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1. 发明申请

US20060276698A1 Automatic registration of images 有权
公开(公告)号：US20060276698A1
公开(公告)日：2006-12-07
申请号：US11146278
申请日：2005-06-07
申请人： Gisli Halldorsson , Einar Stefansson , Jon Benediktsson , Robert Karlsson , Sveinn Hardarson , Thor Eysteinsson , James Beach
发明人： Gisli Halldorsson , Einar Stefansson , Jon Benediktsson , Robert Karlsson , Sveinn Hardarson , Thor Eysteinsson , James Beach
IPC分类号： A61B5/00
CPC分类号： A61B3/1241 , A61B5/14555 , A61B5/7264
摘要： The present invention relates to a system for automatically evaluating oxygen saturation of the optic nerve and retina, said system comprising: image capturing system further comprising: a fundus camera (26), a four wavelengths beam splitter (27), a digital image capturing device (28), a computer system, image processing software performing in real-time the steps of: registering set of multi-spectral images (1) by, binarizing the multi-spectral image (7), find the all the border regions of each image by finding the region including the straight line that passes the most number of points in the region (8), use the orientation of the borders to evaluate the orientation of each spectral image (9), equalize the orientation of each spectral image by rotating the spectral image (10), edge detect each spectral image (11), estimate the translation between the spectral images based on the edges of adjacent images (12), transform the images to a stack of registered images (13), locating blood vessels (2) in each of the multi-spectral images by, retrieving registered spectral images (14), for each spectral image, remove defective pixels (15), enhance image contrast (16), perform top-hat transform using structuring element larger than the largest vessel diameter (17), binarize each image (18), apply filter for smoothing the image (19), combine all the spectral images using binary AND operator (20), skeletonize the resulting image (21), prune the skeleton image (22), re-grow the pruned image (23), locate junction points (24), evaluating the width of the blood vessels (3) by calculating the normal vector to the vessel direction to, estimate the direction and position of the vessel profile, evaluate positions of vessel walls based on the vessel profile obtained, evaluate vessel width based on the position of the vessel walls, selecting samples for calculating optical density, calculating the optical density ratio (4), evaluating oxygen saturation level (5), and presenting the results (6), wherein presenting the results may include presenting numerical and visual representation of the oxygen saturation.

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