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1. 发明申请

US20050214390A1 Bioavailability enhancing activity of Carum carvi extracts and fractions thereof 审中-公开
$Bioavailability enhancing activity of Carum carvi extracts and fractions thereof$
标题翻译： Carum carvi提取物及其馏分的生物利用度提高活性
公开(公告)号：US20050214390A1
公开(公告)日：2005-09-29
申请号：US10992141
申请日：2004-11-18
申请人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhas Sharma , Tasaduaq Abdullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria
发明人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhas Sharma , Tasaduaq Abdullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria
IPC分类号： A61K31/496 , A61K31/497 , A61K31/7048 , A61K36/23 , A61K36/67 , A61K36/9068 , A61K35/78
CPC分类号： A61K31/7048 , A61K31/496 , A61K31/497 , A61K36/23 , A61K36/67 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs.
摘要翻译：本发明涉及Carum carvi提取物作为生物降解剂的用途，单独使用或与胡椒碱或锌盐提取物组合以提高各种药物的生物利用度。

2. 发明申请

US20070020347A1 Bioavailability enhancing activity of Carum carvi extracts and fractions thereof 审中-公开
$Bioavailability enhancing activity of Carum carvi extracts and fractions thereof$
标题翻译： Carum carvi提取物及其馏分的生物利用度提高活性
公开(公告)号：US20070020347A1
公开(公告)日：2007-01-25
申请号：US11478228
申请日：2006-06-29
申请人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhash Sharma , Tasaduaq Abdullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria
发明人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhash Sharma , Tasaduaq Abdullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria
IPC分类号： A61K36/906 , A61K36/18 , A61K31/7048 , A61K31/496 , A61K31/4709 , A61K31/545 , A61K31/43
CPC分类号： A61K31/7048 , A61K31/496 , A61K31/497 , A61K36/23 , A61K36/67 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs.
摘要翻译：本发明涉及Carum carvi提取物作为生物降解剂的用途，单独使用或与胡椒碱或锌盐提取物组合以提高各种药物的生物利用度。

3. 发明申请

US20060257505A1 Bioavailability enhancing activity of carum carvi extracts and fractions thereof 审中-公开
$Bioavailability enhancing activity of carum carvi extracts and fractions thereof$
标题翻译： Carum carvi提取物及其馏分的生物利用度增加活性
公开(公告)号：US20060257505A1
公开(公告)日：2006-11-16
申请号：US11360839
申请日：2006-02-23
申请人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhash Sharma , Tasaduaq Abdullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria
发明人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhash Sharma , Tasaduaq Abdullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria
IPC分类号： A61K36/185 , A61K31/7048 , A61K31/496 , A61K31/4709 , A61K36/906 , A61K31/43 , A61K31/545
CPC分类号： A61K36/23 , A61K31/43 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/7048 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs.
摘要翻译：本发明涉及Carum carvi提取物作为生物降解剂的用途，单独使用或与胡椒碱或锌盐提取物组合以提高各种药物的生物利用度。

4. 发明申请

US20060141080A1 Bioavailability / bioefficacy enhancing activity of cuminum cyminum and extracts and fractions thereof 有权
$Bioavailability / bioefficacy enhancing activity of cuminum cyminum and extracts and fractions thereof$
标题翻译：孜然和提取物及其级分的生物利用度/生物功效增强活性
公开(公告)号：US20060141080A1
公开(公告)日：2006-06-29
申请号：US11360653
申请日：2006-02-23
申请人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhash Sharma , Sheikh Absullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria , Surjit Singh , Anamika Khajuria , Bal Kapahi
发明人： Ghulam Qazi , Kasturi Bedi , Rakesh Johri , Manoj Tikoo , Ashok Tikoo , Subhash Sharma , Sheikh Absullah , Om Suri , Bishan Gupta , Krishan Suri , Naresh Satti , Ravi Khajuria , Surjit Singh , Anamika Khajuria , Bal Kapahi
IPC分类号： A61K36/23
CPC分类号： A61K45/06 , A23L33/105 , A23L33/15 , A23L33/16 , A23L33/175 , A61K31/43 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/704 , A61K31/7048 , A61K33/04 , A61K36/185 , A61K36/19 , A61K36/23 , A61K36/28 , A61K36/47 , A61K36/59 , A61K36/67 , A61K36/75 , A61K36/80 , A61K36/81 , A61K36/8965 , A61K2300/00
摘要： The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceuticaly acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.
摘要翻译：本发明涉及生物增强/生物利用度促进组合物，其包含：有效量的来自孜然的提取物和/或至少一种生物活性级分; 一种或多种选自药物，营养素，维生素，营养品，草药/产品，微量营养素，抗氧化剂以及药用可接受的添加剂/赋形剂的添加剂，以及任选的有效量的胡椒碱或胡椒或胡椒的提取物/级分; 以及从植物孜然中制备这些提取物和活性级分的方法。

