided.
摘要翻译：提供超声波探头，其具有容纳在其外壳中的超声模块，所述超声波模块包括在所述壳体内纵向间隔开的多个换能器以及电耦合到所述换能器的控制和处理系统，用于收集代表靶生物组织的超声数据当超声波探头工作时。电机同样被接收在壳体中以在数据收集模式下旋转，振荡和/或平移超声模块。耦合流体被容纳在壳体中以至少部分地围绕超声模块和电动机。还提供了用于诊断目的的获得表示目标生物组织如膀胱的超声波数据的方法。

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