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1. 发明授权

US4260610A Disubstituted piperazines 失效
标题翻译：二取代哌嗪
公开(公告)号：US4260610A
公开(公告)日：1981-04-07
申请号：US957659
申请日：1978-11-03
申请人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
发明人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
IPC分类号： C07D409/12 , A61K31/495 , A61K31/505 , A61P9/08 , A61P9/12 , A61P25/00 , A61P29/00 , C07D327/00 , C07D327/04 , C07D411/12 , C07D417/12 , C07D411/14 , C07D417/14
CPC分类号： C07D327/04
摘要： Disubstituted piperazines of the formula: ##STR1## in which: n is 1 or 2,X is oxygen and Y is sulfur or sulfonyl or X and Y are both sulfur or sulfonyl, andHet is a 5- or 6-membered heterocyclic radical having from 1 to 3 hetero atoms inclusive selected from nitrogen and sulfur and optionally substituted by one or more alkyl each having from 1 to 5 carbon atoms inclusive.These compounds may be used as medicines, especially in the treatment of central nervous system disorders and Parkinson's disease.
摘要翻译：下式的二取代哌嗪：其中：n为1或2，X为氧，Y为硫或磺酰基或X和Y均为硫或磺酰基，Het为具有5或6元杂环基，包括选自氮和硫的1至3个杂原子，并且任选被一个或多个包含1至5个碳原子的烷基取代。这些化合物可以用作药物，特别是用于治疗中枢神经系统障碍和帕金森病。

2. 发明授权

US4010267A Benzodioxole compounds 失效
标题翻译：苯二酚化合物
公开(公告)号：US4010267A
公开(公告)日：1977-03-01
申请号：US562226
申请日：1975-03-26
申请人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
发明人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
IPC分类号： A61K31/495 , A61P9/08 , A61P25/26 , C07D317/46 , C07D317/72 , C07D405/12 , C07D417/12 , C07D295/08
CPC分类号： C07D317/72 , C07D317/46 , Y10S514/929
摘要： Benzodioxole compounds of the formula: vasodilator ##STR1## WHEREIN R.sub.1 is hydrogen, lower alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl,R.sub.2 is lower-alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl, orR.sub.1 + r.sub.2 are --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.6 -- andHet is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinazolinyl, 1,3,5 triazinyl or 1,3-thiazolyl, each being optionally substituted by lower-alkyl, lower-alkoxy, hydroxyl or phenyl.These compounds are used as medicines especially as peripheral vasocilator agent and central nervous system stimulant.

3. 发明授权

US4177272A Disubstituted piperazines 失效
标题翻译：二取代哌嗪
公开(公告)号：US4177272A
公开(公告)日：1979-12-04
申请号：US864204
申请日：1977-12-27
申请人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
发明人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
IPC分类号： C07D403/04 , A61K31/495 , A61K31/496 , A61P9/00 , A61P9/12 , A61P25/00 , C07D249/14 , C07D271/06 , C07D271/07 , C07D285/08 , C07D285/12 , C07D285/135 , C07D317/00 , C07D319/00 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , A61K31/50
CPC分类号： C07D271/07 , C07D249/14 , C07D285/08 , C07D285/135
摘要： Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, .DELTA..sup.3 -chromenyl, thiochromanyl or .DELTA..sup.3 -thiochromenyl,X is nitrogen and simultaneously Y is oxygen or sulfur, orX is sulfur, imino (NH) or methylimino (N CH.sub.3) and simultaneously Y is nitrogen, andR is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl.These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.
摘要翻译：下式的二取代哌嗪其中：苯并[b]呋喃基，苯并[b]噻吩基，苯并二恶唑基，苯并二氧杂环戊烷基，苯并二恶环庚烷基，香豆素基，苯并二氢吡喃基，DELTA 3-苯并二氢吡喃基，，X是氮，同时Y是氧或硫，或X是硫，亚氨基（NH）或甲基亚氨基（N CH3），同时Y是氮，R是氢，低级烷基，苯基，卤代苯基，低级烷基苯基或低级烷氧基苯基。这些化合物具有有趣的药理和治疗特性，可用作药物，特别是用于治疗高血压，外周血管疾病和帕金森病。

