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1. 发明授权

US4129509A Metalworking fluid compositions and methods of stabilizing same 失效
标题翻译：金属加工液组合物及其稳定方法
公开(公告)号：US4129509A
公开(公告)日：1978-12-12
申请号：US719813
申请日：1976-09-01
申请人： Sudhir K. Shringarpurey , Gerald L. Maurer
发明人： Sudhir K. Shringarpurey , Gerald L. Maurer
IPC分类号： A01N37/36 , A01N37/44 , A01N57/20 , C07C59/265 , C07F1/00 , C10M173/00 , C10M1/04 , C10M3/04
CPC分类号： C07F1/005 , A01N37/36 , A01N37/44 , A01N57/20 , C07C59/265 , C10M173/00 , C10M2201/02 , C10M2207/123 , C10M2207/125 , C10M2207/129 , C10M2207/22 , C10M2207/289 , C10M2207/40 , C10M2207/404 , C10M2209/104 , C10M2215/042 , C10M2215/08 , C10M2215/082 , C10M2215/28 , C10M2219/042 , C10M2219/044 , C10M2223/04 , C10M2223/042 , C10M2225/00 , C10M2225/02 , C10M2227/09 , C10N2210/01 , C10N2210/02 , C10N2210/04 , C10N2210/05 , C10N2210/06 , C10N2210/08 , C10N2240/40 , C10N2240/401 , C10N2240/402 , C10N2240/403 , C10N2240/404 , C10N2240/405 , C10N2240/406 , C10N2240/407 , C10N2240/408 , C10N2240/409 , C10N2250/02 , Y10S516/02 , Y10S516/06
摘要： Stabilized metalworking fluid compositions are disclosed comprising an oil and water dispersion and, as a stabilizer therefor, a metal complex of a metal ion and a polyfunctional organic ligand. The metal complexes have an aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of hydrogen ion concentration. This dissociation property causes a controlled release of metal ion into the oil and water dispersion to impart metal working stability to the dispersion. Metal working emulsions of oil and water are stabilized by the addition thereto of minor amounts of a metal complex, e.g., disodium monocopper(II) citrate, which at alkaline pH metalworking conditions above about 7 to about 9 releases metal cations to the emulsions imparting stabilizing characteristics which prevent emulsion degradation by a number of factors commonly encountered in metalworking operations. The stabilized compositions of this invention have greatly improved service life and offer significant economies in metalworking operations.
摘要翻译：公开了稳定的金属加工液组合物，其包含油和水分散体，并且作为其稳定剂，具有金属离子和多官能有机配体的金属络合物。金属络合物具有质子诱导的离解性质，由金属离子浓度的负对数相对于氢离子浓度的负对数的笛卡尔坐标图上的乙状结构曲线表示。这种离解性导致金属离子被控制释放到油和水分散体中，以赋予分散体金属加工稳定性。油和水的金属加工乳液通过添加少量的金属络合物来稳定，例如柠檬酸二钠，其在高于约7至约9的碱性pH金属加工条件下将金属阳离子释放到赋予稳定性的乳液通过在金属加工操作中常见的许多因素防止乳液降解的特征。本发明的稳定化组合物大大改善了使用寿命并提供了金属加工操作的显着经济性。