5. 发明申请

US20070275006A1 IRIDOID GLYCOSIDE COMPOSITION 审中-公开
标题翻译：红葡萄糖苷组合物
公开(公告)号：US20070275006A1
公开(公告)日：2007-11-29
申请号：US11683975
申请日：2007-03-08
申请人： Anamika Khajuria , Amit Gupta , Singh Surjeet , Fayaz Malik , Jaswant Singh , Kasturi Lal Bedi , Krishan Suri , Naresh Satti , Om Suri , Ghulam Qazi , Vellimedu Srinivas , Krishna Ella
发明人： Anamika Khajuria , Amit Gupta , Singh Surjeet , Fayaz Malik , Jaswant Singh , Kasturi Lal Bedi , Krishan Suri , Naresh Satti , Om Suri , Ghulam Qazi , Vellimedu Srinivas , Krishna Ella
IPC分类号： A61K45/00 , A61K39/385 , A61K47/00
CPC分类号： C07H17/04 , A61K39/0275 , A61K39/12 , A61K39/292 , A61K39/39 , A61K2039/55505 , A61K2039/5555 , A61K2039/55566 , A61K2039/55583 , A61K2039/57 , C12N2730/10134 , Y02A50/484
摘要： The present invention relates to an adjuvants, particularly to the use of a well-characterized plant based iridoid glycoside adjuvant from plant Picrorhiza kurroa, acting as an adjuvant against T-dependent antigen and specifically against HBsAg and typhoid antigens. The present invention also relates to the method of producing the iridoid glycoside adjuvant and the products utilizing such adjuvants for induction of cellular immunity. The adjuvants may be used alone or with specific antigens. The two antigens used in the study represents HBsAg, a recombinant antigen expressed in Pichia pastoris, and typhoid Vi polysaccharide purified from Salmonella typhi broth. These antigens are studied for their immunogenicity with the adjuvant iridoid glycoside adjuvant
摘要翻译：本发明涉及一种佐剂，特别是涉及使用来自植物Pic草的充分表征的植物性环烯醚萜糖苷佐剂的佐剂，其作为对T依赖性抗原的佐剂，特异性地抗HBsAg和伤寒抗原。本发明还涉及生产环烯醚萜苷佐剂的方法和利用这些佐剂诱导细胞免疫的产物。佐剂可以单独使用或与特定抗原一起使用。研究中使用的两种抗原代表HBsAg，一种在巴斯德毕赤酵母中表达的重组抗原，以及从伤寒沙门氏菌培养液中纯化的伤寒Vi多糖。研究这些抗原与佐剂环烯醚萜苷佐剂的免疫原性

