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1. 发明申请

US20120078522A1 SYSTEMS AND METHODS FOR HOLISTIC ANALYSIS AND VISUALIZATION OF PHARMACOLOGICAL DATA 审中-公开
标题翻译：用于血液分析和药物数据可视化的系统和方法
公开(公告)号：US20120078522A1
公开(公告)日：2012-03-29
申请号：US13102880
申请日：2011-05-06
申请人： Gopal Avinash , Zhongmin Lin , Ananth P. Mohan , Ricky R. Wascher
发明人： Gopal Avinash , Zhongmin Lin , Ananth P. Mohan , Ricky R. Wascher
IPC分类号： G06F19/00
CPC分类号： G16H50/70
摘要： Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes accessing data related to drug development; pre-processing the data to prepare the data for measurement and analysis; and analyzing the data based on at least one of a plurality of different metrics. Each metric corresponds to a quantified variation between a first data set of results corresponding to a category in the drug development process. The first data set of results is provided for comparison with a second data set of results corresponding to at least one other category in the drug development process. At least some of the plurality of metrics are aggregated to generate a visual representation representing an integrated comparative visualization for the identified category.
摘要翻译：某些例子提供了整体观察的系统和方法，以在药物开发过程中提供比较分析和决策支持。一个示例性方法包括访问与药物开发有关的数据; 预处理数据以准备数据进行测量和分析; 以及基于多个不同度量中的至少一个来分析数据。每个度量对应于与药物开发过程中的类别相对应的结果的第一数据集合之间的量化变化。提供结果的第一数据集用于与在药物开发过程中与至少一个其他类别对应的结果的第二数据集进行比较。多个度量中的至少一些被聚合以产生表示用于所识别的类别的综合比较可视化的视觉表示。

2. 发明申请

US20120051609A1 SYSTEM AND METHOD FOR ANALYZING AND VISUALIZING LOCAL CLINICAL FEATURES 审中-公开
标题翻译：用于分析和可视化局部临床特征的系统和方法
公开(公告)号：US20120051609A1
公开(公告)日：2012-03-01
申请号：US12870331
申请日：2010-08-27
申请人： Gopal Biligeri Avinash , Ananth P. Mohan
发明人： Gopal Biligeri Avinash , Ananth P. Mohan
IPC分类号： G06K9/00
CPC分类号： G06T7/0014 , G06T11/206 , G06T2200/24 , G06T2207/20104 , G06T2207/30016 , G06T2207/30061
摘要： A system and method for analyzing and visualizing local clinical features includes access of a medical image dataset comprising image data acquired from a patient and identification of a region of interest (ROI) dataset corresponding to an ROI from the medical image dataset. The system also includes application of an automated algorithm to the ROI dataset, identification of an intermediate result used by the automated algorithm to analyze the ROI, and access of reference data corresponding to the intermediate result, the reference data derived from a reference dataset and representing an expected behavior of the intermediate result. Further, the system includes comparison of the intermediate result to the reference data, generation of a deviation metric based on the comparison, the deviation metric representing a deviation of the intermediate result, and creation of a visual representation of the deviation metric.
摘要翻译：用于分析和可视化本地临床特征的系统和方法包括访问包括从患者获取的图像数据的医学图像数据集和来自医学图像数据集的对应于ROI的感兴趣区域（ROI）数据集的识别。该系统还包括将自动化算法应用于ROI数据集，识别由自动算法分析ROI的中间结果，以及访问对应于中间结果的参考数据，从参考数据集导出的参考数据和表示中间结果的预期行为。此外，系统包括中间结果与参考数据的比较，基于比较的偏差度量的生成，表示中间结果的偏差的偏差度量以及偏差度量的视觉表示的创建。

