专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07285569B2 Tricycles, their manufacture and use as pharmaceutical agents 失效
标题翻译：三轮车，其制造和用作药剂
公开(公告)号：US07285569B2
公开(公告)日：2007-10-23
申请号：US11233408
申请日：2005-09-23
申请人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
发明人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/4184 , A61K31/4155 , C07D487/02 , C07D403/04
CPC分类号： A61K31/4184 , C07D487/04 , C07D487/10
摘要： The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在控制或预防癌症等疾病。

2. 发明申请

US20060069145A1 Tricycles, their manufacture and use as pharmaceutical agents 失效
标题翻译：三轮车，其制造和用作药剂
公开(公告)号：US20060069145A1
公开(公告)日：2006-03-30
申请号：US11233408
申请日：2005-09-23
申请人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
发明人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/4184 , C07D487/02
CPC分类号： A61K31/4184 , C07D487/04 , C07D487/10
摘要： The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物

3. 发明申请

US20060235013A1 Tricyclic azole derivatives 审中-公开
标题翻译：三环唑衍生物
公开(公告)号：US20060235013A1
公开(公告)日：2006-10-19
申请号：US11384058
申请日：2006-03-17
申请人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
发明人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/5377 , A61K31/4745 , A61K31/4188 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备，以及这些化合物的用途控制或预防癌症等疾病。

4. 发明申请

US20090143375A1 Tricyclic Lactam Derivatives, Their Manufacture and Use as Pharmaceutical Agents 审中-公开
标题翻译：三环内酰胺衍生物，其制造和用作药剂
公开(公告)号：US20090143375A1
公开(公告)日：2009-06-04
申请号：US12084531
申请日：2006-12-13
申请人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth , Christine Schuell , Mark Stahl
发明人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth , Christine Schuell , Mark Stahl
IPC分类号： A61K31/4188 , C07D487/04 , A61P29/00 , A61P9/00 , A61P35/00 , A61P25/00 , A61K31/5377
CPC分类号： C07D487/04
摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物控制或预防癌症等疾病。

5. 发明申请

US20110070246A1 Antibodies Against CDCP1 for the Treatment of Cancer 有权
标题翻译：抗CDCP1治疗癌症的抗体
公开(公告)号：US20110070246A1
公开(公告)日：2011-03-24
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
IPC分类号： A61K39/395 , C07K16/30 , C12N15/13 , C12N15/85 , C12N5/10 , C12P21/02 , A61P35/04
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译：本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。

6. 发明授权

US06506755B2 Thiazolidinecarboxyl acids 失效
标题翻译：噻唑烷羧酸
公开(公告)号：US06506755B2
公开(公告)日：2003-01-14
申请号：US09767306
申请日：2001-01-23
申请人： Walter-Gunar Friebe , Hans-Willi Krell , Sabine Woelle , Hans-Peter Wolff
发明人： Walter-Gunar Friebe , Hans-Willi Krell , Sabine Woelle , Hans-Peter Wolff
IPC分类号： C07D27720
CPC分类号： C07D277/20 , C07D417/12 , C07D417/14
摘要： 5-Arylidene-4-oxo-2-thioxo-3-thiazolidinecarboxylic acids of formula I in which the symbols R1, R2, A, A1 and A2 have the significance given in the description as medicaments for the treatment of cancer diseases.
摘要翻译：符号R1，R2，A，A1和A2具有在描述中给出的用于治疗癌症疾病的药物的含义的式Iin的5-亚芳基-4-氧代-2-硫代-3-噻唑烷羧酸。

