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1. 发明申请

US20140194598A1 B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 审中-公开
标题翻译： B7相关核酸和多肽可用于免疫调节
公开(公告)号：US20140194598A1
公开(公告)日：2014-07-10
申请号：US14178360
申请日：2014-02-12
申请人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
发明人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
IPC分类号： C07K14/705 , C07K16/28 , A61K47/48
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

2. 发明申请

US20100136575A1 B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
标题翻译： B7相关核酸和多肽可用于免疫调节
公开(公告)号：US20100136575A1
公开(公告)日：2010-06-03
申请号：US12701119
申请日：2010-02-05
申请人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
发明人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
IPC分类号： G01N33/53 , C07K16/00 , C12N5/16
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

3. 发明授权

US07723479B2 BSL3 polypeptides 有权
标题翻译： BSL3多肽
公开(公告)号：US07723479B2
公开(公告)日：2010-05-25
申请号：US11900026
申请日：2007-09-06
申请人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
发明人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
IPC分类号： C07K14/705
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

4. 发明申请

US20120329990A1 B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
标题翻译： B7相关核酸和多肽可用于免疫调节
公开(公告)号：US20120329990A1
公开(公告)日：2012-12-27
申请号：US13331540
申请日：2011-12-20
申请人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
发明人： Glen Eugene Mikesell , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach , Henry Shen
IPC分类号： C07K14/435 , C07H21/04
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

5. 发明申请

US20090215995A1 B-7 related nucleic acids and polypeptides useful for immunomodulation 有权
标题翻译：可用于免疫调节的B-7相关核酸和多肽
公开(公告)号：US20090215995A1
公开(公告)日：2009-08-27
申请号：US11900026
申请日：2007-09-06
申请人： Glen Eugene Mikesell , Han Chang , Joshua N, Finger , Guchen Yang , Robert James Peach , Henry Shen
发明人： Glen Eugene Mikesell , Han Chang , Joshua N, Finger , Guchen Yang , Robert James Peach , Henry Shen
IPC分类号： C07K19/00 , C07K14/47
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

6. 发明授权

US07358354B2 Polynucleotides encoding BSL3 有权
标题翻译：编码BSL3的多核苷酸
公开(公告)号：US07358354B2
公开(公告)日：2008-04-15
申请号：US11355735
申请日：2006-02-16
申请人： Glen Eugene Mikesell , Han Chang , Robert James Peach
发明人： Glen Eugene Mikesell , Han Chang , Robert James Peach
IPC分类号： C07H21/04 , C12N15/00 , C12N1/21 , C12N5/16 , C12P21/02
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

7. 发明授权

US08354513B2 Polynucleotides encoding BSL2vcvc-lg 有权
标题翻译：编码BSL2vcvc-lg的多核苷酸
公开(公告)号：US08354513B2
公开(公告)日：2013-01-15
申请号：US12783968
申请日：2010-05-20
申请人： Glen Eugene Mikesell , Han Chang , Robert James Peach
发明人： Glen Eugene Mikesell , Han Chang , Robert James Peach
IPC分类号： C07H21/04
CPC分类号： C07K14/70532 , A61K38/00 , A61K38/1774 , A61K39/39533 , A61K2039/505 , C07K16/2827 , C07K19/00 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/10 , C07K2319/30 , C07K2319/40 , G01N33/5005 , Y02A50/396
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

8. 发明授权

US07279567B2 Polynucleotides-encoding B7-related polypeptide, BSL2-L165-35B 有权
标题翻译：编码B7的多核苷酸多肽，BSL2-L165-35B
公开(公告)号：US07279567B2
公开(公告)日：2007-10-09
申请号：US10994824
申请日：2004-11-22
申请人： Glen Eugene Mikesell , Han Chang , Robert James Peach
发明人： Glen Eugene Mikesell , Han Chang , Robert James Peach
IPC分类号： C07H21/04 , C12N5/10 , C12N1/21 , C12N15/00 , C12N15/11
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

9. 发明授权

US08664360B2 BSL3 polypeptides 有权
标题翻译： BSL3多肽
公开(公告)号：US08664360B2
公开(公告)日：2014-03-04
申请号：US13331540
申请日：2011-12-20
申请人： Glen Eugene Mikesell , Han Chang , Robert James Peach
发明人： Glen Eugene Mikesell , Han Chang , Robert James Peach
IPC分类号： C07K14/00
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

10. 发明授权

US08080636B2 BSL3 antibodies 有权
标题翻译： BSL3抗体
公开(公告)号：US08080636B2
公开(公告)日：2011-12-20
申请号：US12701119
申请日：2010-02-05
申请人： Glen Eugene Mikesell , Han Chang , Robert James Peach
发明人： Glen Eugene Mikesell , Han Chang , Robert James Peach
IPC分类号： C07K16/00
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

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