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US5538643A Continuous flow apparatus and method for interfacing liquid chromatograph and fourier transform infrared spectrometer 失效
标题翻译：液相色谱仪和傅里叶变换红外光谱仪连续流量仪和方法
公开(公告)号：US5538643A
公开(公告)日：1996-07-23
申请号：US434306
申请日：1995-05-02
申请人： George J. Kallos , Richard R. Papenfuss
发明人： George J. Kallos , Richard R. Papenfuss
IPC分类号： G01N21/35 , G01N30/74 , G01N30/84 , B01D15/08
CPC分类号： G01N30/84 , G01N2021/3595 , G01N2030/743 , G01N2030/8417 , G01N2030/8423 , G01N2030/8464 , G01N2030/8476
摘要： Apparatus for interfacing a liquid chromatograph (LC) with a spectrometer such as a Fourier transform infrared spectrometer, the LC having an eluant, the eluant containing a solvent and a component of interest. The apparatus includes five basic parts. The first is a means for generating a stream of droplets of the eluant, such as a nebulizer. The second is a means for removing most of the solvent from the stream of droplets of the eluant to thereby generate a stream of particles, the particles containing the component of interest and any residual solvent, such as a membrane solvent separator/momentum separator combination. The third is a cryogenic receiving surface, such as a gold drum. The forth is a means for focusing the stream of particles onto the cryogenic receiving surface so that the particles adhere to the cryogenic receiving surface, such as a one and two-tenths millimeter inside diameter stainless steel tube positioned with a gap between the distal end of the tube and the cryogenic receiving surface of one-quarter millimeter. The fifth is a means for controlling the temperature of the cryogenic receiving surface, such as a helium refrigerator. In operation, the cryogenic receiving surface is maintained at a temperature effective to cause the particles to adhere to the cryogenic receiving surface to form a region of adhered particles, such as a temperature of between seventy and one hundred and five degrees Kelvin, the cryogenic receiving surface being maintained in a partial vacuum. Then, the cryogenic receiving surface is warmed, e.g., to between one hundred and five and two hundred degrees Kelvin, to volatilize essentially all of any remaining solvent from the region of adhered particles prior to spectroscopic analysis of the region of adhered particles.
摘要翻译：用于将液相色谱仪（LC）与诸如傅里叶变换红外光谱仪的光谱仪接口的液体色谱仪，具有洗脱剂的LC，含有溶剂的洗脱液和感兴趣的组分。该装置包括五个基本部分。第一种是用于产生洗脱液的液滴流的方法，例如喷雾器。第二种是从洗脱剂液滴流中除去大部分溶剂的手段，从而产生颗粒流，包含目的组分的颗粒和任何残留的溶剂，例如膜溶剂分离器/动量分离器组合。第三个是低温接收表面，例如金鼓。第四是用于将颗粒流聚焦到低温接收表面上的手段，使得颗粒粘附到低温接收表面上，例如一个和十分之二十毫米内径的不锈钢管，定位为在管和低温接收面四分之一毫米。第五种是用于控制低温接收表面的温度的方法，例如氦制冷机。在操作中，低温接收表面保持在有效的温度以使颗粒附着到低温接收表面上以形成附着颗粒的区域，例如七十五百分之一百五十五开尔文之间的温度，低温接收表面保持在部分真空中。然后，低温接收表面被加热，例如在一百五百到二百开尔文之间，在粘附的颗粒区域的光谱分析之前，从粘附的颗粒区域基本上挥发任何剩余的溶剂。

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