4. 发明授权

US4100286A 2-(Substituted heterocyclic amine)benzoic acids 失效
标题翻译： 2-（取代的杂环胺）苯甲酸
公开(公告)号：US4100286A
公开(公告)日：1978-07-11
申请号：US741740
申请日：1976-11-15
申请人： Gilbert Regnier , Roger Canevari , Jean-Claude Poignant , Michel Laubie
发明人： Gilbert Regnier , Roger Canevari , Jean-Claude Poignant , Michel Laubie
IPC分类号： A61K31/505 , A61K31/52 , A61P9/00 , A61P21/02 , A61P25/00 , A61P25/08 , C07D239/48 , C07D473/00 , C07D473/34 , C07D473/40 , C07D487/04
CPC分类号： C07D487/04 , C07D239/48 , C07D473/00 , C07D473/34 , C07D473/40
摘要： Heterocyclic compounds of the formula: ##STR1## WHEREIN ONE OF Y and Z is CH, the other being N, A is a straight or branched saturated hydrocarbon chain from C.sub.2 to C.sub.6 inclusive, X is chlorine, hydroxy, alkoxy or alkylthio each from C.sub.1 to C.sub.5 inclusive, R is hydrogen, alkyl, hydroxyalkyl or dihydroxyalkyl each from C.sub.1 to C.sub.3 inclusive, R' is halogen, alkyl or alkoxy each from C.sub.1 to C.sub.3 inclusive and n is 0, 1 or 2.These compounds, their optical isomers and their physiologically tolerable salts are used as medicines especially in the treatment of central nervous system disorders.
摘要翻译：下式的杂环化合物：Y和Z之一为CH，另一个为N，A为C2至C6的直链或支链饱和烃链，其中X为氯，羟基，烷氧基或烷硫基，各自为C1 为C 5，R为氢，烷基，羟基烷基或二羟基烷基，各自为C 1〜C 3，其中R 1为卤素，烷基或烷氧基，各自为C 1〜C 3，其中n为0,1或2。

5. 发明授权

US3954765A Piperazines derivatives 失效
标题翻译：哌嗪衍生物
公开(公告)号：US3954765A
公开(公告)日：1976-05-04
申请号：US512461
申请日：1974-10-07
申请人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
发明人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignant
IPC分类号： C07D417/12 , A61K31/495 , A61P9/08 , A61P9/12 , A61P25/00 , A61P25/04 , B01J23/00 , C07B61/00 , C07D295/04 , C07D311/04 , C07D417/14 , C07D295/12
CPC分类号： C07D417/14
摘要： Piperazine derivatives of the formula: ##SPC1##Wherein n is 0 or 1, X is oxygen or sulfur, R and R', which are the same or different, are hydrogen or lower alkyl and: ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicine especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and pain.
摘要翻译：下式的哌嗪衍生物：

6. 发明授权

US4112092A 1-Naphthylmethyl-4-(thiazolyl-2)-piperazines 失效
标题翻译： 1-萘基甲基-4-（噻唑基-2） - 哌嗪
公开(公告)号：US4112092A
公开(公告)日：1978-09-05
申请号：US785855
申请日：1977-04-08
申请人： Gilbert Regnier , Roger Canevari , Jean-Claude Poignant
发明人： Gilbert Regnier , Roger Canevari , Jean-Claude Poignant
IPC分类号： C07D277/20 , A61K31/54 , A61P9/08 , A61P9/10 , A61P25/00 , C07D277/42 , C07D417/04 , A61K31/495
CPC分类号： C07D417/04
摘要： Naphthyl derivatives of the formula: ##STR1## wherein: R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, andR.sub.2 and R.sub.3, which are the same or different, are hydrogen, lower alkyl or phenyl,Or R.sub.2 and R.sub.3 joined together are --CH .dbd. CH -- CH .dbd. CH--.These compounds are used as medicines, especially in the treatment of disorders of central nervous system (CNS), Parkinson's disease and cardiovascular disorders.
摘要翻译：下式的萘衍生物：其中：

7. 发明授权

US4267178A Disubstituted piperazines 失效
标题翻译：二取代哌嗪
公开(公告)号：US4267178A
公开(公告)日：1981-05-12
申请号：US14876
申请日：1979-02-26
申请人： Gilbert Regnier , Michel Laubie , Jean-Claude Poignant
发明人： Gilbert Regnier , Michel Laubie , Jean-Claude Poignant
IPC分类号： C07D417/12 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/443 , A61K31/495 , A61K31/505 , A61P9/12 , C07D405/12 , C07D405/14 , A61K31/36 , A61K31/335
CPC分类号： C07D405/14
摘要： Disubstituted piperazines of the formula ##STR1## in which n is 1 or 2,m is 0 or 1, andHet is pyridyl, pyrimidinyl, pyrazinyl, thiazolyl or thiadiazolyl each optionally substituted by one or more alkyl having from 1 to 5 carbon atoms inclusive.These compounds and their physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of hypertension.
摘要翻译：式为“IMAGE”的二取代哌嗪，其中n为1或2，m为0或1，Het为吡啶基，嘧啶基，吡嗪基，噻唑基或噻二唑基，各自任选被一个或多个含有1至5个碳原子的烷基取代。这些化合物及其生理上可耐受的酸加成盐可以用作药物，特别是用于治疗高血压。

