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1. 发明申请

US20060128947A1 Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor 失效
标题翻译：组织因子途径抑制剂的制剂，溶解，纯化和重折叠
公开(公告)号：US20060128947A1
公开(公告)日：2006-06-15
申请号：US11337518
申请日：2006-01-24
申请人： Glenn Dorin , Bo Arve , Gregory Pattison , Robert Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan Rana , Maninder Hora , Hassan Madani , Michael Tsang , Mark Gustafson , Gary Bild , Gary Johnson
发明人： Glenn Dorin , Bo Arve , Gregory Pattison , Robert Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan Rana , Maninder Hora , Hassan Madani , Michael Tsang , Mark Gustafson , Gary Bild , Gary Johnson
IPC分类号： A61K38/54 , C07K14/475
CPC分类号： C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要： Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.
摘要翻译：描述了适合配制TFPI的组合物。增溶剂和稳定剂有助于制备各种浓度的TFPI的药学上可接受的组合物。

2. 发明授权

US07022672B2 Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor 失效
公开(公告)号：US07022672B2
公开(公告)日：2006-04-04
申请号：US09996588
申请日：2001-11-30
申请人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rejsharan K. Bana , Maninder S. Hoba , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
发明人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rejsharan K. Bana , Maninder S. Hoba , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要： A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

3. 发明授权

US06323326B1 Method of solubilizing, purifying, and refolding protein 失效
标题翻译：溶解，纯化和重折叠蛋白质的方法
公开(公告)号：US06323326B1
公开(公告)日：2001-11-27
申请号：US08973211
申请日：1999-06-11
申请人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hoba , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
发明人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hoba , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
IPC分类号： A23J100
CPC分类号： C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要： A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.
摘要翻译：改变蛋白质溶解度的方法使用聚离子聚合物。这些促进蛋白质的溶解，配制，纯化和重折叠，特别是不正确折叠的蛋白质和聚集的蛋白质。描述了适合配制TFPI的组合物。所述组合物允许以高于0.2mg / mL和高于10mg / mL的浓度制备药学上可接受的TFPI组合物。

4. 发明授权

US07226757B2 Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor 失效
标题翻译：组织因子途径抑制剂的制剂，溶解，纯化和重折叠
公开(公告)号：US07226757B2
公开(公告)日：2007-06-05
申请号：US11337518
申请日：2006-01-24
申请人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Raisharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
发明人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Raisharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
IPC分类号： C12P21/02 , C07K1/18 , C07K1/20
CPC分类号： C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要： Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.
摘要翻译：描述了适合配制TFPI的组合物。增溶剂和稳定剂有助于制备各种浓度的TFPI的药学上可接受的组合物。

5. 发明申请

US20080281084A1 Formulation, Solubilization, Purification, and Refolding of Tissue Factor Pathway Inhibitor 审中-公开
标题翻译：组织因子途径抑制剂的制剂，溶解，纯化和再折叠
公开(公告)号：US20080281084A1
公开(公告)日：2008-11-13
申请号：US11697188
申请日：2007-04-05
申请人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Raisharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
发明人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Raisharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
IPC分类号： C07K14/47
CPC分类号： C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要： Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.
摘要翻译：描述了适合配制TFPI的组合物。增溶剂和稳定剂有助于制备各种浓度的TFPI的药学上可接受的组合物。

6. 发明授权

US06319896B1 Method of solubilizing, purifying, and refolding protein 失效
公开(公告)号：US06319896B1
公开(公告)日：2001-11-20
申请号：US09443098
申请日：1999-11-18
申请人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
发明人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
IPC分类号： A61K3816
CPC分类号： C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要： A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