3. 发明授权

US08761479B2 System and method for analyzing and visualizing spectral CT data 有权
标题翻译：用于分析和可视化光谱CT数据的系统和方法
公开(公告)号：US08761479B2
公开(公告)日：2014-06-24
申请号：US12941162
申请日：2010-11-08
申请人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
发明人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
IPC分类号： G06K9/00
CPC分类号： A61B6/482 , A61B6/032 , A61B6/463 , A61B6/465 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T11/001 , G06T2207/10081 , G06T2207/20104
摘要： A system and method for analyzing and visualizing spectral CT data includes access of a set of image data acquired from a patient comprising spectral CT data, identification of a plurality of target regions of interest (TROIs) and a reference region of interest (RROI) from the set of image data, extraction of a plurality of target spectral Hounsfield unit (HU) curves from image data representing the plurality of TROIs, extraction of a reference spectral HU curve from image data representing the RROI, normalization of the plurality of target spectral HU curves with respect to the reference spectral HU curve, and display of the plurality of normalized target spectral HU curves.
摘要翻译：用于分析和可视化频谱CT数据的系统和方法包括从患者获取的一组图像数据的访问，包括频谱CT数据，多个目标感兴趣区域（TROI）和感兴趣的参考区域（RROI）的识别从图像数据集合，从表示多个TROI的图像数据中提取多个目标光谱Hounsfield单位（HU）曲线，从表示RROI的图像数据中提取参考光谱HU曲线，多个目标光谱HU的归一化相对于参考光谱HU曲线的曲线，以及多个归一化的目标光谱HU曲线的显示。

4. 发明申请

US20120114206A1 SYSTEM AND METHOD FOR ANALYZING AND VISUALIZING SPECTRAL CT DATA 有权
标题翻译：用于分析和可视化光谱数据的系统和方法
公开(公告)号：US20120114206A1
公开(公告)日：2012-05-10
申请号：US12941162
申请日：2010-11-08
申请人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
发明人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
IPC分类号： G06K9/00
CPC分类号： A61B6/482 , A61B6/032 , A61B6/463 , A61B6/465 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T11/001 , G06T2207/10081 , G06T2207/20104
摘要： A system and method for analyzing and visualizing spectral CT data includes access of a set of image data acquired from a patient comprising spectral CT data, identification of a plurality of target regions of interest (TROIs) and a reference region of interest (RROI) from the set of image data, extraction of a plurality of target spectral Hounsfield unit (HU) curves from image data representing the plurality of TROIs, extraction of a reference spectral HU curve from image data representing the RROI, normalization of the plurality of target spectral HU curves with respect to the reference spectral HU curve, and display of the plurality of normalized target spectral HU curves.
摘要翻译：用于分析和可视化频谱CT数据的系统和方法包括从患者获取的一组图像数据的访问，包括频谱CT数据，多个目标感兴趣区域（TROI）和感兴趣的参考区域（RROI）的识别从图像数据集合，从表示多个TROI的图像数据中提取多个目标光谱Hounsfield单位（HU）曲线，从表示RROI的图像数据中提取参考光谱HU曲线，多个目标光谱HU的归一化相对于参考光谱HU曲线的曲线，以及多个归一化的目标光谱HU曲线的显示。

5. 发明申请

US20120078526A1 APPARATUS, SYSTEM AND METHODS FOR DETERMINING DRUG ATTRIBUTES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA 审中-公开
标题翻译：使用疾病标志物分析和药理学数据确定药物属性的装置，系统和方法
公开(公告)号：US20120078526A1
公开(公告)日：2012-03-29
申请号：US13169594
申请日：2011-06-27
申请人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
发明人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
IPC分类号： G06F19/10
CPC分类号： G16H50/70
摘要： Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example of the inventive apparatus includes a standardizer to at least one of standardize and normalize data related to drug performance for a known disease signature; and a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric associated with the disease signature.
摘要翻译：某些例子提供了整体观察的系统和方法，以在药物开发过程中提供比较分析和决策支持。本发明的装置的实例包括标准化器，用于标准化和标准化与已知疾病特征的药物性能相关的数据中的至少一个; 以及偏差分析器，用于基于多个不同功效度量中的至少一个来分析所述数据，其中，与识别的目标药物相对应的第一数据结果集合与对应于控制的结果的第二数据集之间的量化变化，其中提供所述第一结果数据集用于与所述第二数据结果集进行比较，并且将其之间的偏差与与所述疾病特征相关联的所述至少一个功效度量进行比较。

