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1. 发明授权

US6131578A Inhibitors of UDP-G1cNAc:Ga1.beta.1-3Ga1NAc.alpha.R .beta.1-6 N-acetylglucosaminyltransferase (core 2 G1cNAc-T) and use of the inhibitors to prevent or treat cardiomyopathy associated with diabetes 失效
标题翻译： UDP-G1cNAc的抑制剂：Ga1β1-3Ga1NAcαRβ1-6-乙酰葡糖胺基转移酶（核心2G1cNAc-T）和抑制剂用于预防或治疗与糖尿病相关的心肌病
公开(公告)号：US6131578A
公开(公告)日：2000-10-17
申请号：US943058
申请日：1997-10-02
申请人： George L. King , Yoshihiko Nishio , Daisuke Koya , James W. Dennis , Charles E. Warren
发明人： George L. King , Yoshihiko Nishio , Daisuke Koya , James W. Dennis , Charles E. Warren
IPC分类号： A61K31/7016 , A61K38/00 , A61P9/00 , C12N9/10 , C12N15/113 , A61B19/00
CPC分类号： C12N15/1137 , A61K31/7016 , C12N9/1048 , A61K38/00
摘要： Cardiomyopathy associated with diabetes and hyperglycemia can be treated by administering to a subject suffering from this condition a substance that inhibits UDP-GlcNAc:Gal.beta.1-3GalNAc.alpha.R.beta.1-6-N-acetylglucosaminyl transferase (core 2 GlcNAc-T) activity.
摘要翻译：与糖尿病和高血糖相关的心肌病可以通过向患有这种病症的受试者施用抑制UDP-GlcNAc：Galβ1-3GalNAcαRβ1-6-N-乙酰葡糖胺基转移酶（核心2 GlcNAc-T）活性的物质来治疗。

2. 外观设计

USD517443S1 Sports rosary 失效
标题翻译：运动念珠
公开(公告)号：USD517443S1
公开(公告)日：2006-03-21
申请号：US29196781
申请日：2004-01-05
申请人： James W. Dennis
设计人： James W. Dennis

3. 发明授权

US5650501A Serine/threonine kinase and nucleic acids encoding same 失效
标题翻译：丝氨酸/苏氨酸激酶和编码相同的核酸
公开(公告)号：US5650501A
公开(公告)日：1997-07-22
申请号：US252995
申请日：1994-06-02
申请人： James W. Dennis , Mike Heffernan , Carol Fode
发明人： James W. Dennis , Mike Heffernan , Carol Fode
IPC分类号： C12N9/12 , C07K14/705 , C07K14/00 , C12N5/10 , C12N15/52
CPC分类号： C12N9/1205 , G01N2333/9121 , G01N2500/04
摘要： A serine/threonine kinase protein which is associated with mitotic and meiotic cell division and which is characterized by having a kinase domain in its N-terminus and three PEST regions in the C-terminus, and nucleic acid molecules encoding the protein. Diagnostic and therapeutic methods using the serine/threonine kinase protein and nucleic acid molecules are also described.
摘要翻译：与有丝分裂和减数分裂细胞分裂相关的丝氨酸/苏氨酸激酶蛋白，其特征在于在其N-末端具有激酶结构域，在C末端具有三个PEST区域，以及编码该蛋白质的核酸分子。还描述了使用丝氨酸/苏氨酸激酶蛋白和核酸分子的诊断和治疗方法。

