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1. 发明授权

US5321013A Pharmaceutical compositions in the form of stable sucralfate suspensions free of suspending agents 失效
标题翻译：不含悬浮剂的稳定的硫糖铝悬浮液形式的药物组合物
公开(公告)号：US5321013A
公开(公告)日：1994-06-14
申请号：US462950
申请日：1990-01-08
申请人： Giorgio G. Z. Zagnoli , Ubaldo Conte , Paolo Colombo , Carla Caramella
发明人： Giorgio G. Z. Zagnoli , Ubaldo Conte , Paolo Colombo , Carla Caramella
IPC分类号： A61K9/00 , A61K9/107 , A61K31/70 , A61K33/06 , A61P1/04 , C07H11/00 , C07H23/00 , C07H1/00
CPC分类号： A61K9/0095 , A61K31/70 , C07H23/00
摘要： Pharmaceutical compositions in the form of stable sucralfate suspensions free of suspending agents, wherein the sucralfate is present in the form of a gel having self-suspending properties and is suspended in an aqueous carbohydrate solution in a quantity of between 1 and 40% of sucralfate by weight.Said gel has a surface area exceeding 200 m.sup.2 /g and is prepared by dissolving powdered sucralfate in an HCl solution and then precipitating it with an NaOH solution added to a pH of between 4 and 4.5.
摘要翻译：形式为不含悬浮剂的稳定的硫糖铝悬浮液形式的药物组合物，其中硫糖铝以具有自身悬浮性质的凝胶的形式存在，并且通过以下方式悬浮在硫糖铝的1至40％之间的碳水化合物水溶液中重量。所述凝胶的表面积超过200m2 / g，通过将硫酸铝糖溶解在HCl溶液中，然后用加入到pH4至4.5之间的NaOH溶液沉淀来制备。

2. 发明授权

US5246697A Use of sucralfate humid gel as vehicle for drugs having topic activity and for cosmetics 失效
标题翻译：用作具有主题活性和化妆品的药物的SUCCALFATE HUMID GEL的用途
公开(公告)号：US5246697A
公开(公告)日：1993-09-21
申请号：US538739
申请日：1990-06-15
申请人： Ubaldo Conte , Paolo Colombo , Giorgio Zagnoli , Carla Caramella
发明人： Ubaldo Conte , Paolo Colombo , Giorgio Zagnoli , Carla Caramella
IPC分类号： A61K9/06 , A61K8/02 , A61K8/60 , A61K8/73 , A61K8/92 , A61K9/00 , A61K9/70 , A61K31/70 , A61K47/26 , A61Q19/00
CPC分类号： A61K47/26 , A61K31/70 , A61K8/0212 , A61K8/042 , A61K8/60 , A61K9/0014 , A61Q19/00 , Y10S514/887 , Y10S514/944
摘要： The use of sucralfate humid gel is described as vehicle for the applicationf drugs having topic activity (dermic and mucosal) and as basis for the formulation of beauty masks and other cosmetic preparations. Therapeutic and cosmetic formulations are described in the form of creams, ointments, aqueous dispersions comprising sucralfate humid gel.

3. 发明授权

US4681755A Delivery device for zero-order release of an active principle into a dissolution fluid and process for its preparation 失效
标题翻译：用于将有效原理零次释放到溶解流体中的输送装置及其制备方法
公开(公告)号：US4681755A
公开(公告)日：1987-07-21
申请号：US757601
申请日：1985-07-22
申请人： Paolo Colombo , Ubaldo Conte , Alberto Reiner
发明人： Paolo Colombo , Ubaldo Conte , Alberto Reiner
IPC分类号： A01N25/00 , A61K9/00 , A61K9/24 , B01J4/04 , A61K9/22 , A61K9/32
CPC分类号： A61K9/209 , Y10S514/965
摘要： A delivery device for zero-order release of an active principle into a dissolution fluid includes a reservoir consisting of a solid matrix of a homogeneous mixture of a polymer material, at least a portion of the active principle and an additive soluble in the dissolution fluid with negative heat of solution, a coating on the solid matrix-type reservoir of a first, release rate-controlling insoluble membrane which modulates the active principle release according to the desired kinetics; and a second, protective membrane on the release rate-controlling membrane of a soluble polymer material.
摘要翻译：用于将有效原理零次释放到溶解流体中的输送装置包括由聚合物材料的均匀混合物的固体基质，活性成分的至少一部分和溶解流体中可溶解的添加剂溶液的负热，固体基质型储层上的涂层，其是根据期望的动力学调节活性原子释放的第一释放速率控制不溶性膜; 以及可溶性聚合物材料的释放速率控制膜上的第二个保护膜。

