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1. 发明申请

US20050142099A1 Composition and method for treatment of hepatic encephalopathy 有权
标题翻译：用于治疗肝性脑病的组合物和方法
公开(公告)号：US20050142099A1
公开(公告)日：2005-06-30
申请号：US10748185
申请日：2003-12-31
申请人： George Halow
发明人： George Halow
IPC分类号： A61K31/7012 , A61K31/765
CPC分类号： A61K31/765 , A61K31/7012
摘要： The inventions provide an improved treatment for hepatic encephalopathy characterized by hyperammonemia and/or constipation, comprising the oral administration of polyethylene glycol (PEG) in amounts sufficient to reduce plasma levels of ammonia and/or to alleviate constipation. Preferably, the PEG is administered in combination with lactulose, which provides a palatable composition for the treatment of HE with excellent therapeutic benefits and reduced side effects as compared to lactulose alone.
摘要翻译：本发明为以高氨血症和/或便秘为特征的肝性脑病提供了改进的治疗方法，其包括以足以降低血浆氨基水平和/或缓解便秘的量口服给予聚乙二醇（PEG）。优选地，PEG与乳果糖组合施用，其与单独的乳果糖相比提供了用于治疗HE的可口组合物，具有优异的治疗益处和降低的副作用。

2. 发明授权

US06745151B2 Remote diagnostics and prognostics methods for complex systems 有权
标题翻译：复杂系统的远程诊断和预测方法
公开(公告)号：US06745151B2
公开(公告)日：2004-06-01
申请号：US10063828
申请日：2002-05-16
申请人： Kenneth A. Marko , Doug Thornburg , George Halow , Shane Rachedi
发明人： Kenneth A. Marko , Doug Thornburg , George Halow , Shane Rachedi
IPC分类号： G06F1130
CPC分类号： G07C5/0808 , G07C5/008
摘要： A diagnostic/prognostic system monitors performance of a vehicle or other apparatus wherein the vehicle has a plurality of operational components. Each operational component has a predetermined nominal operating state and generates respective electrical signals pursuant to its operation. A data collection memory in the vehicle stores samples of the electrical signals in a rolling buffer. An analyzer in the vehicle is responsive to the electrical signals for detecting a trigger event indicative of at least a potential variance of an operational component from its nominal operating state. A computation center located remotely from the vehicle has a database storing representations of electrical signals for classifying nominal and irregular operating states of the operational components. A transmitter is activated by the trigger event to transmit at least some of the stored samples in the rolling buffer at the time of the trigger event to the computation center. The computation center receives the transmitted samples and classifies them according to the nominal or irregular operating states.
摘要翻译：诊断/预测系统监测车辆或其他装置的性能，其中车辆具有多个操作部件。每个操作部件具有预定的标称操作状态，并根据其操作产生相应的电信号。车辆中的数据采集存储器将电信号的样本存储在滚动缓冲器中。车辆中的分析器响应于电信号，用于检测指示操作部件的至少一个潜在变化与其标称操作状态的触发事件。位于远离车辆的计算中心具有存储电信号表示的数据库，用于分类操作部件的标称和不规则操作状态。通过触发事件来激活发射机，以便在触发事件发生时将滚动缓冲器中存储的至少一些样本传送到计算中心。计算中心接收发送的样本，并根据标称或不规则的运行状态进行分类。

3. 发明申请

US20090148413A1 Method for treatment of irritable bowel syndrome 审中-公开
标题翻译：肠易激综合征的治疗方法
公开(公告)号：US20090148413A1
公开(公告)日：2009-06-11
申请号：US12001603
申请日：2007-12-11
申请人： George Halow
发明人： George Halow
IPC分类号： A61K45/00 , A61P1/00
CPC分类号： A61K45/06 , A61K35/744 , A61K35/745 , A61K35/747 , A61K36/00 , A61K2300/00
摘要： A composition and method for treatment for bowel disorders is described. The composition consists of three parts. The first part is a highly purified, insoluble, chemically unmodified fiber from plants which is mixed with an aqueous solution such as water. The second part of the composition is a commercially available probiotic preparation. These commercially probiotic preparations contain large numbers of viable microorganisms of either Lactobacillus sp., Bifidobacter sp., Streptococcus sp. or yeast. The third part of the composition is polyethylene glycol which may be administered simultaneously with the aforementioned fiber. Consumption of the fiber and aqueous solution combination plus probiotic and PEG by patients with constipation or Irritable Bowel Syndrome results in either a resolution of the symptoms or a marked improvement in symptoms without significant side effects. The disclosed combination and treatment method may be administered to patients with constipation and Irritable Bowel Syndrome for long periods of time without significant complications.
摘要翻译：描述了用于肠道疾病的治疗的组合物和方法。组成由三部分组成。第一部分是与水溶液如水混合的来自植物的高度纯化的，不溶的化学未改性的纤维。组合物的第二部分是市售的益生菌制剂。这些商业益生菌制剂含有大量的乳杆菌属，双歧杆菌属，链球菌属的活微生物。或酵母。组合物的第三部分是与上述纤维同时施用的聚乙二醇。便秘或肠易激综合征患者的纤维和水溶液组合加益生菌和PEG的消耗导致症状的消退或症状明显改善，而没有显着的副作用。公开的组合和治疗方法可以长时间施用于便秘和肠易激综合征的患者，而没有明显的并发症。

4. 发明申请

US20070269403A1 Composition and method for treatment of hepatic encephalopathy 审中-公开
公开(公告)号：US20070269403A1
公开(公告)日：2007-11-22
申请号：US11822445
申请日：2007-07-06
申请人： George Halow
发明人： George Halow
IPC分类号： A61K31/75 , A61P1/10 , A61P1/16
CPC分类号： A61K31/765 , A61K31/7012
摘要： The inventions provide an improved treatment for hepatic encephalopathy characterized by hyperammonemia and/or constipation, comprising the oral administration of polyethylene glycol (PEG) in amounts sufficient to reduce plasma levels of ammonia and/or to alleviate constipation. Preferably, the PEG is administered in combination with lactulose, which provides a palatable composition for the treatment of HE with excellent therapeutic benefits and reduced side effects as compared to lactulose alone.

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