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1. 发明授权

US08993574B2 Pyrrole antifungal agents 有权
标题翻译：吡咯抗真菌剂
公开(公告)号：US08993574B2
公开(公告)日：2015-03-31
申请号：US12989410
申请日：2009-04-23
申请人： Graham Edward Morris Sibley , Robert Downham , Lloyd James Payne , Derek Law , Jason David Oliver , Mike Birch , Gareth Morse Davies , Patricia Suling Davies
发明人： Graham Edward Morris Sibley , Robert Downham , Lloyd James Payne , Derek Law , Jason David Oliver , Mike Birch , Gareth Morse Davies
IPC分类号： C07D487/04 , C07D498/04 , A01N43/36 , A01N43/60 , A01N43/76 , A01N43/40 , A01N43/42 , A01N43/84 , A01N43/90
CPC分类号： A61K31/5377 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/60 , A01N43/76 , A01N43/84 , A01N43/90 , A61K31/4025 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K45/06 , C07D487/04 , C07D498/04
摘要： The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
摘要翻译：本发明提供式（I）化合物及其药学上和农业上可接受的盐; 其中：R1，R2，R3，R4，R5，R6，A1，L1和n如本文所定义。这些化合物及其药学上可接受的盐可用于预防或治疗真菌病。式（I）化合物及其农业上可接受的盐也可以用作农业杀真菌剂。

2. 发明申请

US20110152285A1 PYRROLE ANTIFUNGAL AGENTS 有权
标题翻译： PYROROLE反真菌药
公开(公告)号：US20110152285A1
公开(公告)日：2011-06-23
申请号：US12989410
申请日：2009-04-23
申请人： Graham Edward Morris Sibley , Robert Downham , Lloyd James Payne , Derek Law , Jason David Oliver , Mike Birch , Gareth Morse Davies , Patricia Suling Davies
发明人： Graham Edward Morris Sibley , Robert Downham , Lloyd James Payne , Derek Law , Jason David Oliver , Mike Birch , Gareth Morse Davies , Patricia Suling Davies
IPC分类号： A61K31/497 , C07D409/14 , A61P31/10
CPC分类号： A61K31/5377 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/60 , A01N43/76 , A01N43/84 , A01N43/90 , A61K31/4025 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K45/06 , C07D487/04 , C07D498/04
摘要： The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
摘要翻译：本发明提供式（I）化合物及其药学上和农业上可接受的盐; 其中：R1，R2，R3，R4，R5，R6，A1，L1和n如本文所定义。这些化合物及其药学上可接受的盐可用于预防或治疗真菌病。式（I）化合物及其农业上可接受的盐也可以用作农业杀真菌剂。

3. 发明申请

US20110183969A1 ANTIFUNGAL COMBINATION THERAPY 审中-公开
标题翻译：反复组合治疗
公开(公告)号：US20110183969A1
公开(公告)日：2011-07-28
申请号：US12994443
申请日：2009-05-29
申请人： Michael Birch , Graham Edward Morris Sibley , Derek Law , Jason David Oliver
发明人： Michael Birch , Graham Edward Morris Sibley , Derek Law , Jason David Oliver
IPC分类号： A61K31/541 , A01N43/84 , A61K31/437 , A01N43/40 , A61K31/4745 , A61K31/5377 , A61K31/496 , A01N43/60 , A01P3/00 , A61P31/00
CPC分类号： A61K45/06 , A61K31/437 , A61K2300/00
摘要： The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.
摘要翻译：本发明提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐与第二抗真菌剂的组合的药物组合：其中：R1，R2，R3，R4，R5，R6，R7，X和X1分别为如本文所定义。本发明还提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐，第二抗真菌剂和药学上可接受的稀释剂或载体的药物组合物。组合和组合物可用于预防或治疗真菌病。式（I）的中氮茚化合物或其农业上可接受的盐和第二抗真菌剂的组合也可以用作农业杀真菌剂。

