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1. 发明授权

US07026357B2 Diphenylurea compounds 失效
标题翻译：二苯基脲化合物
公开(公告)号：US07026357B2
公开(公告)日：2006-04-11
申请号：US10862546
申请日：2004-06-07
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
IPC分类号： A61K31/17 , C07D233/02 , C07D401/00 , C07D211/70 , C07C273/00
CPC分类号： C07D295/135 , C07D209/08 , C07D235/14 , C07D235/30 , C07D319/20 , C07D401/04 , C07D405/04 , C07D405/12
摘要： Compound of formula (I): and medicinal products containing the same are useful as dual α2/5-HT2c antagonist receptors.
摘要翻译：式（I）化合物：含有该化合物的药物可用作双重α2/5-HT 2C拮抗剂受体。

2. 发明授权

US06747032B2 Pyrimidin-4-one compounds 失效
标题翻译：嘧啶-4-酮化合物
公开(公告)号：US06747032B2
公开(公告)日：2004-06-08
申请号：US10125188
申请日：2002-04-18
申请人： Gilbert Lavielle , Thierry Dubuffet , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
发明人： Gilbert Lavielle , Thierry Dubuffet , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
IPC分类号： C07D51900
CPC分类号： C07D471/04
摘要： Compound of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, alkoxy, polyhaloalkyl, hydroxy, cyano, nitro and amino, or R1 with R2, R2 with R3, or R3 with R4, together with the carbon atoms carrying them, form an optionally substituted benzene ring or an optionally substituted heteroaromatic ring, X represents an oxygen atom or a methylene group, A represents an alkylene chain, represents an optionally substituted, unsaturated, nitrogen-containing heterocycle and R5 represents an alkyl group, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid, a medicinal products containing the same are useful as a double &agr;2/5-HT2c antagonist.
摘要翻译：式（I）化合物：其中：R 1，R 2，R 3和R 4可以相同或不同，表示氢原子，卤素原子或选自烷基，烷氧基，多卤代烷基，羟基，氰基，硝基和氨基，或R 1与R 2，R 2与R 3或R 3与R 4一起形成任选取代的苯环或任选取代的杂芳环，X表示氧原子或亚甲基，A表示亚烷基链表示任选取代的不饱和的含氮杂环，R5表示烷基，其对映异构体和非对映异构体及其与药学上可接受的酸的加成盐，含有该酸的药物可用作双重α2/ 5 -HT2c拮抗剂。

3. 发明授权

US06784183B2 Diphenylurea compounds 失效
标题翻译：二苯基脲化合物
公开(公告)号：US06784183B2
公开(公告)日：2004-08-31
申请号：US09896278
申请日：2001-06-29
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
IPC分类号： A61K31496
CPC分类号： C07D295/135 , C07D209/08 , C07D235/14 , C07D235/30 , C07D319/20 , C07D401/04 , C07D405/04 , C07D405/12
摘要： Compounds of formula (I): and medicinal products containing the same which are useful as dual &agr;2/5-HT2c antagonists.
摘要翻译：式（I）化合物：含有它们的药物，可用作双重α2/ 5-HT2c拮抗剂。

