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1. 发明申请

US20080071089A1 Process for the Manufacture of Rabeprazole Sodium 审中-公开
标题翻译：雷贝拉唑钠制造方法
公开(公告)号：US20080071089A1
公开(公告)日：2008-03-20
申请号：US11910089
申请日：2006-03-16
申请人： Girij Singh , Rajinder Siyan , Gurvinder Singh , Rajendra Mahale
发明人： Girij Singh , Rajinder Siyan , Gurvinder Singh , Rajendra Mahale
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： A process for manufacture of amorphous Rabeprazole sodium with mean particle diameter between 10 to 55 μm said process comprising addition of Rabeprazole to aqueous sodium hydroxide; addition of ethyl alcohol to the solution; distillation of solvents from the solution thus obtained till thick mass is obtained; addition of an organic solvent to the residue to obtain a clear solution; addition of this clear solution to an anti- solvent under agitation and isolation of the product.
摘要翻译：一种平均粒径为10-55μm的无定形雷贝拉唑钠的方法，所述方法包括将雷贝拉唑加入到氢氧化钠水溶液中; 向溶液中加入乙醇; 从得到的溶液中蒸馏出溶剂，直至得到稠质; 向残余物中加入有机溶剂以获得澄清溶液; 在搅拌和分离产物的同时将这种澄清溶液加入到抗溶剂中。

2. 发明申请

US20060149055A1 Process for the manufacture of cefpodoxime proxetil 审中-公开
标题翻译：头孢泊肟酯的制备方法
公开(公告)号：US20060149055A1
公开(公告)日：2006-07-06
申请号：US10541473
申请日：2003-01-06
申请人： Milind Gharpure , Sanjay Deshmukh , Rajendra Mahale
发明人： Milind Gharpure , Sanjay Deshmukh , Rajendra Mahale
IPC分类号： C07D501/14
CPC分类号： C07D501/60 , C07D501/04 , C07D501/12
摘要： A process for obtaining cefpodoxime proxetil of formula (I), of high purity conforming to pharmacopoeial specifications is disclosed. The process comprises addition of a solution of methanesulfonic acid in water to a solution of impure cefpodoxime proxetil of formula (I) in an organic solvent to form the corresponding cefpodoxime proxetil methanesulfonate of formula (II1), followed by addition of a co-solvent and separation of the aqueous phase containing cefpodoxime proxetil methanesulfonate of formula (II1) having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6 and subsequent neutralization of the methaneulfonate salt (II1) with a base to give cefpodoxime proxetil (I) free of impurities and having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6, or, addition of impure cefpodoxime proxetil of formula (I) to a solution of methanesulfonic acid in water to form the corresponding solution of cefpodoxime proxetil methanesulfonate of formula (II1) in water, followed by sequential addition of a first organic solvent and a co-solvent and separation of the aqueous phase containing cefpodoxime proxetil methanesulfonate of formula (II1) having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6 and subsequent neutralization of the methaneulfonate salt (II1) with a base to give cefpodoxime proxetil (I) free of impurities and having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6.
摘要翻译：公开了一种获得符合药典规格的高纯度的式（I）头孢泊肟酯的方法。该方法包括将甲磺酸水溶液加入到有机溶剂中的式（I）不纯的头孢泊肟酯的溶液中以形成相应的式（II）的头孢泊肟甲磺酸盐，随后通过加入共溶剂和含有非对映异构体比率为（R / R + S）为0.5至0.6的式（II-1）的头孢泊肟甲基磺酸酯的水相的分离，随后中和具有碱的甲磺酸盐（II-1），得到不含杂质并且（R / R + S）的非对映异构体比率在0.5至0.6之间的头孢泊肟酯（I），或加入不纯式（I）的头孢泊肟酯与甲磺酸在水中的溶液形成相应的式（II ^{1）的头孢泊肟甲磺酸盐溶液在水中的溶液，然后依次加入第一有机溶剂和共溶剂和水相c的分离使用具有（R / R + S）的非对映异构体比率为0.5至0.6的随后的甲磺酸盐中和的式（II-1）的头孢泊肟甲磺酸酯（II ^{1）），得到不含杂质的头孢泊肟酯（I）和（R / R + S）的非对映异构体比例在0.5至0.6之间。}}

3. 发明申请

US20060293296A1 Process for the preparation of cefpodoxime procetil 审中-公开
标题翻译：头孢泊肟原药的制备方法
公开(公告)号：US20060293296A1
公开(公告)日：2006-12-28
申请号：US10539525
申请日：2002-12-20
申请人： Milind Gharpure , Sanjay Deshmukh , Asok Saha , Rajendra Mahale
发明人： Milind Gharpure , Sanjay Deshmukh , Asok Saha , Rajendra Mahale
IPC分类号： A61K31/545 , C07D501/14
CPC分类号： C07D501/00
摘要： A process for the preparation of cefpodoxime proxetil of high purity conforming to pharmacopoeial specifications.
摘要翻译：制备符合药典规格的高纯度头孢泊肟酯的方法。

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