2. 发明授权

US4652444A Methods and compositions for treating dental structures 失效
标题翻译：治疗牙科结构的方法和组合物
公开(公告)号：US4652444A
公开(公告)日：1987-03-24
申请号：US681565
申请日：1984-12-14
申请人： Gerald L. Maurer
发明人： Gerald L. Maurer
IPC分类号： A61K8/365 , A61Q11/00 , C07C51/41 , C07C59/265 , A61K7/16 , A61K31/28 , A61K31/30
CPC分类号： C07C59/265 , A61K8/365 , A61Q11/00 , C07C51/418 , A61K2800/58
摘要： Novel methods and dental compositions for treating dental structures, such as teeth and subgingival structures, are disclosed. Uniquely, the dental compositions contain metal complexes which are characterized as having an unique aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of the hydrogen ion concentration. This unique dissociation property enables the metal complexes to release therapeutic metal ions in the oral cavity for forming metal coordination complexes or salts within the dental structures. The formation of such complexes or salts within the dental structures is particularly effective and highly resistant to enzymatic degradation associated with microbial activity. Also, the metal ions of this invention are highly effective in inactivating the enzymes secreted by microbes in the oral cavity to further attenuate the disintegration process. The metal complexes of the new and vastly improved dental compositions advantageously are highly soluble yet readily dissociable at pH ranges normally encountered in the human mouth. As the active ingredient, the dental compositions contain a monometal complex of a multivalent heavy metal ion and a polyfunctional organic ligand in a ratio of about 1:1. An example of a dental composition employed is disodium monocopper(II) citrate in an amount of about 4 mg./ml., as copper, in a liquid vehicle having a pH of about 7.
摘要翻译：公开了用于治疗诸如牙齿和龈下结构之类牙科结构的新方法和牙科组合物。独特地，牙科用组合物含有金属络合物，其特征在于具有独特的质子诱导的解离性质，由金属离子浓度的负对数相对于氢离子浓度的负对数的笛卡儿坐标图表示的乙状结构曲线。这种独特的解离性使得金属络合物能够在口腔中释放治疗性金属离子，以在牙科结构内形成金属配位络合物或盐。牙科结构内这种复合物或盐的形成对于与微生物活性相关的酶降解是特别有效的。此外，本发明的金属离子在灭活口腔中微生物分泌的酶方面是非常有效的，以进一步减弱崩解过程。新的和大大改进的牙科组合物的金属络合物有利地是高度可溶的，但在人口通常遇到的pH范围容易解离。作为活性成分，牙科用组合物含有约1:1的多价重金属离子和多官能有机配体的单金属络合物。使用的牙科用组合物的一个实例是柠檬酸二钠（柠檬酸钠），其pH值约为7，液体载体中约4mg./ml，作为铜。

3. 发明授权

US4708864A Method and compositions for treating dental structures 失效
标题翻译：治疗牙科结构的方法和组合物
公开(公告)号：US4708864A
公开(公告)日：1987-11-24
申请号：US28552
申请日：1987-03-20
申请人： Gerald L. Maurer
发明人： Gerald L. Maurer
IPC分类号： A61K8/365 , A61Q11/00 , C07C51/41 , C07C59/265 , A61K7/16 , A61K31/28 , A61K31/30
CPC分类号： C07C59/265 , A61K8/365 , A61Q11/00 , C07C51/418 , A61K2800/58
摘要： Novel methods and dental compositions for treating dental structures, such as teeth and subgingival structures, are disclosed. Uniquely, the dental compositions contain metal complexes which are characterized as having a unique aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of the hydrogen ion concentration. This unique dissociation property enables the metal complexes to release therapeutic metal ions in the oral cavity for forming metal coordination complexes or salts within the dental structures. The formation of such complexes or salts within the dental structures is particularly effective and highly resistant to enzymatic degradation associated with microbial activity. Also, the metal ions of this invention are highly effective in inactivating the enzyme secreted by microbes in the oral cavity to further attenuate the disintegration process. The metal complexes of the new and vastly improved dental compositions advantageously are highly soluble yet readily dissociable at pH ranges normally encountered in the human mouth. As the active ingredient, the dental compositions contain a monometal complex of a multi-valent heavy metal ion and a polyfunctional organic ligand in a ratio of about 1:1. An example of a dental composition employed is disodium monocopper (II) citrate in an amount of about 4 mg./ml., as copper, in a liquid vehicle having a pH of about 7.
摘要翻译：公开了用于治疗诸如牙齿和龈下结构之类牙科结构的新方法和牙科组合物。独特地，牙科用组合物含有金属配合物，其特征在于具有独特的质子诱导的解离性质，由金属离子浓度的负对数相对于氢离子浓度的负对数的笛卡尔坐标图表示的乙状结构曲线。这种独特的解离性使得金属络合物能够在口腔中释放治疗性金属离子，以在牙科结构内形成金属配位络合物或盐。牙科结构内这种复合物或盐的形成对于与微生物活性相关的酶降解是特别有效的。此外，本发明的金属离子在灭活口腔中微生物分泌的酶方面是非常有效的，以进一步减弱崩解过程。新的和大大改进的牙科组合物的金属络合物有利地是高度可溶的，但在人口通常遇到的pH范围容易解离。作为活性成分，牙科用组合物含有比例约为1:1的多价重金属离子和多官能有机配体的单金属络合物。使用的牙科用组合物的一个实例是柠檬酸二钠（柠檬酸钠），其pH值约为7，液体载体中约4mg./ml，作为铜。

