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1. 发明授权

US08258172B2 Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 有权
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US08258172B2
公开(公告)日：2012-09-04
申请号：US12841888
申请日：2010-07-22
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。

2. 发明授权

US08691864B2 Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 失效
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US08691864B2
公开(公告)日：2014-04-08
申请号：US13559186
申请日：2012-07-26
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。

3. 发明申请

US20110021594A1 Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US20110021594A1
公开(公告)日：2011-01-27
申请号：US12841888
申请日：2010-07-22
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。

4. 发明申请

US20120295946A1 Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 失效
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US20120295946A1
公开(公告)日：2012-11-22
申请号：US13559186
申请日：2012-07-26
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。

5. 发明申请

US20090131501A1 Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US20090131501A1
公开(公告)日：2009-05-21
申请号：US12357115
申请日：2009-01-21
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生并且在广泛剂量范围内无毒性的受试者施用此类化合物的方法。已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。

6. 发明申请

US20060270729A1 Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof 审中-公开
标题翻译：可用于还原淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US20060270729A1
公开(公告)日：2006-11-30
申请号：US11455959
申请日：2006-06-20
申请人： Nigel Greig , Karen Shaw , Qiang-Sheng Yu , Harold Holloway , Tada Utsuki , Timothy Soncrant , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel Greig , Karen Shaw , Qiang-Sheng Yu , Harold Holloway , Tada Utsuki , Timothy Soncrant , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61K31/405 , A61K31/381 , A61K31/343
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生并且在广泛剂量范围内无毒性的受试者施用此类化合物的方法。已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。

7. 发明授权

US07786162B2 Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 有权
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US07786162B2
公开(公告)日：2010-08-31
申请号：US12357115
申请日：2009-01-21
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40 , C07D487/00
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。

8. 发明授权

US07153882B2 Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof 有权
标题翻译：可用于减少淀粉样蛋白前体蛋白和治疗消瘦的药剂及其使用方法
公开(公告)号：US07153882B2
公开(公告)日：2006-12-26
申请号：US10415765
申请日：2001-11-02
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/40 , C07D487/02 , C07D491/02
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生的受试者施用这种化合物的方法，并且在广泛的剂量范围内不是曲线。已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。

9. 发明申请

US20050187409A1 Inhibitors of RNase P proteins as antibacterial compounds 审中-公开
标题翻译： RNase P蛋白抑制剂作为抗菌化合物
公开(公告)号：US20050187409A1
公开(公告)日：2005-08-25
申请号：US10970190
申请日：2004-10-21
申请人： Gordon Powers , Michael Sturgess
发明人： Gordon Powers , Michael Sturgess
IPC分类号： A61K20060101 , A61K31/165 , C07C233/65 , C07C279/20
CPC分类号： C07C281/18 , C07D207/16 , C07D215/32 , C07D217/26 , C07D233/64 , C07D235/18 , C07D405/06 , C07D409/06 , C07D417/06 , C07D513/04
摘要： The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazones and benzoic acid compounds.
摘要翻译：本发明具有用于抑制RNase P活性的化合物。这些化合物可用作治疗或预防各种细菌感染的治疗剂。这些化合物属于几类，包括单脒腙和双脒腙和苯甲酸化合物。

10. 发明申请

US20050055377A1 User interface for composing multi-media presentations 审中-公开
标题翻译：用于组合多媒体演示的用户界面
公开(公告)号：US20050055377A1
公开(公告)日：2005-03-10
申请号：US10854461
申请日：2004-05-26
申请人： Richard Dorey , Gordon Powers
发明人： Richard Dorey , Gordon Powers
IPC分类号： G06F9/44 , G06F17/00 , G06F17/30
CPC分类号： G11B27/034 , G06F16/4393
摘要： A method, distributed computer system, and computer software program, stored on a computer readable medium, is configured to generate multimedia presentations. The program includes a database management system. The database management system includes audiovisual content stored in association with icons indicative of the audiovisual content and a memory buffer for storing a multimedia presentation. The memory buffer is configured to store media content in association with an exhibition time within the multimedia presentation. A server stub is configured for storing and recalling data in the database management system in accord with requests for actions received at the server stub from the client computer. The stub also generates messages to the client computer indicative of the media content stored in the memory buffer. A compiler, the compiler is configured to generate a file including the multimedia presentation stored in the memory buffer.
摘要翻译：存储在计算机可读介质上的方法，分布式计算机系统和计算机软件程序被配置为生成多媒体呈现。该程序包括一个数据库管理系统。数据库管理系统包括与指示视听内容的图标相关联地存储的视听内容和用于存储多媒体呈现的存储器缓冲器。存储器缓冲器被配置为在多媒体呈现中与展览时间相关联地存储媒体内容。服务器存根配置为根据从客户端计算机在服务器存根处接收到的动作的请求来存储和调用数据库管理系统中的数据。存根还生成指示存储在存储器缓冲器中的媒体内容的客户端计算机的消息。编译器，编译器被配置为生成包含存储在存储器缓冲器中的多媒体呈现的文件。

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