7. 发明授权

US06472396B1 Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds 失效
标题翻译：巴比妥酸衍生物，其制备方法和含有这些化合物的药剂
公开(公告)号：US06472396B1
公开(公告)日：2002-10-29
申请号：US09594700
申请日：2000-06-16
申请人： Elmar Bosies , Angelika Esswein , Frank Grams , Hans-Willi Krell , Ernesto Menta
发明人： Elmar Bosies , Angelika Esswein , Frank Grams , Hans-Willi Krell , Ernesto Menta
IPC分类号： C07D23962
CPC分类号： C07D401/04 , C07D239/62
摘要： Compounds of formula I, useful as matrix metalloprotease inhibitors, wherein X, Y and Z are each oxygen; R1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and (d) (4-phenoxy)phenyl, wherein the terminal monocycle for moieties (c)-(d) is unsubstituted or substituted by a substituent selected from the group consisting of —NH2, —NO2, —SO2NH2, —SO2CH3, acetyl, hydroxy, methoxy, ethoxy, cyano and halogen; R2 and R3 are each hydrogen; and R4 and R5, together with the nitrogen atom to which they are bound, form a piperazinyl or piperidyl ring, wherein the piperazinyl ring is substituted in the 4-position with a substituent selected from the group consisting of (a) a 6-membered aromatic monocycle having 0, 1 or 2 nitrogen atoms and the remainder of the atoms in the monocycle being carbon and (b) hydroxy-C1-C6 alkyl, wherein the monocycle is unsubstituted or substituted by a substituent selected from the group consisting of halogen, —NH2, —NO2, —SO2NH2, —SO2CH3, acetyl and cyano.
摘要翻译：可用作基质金属蛋白酶抑制剂的式I化合物，其中X，Y和Z各自为氧; R 1选自（a）正辛基，（b）正癸基，（c）联苯和（d）（4-苯氧基）苯基，其中部分（c） - （d）的末端单环是未取代的或被选自-NH 2，-NO 2，-SO 2 NH 2，-SO 2 CH 3，乙酰基，羟基，甲氧基，乙氧基，氰基和卤素; R 2和R 3各自为氢; 和R 4和R 5与它们所连接的氮原子一起形成哌嗪基或哌啶基环，其中哌嗪环在4位被取代基取代，所述取代基选自（a）6元芳族具有0,1或2个氮原子的单环，并且单环中的其余原子为碳和（b）羟基-C 1 -C 6烷基，其中所述单环是未取代的或被选自以下的取代基取代：卤素， NH 2，-NO 2，-SO 2 NH 2，-SO 2 CH 3，乙酰基和氰基。

8. 发明授权

US06110924A Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds 失效
标题翻译：巴比妥酸衍生物，其制备方法和含有这些化合物的药剂
公开(公告)号：US06110924A
公开(公告)日：2000-08-29
申请号：US91352
申请日：1998-06-18
申请人： Elmar Bosies , Angelika Esswein , Frank Grams , Hans-Willi Krell , Ernesto Menta
发明人： Elmar Bosies , Angelika Esswein , Frank Grams , Hans-Willi Krell , Ernesto Menta
IPC分类号： A61K31/00 , A61K31/515 , A61P19/00 , A61P19/02 , A61P19/08 , A61P27/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07D239/62 , C07D239/66 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , A01N43/58 , C07D239/02 , C07D403/00
CPC分类号： C07D401/04 , C07D239/62
摘要： Compounds of formula I, useful as matrix metalloprotease inhibitors, ##STR1## wherein X, Y and Z are each oxygen;R.sub.1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and (d) (4-phenoxy)phenyl, wherein the terminal monocycle for moieties (c)-(d) is unsubstituted or substituted by a substituent selected from the group consisting of --NH.sub.2, --NO.sub.2, --SO.sub.2 NH.sub.2, --SO.sub.2 CH.sub.3, acetyl, hydroxy, methoxy, ethoxy, cyano and halogen;R.sub.2 and R.sub.3 are each hydrogen; andR.sub.4 and R.sub.5, together with the nitrogen atom to which they are bound, form a piperazinyl or piperidyl ring, wherein the piperazinyl ring is substituted in the 4-position with a substituent selected from the group consisting of (a) a 6-membered aromatic monocycle having 0, 1 or 2 nitrogen atoms and the remainder of the atoms in the monocycle being carbon and (b) hydroxy-C.sub.1 -C.sub.6 alkyl, wherein the monocycle is unsubstituted or substituted by a substituent selected from the group consisting of halogen, --NH.sub.2, --NO.sub.2, --SO.sub.2 NH.sub.2, --SO.sub.2 CH.sub.3, acetyl and cyano.
摘要翻译： PCT No.PCT / EP96 / 05766 Sec。 371日期：1998年8月26日 102（e）1998年8月26日PCT 1996年12月20日PCT PCT。公开号WO97 / 23465 PCT 日期1997年7月3日，式I化合物可用作基质金属蛋白酶抑制剂，其中X，Y和Z各自为氧; R 1选自（a）正辛基，（b）正癸基，（c）联苯基和（d）（4-苯氧基）苯基，其中（c） - （d）部分的末端单环，未取代或被选自-NH 2，-NO 2，-SO 2 NH 2，-SO 2 CH 3，乙酰基，羟基，甲氧基，乙氧基，氰基和卤素的取代基取代。 R2和R3各自为氢; 和R 4和R 5与它们所结合的氮原子一起形成哌嗪基或哌啶基环，其中哌嗪环在4-位被取代基取代，所述取代基选自（a）6-元具有0,1或2个氮原子的芳族单环，并且单环中的其余原子为碳和（b）羟基-C 1 -C 6烷基，其中所述单环未被取代或被选自以下的取代基取代：卤素， -NH 2，-NO 2，-SO 2 NH 2，-SO 2 CH 3，乙酰基和氰基。