4. 发明授权

US06303111B1 Nontoxic biocompatible deodorizing compositions 有权
标题翻译：无毒生物相容性除臭组合物
公开(公告)号：US06303111B1
公开(公告)日：2001-10-16
申请号：US09328101
申请日：1999-06-08
申请人： Gerald L. Maurer , David Melzer
发明人： Gerald L. Maurer , David Melzer
IPC分类号： A61L901
CPC分类号： A61L9/01 , A61L9/14
摘要： Nontoxic biocompatible deodorizing compositions are essentially free of nonbiocompatible components and comprise, by volume, from about 0.05 to about 0.5 percent of an odor elimination agent, in combination with a physiologically compatible buffering agent, a wetting agent and a polar diluent. The compositions are suitable dispensed from a spray dispenser and are adapted for reducing malodors in environments where contact of the compositions with humans or animals having compromised or reduced chemical or microbiological resistance is anticipated or not easily prevented, for example in operating rooms, intensive care units, neonatal nurseries, and additional health care facilities.
摘要翻译：无毒生物相容性除臭组合物基本上不含非相容性组分，并且体积含有约0.05％至约0.5％的除味剂，与生理上相容的缓冲剂，润湿剂和极性稀释剂组合。组合物适合从喷雾分配器分配，并且适于在预期或不容易防止组合物与人或动物受损或减少的化学或微生物抗性的接触的环境中减少恶臭，例如在手术室，重症监护室，新生儿托儿所和额外的保健设施。

5. 发明授权

US4278610A Method of making an organic metal salt or complex 失效
标题翻译：制备有机金属盐或络合物的方法
公开(公告)号：US4278610A
公开(公告)日：1981-07-14
申请号：US105623
申请日：1979-12-20
申请人： Gerald L. Maurer , Virginia E. Stefanini
发明人： Gerald L. Maurer , Virginia E. Stefanini
IPC分类号： C07C51/41 , C07F1/00 , C07F5/06 , C07F11/00 , C07F1/08
CPC分类号： C07F11/005 , C07C323/00 , C07C51/412 , C07F1/005 , C07F5/069
摘要： A method of making an organic metal salt or complex is disclosed by reacting a heavy metal hydroxide with an organic Lewis acid or salt thereof in the presence of a gaseous catalyst such as a form of CO.sub.2. The reaction may be controlled by the addition of a buffering agent. Other gaseous catalysts such as CO and SO.sub.2 or their related salts, can be employed. The method produces organic metal complexes or salts in a pure second salt-free state either in a solution or solid state.
摘要翻译：通过使重金属氢氧化物与有机路易斯酸或其盐在气态催化剂如CO 2形式的存在下反应来制备有机金属盐或络合物的方法。反应可以通过加入缓冲剂来控制。可以使用其它气态催化剂如CO和SO 2或它们的相关盐。该方法在溶液或固体状态下以纯的第二无盐状态产生有机金属络合物或盐。

