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1. 发明授权

US4188396A New phenylazacycloalkanes 失效
标题翻译：新的苯基氮杂环烷烃
公开(公告)号：US4188396A
公开(公告)日：1980-02-12
申请号：US867644
申请日：1978-01-06
申请人： Georges Haas , Alberto Rossi , Pier G. Ferrini , Oswald Schier
发明人： Georges Haas , Alberto Rossi , Pier G. Ferrini , Oswald Schier
IPC分类号： A61K20060101 , A61K31/445 , A61K31/4465 , A61K31/451 , A61P25/24 , A61P25/26 , A61P43/00 , C07D20060101 , C07D211/08 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/30 , C07D211/32 , C07D211/52 , C07D211/62 , C07D211/70 , C07D211/74 , C07D211/76 , C07D211/78 , C07F3/02
CPC分类号： C07C255/00 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/52 , C07D211/70 , C07D211/74 , C07D211/78 , C07F3/02
摘要： New 4-(phenyl)-piperidine compounds of the general formula I ##STR1## in which R.sub.1 represents hydrogen or lower alkyl, Ph represents a p-phenylene group optionally substituted by lower alkyl, lower alkoxy, nitro and/or halogen, and R.sub.2 represents lower alkyl, and pharmaceutically acceptable acid addition salts thereof are useful as antidepressant agents.
摘要翻译：新的式（I）的4-（苯基） - 哌啶化合物，其中R 1表示氢或低级烷基，Ph表示任选被低级烷基，低级烷氧基，硝基和/或卤素取代的对亚苯基，R2表示低级烷基，其药学上可接受的酸加成盐可用作抗抑郁剂。

2. 发明授权

US4304912A Piperidine derivatives 失效
标题翻译：哌啶衍生物
公开(公告)号：US4304912A
公开(公告)日：1981-12-08
申请号：US102462
申请日：1979-12-10
申请人： Herbert Schroter , Kurt Eichenberger , Hans Kuhnis , Christian Egli , Oswald Schier , Franz Ostermayer
发明人： Herbert Schroter , Kurt Eichenberger , Hans Kuhnis , Christian Egli , Oswald Schier , Franz Ostermayer
IPC分类号： C07D401/04 , C07D209/12 , C07D217/22 , C07D241/18
CPC分类号： C07D401/04 , Y10S514/821
摘要： Piperidines of the formula ##STR1## in which R.sub.1 is a substituted or unsubstituted heteroaryl radical, alk.sub.1 and alk.sub.2 independently of one another are lower alkylene radicals, each of which separates by 2 carbon atoms the nitrogen atom bonded thereto from the methane group bonded thereto, R.sub.2 is a free or acylated hydroxyl group, Ph is a substituted or unsubstituted o-phenylene radical, n is 0 or 1, R.sub.3 is a hydrogen atom, a lower alkyl radical or a hydroxyl group and R.sub.5 is a lower alkyl radical or a hydrogen atom, or R.sub.3 and R.sub.5 together are a second bond and R.sub.4 and R.sub.6 are each a hydrogen atom, or R.sub.4 together with R.sub.3 is an oxo group, R.sub.5 is a lower alkyl radical or a hydrogen atom and R.sub.6 is a hydrogen atom, or R.sub.6 together with R.sub.5 is an oxo group, R.sub.3 is a hydrogen atom, a lower alkyl radical or a hydroxyl group and R.sub.4 is a hydrogen atom, or salts thereof are antihypertensive and antiarrhythmic agents.
摘要翻译：其中R1是取代或未取代的杂芳基，alk1和alk2彼此独立的式（I）的哌啶子是低级亚烷基，其各自分开2个碳原子，与甲烷基团键合的氮原子 R 2为游离或酰化羟基，Ph为取代或未取代的邻苯基，n为0或1，R3为氢原子，低级烷基或羟基，R5为低级烷基或氢原子，或者R 3和R 5一起为第二键，并且R 4和R 6各自为氢原子，或者R 4与R 3一起为氧基，R5为低级烷基或氢原子，R6为氢原子或R6与R5一起为氧基，R3为氢原子，低级烷基或羟基，R4为氢原子，或其盐为抗高血压药和抗心律失常药。

3. 发明授权

US4029795A 4(2' Isoquinolin-1-one)piperidines 失效
标题翻译： 4（2 {40 {0-异喹啉-1-酮）哌啶
公开(公告)号：US4029795A
公开(公告)日：1977-06-14
申请号：US595456
申请日：1975-07-14
申请人： Kurt Eichenberger , Christian Egli , Hans Kuhnis , Oswald Schier
发明人： Kurt Eichenberger , Christian Egli , Hans Kuhnis , Oswald Schier
IPC分类号： C07D213/74 , A61K31/47 , C07D217/00
CPC分类号： C07D213/74 , Y10S514/821
摘要： 1-(3-Aryloxy-2-hydroxypropyl)-4-(1-oxoisoquinolino)-piperidines, e.g. those of the formula ##STR1## R' = H, alkanoylaminoethenyl, carbamoyl, alkanoyl, CN, alkoxycarbonylamino-lower alkyl, halo, OH, alkanoylamino, alkyl, alkoxy, alkenyl, alkenyloxyR" = H, alkyl, alkoxy, alkenyl, alkenyloxy,R'" = alkanoylamino, NH.sub.2, NO.sub.2, alkyl, alkoxy, halo CF.sub.3, OH2-alkanoic acid esters and acid addition salts thereof are antihypertensive and antiarrhythmic agents.
摘要翻译： 1-（3-芳氧基-2-羟丙基）-4-（1-氧代异喹啉） - 哌啶，例如 R'= H，烷酰基氨基乙烯基，氨基甲酰基，烷酰基，CN，烷氧基羰基氨基 - 低级烷基，卤素，OH，烷酰基氨基，烷基，烷氧基，烯基，链烯氧基，R“= H，烷基，烷氧基，烯基，烯氧基，R，烷酰氨基，NH 2，NO 2，烷基，烷氧基，卤代CF 3，OH 2 - 链烷酸酯及其酸加成盐是抗高血压药和抗心律失常剂。

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