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1. 发明申请

US20120041079A1 DEXTRAN FUNCTIONALIZED BY HYDROPHOBIC AMINO ACIDS 审中-公开
标题翻译：由疏水性氨基酸功能化的地西泮
公开(公告)号：US20120041079A1
公开(公告)日：2012-02-16
申请号：US13250803
申请日：2011-09-30
申请人： Gerard SOULA , Olivier Soula , Remi Soula , Richard Charvet
发明人： Gerard SOULA , Olivier Soula , Remi Soula , Richard Charvet
IPC分类号： A61K47/36 , C07H15/18 , C07H15/04 , C07H17/02
CPC分类号： A61K31/721 , A61K47/36 , C08B37/0021
摘要： Dextran of the following general formula I: is described, wherein R represents a chain containing from 1 to 15 carbon atoms and having at least one acid functional group prior to attachment to AA, the chain optionally being branched and/or unsaturated and containing one or more heteroatoms, such as O, N or/and S, F represents an ester, a carbamate or an ether, AA represents a hydrophobic amino acid radical, L or D, derived from a coupling between an amine of an amino acid and at least one acid functional group of R; the amino acid, prior to attachment to R, being selected from the group consisting of tryptophan, phenylalanine, leucine, isoleucine, alanine and valine, and alcohol, amide or decarboxylated derivatives thereof, and alkaline cation salts thereof, i represents the molar fraction of substituent F—R-[AA]n per glycosidic unit and is from 0.1 to 2, n represents the molar fraction of R groups substituted by AA and is from 0.05 to 1, and wherein for R groups not substituted by AA, the acid(s) of the group R are alkaline cation carboxylates such as Na or K.
摘要翻译：描述了以下通式I的葡聚糖，其中R表示含有1至15个碳原子并且在与AA连接之前具有至少一个酸官能团的链，该链任选是支链和/或不饱和的，并且含有一个或更多的杂原子，例如O，N或/和S，F代表酯，氨基甲酸酯或醚，AA代表疏水性氨基酸基团，L或D衍生自氨基酸的胺与至少一个酸官能团的R; 氨基酸在与R连接之前选自色氨酸，苯丙氨酸，亮氨酸，异亮氨酸，丙氨酸和缬氨酸，以及其醇，酰胺或其脱羧基衍生物及其碱性阳离子盐，i表示取代基F-R- [AA] n，为0.1〜2，n表示被AA取代的R基的摩尔分数，为0.05〜1，对于不被AA取代的R基，酸（的基团R是碱性阳离子羧酸盐，例如Na或K.

2. 发明申请

US20110178011A1 Polysaccharide/BMP complexes which are soluble at physiological pH 审中-公开
标题翻译：在生理pH下可溶的多糖/ BMP复合物
公开(公告)号：US20110178011A1
公开(公告)日：2011-07-21
申请号：US12950616
申请日：2010-11-19
申请人： Remi SOULA , Olivier SOULA , Gerard SOULA , Richard CHARVET , David DURACHER
发明人： Remi SOULA , Olivier SOULA , Gerard SOULA , Richard CHARVET , David DURACHER
IPC分类号： A61K38/18 , C07K14/51
CPC分类号： A61K47/61 , A61K31/70 , A61K38/00 , A61K47/36 , C08B37/0018 , C08B37/0021 , C08L5/00 , C08L5/02
摘要： A complex of a polysaccharide and recombinant human BMP-2 and BMP-7, soluble at physiological pH, wherein the polysaccharide/BMP mass ratio is less than 15, the polysaccharide being selected from the group of polysaccharides having carboxyl functional groups, at least one of which is substituted with at least one hydrophobic radical.
摘要翻译：在生理pH可溶的多糖和重组人BMP-2和BMP-7的复合物，其中多糖/ BMP质量比小于15，多糖选自具有羧基官能团的多糖，至少一种其中至少一个疏水基团被取代。

3. 发明申请

US20110027363A1 Nouvelle forme d'administration de proteines osteogeniques 审中-公开
标题翻译：新颖的营养成分
公开(公告)号：US20110027363A1
公开(公告)日：2011-02-03
申请号：US12591447
申请日：2009-11-19
申请人： Remi SOULA , Olivier SOULA , Gerard SOULA
发明人： Remi SOULA , Olivier SOULA , Gerard SOULA
IPC分类号： A61K38/18 , A61K38/02 , A61K38/16
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K33/06 , A61K33/42 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K45/06 , A61K47/02 , A61L27/227 , A61L27/46 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/45 , A61K2300/00
摘要： Osteogenic compositions are formed from a coprecipitate that contains at least one insoluble calcium salt and at least one osteogenic protein, the coprecipitate being in divided form. A process for preparing the coprecipitate in divided form contains at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide. The invention also relates to the formulations, pharmaceutical products, kits and medical devices comprising the coprecipitate.
摘要翻译：成骨组合物由共沉淀物形成，共沉淀物含有至少一种不溶性钙盐和至少一种成骨蛋白质，共沉淀物是分开形式的。制备分散形式的共沉淀物的方法包含至少一种不溶性钙盐和至少一种成骨蛋白质和多糖之间的复合物。本发明还涉及包含共沉淀物的制剂，药物产品，试剂盒和医疗装置。

4. 发明申请

US20100166867A1 Novel administration form of osteogenic protein complexes 失效
标题翻译：成骨蛋白复合物的新型管理形式
公开(公告)号：US20100166867A1
公开(公告)日：2010-07-01
申请号：US12591442
申请日：2009-11-19
申请人： Olivier SOULA , Remi SOULA , Gerard SOULA
发明人： Olivier SOULA , Remi SOULA , Gerard SOULA
IPC分类号： A61K38/18 , A61K9/14 , A61P19/00
CPC分类号： A61K31/721 , A61K9/0019 , A61K9/0024 , A61K9/143 , A61K9/146 , A61K9/19 , A61K33/06 , A61K33/42 , A61K38/1858 , A61K38/1875 , A61K47/02 , A61K47/36 , A61L27/227 , A61L27/26 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/45 , A61L2300/802 , C08B37/0021 , A61K2300/00 , C08L89/00
摘要： The invention relates to osteogenic compositions composed of a coprecipitate that contains at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide, said coprecipitate being in divided form. The invention also relates to kits for performing the invention.The invention also relates to the process for preparing the coprecipitate in divided form, containing at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide.The invention also relates to the formulations, pharmaceutical products and medical devices comprising said coprecipitate.
摘要翻译：本发明涉及由含有至少一种不溶性钙盐和至少一种成骨蛋白质和多糖之间的复合物的共沉淀物组成的成骨组合物，所述共沉淀物是分开形式的。本发明还涉及用于实施本发明的试剂盒。本发明还涉及分离形式的共沉淀物的制备方法，其含有至少一种不溶性钙盐和至少一种成骨蛋白质和多糖之间的复合物。本发明还涉及包含所述共沉淀物的制剂，药物产品和医疗装置。

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