6. 发明授权

US4055655A Complexes of heavy metal ions and polyfunctional organic ligands used as antimicrobial agents 失效
标题翻译：用作抗菌剂的重金属离子和多官能有机配体的复合物
公开(公告)号：US4055655A
公开(公告)日：1977-10-25
申请号：US597756
申请日：1975-07-21
申请人： Gerald L. Maurer , Sudhir K. Shringarpurey
发明人： Gerald L. Maurer , Sudhir K. Shringarpurey
IPC分类号： A01N37/36 , A01N37/44 , A01N57/20 , C07C59/265 , C07F1/00 , C10M173/00 , A01N9/00
CPC分类号： C07F1/005 , A01N37/36 , A01N37/44 , A01N57/20 , C07C59/265 , C10M173/00 , C10M2201/02 , C10M2207/123 , C10M2207/125 , C10M2207/129 , C10M2207/22 , C10M2207/289 , C10M2207/40 , C10M2207/404 , C10M2209/104 , C10M2215/042 , C10M2215/08 , C10M2215/082 , C10M2215/28 , C10M2219/042 , C10M2219/044 , C10M2223/04 , C10M2223/042 , C10M2225/00 , C10M2225/02 , C10M2227/09 , C10N2210/01 , C10N2210/02 , C10N2210/04 , C10N2210/05 , C10N2210/06 , C10N2210/08 , C10N2240/40 , C10N2240/401 , C10N2240/402 , C10N2240/403 , C10N2240/404 , C10N2240/405 , C10N2240/406 , C10N2240/407 , C10N2240/408 , C10N2240/409 , C10N2250/02 , Y10S516/02 , Y10S516/06
摘要： Antimicrobial agents are disclosed containing as the active ingredient a metal complex of a metal ion and a polyfunctional organic ligand. The antimicrobial metal complexes are characterized by a very unexpected aqueous proton induced dissociation property which causes the controlled release of toxic metal ion at a pH compatible with microorganism growth. This dissociation property is represented by a sigmoidally shaped curve, i.e., one curved in two different directions like the letter "S," on a cartesian coordinate plot of the negative logarithm (log) of metal ion concentration versus the negative logarithm (log) of hydrogen ion concentration (or otherwise known as a pM-pH diagram). Antimicrobial metal complexes are also disclosed which are extremely effective in the controlled release of metal ion from the complex in about the normal range of physiological pH, i.e., about 10.sup.- 4 to 10.sup.-9 moles of hydrogen ion per liter.
摘要翻译：公开了含有金属离子和多官能有机配体的金属络合物作为活性成分的抗微生物剂。抗微生物金属络合物的特征在于非常意外的水性质子诱导的解离性质，其导致在与微生物生长相容的pH下有毒金属离子的受控释放。这种解离特性由S形表示的曲线表示，即在金属离子浓度的负对数（log）对笛卡儿坐标图上的两个不同方向上的一个曲线，如字母“S”，相对于负的对数（log）氢离子浓度（或称为pM-pH图）。还公开了抗微生物金属络合物，它们在生理pH的正常范围内，即每升约10 -4至10-9摩尔氢离子中，从配合物中控制释放金属离子非常有效。

7. 发明授权

US06200939B1 Biocompositible cleaning and deodorizing compositions for medical devices 有权
标题翻译：用于医疗器械的生物复合清洁和除臭组合物
公开(公告)号：US06200939B1
公开(公告)日：2001-03-13
申请号：US09335942
申请日：1999-06-18
申请人： Gerald L. Maurer
发明人： Gerald L. Maurer
IPC分类号： C11D950
CPC分类号： C11D3/2082 , C11D1/66 , C11D3/2065 , C11D3/50
摘要： Biocompatible aqueous biocompatible cleaning and deodorizing compositions comprise (i) a biocompatible high osmotic pressure material, (ii) a Polycarboxylic acid salt, (iii) a polyhydric alcohol, (iv) a nonionic surfactant, and (v) an odor elimination agent, in water. The compositions are particularly suitable for cleaning and deodorizing medical devices which are designed for receiving and/or holding human waste. Preferably, the compositions are free of non-biocompatible or toxic components and have a relatively neutral pH, whereby the compositions are not harmful to human skin upon contact.
摘要翻译：生物相容性水性生物相容性清洁和除臭组合物包含（i）生物相容性高渗透压材料，（ii）多元羧酸盐，（iii）多元醇，（iv）非离子表面活性剂和（v）除臭剂，水。该组合物特别适用于设计用于接收和/或保持人类废物的医疗装置的清洁和除臭。优选地，组合物不含非生物相容性或毒性组分，并且具有相对中性的pH，由此组合物在接触时对人体皮肤无害。

8. 发明授权

US5534249A Method of reducing malodor using metal complex 失效
标题翻译：使用金属络合物减少恶臭的方法
公开(公告)号：US5534249A
公开(公告)日：1996-07-09
申请号：US440828
申请日：1995-05-15
申请人： Gerald L. Maurer
发明人： Gerald L. Maurer
IPC分类号： A61L9/00 , A61L9/01 , B01D53/86 , B01J31/22
CPC分类号： A61L9/01
摘要： A method of reducing malodor in the environment by using a (1:1) dialkali monometal polyfunctional organic ligand chelate is disclosed. The 1:1 metal complex functions as an oxidation catalyst in the presence of oxygen to neutralize odor causing materials. The odor is chemically neutralized by the 1:1 metal complex, not just masked by a stronger scent.
摘要翻译：公开了通过使用（1：1）二碱基单官能多官能有机配体螯合物来减少环境恶臭的方法。 1：1金属络合物在氧气存在下用作氧化催化剂，以中和产生气味的材料。气味被1：1金属配合物化学中和，不仅仅是被更强烈的香味掩盖。

