专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07071196B2 Chemical compounds 失效
公开(公告)号：US07071196B2
公开(公告)日：2006-07-04
申请号：US10637825
申请日：2003-08-08
申请人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
发明人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
IPC分类号： A61K31/4965 , C07C241/04
CPC分类号： C07D401/06 , A61K31/135 , A61K31/196 , A61K31/495 , A61K31/496 , C07D241/04 , C07D403/06 , A61K2300/00
摘要： The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins.

2. 发明授权

US07625904B2 Methods for the treatment of sleep disorders 失效
标题翻译：睡眠障碍治疗方法
公开(公告)号：US07625904B2
公开(公告)日：2009-12-01
申请号：US11955847
申请日：2007-12-13
申请人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
发明人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
IPC分类号： A61K31/495 , A61K31/50 , C07D401/00 , C07D403/00 , C07D241/04 , C07D295/00
CPC分类号： C07D401/06 , A61K31/135 , A61K31/196 , A61K31/495 , A61K31/496 , C07D241/04 , C07D403/06 , A61K2300/00
摘要： The invention relates to methods for the treatment of a sleep disorder in a mammal comprising administering to said mammal an effective amount of a compound of formula (I): wherein all variables are as defined herein.
摘要翻译：本发明涉及治疗哺乳动物睡眠障碍的方法，包括向所述哺乳动物施用有效量的式（I）化合物：其中所有变量如本文所定义。

3. 发明授权

US07345041B2 Chemical compounds 有权
标题翻译：化合物
公开(公告)号：US07345041B2
公开(公告)日：2008-03-18
申请号：US11334267
申请日：2006-01-18
申请人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
发明人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
IPC分类号： A61K31/495 , A61K31/50
CPC分类号： C07D401/06 , A61K31/135 , A61K31/196 , A61K31/495 , A61K31/496 , C07D241/04 , C07D403/06 , A61K2300/00
摘要： The invention relates to methods for the treatment of a sleep disorder comprising administering a compound of formula (I): wherein all variables are as defined herein.
摘要翻译：本发明涉及治疗睡眠障碍的方法，包括给予式（I）化合物：其中所有变量如本文所定义。

4. 发明申请

US20060122192A1 Chemical compounds 有权
公开(公告)号：US20060122192A1
公开(公告)日：2006-06-08
申请号：US11334267
申请日：2006-01-18
申请人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
发明人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D401/06 , A61K31/135 , A61K31/196 , A61K31/495 , A61K31/496 , C07D241/04 , C07D403/06 , A61K2300/00
摘要： The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins.

5. 发明授权

US06951861B1 Chemical compounds 有权
标题翻译：化合物
公开(公告)号：US06951861B1
公开(公告)日：2005-10-04
申请号：US10089964
申请日：2000-10-05
申请人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini , Mauro Corsi , Sergio Melotto
发明人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini , Mauro Corsi , Sergio Melotto
IPC分类号： A61K31/495 , A61K31/496 , A61P1/04 , A61P11/06 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , C07D241/04 , C07D401/06 , C07D403/06 , A61K31/4965
CPC分类号： C07D401/06 , A61K31/135 , A61K31/196 , A61K31/495 , A61K31/496 , C07D241/04 , C07D403/06 , A61K2300/00
摘要： The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins.
摘要翻译：本发明涉及哌嗪衍生物，其制备方法，含有它们的药物组合物及其医疗用途。新化合物是速激肽的拮抗剂，包括物质P和其他神经激肽。

6. 发明授权

US06642240B2 Treating emesis in a mammal 有权
标题翻译：化合物
公开(公告)号：US06642240B2
公开(公告)日：2003-11-04
申请号：US10190170
申请日：2002-07-03
申请人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
发明人： Giuseppe Alvaro , Romano Di Fabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
IPC分类号： A61K31522
CPC分类号： C07D401/06 , A61K31/135 , A61K31/196 , A61K31/495 , A61K31/496 , C07D241/04 , C07D403/06 , A61K2300/00
摘要： The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins.
摘要翻译：本发明涉及哌嗪衍生物，其制备方法，含有它们的药物组合物及其医疗用途。新化合物是速激肽的拮抗剂，包括物质P和其他神经激肽。

7. 发明申请

US20080249108A1 Chemical Compounds 失效
标题翻译：化学化合物
公开(公告)号：US20080249108A1
公开(公告)日：2008-10-09
申请号：US11955847
申请日：2007-12-13
申请人： Giuseppe Alvaro , Romano DI FABIO , Riccardo GIOVANNINI , Giuseppe GUERCIO , Yves ST-DENIS , Antonella URSINI
发明人： Giuseppe Alvaro , Romano DI FABIO , Riccardo GIOVANNINI , Giuseppe GUERCIO , Yves ST-DENIS , Antonella URSINI
IPC分类号： A61K31/495 , A61P25/00
CPC分类号： C07D401/06 , A61K31/135 , A61K31/196 , A61K31/495 , A61K31/496 , C07D241/04 , C07D403/06 , A61K2300/00
摘要： The invention relates to methods for the treatment of medical conditions comprising administering an effective amount of a compound of formula (I): wherein all variables are as defined herein.
摘要翻译：本发明涉及治疗医学病症的方法，包括施用有效量的式（I）化合物：其中所有变量如本文所定义。