4. 发明授权

US5605807A Process for screening for malignant tumors by determining the amount of GlcNAc transferase V activity 失效
标题翻译：通过测定GlcNAc转移酶V活性的量来筛选恶性肿瘤的方法
公开(公告)号：US5605807A
公开(公告)日：1997-02-25
申请号：US304952
申请日：1994-09-13
申请人： James W. Dennis
发明人： James W. Dennis
IPC分类号： C12Q1/48 , G01N33/574 , G01N33/48
CPC分类号： C12Q1/48 , G01N33/57484 , Y10S435/81 , Y10S435/96 , Y10S436/813 , Y10S436/815 , Y10S436/827
摘要： A process is provided for screening for a malignant tumor. The process comprises the steps of determining the amount of GlcNAc transferase V activity in a tumor sample by reacting the GlcNAc transferase V in a tumor sample with an acceptor substrate and a sugar nucleotide donor to produce a detectable change, and detecting the change. The acceptor substrate is an oligosaccharide, a glycopeptide or a glycoprotein having the structure GlcNAc .beta.1-2Man .alpha.1-6Man-R.sub.1. R.sub.1 is GlcNAc .beta.1-4GlcNAc with or without fucose or a synthetic linker. The sugar nucleotide donor is uridine diphospho-N-acetylglycosamine. The amount of GlcNAc transferase V activity in the sample is thereby determined. A determination of the malignancy of the tumor is made by comparing the amount of GlcNAc transferase V activity in the sample with an amount of GlcNAc transferase V associated with normal tissues or with known malignant tumors. A diagnostic kit for screening for a malignant tumor is provided. The kit comprises an acceptor substrate and a sugar nucleotide donor to interact with GlcNAc transferase V in a tumor sample to produce a detectable change, and means for detecting the change.
摘要翻译：提供了筛选恶性肿瘤的方法。该方法包括通过使肿瘤样品中的GlcNAc转移酶V与受体底物和糖核苷酸供体反应以产生可检测的变化并检测该变化来确定肿瘤样品中GlcNAc转移酶V活性的量的步骤。受体底物是具有GlcNAcβ1-2Manα1-6Man-R1结构的寡糖，糖肽或糖蛋白。 R1是具有或不具有岩藻糖的GlcNAcβ1-4GlcNAc或合成接头。糖核苷酸供体是尿苷二磷酸-N-乙酰氨基糖。由此确定样品中GlcNAc转移酶V活性的量。通过将样品中GlcNAc转移酶V活性的量与正常组织或已知恶性肿瘤相关的GlcNAc转移酶V的量进行比较来确定肿瘤恶性。提供了一种用于筛选恶性肿瘤的诊断试剂盒。试剂盒包括受体底物和糖核苷酸供体，其与肿瘤样品中的GlcNAc转移酶V相互作用以产生可检测的变化，以及用于检测变化的装置。

5. 外观设计

USD325500S Vacuum seal cracking tool for jars 失效
公开(公告)号：USD325500S
公开(公告)日：1992-04-21
申请号：US562961
申请日：1990-08-06
申请人： James W. Dennis , Vonda J. Dennis
设计人： James W. Dennis , Vonda J. Dennis

6. 发明授权

US5981483A Compositions comprising modulators of cytokines of the TGF-.beta. superfamily 失效
标题翻译：包含TGF-β超家族细胞因子调节剂的组合物
公开(公告)号：US5981483A
公开(公告)日：1999-11-09
申请号：US737045
申请日：1997-03-20
申请人： James W. Dennis , Michael Demetriou
发明人： James W. Dennis , Michael Demetriou
IPC分类号： G01N33/566 , A61K38/00 , A61K38/17 , A61K38/22 , A61P1/16 , A61P3/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , G01N33/15 , G01N33/68 , G01N33/74 , C07K14/47 , A61K38/04
CPC分类号： G01N33/6863 , A61K38/1793 , G01N33/74 , G01N2333/495 , G01N2500/00 , G01N2500/20 , Y10S514/885
摘要： Compositions consisting of at least one TGFb receptor II homo 1b (TRH1b) subdomain or at least one TGFb receptor II homology 1 (TRH1) domain and a carrier, auxiliary or excipient. The TRH1b subdomain has a sequence with the following amino acid pattern:Cys--X.sub.j --Lys/Arg--X.sub.k --Ser/Thr--X.sub.l --Cys--X.sub.m --Asp--X.sub.n --Asp/Glu, wherein X.sub.j, X.sub.k, X.sub.l, X.sub.m, X.sub.n, represent any amino acid and j is 4 to 5, k is 2 to 6, 1 is 4 to 9, m is 0 to 2, and n is 5 to 6. The TRH1 domain has a sequence with the following amino acid pattern:Cys--X.sub.h --Asn/Gln--X.sub.i --Cys--X.sub.i --Lys/Arg--X.sub.k --Ser/Thr--X.sub.l --Cys--X.sub.m --Asp--X.sub.n --Asp/Glu, wherein X.sub.h, X.sub.i, X.sub.j, X.sub.k, X.sub.l, X.sub.m, X.sub.n, represent any amino acid and h is 8 to 14, i is 12 to 16, j is 4 to 5, k is 2 to 6, l is 4 to 9, m is 0 to 2, and n is 5 to 6.
摘要翻译： PCT No.PCT / CA95 / 00290 Sec。 371日期1997年3月20日 102（e）1997年3月20日PCT PCT 1995年5月4日PCT公布。公开号WO95 / 30900 日期1995年11月16日由至少一种TGFb受体II同位素1b（TRH1b）亚结构域或至少一种TGFb受体II同源1（TRH1）结构域和载体，辅助剂或赋形剂组成的组合物。 TRH1b亚结构域具有以下氨基酸序列：Cys-Xj-Lys / Arg-Xk-Ser / Thr-X1-Cys-Xm-Asp-Xn-Asp / Glu，其中Xj，Xk，X1，Xm， Xn表示任何氨基酸，j为4〜5，k为2〜6，1为4〜9，m为0〜2，n为5〜6。TRH1结构域具有以下氨基酸序列：Cys-Xh-Asn / Gln-Xi-Cys-Xi-Lys / Arg-Xk-Ser / Thr-X1-Cys-Xm-Asp-Xn-Asp / Glu，其中Xh，Xi，Xj，Xk， Xm，Xn表示任何氨基酸，h为8〜14，i为12〜16，j为4〜5，k为2〜6，l为4〜9，m为0〜2，n为5〜 6。