6. 发明申请

US20120078525A1 APPARATUS, SYSTEM AND METHODS FOR SELECTING DRUG CANDIDATES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA 审中-公开
标题翻译：使用疾病标志分析和药理学数据选择药物候选药物的方法，系统和方法
公开(公告)号：US20120078525A1
公开(公告)日：2012-03-29
申请号：US13169585
申请日：2011-06-27
申请人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
发明人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
IPC分类号： G06F19/00 , G06F7/60
CPC分类号： G16H50/70
摘要： Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes providing a first set of data corresponding to a drug of interest: providing a disease signature; providing a reference set of drug interaction data associated with the disease signature, comparing the first set of data to the reference set using a holistic analysis, and reporting the results of the comparison. An example of the apparatus includes, a standardizer to at least one of standardize and normalize drug interaction data related to a pre-selected disease signature: a deviation analyzer to compare the drug interaction data to data corresponding to a drug under review using a holistic analysis, and a reporter for reporting the output of the deviation analyzer.
摘要翻译：某些例子提供了整体观察的系统和方法，以在药物开发过程中提供比较分析和决策支持。示例性方法包括提供与感兴趣的药物相对应的第一组数据：提供疾病特征; 提供与疾病签名相关联的药物相互作用数据的参考集合，使用整体分析将第一组数据与参考集进行比较，并报告比较结果。该装置的一个实例包括标准化器，其至少标准化和规范与预先选择的疾病特征相关的药物相互作用数据中的至少一个：偏差分析器，以使用整体分析将药物相互作用数据与对应于正在审查的药物的数据进行比较和报告偏差分析仪的输出的记者。

7. 发明授权

US09514250B2 System and method for analyzing and visualizing enumerated information 有权
标题翻译：用于分析和可视化枚举信息的系统和方法
公开(公告)号：US09514250B2
公开(公告)日：2016-12-06
申请号：US12845853
申请日：2010-07-29
申请人： Gopal Biligeri Avinash , Eric David Kiger Garland , Ananth P. Mohan
发明人： Gopal Biligeri Avinash , Eric David Kiger Garland , Ananth P. Mohan
IPC分类号： G06F17/30 , G06F7/00 , G06Q50/24 , G06F19/00
CPC分类号： G06F17/30994 , G06F17/30985 , G06F19/00 , G06F19/324 , G16H10/60
摘要： A system and method for analyzing clinical data includes a reference database comprising a stored set of reference data comprising enumerated results of a reference population for a clinical test. The system also includes a patient database comprising a stored set of clinical data corresponding to a patient result for the clinical test that is selected from the enumerated results. A processor is included in the system and is programmed to access the patient and reference databases, identify a distribution of reference data over the enumerated test results, and calculate a relevance index based on the distribution of reference data. The processor is further programmed to compare the patient result to the distribution of reference data, calculate a disagreement index based on the comparison, and calculate a deviation index from the relevance and disagreement indices. A graphical user interface is also included to output a visualization of the deviation index.
摘要翻译：用于分析临床数据的系统和方法包括参考数据库，其包括存储的一组参考数据，其包括用于临床测试的参考群的列举结果。该系统还包括患者数据库，其包括对应于从列举的结果中选择的用于临床测试的患者结果的存储的一组临床数据。处理器被包括在系统中，并被编程以访问患者和参考数据库，通过枚举的测试结果识别参考数据的分布，并且基于参考数据的分布来计算相关性指数。处理器进一步编程为将患者结果与参考数据的分布进行比较，根据比较计算分歧指数，并计算相关性和不一致指数的偏差指数。还包括图形用户界面以输出偏差指数的可视化。

