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1. 发明授权

US08476461B2 Dipyrromethene-boron hydrophilic fluorescent compounds 有权
标题翻译：二吡咯亚甲基 - 硼亲水性荧光化合物
公开(公告)号：US08476461B2
公开(公告)日：2013-07-02
申请号：US13142845
申请日：2009-12-18
申请人： Gilles Ulrich , Raymond Ziessel , Song-Lin Niu , Alexandre Haefele , Thomas Bura
发明人： Gilles Ulrich , Raymond Ziessel , Song-Lin Niu , Alexandre Haefele , Thomas Bura
IPC分类号： C07D209/56 , C07F5/02 , G01N21/76
CPC分类号： C07F5/02
摘要： Dipyrromethene-boron hydrophilic fluorescent compoundsThe invention concerns fluorescent and hydrophilic compounds meeting following formula (I): wherein: S1 is a group of formula —C≡C-L′-A where L′ is a linkage group and A is a polar functional group; S2 is a —C≡C-L′-A group the same or different from S1; —F; —H; or a hydrocarbon chain optionally interrupted by one or more oxygen atoms, and use thereof, in particular in aqueous or hydrophilic media.
摘要翻译：二吡咯亚甲基 - 硼亲水性荧光化合物本发明涉及符合下列通式（I）的荧光和亲水性化合物：其中：S1为式-C = C-L'-A的基团，其中L'为连接基团，A为极性官能团组; S2是与S1相同或不同的-C = C-L-A基团; -F; -H; 或任选被一个或多个氧原子中断的烃链，及其用途，特别是在水性或亲水介质中。

2. 发明申请

US20120009615A1 DIPYRROMETHENE-BORON HYDROPHILIC FLUORESCENT COMPOUNDS 有权
标题翻译： DIPYRROMETHENE-BORON水解荧光化合物
公开(公告)号：US20120009615A1
公开(公告)日：2012-01-12
申请号：US13142845
申请日：2009-12-18
申请人： Gilles Ulrich , Raymond Ziessel , Song-Lin Niu , Alexandre Haefele , Thomas Bura
发明人： Gilles Ulrich , Raymond Ziessel , Song-Lin Niu , Alexandre Haefele , Thomas Bura
IPC分类号： G01N21/64 , C12Q1/02 , C07F5/02
CPC分类号： C07F5/02
摘要： Dipyrromethene-boron hydrophilic fluorescent compoundsThe invention concerns fluorescent and hydrophilic compounds meeting following formula (I): wherein: S1 is a group of formula —C≡C-L′-A where L′ is a linkage group and A is a polar functional group; S2 is a —C≡C-L′-A group the same or different from S1; —F; —H; or a hydrocarbon chain optionally interrupted by one or more oxygen atoms, and use thereof, in particular in aqueous or hydrophilic media.
摘要翻译：二吡咯亚甲基 - 硼亲水性荧光化合物本发明涉及符合下列通式（I）的荧光和亲水化合物：其中：S1为式-C≡C-L'-A的基团，其中L'为连接基团，A为极性官能团; S2是与S1相同或不同的-C≡C-L'-A基团; -F; -H; 或任选被一个或多个氧原子中断的烃链，及其用途，特别是在水性或亲水介质中。

3. 发明授权

US08993781B2 Fluorescent boron-substituted dipyrromethenes and use thereof for diagnosis 有权
标题翻译：荧光硼取代二吡咯并芘及其用于诊断
公开(公告)号：US08993781B2
公开(公告)日：2015-03-31
申请号：US13141850
申请日：2009-12-28
申请人： Jean De Barry , Corinne Liegeois , Alexandre Haefele , Thomas Bura , Gilles Ulrich , Raymond Ziessel
发明人： Jean De Barry , Corinne Liegeois , Alexandre Haefele , Thomas Bura , Gilles Ulrich , Raymond Ziessel
IPC分类号： C07D209/56 , C07F5/02
CPC分类号： C07F5/02 , C07D209/56
摘要： The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.
摘要翻译：本发明涉及衍生自非氟化二吡咯亚甲基 - 硼的新型荧光化合物，其制备方法及其用于生物分子荧光标记的用途。本发明还涉及标记有所述荧光化合物的生物分子，以及其在诸如医学诊断方法的检测方法中的用途。更具体地，本发明的检测方法对于诊断神经变性疾病如阿尔茨海默病特别有用。