7. 发明授权

US5830671A Method for assaying for modulators of cytokines of the TFG .beta. superfamily 失效
标题翻译：测定TFGβ超家族细胞因子调节剂的方法
公开(公告)号：US5830671A
公开(公告)日：1998-11-03
申请号：US854768
申请日：1997-05-12
申请人： James W. Dennis , Michael Demetriou
发明人： James W. Dennis , Michael Demetriou
IPC分类号： G01N33/566 , A61K38/00 , A61K38/17 , A61K38/22 , A61P1/16 , A61P3/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , G01N33/15 , G01N33/68 , G01N33/74 , G01N33/53
CPC分类号： G01N33/6863 , A61K38/1793 , G01N33/74 , G01N2333/495 , G01N2500/00 , G01N2500/20 , Y10S514/885
摘要： The invention relates to a method for assaying for the presence of a substance that modulates a cytokine of the TGF.beta. superfamily. A substance which is suspected of modulating a cytokine of the TGF.beta. superfamily and a TGF.beta. binding compound which is not a TGF.beta. receptor and which contains a TRH1 domain, or a portion or mimetic thereof, is reacted with a cytokine of the TGF.beta. superfamily under conditions where the compound, portion or mimetic thereof, and the cytokine are capable of forming a complex. Complexes, free compound and/or cytokine are assayed and compared with a control. The invention also relates to a composition comprising at least one compound which is not a TGF.beta. receptor and which contains the TRH1 domain or a portion, or a mimetic thereof, and a pharmaceutically acceptable carrier, auxiliary or excipient and to methods of treatment using the composition. Further the invention relates to a method of enhancing the activity of growth factors.
摘要翻译：本发明涉及一种用于测定调节TGFβ超家族的细胞因子的物质的存在的方法。涉及调节TGFβ超家族的细胞因子的物质和不是TGFβ受体并且含有TRH1结构域或其部分或模拟物的TGFβ结合化合物与TGFβ的细胞因子反应超家族在其化合物，部分或模拟物和细胞因子能够形成复合物的条件下。测定复合物，游离化合物和/或细胞因子，并与对照进行比较。本发明还涉及包含至少一种不是TGFβ受体并且含有TRH1结构域或其部分或其模拟物和药学上可接受的载体，辅助剂或赋形剂的化合物以及使用组成。此外，本发明涉及增强生长因子活性的方法。

