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1. 发明授权

US5045455A Factor VIII:C cDNA cloning and expression 失效
标题翻译：因子VIII：C cDNA克隆和表达
公开(公告)号：US5045455A
公开(公告)日：1991-09-03
申请号：US538691
申请日：1990-06-14
申请人： George Kuo , Frank Masiarz , Martha Truett , Pablo Valenzuela , Mirella E. Rasmussen , Jennifer M. Favaloro , Daniel Caput , Rae L. Burke , Carol Pachl
发明人： George Kuo , Frank Masiarz , Martha Truett , Pablo Valenzuela , Mirella E. Rasmussen , Jennifer M. Favaloro , Daniel Caput , Rae L. Burke , Carol Pachl
IPC分类号： A61K38/00 , C07K14/755 , C07K16/36 , C12N1/21 , C12N15/12 , C12Q1/68
CPC分类号： C07K16/36 , C07K14/755 , C12Q1/6876 , A61K38/00
摘要： Methods and compositions are provided for recombinant DNA production of Factor VIIIC and truncated derivatives thereof. Based on amino acid sequences, probes are developed for isolating messenger RNA, cDNA and/or chromosomal DNA encoding for Factor VIIIC. The Factor VIIIC gene in its entirety, a fragment thereof, or a cDNA is then used for expression of Factor VIIIC in a host.The bacteriophage .lambda.FVIII23D containing the 14.43kb EcoRI fragment was deposited at the A.T.C.C. on Jan. 4, 1984 and given Accession No. 40094. Also, the vector pSVF8-200 was deposited at the A.T.C.C. on July 17, 1985 and given Accession No. 40190.
摘要翻译：提供了用于重组DNA生成因子VIIIC及其截短衍生物的方法和组合物。基于氨基酸序列，开发了用于分离编码因子VIIIC的信使RNA，cDNA和/或染色体DNA的探针。然后将因子VIIIC基因整体，其片段或cDNA用于在宿主中表达因子VIIIC。含有14.43kb EcoRI片段的噬菌体λFVIII23D保藏在A.T.C.C. 1984年1月4日，加拿大号为40094.另外，载体pSVF8-200保藏在A.T.C.C. 1985年7月17日，加拿大号为40190。

2. 发明授权

US07138505B1 Factor VIII:C nucleic acid molecules 失效
标题翻译：因子VIII：C核酸分子
公开(公告)号：US07138505B1
公开(公告)日：2006-11-21
申请号：US07569376
申请日：1990-08-13
申请人： George Kuo , Frank Masiarz , Martha Truett , Pablo Valenzuela , Mirella Ezban Rasmussen , Daniel Caput , Rae Lyn Burke , Carol Pachl
发明人： George Kuo , Frank Masiarz , Martha Truett , Pablo Valenzuela , Mirella Ezban Rasmussen , Daniel Caput , Rae Lyn Burke , Carol Pachl
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , A01N43/04 , A61K31/70
CPC分类号： C07K14/755
摘要： Methods and compositions are provided for recombinant DNA production of Factor VIIIC and truncated derivatives thereof. Based on amino acid sequences, probes are developed for isolating messenger RNA, cDNA and/or chromosomal DNA encoding for Factor VIIIC. The Factor VIIIC gene in its entirety, a fragment thereof, or a cDNA is then used for expression of Factor VIIIC in a host.The bacteriophage λFVIII23D containing the 14.43 kb EcoRI fragment was deposited at the A.T.C.C. on Jan. 4, 1984 and given Accession No. 40094. Also, the vector pSVF8-200 was deposited at the A.T.C.C. on Jul. 17, 1985 and given Accession No. 40190.
摘要翻译：提供了用于重组DNA生成因子VIIIC及其截短衍生物的方法和组合物。基于氨基酸序列，开发了用于分离编码因子VIIIC的信使RNA，cDNA和/或染色体DNA的探针。然后将因子VIIIC基因整体，其片段或cDNA用于在宿主中表达因子VIIIC。含有14.43kb EcoRI片段的噬菌体λFVIII23D保藏在A.T.C.C. 1984年1月4日，加拿大号为40094.另外，载体pSVF8-200保藏在A.T.C.C. 1985年7月17日，加拿大号为40190。