6. 发明申请

US20050226950A1 Process for isolation of withaferin-A from plant materials and products therefrom 有权
标题翻译：从植物材料和产品中分离嗜铬蛋白A的方法
公开(公告)号：US20050226950A1
公开(公告)日：2005-10-13
申请号：US10822858
申请日：2004-04-13
申请人： Rajender Sangwan , Narayan Chaurasiya , Laxmi Misra , Payare Lal , Girish Uniyal , Neelam Sangwan , Avdhesh Srivastava , Krishan Suri , Ghulam Qazi , Rakesh Tuli
发明人： Rajender Sangwan , Narayan Chaurasiya , Laxmi Misra , Payare Lal , Girish Uniyal , Neelam Sangwan , Avdhesh Srivastava , Krishan Suri , Ghulam Qazi , Rakesh Tuli
IPC分类号： A61K36/81 , A61K35/78
CPC分类号： A61K36/81
摘要： The present invention relates to an improved process of analytical and quantitative isolation of withaferin-A from Withania somnifera (Sanskrit: Ashwagandha, English: winter cherry) and other plants and products therefrom, said method comprising steps of selecting most appropriate extraction medium composition, with extraction solvent system consisting of a defined admixture of water and alcohol in a range of proportion of alcohol within a narrow range of (methanol, ethanol etc.) (preferably 60% alcohol and 40% water) for the dry plant material and from 60% to 80% alcohol in the alcohol-water mixture for fresh plant material, the invented extractant composition leading to better/improved yields and accurate quantitative estimations of withaferin A existent in planta or in materia, selecting effective state of the tissue particularly use of the fresh materials improving yields, providing logistic benefits of isolations and diagnosis, and according several other advantages including technological, economic, preventing contaminations etc., the said method being valuable and advantageous for standardization of botanicals, metabolomic characterization of plants particularly chemotypes, analyzing metabolic transitions under physiological, genetical, environmental and biotic perturbations.
摘要翻译：本发明涉及一种分离和定量分离来自隐翅藻（梵语：Ashwagandha，英语：冬樱桃）和其他植物及其产物的咖啡因-A的改进方法，所述方法包括以下步骤：选择最合适的提取培养基组合物，萃取溶剂体系，由干燥植物材料的（甲醇，乙醇等）（优选60％酒精和40％水）的窄范围内的醇的比例范围内的水和醇的混合物组成，到新鲜植物材料的酒精 - 水混合物中的80％酒精，本发明的提取剂组合物导致在植物或物质中存在的更好/提高的产量和准确的定量估计，选择组织的有效状态，特别是使用新鲜的材料提高产量，提供隔离和诊断的后勤优势，以及其他几个优势，包括技术所述方法对于植物学的标准化，植物的代谢组学特征，特别是化学型，分析生理，遗传，环境和生物扰动下的代谢转变是有价值和有利的。

7. 发明申请

US20050266100A1 Process isolation of withaferin-A from plant materials and products therefrom 审中-公开
标题翻译：从植物材料和产品中过程分离嗜铬蛋白A
公开(公告)号：US20050266100A1
公开(公告)日：2005-12-01
申请号：US10812363
申请日：2004-03-30
申请人： Rajender Sangwan , Narayan Chaurasiya , Laxmi Misra , Krishan Suri , Ghulam Qazi , Rakesh Tuli , Payare Lal , Girish Uniyal , Neelam Sangwan , Avdhesh Srivastava
发明人： Rajender Sangwan , Narayan Chaurasiya , Laxmi Misra , Krishan Suri , Ghulam Qazi , Rakesh Tuli , Payare Lal , Girish Uniyal , Neelam Sangwan , Avdhesh Srivastava
IPC分类号： A61K35/78
CPC分类号： A61K36/81
摘要： The present invention relates to an improved process of analytical and quantitative isolation of withaferin-A from Withania somnifera (Sanskrit: Ashwagandha, English: winter cherry) and other plants and products therefrom, said method comprising steps of selecting most appropriate extraction medium composition, with extraction solvent system consisting of a defined admixture of water and alcohol in a range of proportion of alcohol within a narrow range of (methanol, ethanol etc.) (preferably 60% alcohol and 40% water) for the dry plant material and from 60 % to 80% alcohol in the alcohol-water mixture for fresh plant material, the invented extractant composition leading to better/improved yields and accurate quantitative estimations of withaferin A existent in planta or in materia, selecting effective state of the tissue particularly use of the fresh materials improving yields, providing logistic benefits of isolations and diagnosis, and according several other advantages including technological, economic, preventing contaminations etc., the said method being valuable and advantageous for standardization of botanicals, metabolomic characterization of plants particularly chemotypes, analyzing metabolic transitions under physiological, genetical, environmental and biotic perturbations.
摘要翻译：本发明涉及一种分离和定量分离来自隐翅藻（梵语：Ashwagandha，英语：冬樱桃）和其他植物及其产物的咖啡因-A的改进方法，所述方法包括以下步骤：选择最合适的提取培养基组合物，萃取溶剂体系，由干燥植物材料的（甲醇，乙醇等）（优选60％酒精和40％水）的窄范围内的醇的比例范围内的水和醇的混合物组成，到新鲜植物材料的酒精 - 水混合物中的80％酒精，本发明的提取剂组合物导致在植物或物质中存在的更好/提高的产量和准确的定量估计，选择组织的有效状态，特别是使用新鲜的材料提高产量，提供隔离和诊断的后勤优势，以及其他一些优势，包括tec 生物学，经济学，预防污染等，所述方法对于植物学的标准化，植物的代谢组学特征，特别是化学型，分析生理，遗传，环境和生物扰动下的代谢转变是有价值和有利的。

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