8. 发明授权

US5976893A Methods for identifying binding partners, agonists, and antagonist of a serine/threonine tyrosine kinase 失效
标题翻译：用于鉴定丝氨酸/苏氨酸酪氨酸激酶的结合配偶体，激动剂和拮抗剂的方法
公开(公告)号：US5976893A
公开(公告)日：1999-11-02
申请号：US834108
申请日：1997-04-14
申请人： James W. Dennis , Mike Heffernan , Carol Fode
发明人： James W. Dennis , Mike Heffernan , Carol Fode
IPC分类号： C12N9/12 , C12Q1/48 , C12Q1/00
CPC分类号： C12N9/1205 , G01N2333/9121 , G01N2500/04
摘要： A serine/theonine kinase protein which is associated with mitotic and meiotic cell division and which is characterized by having a kinase domain in its N-terminus and three PEST regions in the C-terminus, and nucleic acid molecules encoding the protein. Diagnostic and therapeutic methods using the serine/threonine kinase protein and nucleic acid molecules are also described.
摘要翻译：与有丝分裂和减数分裂细胞分裂相关的丝氨酸/雄激素蛋白，其特征在于在其N-末端具有激酶结构域，在C末端具有三个PEST区域，以及编码该蛋白质的核酸分子。还描述了使用丝氨酸/苏氨酸激酶蛋白和核酸分子的诊断和治疗方法。

9. 发明授权

US5821227A Modulators of cytokines of the tgf .beta. superfamily 失效
标题翻译： tgfβ超家族的细胞因子调节剂
公开(公告)号：US5821227A
公开(公告)日：1998-10-13
申请号：US483926
申请日：1995-06-07
申请人： James W. Dennis , Michael Demetriou
发明人： James W. Dennis , Michael Demetriou
IPC分类号： G01N33/566 , A61K38/00 , A61K38/17 , A61K38/22 , A61P1/16 , A61P3/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , G01N33/15 , G01N33/68 , G01N33/74 , C07K14/47 , A61K38/04
CPC分类号： G01N33/6863 , A61K38/1793 , G01N33/74 , G01N2333/495 , G01N2500/00 , G01N2500/20 , Y10S514/885
摘要： The invention relates to a method for assaying for the presence of a substance that modulates a cytokine of the TGF.beta. superfamily. A substance which is suspected of modulating a cytokine of the TGF.beta. superfamily and a TGF.beta. binding compound which is not a TGF.beta. receptor and which contains a TRH1 domain, or a portion or mimetic thereof, is reacted with a cytokine of the TGF.beta. superfamily under conditions where the compound, portion or mimetic thereof, and the cytokine are capable of forming a complex. Complexes, free compound and/or cytokine are assayed and compared with a control. The invention also relates to a composition comprising at least one compound which is not a TGF.beta. receptor and which contains the TRH1 domain or a portion, or a mimetic thereof, and a pharmaceutically acceptable carrier, auxiliary or excipient and to methods of treatment using the composition. Further the invention relates to a method of enhancing the activity of growth factors.
摘要翻译：本发明涉及一种用于测定调节TGFβ超家族的细胞因子的物质的存在的方法。涉及调节TGFβ超家族的细胞因子的物质和不是TGFβ受体并且含有TRH1结构域或其部分或模拟物的TGFβ结合化合物与TGFβ的细胞因子反应超家族在其化合物，部分或模拟物和细胞因子能够形成复合物的条件下。测定复合物，游离化合物和/或细胞因子，并与对照进行比较。本发明还涉及包含至少一种不是TGFβ受体并且含有TRH1结构域或其部分或其模拟物和药学上可接受的载体，辅助剂或赋形剂的化合物以及使用组成。此外，本发明涉及增强生长因子活性的方法。

10. 发明授权

US06395745B1 Alkaloid halide salts of swainsonine and methods of use 有权
标题翻译：磺胺类的碱性卤化物盐及其使用方法
公开(公告)号：US06395745B1
公开(公告)日：2002-05-28
申请号：US09403000
申请日：2000-03-27
申请人： James W. Dennis , Rajan N. Shah , Lothar Ziser
发明人： James W. Dennis , Rajan N. Shah , Lothar Ziser
IPC分类号： A61K3144
CPC分类号： A61K31/437 , C07D471/04
摘要： Crystalline salts of swainsonine, and methods using same.
摘要翻译：磺胺酸的结晶盐及其使用方法

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