4. 发明授权

US6154159A Electronic sampling circuit 失效
标题翻译：电子采样电路
公开(公告)号：US6154159A
公开(公告)日：2000-11-28
申请号：US129815
申请日：1998-08-06
申请人： Derek Law , Graham A. Fuggle , Stephen J. Edwards
发明人： Derek Law , Graham A. Fuggle , Stephen J. Edwards
IPC分类号： G01N27/414 , G01N27/416 , G01N27/48 , H03M1/12 , H03M3/04 , H03M1/00
CPC分类号： H03M3/00 , H03M1/12
摘要： An electronic sampling circuit for determining redox potentials, and consequently specie concentration, in a photographic solution, applies a linear ramp of a square wave voltage to a first electrode (6) immersed in the solution. The current drawn by an adjacent electrode (12) is converted to a voltage for sampling. A pair of sample-and-hold circuits (40,42) store signals sampled at the peak and adjacent trough respectively of a square wave pulse, and a subsequent analogue difference circuit (44) subtracts the two signals. The resulting signal is converted to a digital code by a low cost, low bit count analogue-to-digital converter (46), which is stored on a microprocessor (48). The sampling process is repeated for successive square waves along the ramp. This circuit configuration enables the difference between analogue signals to be measured where the signals differ in amplitude by small amounts but have a wide dynamic range, without the need for an expensive, high bit count analogue-to-digital converter.
摘要翻译：用于确定照相溶液中的氧化还原电位，并因此确定特征浓度的电子采样电路向沉浸在溶液中的第一电极（6）施加方波电压的线性斜坡。由相邻电极（12）引出的电流被转换成用于采样的电压。一对采样保持电路（40,42）分别存储在方波脉冲的峰值和相邻槽处采样的信号，随后的模拟差分电路（44）减去两个信号。所得到的信号由存储在微处理器（48）上的低成本，低位计数模数转换器（46）转换成数字代码。对沿着斜坡的连续方波重复采样过程。该电路配置使得能够测量模拟信号之间的差异，其中信号幅度小幅度不同但具有宽的动态范围，而不需要昂贵的高位数模数转换器。

5. 发明申请

US20070195859A1 Temperature sensor apparatus 有权
标题翻译：温度传感器装置
公开(公告)号：US20070195859A1
公开(公告)日：2007-08-23
申请号：US11358964
申请日：2006-02-22
申请人： Guruprasad Krishnamurthy , Ramesh Anllkumar , Derek Law
发明人： Guruprasad Krishnamurthy , Ramesh Anllkumar , Derek Law
IPC分类号： G01K1/00
CPC分类号： G01K1/14 , G01K2205/04
摘要： An apparatus for temperature sensing is disclosed that includes a sensor tube and a cable assembly connected to and extending from said sensor tube wherein said cable assembly communicates electrically with the sensor tube for temperature sensing operations thereof. An O-ring component can be selected based on an inner diameter of said sensor tube and an outer diameter of said cable assembly, wherein said o-ring component is crimped in order to seal and protect said sensor tube from de-alignment and misplacement and located co-axial to said sensor tube and said cable assembly, thereby providing an enhanced mechanical strength and prevention against leakage or ingress of moisture from or to said sensor tube.
摘要翻译：公开了一种用于温度感测的装置，其包括传感器管和连接到所述传感器管并从所述传感器管延伸的电缆组件，其中所述电缆组件与用于其感测操作的传感器管电连通。可以基于所述传感器管的内径和所述电缆组件的外径来选择O形环部件，其中所述O形环部件被压接以便密封和保护所述传感器管不被对准和错位，并且与所述传感器管和所述电缆组件同轴地设置，从而提供增强的机械强度并防止防止来自或传递到所述传感器管的湿气的渗漏或侵入。

6. 发明授权

US07360947B2 Temperature sensor apparatus 有权
标题翻译：温度传感器装置
公开(公告)号：US07360947B2
公开(公告)日：2008-04-22
申请号：US11358964
申请日：2006-02-22
申请人： Guruprasad Krishnamurthy , Ramesh Anllkumar , Derek Law
发明人： Guruprasad Krishnamurthy , Ramesh Anllkumar , Derek Law
IPC分类号： G01K1/08
CPC分类号： G01K1/14 , G01K2205/04
摘要： An apparatus for temperature sensing is disclosed that includes a sensor tube and a cable assembly connected to and extending from said sensor tube wherein said cable assembly communicates electrically with the sensor tube for temperature sensing operations thereof. An O-ring component can be selected based on an inner diameter of said sensor tube and an outer diameter of said cable assembly, wherein said o-ring component is crimped in order to seal and protect said sensor tube from de-alignment and misplacement and located co-axial to said sensor tube and said cable assembly, thereby providing an enhanced mechanical strength and prevention against leakage or ingress of moisture from or to said sensor tube.
摘要翻译：公开了一种用于温度感测的装置，其包括传感器管和连接到所述传感器管并从所述传感器管延伸的电缆组件，其中所述电缆组件与用于其感测操作的传感器管电连通。可以基于所述传感器管的内径和所述电缆组件的外径来选择O形环部件，其中所述O形环部件被压接以便密封和保护所述传感器管不被对准和错位，并且与所述传感器管和所述电缆组件同轴地设置，从而提供增强的机械强度并防止防止来自或传递到所述传感器管的湿气的渗漏或侵入。

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