9. 发明授权

US5624811A Bilirubin oxidase from alfalfa and use of the enzyme 失效
标题翻译：苜蓿中的胆红素氧化酶和酶的使用
公开(公告)号：US5624811A
公开(公告)日：1997-04-29
申请号：US210371
申请日：1994-03-18
申请人： Gunter Lang , Ingo Bohn , Hans-Willi Krell
发明人： Gunter Lang , Ingo Bohn , Hans-Willi Krell
IPC分类号： B01D15/08 , C12N9/00 , C12N9/02 , C12Q1/26 , G01N30/88 , C07K1/00
CPC分类号： C12Y103/03005 , C12N9/001 , C12Q1/26 , Y10S436/811 , Y10T436/146666
摘要： Enzyme specific for bilirubin which has a phenol oxidase activity of less than 0.5% and an activity for biliverdin of less than 10%, a broad pH optimum as well as a good thermostability. The enzyme is obtainable from plants such as alfalfa and is suitable for the determination as well as for the degradation of bilirubin in particular in biological liquids.
摘要翻译：对于胆红素特异性的酶，其酚氧化酶活性小于0.5％，胆红素活性小于10％，宽pH最佳，热稳定性好。该酶可从诸如苜蓿的植物获得，并且适用于测定以及特别是生物液体中胆红素的降解。

10. 发明申请

US20110306094A1 METHOD FOR OBTAINING IMMUNOGLOBULIN ENCODING NUCLEIC ACID 有权
标题翻译：获得免疫球蛋白编码核酸的方法
公开(公告)号：US20110306094A1
公开(公告)日：2011-12-15
申请号：US13202446
申请日：2010-02-18
申请人： Hans-Willi Krell , Alexander Lifke , Valeria Lifke , Kairat Madin , Christian Weilke
发明人： Hans-Willi Krell , Alexander Lifke , Valeria Lifke , Kairat Madin , Christian Weilke
IPC分类号： C12P19/34 , C12P21/00
CPC分类号： C12P21/005 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C12P19/34 , C12Q1/6804 , C12Q1/6858 , C12Q1/6881 , C12Q2600/16 , C12Q2549/119 , C12Q2537/143
摘要： The current invention is directed to a method for obtaining a nucleic acid encoding an immunoglobulin variable domain from a single cell comprising the following steps:—performing a first polymerase chain reaction with three to six 5′-primer and one 3′-primer, performing with the product of the first polymerase chain reaction a second polymerase chain reaction with thirteen to sixteen 5′-primer and one 3′-primer, whereby the distance of the binding locations of the primer employed in the second polymerase chain reaction is reduced compared to the first polymerase chain reaction.
摘要翻译：本发明涉及从单细胞获得编码免疫球蛋白可变结构域的核酸的方法，包括以下步骤： - 用3至6个5'-引物和1个3'-引物进行第一聚合酶链反应，进行与第一聚合酶链反应的产物进行第二聚合酶链反应与十三至十六个5'-引物和一个3'-引物，由此在第二聚合酶链式反应中使用的引物的结合位置的距离比第一次聚合酶链反应。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式