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    • 6. 发明申请
    • MULTIFUNCTIONAL PROSTHESES WITH MULTILAYER COVERING AND METHODS OF PRODUCTION THEREOF
    • 具有多层覆盖的多功能展开方法及其生产方法
    • US20130261764A1
    • 2013-10-03
    • US13989813
    • 2011-11-30
    • Paolo GuerraAlessio Giuliani
    • Paolo GuerraAlessio Giuliani
    • A61F2/28
    • A61F2/28A61F2/30767A61F2002/3084A61F2002/30929A61F2002/3093A61F2002/30932A61F2002/3098A61F2250/0051A61F2310/00616A61L27/06A61L2400/12A61L2420/08
    • Multifunctional prostheses which include a prosthesis body having at least one interface wall suitable for interfacing with at least one bone tissue, and which also include a substrate are provided. Advantageously, a first covering comprising first functional groups suitable to form chemical bonds, is applied to said substrate. On the side of the first covering the substrate may include protuberances and/or recesses suitable for promoting the attachment of said first functional groups. A second covering comprising nanostructures may be applied to the first covering, on the side opposite the substrate, and an interface covering comprising molecules may be applied to the second covering on the side opposite the first covering. Second functional groups suitable to form chemical bonds, so as to strengthen the bonds between the second covering and the interface covering may be inserted between the interface covering and the second covering. Methods of making such prostheses are also provided.
    • 提供了包括具有适于与至少一个骨组织接合并且还包括基底的至少一个界面壁的假体的多功能假体。 有利地,包括适于形成化学键的第一官能团的第一覆盖物被施加到所述基底。 在第一覆盖层的一侧,基底可以包括适于促进所述第一官能团附着的突起和/或凹部。 包括纳米结构的第二覆盖物可以施加到第一覆盖层,在与衬底相对的一侧上,并且包含分子的界面覆盖层可以施加到与第一覆盖层相对的一侧上的第二覆盖物。 适于形成化学键的第二官能团,以便加强第二覆盖物和界面覆盖物之间的结合可以插入在界面覆盖物和第二覆盖物之间。 还提供了制造这种假体的方法。