4. 发明申请

US20110287473A1 Novel Fluorescent Boron-Substituted Dipyrromethenes and Use Thereof for Diagnosis 有权
标题翻译：新型荧光硼取代Dipyrromethenes及其用途诊断
公开(公告)号：US20110287473A1
公开(公告)日：2011-11-24
申请号：US13141850
申请日：2009-12-28
申请人： Jean De Barry , Corinne Liegeois , Alexandre Haefele , Thomas Bura , Gilles Ulrich , Raymond Ziessel
发明人： Jean De Barry , Corinne Liegeois , Alexandre Haefele , Thomas Bura , Gilles Ulrich , Raymond Ziessel
IPC分类号： C12Q1/02 , C07H19/04 , C07K14/435 , G01N21/64 , C07F5/02
CPC分类号： C07F5/02 , C07D209/56
摘要： The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.
摘要翻译：本发明涉及衍生自非氟化二吡咯亚甲基 - 硼的新型荧光化合物，其制备方法及其用于生物分子荧光标记的用途。本发明还涉及标记有所述荧光化合物的生物分子，以及其在诸如医学诊断方法的检测方法中的用途。更具体地，本发明的检测方法对于诊断神经变性疾病如阿尔茨海默病特别有用。

5. 发明申请

US20080102534A1 Unsaturated Dipyrromethene-Boron Borocarbons 有权
标题翻译：不饱和二吡咯亚甲基硼硼烷
公开(公告)号：US20080102534A1
公开(公告)日：2008-05-01
申请号：US11884360
申请日：2006-02-14
申请人： Gilles Ulrich , Raymond Ziessel , Christine Goze
发明人： Gilles Ulrich , Raymond Ziessel , Christine Goze
IPC分类号： G01N21/76 , C07F5/02
CPC分类号： C07F5/02
摘要： The invention relates to unsaturated dipyrromethene-boron borocarbons of formula (I) and the use thereof for fluorescence or electroluminescent analysis. The fluorescent properties are provided by the central ring of six atoms comprising the —N—B—N— sequence, R1 to R7 permitting the modification of the compound properties (fluorescence emission wavelength, quantitative fluorescent yield), at least one of the substituents S1 and S2 has a chromophore end group which permits an excitation of the molecule at wavelengths close to those of the substituent chromophore. A preferably selected from the chromophore substituents with a wavelength close to the ultraviolet which significantly increases the Stokes displacement.
摘要翻译：本发明涉及式（I）的不饱和二吡咯甲硼 - 硼硼烷及其用于荧光或电致发光分析的用途。荧光性质由包含-NBN-序列，R 1至R 7的六个原子的中心环提供，允许修饰化合物性质（荧光发射波长，定量荧光产率），至少一个取代基S 1和S 2 2具有发色团端基，其允许在接近于取代基的波长处的分子的激发发色团优选选自具有接近紫外线的波长的发色团取代基，其显着增加斯托克斯位移。

6. 发明授权

US07897786B2 Unsaturated dipyrromethene-boron borocarbons 有权
标题翻译：不饱和二吡咯亚甲基硼硼烷
公开(公告)号：US07897786B2
公开(公告)日：2011-03-01
申请号：US11884360
申请日：2006-02-14
申请人： Gilles Ulrich , Raymond Ziessel , Christine Goze
发明人： Gilles Ulrich , Raymond Ziessel , Christine Goze
IPC分类号： C07D209/56
CPC分类号： C07F5/02
摘要： The invention relates to unsaturated dipyrromethene-boron borocarbons of formula (I) and the use thereof for fluorescence or electroluminescent analysis. The fluorescent properties are provided by the central ring of six atoms comprising the —N—B—N— sequence, R1 to R7 permitting the modification of the compound properties (fluorescence emission wavelength, quantitative fluorescent yield), at least one of the substituents S1 and S2 has a chromophore end group which permits an excitation of the molecule at wavelengths close to those of the substituent chromophore. A preferably selected from the chromophore substituents with a wavelength close to the ultraviolet which significantly increases the Stokes displacement.
摘要翻译：本发明涉及式（I）的不饱和二吡咯甲硼 - 硼硼烷及其用于荧光或电致发光分析的用途。荧光性质由包含-N-B-N-序列的六个原子的中心环提供，R1至R7允许修饰化合物性质（荧光发射波长，定量荧光产率），至少一个取代基S1 且S2具有允许以接近于取代基发色团的波长的波长激发分子的发色团端基。优选选自具有接近紫外线的波长的发色团取代基，其显着增加斯托克斯位移。

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