9. 发明授权

US5198250A Food and pharmaceutical compositions containing short chain monounsaturated fatty acids and methods of using 失效
标题翻译：含短链脂肪酸的食品和药物组合物及其使用方法
公开(公告)号：US5198250A
公开(公告)日：1993-03-30
申请号：US552588
申请日：1990-07-16
申请人： Donald D. Brillhart , Gerald L. Maurer
发明人： Donald D. Brillhart , Gerald L. Maurer
IPC分类号： A23D9/00 , A23K1/16 , A23L1/03 , A23L1/30 , A61K31/20 , A61K31/23 , A61P1/16 , A61P3/06 , A61P3/08 , A61P9/10 , C11B3/12
CPC分类号： A23D9/00 , A23K20/158 , A23L33/115 , A23L33/12 , A61K31/20 , A61K31/23 , C11B3/12
摘要： Food and pharmaceutical compositions are disclosed which contain amounts of short chain monounsaturated fatty acids or their derivatives sufficient to increase the content of the fatty acids within the tissues when said compositions are administered and to substantially improve the metabolic processing of lipids within animals.
摘要翻译：公开了食物和药物组合物，其含有足量的短链单不饱和脂肪酸或其衍生物，当所述组合物被施用时足以增加组织内脂肪酸的含量，并且基本上改善了动物体内脂质的代谢加工。

10. 发明授权

US4680309A Methods and compositions for treating inflammation or arthritis 失效
标题翻译：用于治疗炎症或关节炎的方法和组合物
公开(公告)号：US4680309A
公开(公告)日：1987-07-14
申请号：US825674
申请日：1986-02-03
申请人： Gerald L. Maurer
发明人： Gerald L. Maurer
IPC分类号： A61K31/28 , A61K31/30 , A61K31/315 , C07C59/235 , C07C59/245 , C07C59/255 , C07C59/265 , A01N55/02
CPC分类号： C07C59/245 , A61K31/28 , A61K31/30 , A61K31/315 , C07C59/235 , C07C59/255 , C07C59/265
摘要： A method of treating inflammation or arthritis with metal complexes that can traverse skin and animal cell membranes intact and effectively deliver and release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes have an aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of hydrogen ion concentration. This dissociation property enables the metal complexes to release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes can be effectively administered either topically or subcutaneously. Upon topical application, the metal complexes are dispersed in a vehicle to provide a buffered composition to neutralize the initial acidic layer of the skin. These unique and advantageous properties permit the metal complexes to be incorporated into vehicles with an adjusted pH minimizing premature release of the metal ions prior to reaching the targeted inflammatory or arthritic areas. Further, the metal complexes can be dispersed in a greaseless cold cream vehicle formulated to avoid or minimize undesirable chemical incompatibilities. An example of a topical composition employed is disodiummonocopper(II) citrate in an amount of about 10% w/w in a water-dispersible cream base vehicle comprising an oil-in-water emulsion having a pH of about 7.0.
摘要翻译：用金属络合物治疗炎症或关节炎的方法，其可以在需要含有需要金属离子的内源性反应部分的靶向炎性或关节炎区域的情况下以受控的方式完整地穿过皮肤和动物细胞膜并有效递送和释放金属离子。金属络合物具有质子诱导的离解性质，由金属离子浓度的负对数相对于氢离子浓度的负对数的笛卡尔坐标图上的乙状结构曲线表示。这种解离性使得金属络合物能够在需要含有需要金属离子的内源性反应部分的靶向炎性或关节炎区域的受控方式释放金属离子。金属络合物可以有效地局部或皮下给药。在局部施用时，将金属络合物分散在载体中以提供缓冲的组合物以中和皮肤的初始酸性层。这些独特和有利的性质允许金属配合物掺入车辆中，其中调节的pH最小化到达靶向的炎性或关节炎区域之前金属离子的过早释放。此外，金属络合物可以分散在配制成避免或最小化不期望的化学不相容性的无油冷奶油车中。使用的局部组合物的实例是在包含pH为约7.0的水包油乳液的水分散性乳膏基载体中，柠檬酸二钠（II）柠檬酸盐的量为约10％w / w。

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