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1. 发明授权

US5185345A 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them 失效
标题翻译： 4-脒基吡喃并（3,2-c）吡啶衍生物，以及含有它们的药物组合物
公开(公告)号：US5185345A
公开(公告)日：1993-02-09
申请号：US850994
申请日：1992-03-12
申请人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
发明人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
IPC分类号： C07D405/04 , C07D491/04 , C07D491/052
CPC分类号： C07D405/04 , C07D491/04
摘要： The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## in which: A+B.dbd.--CH.dbd.CH--CH.dbd.N-- ou --CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--; X.dbd.N,N.fwdarw.O, C--Z;R.sub.1 .dbd.H, CN, NO.sub.2, C.sub.1 -C.sub.4, alkyl, OH, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --, .rho.--SO.sub.2 --;R.sub.2 .dbd.H;R.sub.3 .dbd.OH ou OCOCH.sub.3 ou R.sub.2 +R.sub.3 .dbd.double bond.
摘要翻译：本发明涉及4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物。所述衍生物具有抗高血压和抗血栓活性。它们响应式（I）其中：A + B = -CH = CH-CH = N-O -CH = CR4-CR5 = CH-; X = N，N-> O，C-Z; R1 = H，CN，NO2，C1-C4，烷基，OH，C1-C4烷氧基，CF3CO-，CH3-SO2-， R2 = H; R3 = OH o OCOCH3 ou R2 + R3 =双键。

2. 发明授权

US5116849A 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： 4-氨基吡唑和4-氨基吡啶（3,2-C）吡啶衍生物，其制备和含有它们的药物组合物的方法
公开(公告)号：US5116849A
公开(公告)日：1992-05-26
申请号：US606864
申请日：1990-10-31
申请人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
发明人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/443 , A61K31/505 , A61P9/06 , A61P9/12 , C07D213/74 , C07D405/04 , C07D491/04 , C07D491/052 , C07D493/04
CPC分类号： C07D405/04 , C07D491/04
摘要： The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarrhythmic activities. They respond to formula ##STR1## in which: A+B=--CH.dbd.CH--CH.dbd.N--or--CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--;X=N, N.fwdarw.O, C--Z;R.sub.1 =H, CN, NO.sub.2, C.sub.1 -C.sub.4 alkyl, OH, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --, .phi.--SO.sub.2 --;R.sub.2 =H;R.sub.3 =OH or OCOCH.sub.3 or R.sub.2 +R.sub.3 =double bond.
摘要翻译：本发明涉及4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物。所述衍生物具有抗高血压和抗心律失常作用。它们响应式（I）其中：A + B = -CH = CH-CH = N-或-CH = CR 4 -CR 5 = CH-; X = N，N-> O，C-Z; R 1 = H，CN，NO 2，C 1 -C 4烷基，OH，C 1 -C 4烷氧基，CF 3 CO-，CH 3 -SO 2 - ，Phi -SO 2 - R2 = H; R3 = OH或OCOCH3或R2 + R3 =双键。

3. 发明授权

US5225415A 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： 4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5225415A
公开(公告)日：1993-07-06
申请号：US850993
申请日：1992-03-12
申请人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
发明人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/443 , A61K31/505 , A61P9/06 , A61P9/12 , C07D213/74 , C07D405/04 , C07D491/04 , C07D491/052 , C07D493/04
CPC分类号： C07D405/04 , C07D491/04
摘要： The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## in which: A+B=--CH.dbd.CH--CH.dbd.N-- ou --CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--;X=N, N.fwdarw.O, C-Z;R.sub.1 =H, CN, NO.sub.2, C.sub.1 -C.sub.4 alkyl, OH, C.sub.1 -C.sub.4 alcoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --,.rho.--SO.sub.2 --;R.sub.2 =H;R.sub.3 =OH ou OCOCH.sub.3ou R.sub.2 +R.sub.3 =double bond.
摘要翻译：本发明涉及4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物。所述衍生物具有抗高血压和抗血栓活性。它们响应式（I）其中：A + B = -CH = CH-CH = N-O -CH = CR4-CR5 = CH-; X = N，N-> O，C-Z; R1 = H，CN，NO2，C1-C4烷基，OH，C1-C4烷氧基，CF3CO-，CH3-SO2-， R2 = H; R3 = OH o OCOCH3 ou R2 + R3 =双键。

4. 发明授权

US5284838A Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma 失效
标题翻译：使用2,2-二甲基苯并二氢吡喃-3-醇衍生物治疗哮喘
公开(公告)号：US5284838A
公开(公告)日：1994-02-08
申请号：US19314
申请日：1993-02-18
申请人： Georges Garcia , Richard Roux , Dino Nisato , Patrick Gautier
发明人： Georges Garcia , Richard Roux , Dino Nisato , Patrick Gautier
IPC分类号： C07D405/04 , C07F9/6558 , A61K31/44
CPC分类号： C07D405/04 , C07F9/65586
摘要： The invention relates to 2,2-dimethylchroman-3-ol derivatives of the formula: ##STR1## in which: A, between N and CO, represents the group --CH.dbd.CH--E.dbd.CH-- or the group ##STR2## Z represents a halogen or a cyano, acetyl, trifluoroacetyl, nitro, alkylthio, carboxyl, phosphono, dial-koxyphosphoryl or alkoxycarbonyl group, the alkylthio and alkoxy groups containing from 1 to 3 carbon atoms;E represents a nitrogen atom or a group C(R.sub.4);R.sub.1 represents hydrogen, a methyl group or a hydroxyl group and R.sub.2 and R.sub.3 each independently represent hydrogen or a methyl group, it being possible for only one of the substituents R.sub.1, R.sub.2 and R.sub.3 to be methyl; andR.sub.4 represents a hydrogen atom, a halogen atom, a methyl group or a hydroxyl group;and to the pharmaceutically acceptable salts of the phosphono or carboxyl group.These derivatives have an antiarrhythmic, antiasthma and antihypertensive activity.
摘要翻译：本发明涉及下式的2,2-二甲基苯并二氢吡喃-3-醇衍生物：其中：A在N和CO之间代表基团-CH = CH-E = CH-或基团< Z表示卤素或氰基，乙酰基，三氟乙酰基，硝基，烷硫基，羧基，膦酰基，二烷氧基磷酰基或烷氧基羰基，含有1至3个碳原子的烷硫基和烷氧基; E表示氮原子或C（R4）基团; R1表示氢，甲基或羟基，R2和R3各自独立地表示氢或甲基，只有一个取代基R 1，R 2和R 3可以是甲基; R 4表示氢原子，卤素原子，甲基或羟基; 和膦酰基或羧基的药学上可接受的盐。这些衍生物具有抗心律失常，抗哮喘和抗高血压作用。