7. 发明授权

US08527639B1 Content server selection for accessing content in a content distribution network 有权
标题翻译：用于访问内容分发网络中的内容的内容服务器选择
公开(公告)号：US08527639B1
公开(公告)日：2013-09-03
申请号：US09642165
申请日：2000-08-18
申请人： Barbara Liskov , James O'Toole , M. Frans Kaashoek , Kirk Johnson
发明人： Barbara Liskov , James O'Toole , M. Frans Kaashoek , Kirk Johnson
IPC分类号： G06F15/173 , G06F15/16
CPC分类号： H04L67/1004 , H04L67/101 , H04L67/1021
摘要： Content servers are directed to send messages to network nodes which are used to obtain IP addresses and to receive responses from the network nodes. The responses provide network service information. The content servers collect data based on the responses and feed the data to a routing server. Based on the data fed to the routing server, respective choices of content servers are selected and provided to the network nodes to respond to clients requesting content server addresses from the network nodes.
摘要翻译：内容服务器旨在向用于获取IP地址并从网络节点接收响应的网络节点发送消息。响应提供网络服务信息。内容服务器根据响应收集数据，并将数据提供给路由服务器。基于馈送到路由服务器的数据，选择内容服务器的各个选择并提供给网络节点以响应来自网络节点的请求内容服务器地址的客户端。

8. 发明授权

US08313909B2 Herbicide tolerant rice plants and methods for identifying same 有权
标题翻译：除草剂耐受性水稻植物及其鉴定方法
公开(公告)号：US08313909B2
公开(公告)日：2012-11-20
申请号：US13037573
申请日：2011-03-01
申请人： Marc De Beuckeleer , Kirk Johnson , Frank Michiels
发明人： Marc De Beuckeleer , Kirk Johnson , Frank Michiels
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12N15/8277 , A01H5/10
摘要： The invention provides specific transgenic rice plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the rice genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.
摘要翻译：本发明提供特定的转基因水稻植物，植物材料和种子，其特征在于这些产品在水稻基因组中的特定位置处具有特异性转化事件。还提供了允许快速且明确地识别生物样品中的事件的工具。

9. 发明授权

US07886023B1 Method and apparatus for a minimalist approach to implementing server selection 有权
标题翻译：实现服务器选择的简约方法和方法
公开(公告)号：US07886023B1
公开(公告)日：2011-02-08
申请号：US09824527
申请日：2001-04-02
申请人： Kirk Johnson
发明人： Kirk Johnson
IPC分类号： G06F15/16
CPC分类号： H04L67/1002 , H04L67/1019 , H04L67/1025
摘要： Server selection is optimized using randomness, feedback, and fanout. A central server maintains a vector of server selection probabilities and provides a subset of candidate servers from the vector for the client in response to receiving from a client a request for a server address to provide substantive service. An interrogating node (i.e., the client or DNS proxy) probes the candidate servers and selects a best server based on at least one criterion. The client accesses the selected server for the substantive data, and the selected server updates a counter used to keep track of the number of times the server is selected. The servers feedback the number of times selected to the central server, which, in turn, updates weightings in the vector of server selection probabilities.
摘要翻译：服务器选择使用随机性，反馈和扇出优化。中央服务器维护服务器选择概率的向量，并响应于从客户端接收到服务器地址提供实质性服务的请求，向客户端向量提供候选服务器的子集。询问节点（即，客户端或DNS代理）探测候选服务器并基于至少一个标准选择最佳服务器。客户端访问所选服务器的实体数据，所选择的服务器更新用于跟踪服务器被选择次数的计数器。服务器将选择的次数反馈给中央服务器，这反过来更新了服务器选择概率向量中的权重。

10. 发明申请

US20060289772A1 Visible light and IR combined image camera with a laser pointer 有权
公开(公告)号：US20060289772A1
公开(公告)日：2006-12-28
申请号：US11294752
申请日：2005-12-05
申请人： Kirk Johnson , Thomas McManus , John Pratten
发明人： Kirk Johnson , Thomas McManus , John Pratten
IPC分类号： G01T1/24
CPC分类号： G01C3/08 , G01J5/025 , G01J5/0265 , G01J5/0295 , G01J5/0859 , G01J5/089 , G01J5/0896 , H01L27/14618 , H01L27/14625 , H01L2924/0002 , H04N5/2254 , H04N5/2258 , H04N5/23212 , H04N5/23293 , H04N5/33 , H04N5/332 , H01L2924/00
摘要： Methods and apparatuses of registering on a camera display separate fields of view of a visible light camera module and an infrared camera module by focusing the IR camera module. The fields of view can be displayed in several display modes including 1) full screen visible, infrared and/or blended, 2) picture-in-a-picture such as partial infrared image in a full screen visible image, and 3) infrared color alarms in visible-light images.

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