8. 发明授权

US08934685B2 System and method for analyzing and visualizing local clinical features 有权
标题翻译：用于分析和可视化局部临床特征的系统和方法
公开(公告)号：US08934685B2
公开(公告)日：2015-01-13
申请号：US12886932
申请日：2010-09-21
申请人： Gopal Biligeri Avinash , Ananth P. Mohan , Saad Ahmed Sirohey , Zhongmin Steve Lin
发明人： Gopal Biligeri Avinash , Ananth P. Mohan , Saad Ahmed Sirohey , Zhongmin Steve Lin
IPC分类号： G06K9/00 , G06T7/00 , G06K9/32
CPC分类号： G06T7/0014 , G06K9/3233 , G06T2200/24 , G06T2207/20104 , G06T2207/30016
摘要： A system and method for analyzing and visualizing a local feature of interest includes access of a clinical image dataset comprising clinical image data acquired from a patient, identification of a region of interest (ROI) from the clinical image dataset, and extraction of at least one local feature corresponding to the ROI. The system and method also include definition of a local feature dataset comprising data representing at least one local feature, access of a pre-computed reference dataset comprising image data representing an expected value of the at least one identified derived characteristic of interest, and comparison of the characteristic dataset to the pre-computed reference dataset. Further, the system and method include calculation of at least one deviation metric from the comparison and output of a visualization of the at least one deviation metric.
摘要翻译：用于分析和可视化感兴趣的局部特征的系统和方法包括访问包括从患者获取的临床图像数据的临床图像数据集，从临床图像数据集识别感兴趣区域（ROI），以及提取至少一个局部特征对应于ROI。该系统和方法还包括定义包括代表至少一个局部特征的数据的局部特征数据集，预先计算的参考数据集的访问包括表示所述至少一个识别的感兴趣的导出特征的期望值的图像数据，以及特征数据集到预先计算的参考数据集。此外，该系统和方法包括计算与至少一个偏差度量的可视化的比较和输出中的至少一个偏差度量。

9. 发明申请

US20120078528A1 PATIENT DIAGNOSIS USING DRUG RELATED HOLISTIC DATA 审中-公开
标题翻译：使用药物相关HOLISTIC数据的患者诊断
公开(公告)号：US20120078528A1
公开(公告)日：2012-03-29
申请号：US13245484
申请日：2011-09-26
申请人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
发明人： Gopal B. Avinash , Ananth P. Mohan , Zhongmin S. Lin , Rick R. Wascher
IPC分类号： G06F19/10
CPC分类号： G16H50/70
摘要： Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. A computer-implemented method for integrated comparative holistic analysis of drug development and related quantifiable patient treatment decision support for a medical condition having a known disease signature.
摘要翻译：某些例子提供了整体观察的系统和方法，以在药物开发过程中提供比较分析和决策支持。用于药物开发和相关的可量化的患者治疗决定的综合比较整体分析的计算机实施方法支持具有已知疾病特征的医学病症。

10. 发明申请

US20120070044A1 SYSTEM AND METHOD FOR ANALYZING AND VISUALIZING LOCAL CLINICAL FEATURES 有权
标题翻译：用于分析和可视化局部临床特征的系统和方法
公开(公告)号：US20120070044A1
公开(公告)日：2012-03-22
申请号：US12886932
申请日：2010-09-21
申请人： Gopal Biligeri Avinash , Ananth P. Mohan , Saad Ahmed Sirohey , Zhongmin Steve Lin
发明人： Gopal Biligeri Avinash , Ananth P. Mohan , Saad Ahmed Sirohey , Zhongmin Steve Lin
IPC分类号： G06K9/62
CPC分类号： G06T7/0014 , G06K9/3233 , G06T2200/24 , G06T2207/20104 , G06T2207/30016
摘要： A system and method for analyzing and visualizing a local feature of interest includes access of a clinical image dataset comprising clinical image data acquired from a patient, identification of a region of interest (ROI) from the clinical image dataset, and extraction of at least one local feature corresponding to the ROI. The system and method also include definition of a local feature dataset comprising data representing at least one local feature, access of a pre-computed reference dataset comprising image data representing an expected value of the at least one identified derived characteristic of interest, and comparison of the characteristic dataset to the pre-computed reference dataset. Further, the system and method include calculation of at least one deviation metric from the comparison and output of a visualization of the at least one deviation metric.
摘要翻译：用于分析和可视化感兴趣的局部特征的系统和方法包括访问包括从患者获取的临床图像数据的临床图像数据集，从临床图像数据集识别感兴趣区域（ROI），以及提取至少一个局部特征对应于ROI。该系统和方法还包括定义包括代表至少一个局部特征的数据的局部特征数据集，预先计算的参考数据集的访问包括表示所述至少一个识别的感兴趣的导出特征的期望值的图像数据，以及特征数据集到预先计算的参考数据集。此外，该系统和方法包括计算与至少一个偏差度量的可视化的比较和输出中的至少一个偏差度量。

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