4. 发明授权

US5500443A New benzodioxane compounds 失效
标题翻译：新的苯并二恶烷化合物
公开(公告)号：US5500443A
公开(公告)日：1996-03-19
申请号：US392203
申请日：1995-02-22
申请人： Gilbert Lavielle , Patrick Hautefaye , Olivier Muller , Mark Millan , Mauricette Brocco
发明人： Gilbert Lavielle , Patrick Hautefaye , Olivier Muller , Mark Millan , Mauricette Brocco
IPC分类号： C07D319/16 , A61K31/00 , A61K31/335 , A61K31/357 , A61K31/40 , A61K31/4025 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/55 , A61P25/18 , A61P25/22 , C07D319/18 , C07D319/20 , C07D405/12 , C07D405/14 , C07D413/14 , C07D207/04
CPC分类号： C07D405/12 , C07D319/18 , C07D319/20 , C07D405/14 , C07D413/14
摘要： A compound of formula (I): ##STR1## in which: X represents oxygen or methylene,n represents 1, 2 or 3,R.sub.1 represents hydrogen, aminocarbonyl or hydroxymethyl,R.sub.2 represents: ##STR2## in which R.sub.3 and R.sub.4 are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of schizophrenia.
摘要翻译：式（I）的化合物：其中：X表示氧或亚甲基，n表示1,2或3，R1表示氢，氨基羰基或羟甲基，R2表示：其中R3和R4 如本说明书中所定义，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物可用于治疗精神分裂症。

5. 发明授权

US06492366B1 Cyano-indole serotonin-reuptake inhibitor compound 失效
标题翻译：氰基吲哚5-羟色胺再摄取抑制剂化合物
公开(公告)号：US06492366B1
公开(公告)日：2002-12-10
申请号：US09686056
申请日：2000-10-11
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Didier Cussac , Anne Dekeyne
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Didier Cussac , Anne Dekeyne
IPC分类号： A61K31495
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： A compound selected from those of formula (I): wherein: R1 and R2 each independently represent hydrogen or, alkyl, T1 and T2 each independently represent alkylene, G represents a heterocyclic group selected of formula (&agr;): wherein: W1 to W5 and X1 to X4 are so defined in the description. Medicinal products containing the same are useful as serotonin-reuptake inhibitors.
摘要翻译：选自式（I）的化合物：其中：R1和R2各自独立地表示氢或烷基，T1和T2各自独立地表示亚烷基，G表示选自式（α）的杂环基：其中：W1至W5和 X1至X4在描述中如此定义。含有它们的药物可用作5-羟色胺再摄取抑制剂。

6. 发明授权

US07053108B2 Indoline compounds 失效
标题翻译：二氢吲哚化合物
公开(公告)号：US07053108B2
公开(公告)日：2006-05-30
申请号：US10813347
申请日：2004-03-30
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Alain Gobert
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Alain Gobert
IPC分类号： A61K31/443 , C07D401/12
CPC分类号： C07D401/12
摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 represents hydrogen,orR1 represents hydrogen, and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl,its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicaments.
摘要翻译：式（I）化合物：其中：R 1和R 2一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，R 3表示氢，或R 1表示氢，R 2和R 3 硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，其对映异构体，非对映异构体及其与药学上可接受的酸或碱的加成盐共同形成任选被卤素取代的苯并环，和药物。

7. 发明申请

US20050059675A1 Benzoindoline compounds 失效
标题翻译：苯并二氢吲哚化合物
公开(公告)号：US20050059675A1
公开(公告)日：2005-03-17
申请号：US10925712
申请日：2004-08-25
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Alain Gobert , Benjamin Di Cara
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Alain Gobert , Benjamin Di Cara
IPC分类号： A61K31/496 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D209/60 , C07D401/12 , C07D403/12 , C07D43/02
CPC分类号： C07D209/60
摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 and R4 represent hydrogen, or R1 and R4 represent hydrogen and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, or R1 and R2 represent hydrogen and R3 and R4 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, addition salts thereof with a pharmaceutically acceptable acid or base, and methods of treating conditions susceptible to α2-AR/5-HT2C antagonists.
摘要翻译：式（I）化合物：其中：R 1和R 2一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，R R 3和R 4代表氢，或R 1和R 4代表氢，R 2和R 3一起形成任选地被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，或R 1和R 2表示氢，R 3和R 4一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，其与药学上可接受的酸或碱的加成盐，以及治疗对α2-AR / 5-HT2C拮抗剂敏感的病症的方法。