3. 发明授权

US5171568A Recombinant herpes simplex gb-gd vaccine 失效
标题翻译：重组草药SIMPLEX GB-GD VACCINE
公开(公告)号：US5171568A
公开(公告)日：1992-12-15
申请号：US416425
申请日：1989-10-02
申请人： Rae L. Burke , Carol Pachl , Pablo D. T. Valenzuela
发明人： Rae L. Burke , Carol Pachl , Pablo D. T. Valenzuela
IPC分类号： A61K39/00 , A61K39/245 , C07K14/035 , C12N15/81
CPC分类号： C12N15/81 , A61K39/12 , A61K39/245 , C07K14/005 , A61K2039/54 , A61K2039/541 , A61K2039/55505 , A61K2039/5555 , A61K2039/55555 , A61K2039/55566 , A61K39/00 , C12N2710/16622 , C12N2710/16634 , Y10S424/812
摘要： Vaccines and therapeutic compositions and methods for their production and use against Herpes Simplex Virus (HSV) are provided employing recombinant HSV glycoproteins B and D.The following E. coli HB 101 strains were deposited at the A.T.C.C., where the plasmid indicates the plasmid employed to transform the strain; pH203; pHS112; pHS114; pHS127A and pHS206 were deposited on Apr. 4, 1984, and assigned Accession Nos. 39649-39653, respectively; pYHS109 and pYHS118 were deposited on Jul. 11, 1984, and given Accession Nos. 39762 and 39763, respectively.
摘要翻译：使用重组HSV糖蛋白B和D提供其针对单纯疱疹病毒（HSV）的生产和使用的疫苗及其治疗组合物和方法。将以下大肠杆菌HB 101菌株保藏在ATCC，其中质粒表示用于转变菌株; pH203; pHS112; pHS114; pHS127A和pHS206于1984年4月4日保藏，分别登录号为39649-39653; pYHS109和pYHS118于1984年7月11日保藏，分别登录号为39762和39763。

4. 发明授权

US5759814A Expression of recombinant glycoprotein B from herpes simplex virus 失效
标题翻译：来自单纯疱疹病毒的重组糖蛋白B的表达
公开(公告)号：US5759814A
公开(公告)日：1998-06-02
申请号：US465467
申请日：1995-06-05
申请人： Rae L. Burke , Carol Pachl , Pablo D.T. Valenzuela
发明人： Rae L. Burke , Carol Pachl , Pablo D.T. Valenzuela
IPC分类号： A61K39/00 , C07K14/035 , C12N15/81 , C12P21/02
CPC分类号： C12N15/81 , C07K14/005 , A61K39/00 , C12N2710/16622
摘要： The glycoprotein B ("gB") and analogs thereof are provided by recombinant DNA technology. Oligonucleotide sequences are provided coding the glycoprotein, its precursor and fragments thereof. Methods and compositions are disclosed for the production of the glycoprotein and analogous proteins as well as oligonucleotide sequences, which may be used for probes or other applications, and particularly may be used for vaccines.
摘要翻译：糖蛋白B（“gB”）及其类似物由重组DNA技术提供。提供编码糖蛋白，其前体及其片段的寡核苷酸序列。公开了用于生产糖蛋白和类似蛋白质以及可用于探针或其它应用的寡核苷酸序列的方法和组合物，特别可用于疫苗。

5. 发明授权

US5648079A Herpes simplex virus glycoprotein B vaccine 失效
标题翻译：单纯疱疹病毒糖蛋白B疫苗
公开(公告)号：US5648079A
公开(公告)日：1997-07-15
申请号：US351875
申请日：1994-12-08
申请人： Rae L. Burke , Carol Pachl , Pablo D. T. Valenzuela
发明人： Rae L. Burke , Carol Pachl , Pablo D. T. Valenzuela
IPC分类号： A61K39/00 , C07K14/035 , C12N15/81 , A61K39/245
CPC分类号： C12N15/81 , C07K14/005 , A61K39/00 , C12N2710/16622
摘要： The glycoprotein B ("gB") and analogs thereof are provided by recombinant DNA technology. Oligonucleotide sequences are provided coding the glycoprotein, its precursor and fragments thereof. Methods and compositions are disclosed for the production of the glycoprotein and analogous proteins as well as oligonucleotide sequences, which may be used for probes or other applications, and particularly may be used for vaccines.
摘要翻译：糖蛋白B（“gB”）及其类似物由重组DNA技术提供。提供编码糖蛋白，其前体及其片段的寡核苷酸序列。公开了用于生产糖蛋白和类似蛋白质以及可用于探针或其它应用的寡核苷酸序列的方法和组合物，特别可用于疫苗。