8. 再颁专利

USRE39921E1 Chemical compounds 有权
标题翻译：化合物
公开(公告)号：USRE39921E1
公开(公告)日：2007-11-13
申请号：US10958744
申请日：2004-10-05
申请人： Giuseppe Alvaro , Romano DiFabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
发明人： Giuseppe Alvaro , Romano DiFabio , Riccardo Giovannini , Giuseppe Guercio , Yves St-Denis , Antonella Ursini
IPC分类号： A61K31/4965
CPC分类号： C07D401/06 , A61K31/496 , C07D241/04 , C07D403/06
摘要： The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins.
摘要翻译：本发明涉及哌嗪衍生物，其制备方法，含有它们的药物组合物及其医疗用途。新化合物是速激肽的拮抗剂，包括物质P和其他神经激肽。

9. 发明申请

US20060128752A1 Chemical compounds 审中-公开
公开(公告)号：US20060128752A1
公开(公告)日：2006-06-15
申请号：US10520143
申请日：2003-07-02
申请人： Giuseppe Alvaro , Francesca Cardullo , Romano Di Fabio , Riccardo Giovannini , Elisabeth Piga , Maria Tranquillini
发明人： Giuseppe Alvaro , Francesca Cardullo , Romano Di Fabio , Riccardo Giovannini , Elisabeth Piga , Maria Tranquillini
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D211/34 , C07D211/64 , C07D223/04 , C07D223/06
摘要： The present invention relates to cyclic amine derivatives of formula(l) wherein R represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy; R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, cyano or C1-4 alkyl optionally substituted by halogen, cyano or C1-4 alkoxy; R2 represents hydrogen or C1-4 alkyl; R3 and R4 independently represent hydrogen, cyano, C1-4 alkyl or R3 together with R4 represents C3-7 cycloalkyl; R5 represents trifluoromethyl, S(O)t C1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy, halogen or cyano; R6 represents hydrogen or (CH2)rR7; R7 represents hydrogen, C37 cycloalkyl, NH(C1-4alkylOC1-4alkoxy), NH(C1-4alkyl), N(C1-4alkyl)2, OC(O)NR9R8, NR8C(O)R9 or C(O)NR9R8; R9 and R8 independently represent hydrogen, C1-4 alkyl or C3-7 cycloalkyl; m represents zero or an integer from 1 to 4; n represents 1 or 2; p is zero or an integer from 1 to 3; q is an integer from 1 to 3; r is an integer from 1 to 4; t is 0, 1 or 2; provided that when m is 0, p is 2, q , r and n represent 1, R1, R2,R3, R4, R5 and R7 are hydrogen and R is chlorine, R5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein.

10. 发明申请

US20100152175A1 Pyridine Derivatives and Their Use in The Treatment of Psychotic Disorders 有权
公开(公告)号：US20100152175A1
公开(公告)日：2010-06-17
申请号：US12636849
申请日：2009-12-14
申请人： Giuseppe Alvaro , Daniele Andreotti , Sandro Belvedere , Romano Di Fabio , Alessandro Falchi , Riccardo Giovannini
发明人： Giuseppe Alvaro , Daniele Andreotti , Sandro Belvedere , Romano Di Fabio , Alessandro Falchi , Riccardo Giovannini
IPC分类号： A61K31/5383 , A61P25/30
CPC分类号： C07D487/04 , C07D513/04
摘要： There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein: X represents a nitrogen atom; Y represents —C(H2)—, (—C(H2)—)2, —S(O2)— or —C(═O)—; Z represents —C(H2)—, —S(O2)—, —N(Rz)—, or an oxygen or sulphur atom; A represents hydrogen or —CH2OH; Rz represents hydrogen, C1-6 alkyl, C1-6 alkoxy, —COR7 or —SO2R7; R1 represents halogen, C1-6 alkyl, C1-6 alkoxy, ═O, haloC1-6 alkyl, haloC1-6 alkoxy, hydroxyl or —CH2OH; m represents an integer from 0 to 3; R2 represents halogen, ═O, C1-6 alkyl (optionally substituted by one or more hydroxyl groups), —COOR7, —CONR7R8, C1-6 alkoxy, haloC1-6 alkyl, haloC1-6 alkoxy or C1-6alkylOC1-6alkyl; n represents an integer from 0 to 3; p and q independently represent an integer from 0 to 2; R3 represents an -aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-heteroaryl, -aryl-heterocyclyl, -heteroaryl-aryl, -heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl or -heterocyclyl-heterocyclyl group, all of which may be optionally substituted by one or more (e.g. 1, 2 or 3) halogen, C1-6 alkyl (optionally substituted by one or more hydroxyl groups), C3-8 cycloalkyl, C1-6 alkoxy, hydroxyl, haloC1-6 alkyl, haloC1-6 alkoxy, cyano, —S—C1-6 alkyl, —SO—C1-6 alkyl, —SO2—C1-6 alkyl, —COR7, —CONR7R8, —NR7R8, —NR7COC1-6 alkyl, —NR7SO2—C1-6 alkyl, C1-6 alkyl-NR7R8, —OCONR7R8, —NR7CO2R8 or —SO2NR7R8 groups; R4 and R5 independently represent C1-6 alkyl, or R4 and R5 together with the carbon atom to which they are attached may together form a C3-8 cycloalkyl group; R6 represents halogen, C1-6 alkyl, C3-8 cycloalkyl, C1-6 alkoxy, haloC1-6 alkyl or haloC1-6 alkoxy; s represents an integer from 0 to 4; R7 and R8 independently represent hydrogen, C1-6 alkyl or C3-8 cycloalkyl; or solvates thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式