4. 发明授权

US4839177A System for the controlled-rate release of active substances 失效
标题翻译：控制释放活性物质的系统
公开(公告)号：US4839177A
公开(公告)日：1989-06-13
申请号：US939810
申请日：1986-12-09
申请人： Paolo Colombo , Aldo La Manna , Ubaldo Conte
发明人： Paolo Colombo , Aldo La Manna , Ubaldo Conte
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/32
CPC分类号： A61K9/2054 , A61K9/2027 , A61K9/2072 , A61K9/2086 , A61K9/209
摘要： A system for the controlled-rate release of active substances, consisting of:(a) a deposit-core comprising the active substance and having defined geometric form;(b) a support-platform applied to said deposit-core.Said deposit-core contains, mixed with the active substance, a polymeric material having a high degree of swelling on contact with water or aqueous liqids, a gellable polymeric material, said polymeric materials being replaceable by a single polymeric material having both swelling and gelling properties, and other adjuvants able to provide the mixture with suitable characteristics for its compression and for its intake of water.
摘要翻译：一种用于控制释放活性物质的系统，包括：（a）包含活性物质并具有确定的几何形式的沉积物芯; （b）应用于所述存款核心的支持平台。所述沉积物芯与活性物质混合，与水或水性液体接触时具有高度溶胀度的聚合物材料，可凝胶聚合物材料，所述聚合物材料可由具有溶胀和胶凝性质的单一聚合材料代替，以及能够为混合物提供适合其压缩和摄入水的特性的其它佐剂。

5. 发明授权

US4605741A Pharmaceutically active salt derivative of 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde phosphate 失效
标题翻译： 3-羟基-5-（羟甲基）-2-甲基异烟酸磷酸酯的药学活性盐衍生物
公开(公告)号：US4605741A
公开(公告)日：1986-08-12
申请号：US797487
申请日：1985-11-13
申请人： Giorgio Zagnoli , Ubaldo Conte , Paolo Colombo
发明人： Giorgio Zagnoli , Ubaldo Conte , Paolo Colombo
IPC分类号： C07F9/58 , C07D401/12
CPC分类号： C07F9/582
摘要： The present invention relates to a novel pharmacologically active salt derivative, constituted by 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy-phenyl)-1-butanone 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphate, to the process for the production thereof, and to the related pharmaceutical compositions.Said salt derivative is produced by reacting 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphoric acid with 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-3-butanone in an organic solvent and subsequently crystallizing the reaction product.Said salt derivative carries out an important pharmacological activity as inhibitor of platelet aggregation with vasodilative action.
摘要翻译：本发明涉及由4-（1-吡咯烷基）-1-（2,4,6-三甲氧基 - 苯基）-1-丁酮3-羟基-5-（羟甲基）-2 - 甲基异烟碱-5-磷酸，其制备方法和相关药物组合物。所述盐衍生物是通过使3-羟基-5-（羟甲基）-2-甲基异烟醛-5-磷酸与4-（1-吡咯烷基）-1-（2,4,6-三甲氧基苯基）-3-丁酮反应制得的有机溶剂，随后使反应产物结晶。所述盐衍生物作为血小板聚集抑制剂具有重要的药理作用，具有血管扩张作用。

6. 发明授权

US5422123A Tablets with controlled-rate release of active substances 失效
标题翻译：具有控制释放活性物质的片剂
公开(公告)号：US5422123A
公开(公告)日：1995-06-06
申请号：US123982
申请日：1993-09-21
申请人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
发明人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
IPC分类号： A61K9/24 , A61K9/20 , A61K9/22 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/36 , A61K9/32
CPC分类号： A61K9/2086
摘要： Tablets with zero order controlled-rate of release of the active substances, consisting of a core of defined geometrical form containing the active substance, polymer substances which swell on contact with aqueous liquids and polymer substances with gelling properties, and a support applied to said core to partly cover its surface, the support consisting of polymer substances which are slowly soluble and/or slowly gellable in aqueous liquids, plasticizing substances, and possibly substances with an adjuvant function.
摘要翻译：含有活性物质的零级控制速率的片剂，由含有活性物质的限定几何形式的核心组成，与水性液体接触时膨胀的聚合物物质和具有胶凝性质的聚合物物质，以及用于所述核心为了部分地覆盖其表面，载体由在水性液体中缓慢溶解和/或缓慢凝胶化的聚合物物质，增塑物质和可能具有佐剂功能的物质组成。

7. 发明授权

US4865849A Tablet for pharmaceutical use able to release active substances at successive times 失效
标题翻译：用于制药的片剂能够连续释放活性物质
公开(公告)号：US4865849A
公开(公告)日：1989-09-12
申请号：US139635
申请日：1987-12-30
申请人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
发明人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
IPC分类号： A61K9/20 , A61K9/24
CPC分类号： A61K9/2072 , A61K9/209
摘要： A tablet for pharmaceutical use able to release active substances at successive times, comprising at least; a first layer containing a portion of the active substance with suitable excipients, a barrier layer of polymer material gellable and/or soluble in water and/or aqueous liquids, which is interposed between said first layer and a third layer containing the remaining portion of active substance with suitable excipients, said barrier layer and said third layer being housed in a casing consisting of polymer material impermeable and insoluble in water or soluble in an alkaline environment.That part of the active substance not inserted in the casing is immediately available for dissolving, whereas the part inserted in the casing is available only after dissolution or rupture of the barrier layer and/or after solubilization of the casing.