6. 发明授权

US5244792A Expression of recombinant glyoprotein B from herpes simplex virus 失效
标题翻译：来自单纯疱疹病毒的重组糖蛋白B的表达
公开(公告)号：US5244792A
公开(公告)日：1993-09-14
申请号：US587179
申请日：1990-09-20
申请人： Rae L. Burke , Carol Pachl , Pablo D. T. Valenzuela
发明人： Rae L. Burke , Carol Pachl , Pablo D. T. Valenzuela
IPC分类号： A61K39/00 , C07K14/035 , C12N15/81
CPC分类号： C12N15/81 , C07K14/005 , A61K39/00 , C12N2710/16622
摘要： The glycoprotein B ("gB") and functional fragments thereof are provided by recombinant DNA technology. Oligonucleotide sequences are provided coding the glycoprotein, its precursor and fragments thereof. Methods and compositions are disclosed for the production of the glycoprotein and functional fragments thereof as well as oligonucleotide sequences, which may be used for probes or other applications, and particularly may be used for vaccines. The following E. coli HB101 strains were deposited at the A.T.C.C. on April 4, 1984, where the plasmid indicates the plasmid employed to transform the strain; pHS112; pHS114 (gB1 mammalian); pHS127A (gB1 yeast); pHS203; and pHS206 (gB2), and assigned Accession Nos. 39649-39653, respectively, where the nature of the plasmid is indicated in parentheses and the number refers back to the number employed in the Experimental section.
摘要翻译：通过重组DNA技术提供糖蛋白B（“gB”）及其功能片段。提供编码糖蛋白，其前体及其片段的寡核苷酸序列。公开了用于生产糖蛋白及其功能片段的方法和组合物以及可用于探针或其它应用的寡核苷酸序列，特别可用于疫苗。以下大肠杆菌HB101菌株保藏在A.T.C.C. 1984年4月4日，其中质粒表示用于转化菌株的质粒; pHS112; pHS114（哺乳动物gB1）; pHS127A（gB1酵母）; pHS203; 和pHS206（gB2），并分别命名为登录号39649-39653，其中质粒的性质在括号中表示，数字指的是实验部分中使用的数字。

7. 发明授权

US5750114A Recombinant herpes simplex gB-gD vaccine 失效
公开(公告)号：US5750114A
公开(公告)日：1998-05-12
申请号：US452963
申请日：1995-05-30
申请人： Rae Lyn Burke , Carol Pachl , Pablo D. T. Valenzuela
发明人： Rae Lyn Burke , Carol Pachl , Pablo D. T. Valenzuela
IPC分类号： A61K39/00 , A61K39/245 , C07K14/035 , C12N15/81 , C12P21/02
CPC分类号： C12N15/81 , A61K39/12 , A61K39/245 , C07K14/005 , A61K2039/54 , A61K2039/541 , A61K2039/55505 , A61K2039/5555 , A61K2039/55555 , A61K2039/55566 , A61K39/00 , C12N2710/16622 , C12N2710/16634 , Y10S424/812
摘要： Vaccines and therapeutic compositions and methods for their production and use against Herpes Simplex Virus (HSV) are provided employing recombinant HSV glycoproteins B and D. The following E. coli HB101 strains were deposited at the A.T.C.C., where the plasmid indicates the plasmid employed to transform the strain; pHS203; pHS112; pHS114; pHS127A and pHS206 were deposited on Apr. 4, 1984, and assigned Accession Nos. 39649-39653, respectively; pYHS109 and pYHS118 were deposited on Jul. 11, 1984, and given Accession Nos. 39762 and 39763, respectively.