5. 发明授权

US5849780A 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present 失效
标题翻译： 1-苯磺酰基-1,1,3-二氢吲哚-2-酮衍生物及其制备方法及其存在的药物组合物
公开(公告)号：US5849780A
公开(公告)日：1998-12-15
申请号：US323921
申请日：1994-10-17
申请人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
发明人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
IPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10 , A61K31/40 , A61K31/44
CPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10
摘要： The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.
摘要翻译：本发明涉及式（I）的1-苯磺酰基-1,3-二氢吲哚-2-酮衍生物及其盐，在适当情况下为它们的制备及其存在于其中的药物组合物。这些化合物对血管加压素和/或卵母细胞受体具有亲和力。

6. 发明授权

US5728723A 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present 失效
标题翻译： 1-苯磺酰基-1,3-二氢 - 吲哚-2-酮衍生物，其制备方法及其存在的药物组合物
公开(公告)号：US5728723A
公开(公告)日：1998-03-17
申请号：US478738
申请日：1995-06-07
申请人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
发明人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
IPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10 , A61K31/405 , C07D209/04
CPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10
摘要： The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.
摘要翻译：本发明涉及式（I）的1-苯磺酰基-1,3-二氢吲哚-2-酮衍生物及其盐，在适当情况下为它们的制备及其存在于其中的药物组合物。这些化合物对血管加压素和/或卵母细胞受体具有亲和力。

7. 发明授权

US5726322A 1-benzenesulfonyl-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present 失效
标题翻译： 1-苯磺酰基-1,3-二氢吲哚-2-酮衍生物及其制备方法及其存在的药物组合物
公开(公告)号：US5726322A
公开(公告)日：1998-03-10
申请号：US824305
申请日：1997-03-26
申请人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
发明人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
IPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10 , C07D491/107
CPC分类号： C07D401/12 , C07D209/34 , C07D209/92 , C07D209/96 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10
摘要： The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.
摘要翻译：本发明涉及式（I）的1-苯磺酰基-1,3-二氢吲哚-2-酮衍生物及其盐，在适当情况下为它们的制备及其存在于其中的药物组合物。这些化合物对血管加压素和/或卵母细胞受体具有亲和力。

8. 发明授权

US5686624A 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present 失效
标题翻译： 1-苯磺酰基-1,3-二氢 - 吲哚-2-酮衍生物，其制备方法及其存在的药物组合物
公开(公告)号：US5686624A
公开(公告)日：1997-11-11
申请号：US473302
申请日：1995-06-07
申请人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
发明人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
IPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10 , C07D491/107
CPC分类号： C07D401/12 , C07D209/34 , C07D209/92 , C07D209/96 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10
摘要： The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.
摘要翻译：本发明涉及式（I）的1-苯磺酰基-1,3-二氢吲哚-2-酮衍生物及其盐，在适当情况下为它们的制备及其存在于其中的药物组合物。这些化合物对血管加压素和/或卵母细胞受体具有亲和力。

9. 发明授权

US5663431A 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present 失效
公开(公告)号：US5663431A
公开(公告)日：1997-09-02
申请号：US477571
申请日：1995-06-07
申请人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
发明人： Alain Di Malta , Loic Foulon , Georges Garcia , Dino Nisato , Richard Roux , Claudine Serradeil-Legal , Gerard Valette , Jean Wagnon
IPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10 , C07C303/08
CPC分类号： C07D209/34 , C07D209/92 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10
摘要： The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.

10. 发明授权

US5585394A 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives 失效
标题翻译： 1-苯磺酰基-1,3-二氢-2H-苯并咪唑-2-酮衍生物
公开(公告)号：US5585394A
公开(公告)日：1996-12-17
申请号：US282547
申请日：1994-07-29
申请人： Alain Di Malta , Georges Garcia , Daniel Mettefeu , Dino Nisato , Richard Roux , Claudine Serradeil-Legal
发明人： Alain Di Malta , Georges Garcia , Daniel Mettefeu , Dino Nisato , Richard Roux , Claudine Serradeil-Legal
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/454 , A61P1/00 , A61P9/00 , A61P13/02 , A61P13/12 , A61P15/00 , A61P25/00 , A61P25/02 , C07D235/26 , C07D401/04 , C07D401/12 , C07D405/04 , C07D417/12 , A16K31/415 , C07D235/22 , C07D403/02
CPC分类号： C07D401/04 , C07D235/26 , C07D401/12 , C07D405/04 , C07D417/12
摘要： The present invention relates to 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives of the formula: ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.
摘要翻译：本发明涉及其制备的下式的1-苯磺酰基-1,3-二氢-2H-苯并咪唑-2-酮衍生物及其制备的药物组合物。这些衍生物对血管加压素和催产素受体具有亲和力。

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