8. 发明授权

US09638152B2 Electric heater, heating device and heating system 有权
公开(公告)号：US09638152B2
公开(公告)日：2017-05-02
申请号：US13508092
申请日：2010-11-02
申请人： Mauro Zorzetto , Alberto Barbano , Paolo Colombo , Mirco Arata
发明人： Mauro Zorzetto , Alberto Barbano , Paolo Colombo , Mirco Arata
IPC分类号： F24H1/10 , H05B3/08 , F02B3/00 , F02M53/02 , F02M53/06
CPC分类号： F02M53/02 , F02M53/06
摘要： An electric heater for fuel of endothermal engines, in particular for fuel systems called “common rail” and the like, includes a heating part and a terminal adapted to be associated with one end of the hollow body of a fuel feeding duct; advantageously, the terminal is at least partly made of plastic material. A fuel feeding duct to which the heater is applied, as well as to a fuel warm-up device, are also provided.

9. 发明授权

US09109938B2 Level sensor and associated control circuit, in particular for a filter for vehicles 有权
标题翻译：液位传感器和相关的控制电路，特别是用于车辆的过滤器
公开(公告)号：US09109938B2
公开(公告)日：2015-08-18
申请号：US13322411
申请日：2010-05-25
申请人： Marco Molinaro , Mauro Zorzetto , Paolo Colombo
发明人： Marco Molinaro , Mauro Zorzetto , Paolo Colombo
IPC分类号： G01F23/24
CPC分类号： G01F23/244 , G01F23/242
摘要： A sensing device includes at least one electrode pair (2, 3, 4) and one sensing circuit (140) connected to the electrode pair (2, 3, 4). The sensing circuit (140) switches the value of its own output voltage when a substance establishes contact across the electrodes (2, 3, 4). The device further includes one output circuit (180) connected to the output of the sensing circuit (140) and adapted to provide an output signal (s7) representative of the presence of a substance across the electrode pair (2, 3, 4). The device also allows the output signal to take different voltage and/or current and/or frequency values, in particular such that values can be discerned which are representative of the presence or level of substances and/or representative of faults of the device.
摘要翻译：感测装置包括连接到电极对（2,3,4）的至少一个电极对（2,3,4）和一个感测电路（140）。当物质在电极（2,3,4）之间建立接触时，感测电路（140）切换其自身输出电压的值。该装置还包括连接到感测电路（140）的输出的一个输出电路（180），并且适于提供表示跨过电极对（2,3,4）的物质的存在的输出信号（s7）。该装置还允许输出信号采取不同的电压和/或电流和/或频率值，特别是使得可以识别代表物质的存在或水平和/或代表装置的故障的值。

10. 发明授权

US08988209B2 Device for monitoring a vehicle wheel 有权
标题翻译：用于监控车轮的装置
公开(公告)号：US08988209B2
公开(公告)日：2015-03-24
申请号：US13514844
申请日：2010-12-10
申请人： Domenico Cantarelli , Paolo Colombo
发明人： Domenico Cantarelli , Paolo Colombo
IPC分类号： B60Q1/00 , B60C23/02 , G01L27/00 , G01M17/02 , B60C23/00 , B60C23/04
CPC分类号： B60C23/0408 , B60C23/0452 , B60C23/0494
摘要： A monitoring device (20) of a vehicle wheel (11) is configured for detecting and transmitting, by a wireless connection, information relating to at least one characteristic quantity of the status of the wheel (11), such as the inflating pressure of a tire thereof. The device (20) has a casing (21-22) housing a circuit (30) adapted to transmit said information, the casing (21-22) being designed for coupling to an end portion (3a) of electrically conductive body (3) of a tire valve (2) of the wheel (11). The casing (21-22) includes a casing body (21) integrating interconnection means (28, 29, 40) prearranged to obtain both an electric connection of the circuit (30) to the end portion (3a) of the electrically conductive body (3) of the valve (2; 2′; 2″), and a mechanical coupling of the casing (21-22) to the end portion (3a) of the electrically conductive body (3) of the valve (2; 2′; 2″).
摘要翻译：车轮（11）的监视装置（20）被配置为通过无线连接来检测和发送与轮（11）的状态的至少一个特征量有关的信息，例如，其轮胎。设备（20）具有容纳适于传输所述信息的电路（30）的壳体（21-22），所述壳体（21-22）被设计成耦合到导电体（3）的端部（3a）的轮胎（11）的轮胎气门（2）。壳体（21-22）包括集成互连装置（28,29,40）的壳体（21），该互连装置预先布置成获得电路（30）到导电体的端部（3a）的电连接的阀（2; 2'; 2“）的导电体（3）的端部（3a）的机械联接， ; 2“）。

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