8. 发明授权

US5747039A Recombinant herpes simplex gB-gD vaccine 失效
标题翻译：重组单纯疱疹gB-gD疫苗
公开(公告)号：US5747039A
公开(公告)日：1998-05-05
申请号：US385731
申请日：1995-02-08
申请人： Rae Lyn Burke , Carol Pachl , Pablo D. T. Valenzuela
发明人： Rae Lyn Burke , Carol Pachl , Pablo D. T. Valenzuela
IPC分类号： A61K39/00 , A61K39/245 , C07K14/035 , C12N15/81 , A61K9/127 , A61K45/00
CPC分类号： C12N15/81 , A61K39/12 , A61K39/245 , C07K14/005 , A61K2039/54 , A61K2039/541 , A61K2039/55505 , A61K2039/5555 , A61K2039/55555 , A61K2039/55566 , A61K39/00 , C12N2710/16622 , C12N2710/16634 , Y10S424/812
摘要： Vaccines and therapeutic compositions and methods for their production and use against Herpes Simplex Virus (HSV) are provided employing recombinant HSV glycoproteins B and D. The following E. coli HB101 strains were deposited at the A.T.C.C., where the plasmid indicates the plasmid employed to transform the strain; pHS203; pHS112; pHS114; pHS127A and pHS206 were deposited on Apr. 4, 1984, and assigned Accession Nos. 39649-39653, respectively; pYHS109 and pYHS118 were deposited on Jul. 11, 1984, and given Accession Nos. 39762 and 39763, respectively.
摘要翻译：使用重组HSV糖蛋白B和D提供其针对单纯疱疹病毒（HSV）的生产和使用的疫苗及其治疗组合物和方法。将以下大肠杆菌HB101菌株保藏在ATCC，其中质粒表示用于转化的质粒应变; pHS203; pHS112; pHS114; pHS127A和pHS206于1984年4月4日保藏，分别登录号为39649-39653; pYHS109和pYHS118于1984年7月11日保藏，分别登录号为39762和39763。

9. 发明授权

US6100064A Secreted viral proteins useful for vaccines and diagnostics 失效
标题翻译：分泌的病毒蛋白可用于疫苗和诊断
公开(公告)号：US6100064A
公开(公告)日：2000-08-08
申请号：US282995
申请日：1994-07-29
申请人： Rae Lyn Burke , Karin Hartog , Carol Pachl
发明人： Rae Lyn Burke , Karin Hartog , Carol Pachl
IPC分类号： A61K39/00 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/18 , C12N15/38 , C12Q1/70 , C12N1/19 , C12N15/00 , C12N15/85
CPC分类号： C07K14/005 , C12Q1/701 , A61K39/00 , C07K2319/00 , C07K2319/02 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2740/16122 , C12N2770/24222
摘要： The present invention relates generally to modified secreted viral proteins, to the genes which express these proteins and to antibodies produced against such proteins, and to the use of these materials in diagnostic and vaccine applications. In particular, the present invention describes deletion of the transmembrane region only and retention of at least part of the cytoplasmic domain itself or fusion with at least part of an alternate cytoplasmic domain. The result will generally be the secretion of proteins which are normally membrane-bound (nonsecretory). This invention greatly increases the efficiency of secretion of the derivative protein. Specific viral proteins of interest include, but are not limited to, those from CMV, HSV, EBV, VZV, HCV, HIV, and influenza.
摘要翻译：本发明一般涉及修饰的分泌型病毒蛋白，表达这些蛋白质的基因和针对这种蛋白质产生的抗体，以及这些材料在诊断和疫苗应用中的用途。特别地，本发明仅描述跨膜区的缺失和至少部分细胞质结构域本身的保留或与至少部分替代细胞质结构域的融合。结果通常是通常是膜结合（不分泌）的蛋白质的分泌。本发明大大增加了衍生蛋白的分泌效率。感兴趣的特定病毒蛋白包括但不限于来自CMV，HSV，EBV，VZV，HCV，HIV和流感的那些。

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