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1. 发明授权

US08368884B2 Spectroscopic determination of analyte concentration 失效
标题翻译：分析物浓度的光谱测定
公开(公告)号：US08368884B2
公开(公告)日：2013-02-05
申请号：US11911557
申请日：2006-04-19
申请人： Gerhardus Wilhelmus Lucassen , Rufus Driessen , Kristiane Anne Schmidt , Gerwin Jan Puppels , Peter Jacobus Caspers
发明人： Gerhardus Wilhelmus Lucassen , Rufus Driessen , Kristiane Anne Schmidt , Gerwin Jan Puppels , Peter Jacobus Caspers
IPC分类号： G01J3/30 , A61B5/1455
CPC分类号： A61B5/14532 , A61B5/489
摘要： A spectroscopic apparatus for determining a concentration and/or spatial gradient of an analyte of a bodily fluid that provides determination of a position of a capillary vessel within a biological sample in order to focus spectroscopic excitation radiation to a volume that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus exploits the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel. Spectroscopic analysis of a volume outside the capillary vessel can therefore serve for a precise and reliable analyte concentration determination inside the capillary vessel.
摘要翻译：一种用于确定体液分析物的浓度和/或空间梯度的分光装置，其提供对生物样品内毛细血管位置的确定，以便将分光激发辐射聚焦到接近于毛细血管，但不与毛细血管重叠。所提供的装置相对于经受分析物浓度测定的分析物利用血管壁的渗透性。通过生物传输过程，位于毛细管中的体液分析物的浓度影响毛细血管周围的浓度。因此，毛细血管外部的体积的光谱分析可用于在毛细血管内进行精确和可靠的分析物浓度测定。

2. 发明申请

US20100309466A1 SPECTROSCOPIC DETERMINATION OF ANALYTE CONCENTRATION 失效
标题翻译：分析浓度的光谱测定
公开(公告)号：US20100309466A1
公开(公告)日：2010-12-09
申请号：US11911557
申请日：2006-04-19
申请人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
发明人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
IPC分类号： G01J3/40
CPC分类号： A61B5/14532 , A61B5/489
摘要： A spectroscopic apparatus, a method of determining a concentration and/or spatial gradient of an analyte of a bodily fluid and a corresponding computer program product are provided. The spectroscopic apparatus provides determination of a position of a capillary vessel (104) within a biological sample in order to focus spectroscopic excitation radiation to a volume (122). that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus, method, and computer program product advantageously exploit the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel. Spectroscopic analysis of a volume outside the capillary vessel can therefore serve for a precise and reliable analyte concentration determination inside the capillary vessel.
摘要翻译：提供了一种分光装置，确定体液分析物和相应的计算机程序产品的浓度和/或空间梯度的方法。分光装置提供对生物样品内的毛细血管（104）的位置的确定，以便将分光激发辐射聚焦到体积（122）。其紧邻毛细血管，但不与毛细血管重叠。所提供的装置，方法和计算机程序产品有利地利用容器壁相对于经受分析物浓度测定的分析物的渗透性。通过生物传输过程，位于毛细管中的体液分析物的浓度影响毛细血管周围的浓度。因此，毛细血管外部的体积的光谱分析可用于在毛细血管内进行精确和可靠的分析物浓度测定。

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