8. 发明授权

US06759421B2 Indoline compounds, a process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：二氢吲哚化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US06759421B2
公开(公告)日：2004-07-06
申请号：US10400358
申请日：2003-03-27
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Alain Gobert
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Alain Gobert
IPC分类号： A61K31443
CPC分类号： C07D401/12
摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 represents hydrogen, or R1 represents hydrogen, and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicaments.
摘要翻译：式（I）化合物：其中：R 1和R 2一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，R 3表示氢，或R 1表示氢，R 2和R 3一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，其对映体，非对映异构体及其与药学上可接受的酸或碱的加成盐，以及药物。

9. 发明授权

US06239129B1 Cyano-indole serotonin-reuptake inhibitor compounds 失效
标题翻译：氰基吲哚5-羟色胺再摄取抑制剂化合物
公开(公告)号：US06239129B1
公开(公告)日：2001-05-29
申请号：US09490909
申请日：2000-01-25
申请人： Gilbert Lavielle , Olivier Muller , Bernard Cimetiere , Mark Millan , Alain Gobert , Jean-Michel Rivet
发明人： Gilbert Lavielle , Olivier Muller , Bernard Cimetiere , Mark Millan , Alain Gobert , Jean-Michel Rivet
IPC分类号： A61K31404
CPC分类号： C07D401/12 , C07D209/08 , C07D403/06 , C07D403/12 , C07D403/14 , C07D513/04
摘要： Compound of formula (I): wherein: R1 and R2 each independently of the other represents hydrogen or alkyl, A represents alkylene, alkenylene or alkynylene, G1 represents wherein R3 and R4 each independently of the other represents hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl or optionally substituted arylalkyl, or G1 represents heterocycloalkyl optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, nitrile, carboxy, alkoxycarbonyl, carbamoyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, and which medicinal products containing the same/are useful as serotonin-reuptake inhibitors.
摘要翻译：式（I）化合物：其中：R 1和R 2各自独立地表示氢或烷基，A表示亚烷基，亚烯基或亚炔基，G 1表示其中R 3和R 4各自独立地表示氢，烷基，环烷基，环烷基烷基，任选地取代的芳基或任选取代的芳基烷基，或G 1表示任选被烷基，环烷基，环烷基烷基，腈，羧基，烷氧基羰基，氨基甲酰基，任选取代的芳基，任选取代的芳基烷基，任选取代的杂芳基或任选取代的杂芳基烷基取代的杂环烷基， /作为5-羟色胺再摄取抑制剂是有用的。

10. 发明授权

US5703070A Indole, indazole and benzisoxazole compounds 失效
标题翻译：吲哚，吲唑和苯并异恶唑化合物
公开(公告)号：US5703070A
公开(公告)日：1997-12-30
申请号：US663464
申请日：1996-06-06
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Valerie Audinot
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Valerie Audinot
IPC分类号： A61K31/40 , A61K31/415 , A61K31/42 , A61K31/55 , A61P25/18 , A61P43/00 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D209/04 , A61K31/41 , C07D231/56
CPC分类号： C07D403/06 , C07D413/06
摘要： Compound of formula (I): ##STR1## in which: R.sub.1 represents hydrogen, halogen, alkyl, alkoxy, trihalomethyl or hydroxyl, R.sub.2 represents hydrogen, alkyl or phenyl which is optionally substituted, ##STR2## or alternatively ##STR3## represents --O--N.dbd., 1.ltoreq.n.ltoreq.6, ##STR4## represents any one of the groups defined in the description, its isomers and its addition salts with a pharmaceutically acceptable acid or base, a medicinal products containing the same are useful in the treatment of schizophrenia.
摘要翻译：式（I）的化合物：其中：R 1表示氢，卤素，烷基，烷氧基，三卤甲基或羟基，R 2表示氢，任选被取代的烷基或苯基，表示-ON =，1 表示在说明书中定义的组中的任何一个，其异构体及其与药学上可接受的酸或碱的加成盐，含有它们的药用产品可用于治疗精神分裂症。

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