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1. 发明授权

US07329501B2 Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance 失效
标题翻译： Interalpha胰蛋白酶抑制剂生物聚合物标志物表明胰岛素抵抗
公开(公告)号：US07329501B2
公开(公告)日：2008-02-12
申请号：US11439587
申请日：2006-05-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/53
CPC分类号： C07K14/8114 , Y10T436/24
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

2. 发明申请

US20070031979A1 Protein biopolymer markers predictive of type II diabetes 审中-公开
标题翻译：预测II型糖尿病的蛋白质生物聚合物标记物
公开(公告)号：US20070031979A1
公开(公告)日：2007-02-08
申请号：US11580470
申请日：2006-10-12
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/50 , G01N33/543
CPC分类号： C07K14/47 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

3. 发明申请

US20060211146A1 Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance 审中-公开
公开(公告)号：US20060211146A1
公开(公告)日：2006-09-21
申请号：US11439588
申请日：2006-05-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/543
CPC分类号： C07K14/8114 , Y10T436/24
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

4. 发明申请

US20060211143A1 Fibronectin and fibrinogen biopolymer markers indicative of insulin resistance 审中-公开
公开(公告)号：US20060211143A1
公开(公告)日：2006-09-21
申请号：US11439577
申请日：2006-05-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/543
CPC分类号： C07K14/78 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

5. 发明申请

US20060211048A1 Biopolymer marker indicative of disease state having a molecular weight of 1211 daltons 审中-公开
公开(公告)号：US20060211048A1
公开(公告)日：2006-09-21
申请号：US11437969
申请日：2006-05-19
申请人： George Jackowski , Brad Thatcher , John Marshall , Jason Yantha , Tammy Vrees
发明人： George Jackowski , Brad Thatcher , John Marshall , Jason Yantha , Tammy Vrees
IPC分类号： G01N33/53 , G01N33/00
CPC分类号： G01N33/6893 , Y10T436/24
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

6. 发明授权

US07097989B2 Complement C3 precursor biopolymer markers predictive of type II diabetes 失效
标题翻译：补充C3前体生物聚合物标志物预测II型糖尿病
公开(公告)号：US07097989B2
公开(公告)日：2006-08-29
申请号：US09993287
申请日：2001-11-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/567 , A61K38/00
CPC分类号： G01N33/564 , G01N2800/042 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的至少一种疾病状态的存在或不存在的能力，预测疾病风险评估以及开发针对该疾病的治疗途径。

7. 发明授权

US07074576B2 Protein biopolymer markers indicative of alzheimer's disease 失效
标题翻译：指示阿尔茨海默病的蛋白质生物聚合物标记物
公开(公告)号：US07074576B2
公开(公告)日：2006-07-11
申请号：US09992672
申请日：2001-11-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/567 , A61K38/00
CPC分类号： G01N33/6848 , C07K7/08 , G01N33/6851 , Y10S436/811
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的至少一种疾病状态的存在或不存在的能力，预测疾病风险评估以及开发针对该疾病的治疗途径。

8. 发明申请

US20060134699A1 Inter-alpha trypsin inhibitor biopolymer marker indicative of insulin resistance 审中-公开
标题翻译：表示胰岛素抵抗的α型间胰蛋白酶抑制剂生物聚合物标记物
公开(公告)号：US20060134699A1
公开(公告)日：2006-06-22
申请号：US11351461
申请日：2006-02-10
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/53 , G01N33/00
CPC分类号： G01N33/6848 , C07K14/47 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的至少一种疾病状态的存在或不存在的能力，预测疾病风险评估以及开发针对该疾病的治疗途径。

9. 发明申请

US20060084112A1 Apolipoprotein biopolymer marker indicative of normal human 失效
标题翻译：代表正常人的载脂蛋白生物聚合物标记物
公开(公告)号：US20060084112A1
公开(公告)日：2006-04-20
申请号：US09993300
申请日：2001-11-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , C07K14/4711 , G01N33/564 , G01N2500/00 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

10. 发明申请

US20050287599A1 Biopolymer marker indicative of disease state having a molecular weight of 1518 daltons 失效
标题翻译：指示分子量为1518道尔顿的疾病状态的生物聚合物标记物
公开(公告)号：US20050287599A1
公开(公告)日：2005-12-29
申请号：US11144402
申请日：2005-06-03
申请人： George Jackowski , Brad Thatcher , John Marshall , Jason Yantha , Tammy Vrees
发明人： George Jackowski , Brad Thatcher , John Marshall , Jason Yantha , Tammy Vrees
IPC分类号： G01N33/68 , C12Q1/68 , G01N33/00 , G01N33/53
CPC分类号： G01N33/6893
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

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