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1. 发明申请

US20090143387A1 SUSTAINED-RELEASE TABLET COMPOSITION 审中-公开
标题翻译：持续释放片组成
公开(公告)号：US20090143387A1
公开(公告)日：2009-06-04
申请号：US12339212
申请日：2008-12-19
申请人： Gregory E. Amidon , Loksidh D. Ganorkar , John M. Heimlich , Ernest J. Lee , Alice C. Martino , Robert M. Noack , Joseph P. Reo , Connie J. Skoug
发明人： Gregory E. Amidon , Loksidh D. Ganorkar , John M. Heimlich , Ernest J. Lee , Alice C. Martino , Robert M. Noack , Joseph P. Reo , Connie J. Skoug
IPC分类号： A61K31/535 , A61P25/24
CPC分类号： A61K31/428 , A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/4745 , A61K31/5375
摘要： A sustained-release pharmaceutical composition in a form of an orally deliverable tablet containing reboxetine, or a pharmaceutically acceptable salt thereof, dispersed in a matrix containing a hydrophilic polymer and a starch, wherein the starch has a tensile strength of at least 0.15 kN cm−2 at a solid fraction of 0.75 to 0.85.
摘要翻译：一种含有分散在含有亲水性聚合物和淀粉的基质中的瑞波西汀或其药学上可接受的盐的可口服递送片剂形式的持续释放药物组合物，其中淀粉具有至少0.15kN cm -1的拉伸强度， 2，固体分数为0.75至0.85。

2. 发明授权

US08679533B2 Pramipexole once-daily dosage form 有权
标题翻译：普拉克索每日一次剂型
公开(公告)号：US08679533B2
公开(公告)日：2014-03-25
申请号：US10626275
申请日：2003-07-24
申请人： Ernest J. Lee , Gerard M. Bredael , John R. Baldwin , Steven R. Cox , Mark J. Heintz
发明人： Ernest J. Lee , Gerard M. Bredael , John R. Baldwin , Steven R. Cox , Mark J. Heintz
IPC分类号： A61K9/22 , A61K9/32 , A61K31/428
CPC分类号： A61K31/428 , A61K9/2054 , A61K9/2059 , A61K9/28 , A61K9/2866 , A61K31/4745
摘要： An orally deliverable pharmaceutical composition comprises a therapeutically effective amount of pramipexole or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, said composition exhibiting at least one of (a) an in vitro release profile wherein on average no more than about 20% of the pramipexole is dissolved within 2 hours after placement of the composition in a standard dissolution test; and (b) an in vivo pramipexole absorption profile following single dose administration to healthy adult humans wherein the time to reach a mean of 20% absorption is greater than about 2 hours and/or the time to reach a mean of 40% absorption is greater than about 4 hours. The composition is useful for oral administration, not more than once daily, to a subject having a condition or disorder for which a dopamine receptor agonist is indicated.
摘要翻译：可口服递送的药物组合物包含治疗有效量的普拉克索或其药学上可接受的盐和至少一种药学上可接受的赋形剂，所述组合物显示以下至少一种：（a）体外释放曲线，其平均不超过约20％的普拉克索在将组合物放入标准溶出试验后2小时内溶解; 并且（b）对健康成年人单剂量给药后的体内普拉克索吸收曲线，其中达到平均20％吸收的时间大于约2小时和/或达到平均40％吸收的时间更大超过约4小时。该组合物可用于每天不超过一次给予具有指示多巴胺受体激动剂的病症或病症的受试者。

3. 发明授权

US08399016B2 Sustained-release tablet composition of pramipexole 有权
标题翻译：普拉克索的缓释片组合物
公开(公告)号：US08399016B2
公开(公告)日：2013-03-19
申请号：US12716755
申请日：2010-03-03
申请人： Gregory Everett Amidon , Loksidh Devi Ganorkar , John Mark Heimlich , Ernest J. Lee , Robert Martin Noack , Joseph Peter Reo , Connie Jo Skoug
发明人： Gregory Everett Amidon , Loksidh Devi Ganorkar , John Mark Heimlich , Ernest J. Lee , Robert Martin Noack , Joseph Peter Reo , Connie Jo Skoug
IPC分类号： A61K9/22
CPC分类号： A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/428 , A61K31/4745
摘要： A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm−2 at a solid fraction representative of the tablet.
摘要翻译：口服递送片剂形式的缓释药物组合物包含普拉克索的水溶性盐，其分散在包含亲水性聚合物的基质和在固体中具有至少约0.15kN cm -2的拉伸强度的淀粉片剂代表片剂。

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