8. 发明授权

US3944551A N-Coumaranyl and chromanyl -methyl-or sulfur analogs thereof-N'- thiazolyl piperazines 失效
标题翻译： N-香叶基和苯并二氢吡喃基 - 甲基或硫磺类似物-N {40-噻唑基哌嗪
公开(公告)号：US3944551A
公开(公告)日：1976-03-16
申请号：US454665
申请日：1974-03-25
申请人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignantw
发明人： Gilbert Regnier , Roger Canevari , Michel Laubie , Jean-Claude Poignantw
IPC分类号： C07D307/79 , A61K31/495 , A61K31/50 , A61K31/505 , A61P9/08 , A61P9/12 , A61P25/08 , B01J23/00 , C07B61/00 , C07D213/74 , C07D295/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D417/14 , C07D295/12
CPC分类号： C07D409/06 , C07D417/14 , Y10S514/843 , Y10S514/929
摘要： Disubstituted piperazines of the formula: ##SPC1##Wherein:n is 1 or 2;X is oxygen or sulfur;R is hydrogen or lower alkyl;Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl, quinazolyl, thiazolyl or benzothiazolyl, each optionally substituted by one or more lower alkyl, lower alkoxy, phenyl, amino, mono or di-lower-alkylamino, or hydroxy, and, ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicines especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and as antipregnancy drugs.
摘要翻译：下式的二取代哌嗪：

9. 发明授权

US4613601A (1-benzodioxin-6-ylmethyl)-4-substituted piperazines having antipsychotic activity 失效
标题翻译：（1-苯并二恶英-6-基甲基）-4-取代的哌嗪具有抗精神病活性
公开(公告)号：US4613601A
公开(公告)日：1986-09-23
申请号：US693278
申请日：1985-01-22
申请人： Gilbert Regnier , Jean-Claude Poignant
发明人： Gilbert Regnier , Jean-Claude Poignant
IPC分类号： A61K31/44 , A61K31/443 , A61P25/00 , C07D405/12 , C07D413/12 , C07D417/12 , C07D401/04 , A61K31/495 , A61K31/505 , C07D403/04
CPC分类号： C07D405/12 , C07D413/12 , C07D417/12
摘要： Benzodioxine compounds of the formula: ##STR1## in which Het is a five- or six-membered heterocyclic radical containing from one to three hetero atoms, and from one to three double bonds, optionally substituted by one or more alkyl or alkoxy radicals each from C.sub.1 to C.sub.5.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines, especially in the treatment of psychoses.
摘要翻译：下式的苯并二恶英化合物：其中Het是含有1至3个杂原子的5或6元杂环基团和1至3个双键，任选被一个或多个烷基或烷氧基取代， C1至C5。这些化合物和其生理上可耐受的酸加成盐可以用作药物，特别是用于治疗精神病。

10. 发明授权

US4529729A Piperazine and homopiperazine compounds 失效
标题翻译：哌嗪和高哌嗪化合物
公开(公告)号：US4529729A
公开(公告)日：1985-07-16
申请号：US622557
申请日：1984-06-20
申请人： Gilbert Regnier , Michel Laubie , Jacques Duhault
发明人： Gilbert Regnier , Michel Laubie , Jacques Duhault
IPC分类号： A61K31/505 , A61K31/53 , A61P9/00 , C07D405/12 , C07D409/12 , C07D405/14
CPC分类号： C07D405/12 , C07D409/12
摘要： Piperazine and homopiperazine compounds of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5, in a straight or branched chain, which may contain one or two double bonds, and optionally substituted by one or more OH;B is CH or a nitrogen atom;m is 2 or 3;X--Y-- represents --CH.dbd.CH--(CR'R").sub.n - in which n is zero or 1, and R' and R" are hydrogen or methyl;Z is oxygen or sulfur,R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.3 to C.sub.7, or phenyl optionally substituted by fluorine, chlorine or alkyl from C.sub.1 to C.sub.5, andT is hydrogen, fluorine, chlorine or alkyl from C.sub.1 to C.sub.5.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxia.
摘要翻译：哌嗪和下式的高哌嗪化合物：其中：A为C3至C5的直链或支链的烃基，其可含有一个或两个双键，并且任选被一个或多个OH取代; B是CH或氮原子; m为2或3; X-Y-表示-CH = CH-（CR'R“）n - ，其中n为0或1，R'和R”为氢或甲基; Z为氧或硫，R为氢，C1至C5的烷基，C3至C7的环烷基，或任选被氟，氯或C1至C5的烷基取代的苯基，T为氢，氟，氯或C1- C5。这些化合物和其生理上可耐受的酸加成盐可以用作药物，特别是用于治疗各种组织缺氧。

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