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1. 发明授权

US4517985A Neonate ultrasonic scanner 失效
标题翻译：新生儿超声波扫描仪
公开(公告)号：US4517985A
公开(公告)日：1985-05-21
申请号：US598492
申请日：1984-04-09
申请人： Georg Teslawski , Paul D. Corl
发明人： Georg Teslawski , Paul D. Corl
IPC分类号： A61B8/08 , G10K11/35 , A61B10/00
CPC分类号： G10K11/355 , A61B8/08
摘要： An ultrasonic scanner for medical diagnostics is disclosed. The scanner includes an upper head assembly and a lower drive assembly. The upper head assembly includes a fluid chamber filled with a liquid acoustic couplant. An oscillating transducer is driven in an asymmetric motion by a linkage coupled off-center to a flywheel within the fluid chamber. An inflatable bladder is provided in the upper assembly which is in fluid communication with the fluid chamber. The application of force to the membrane boot of the scanner forces fluid into the bladder. Once the external pressure is removed, the bladder is biased such that it is compressed, thereby forcing fluid to return to the fluid chamber and maintaining a generally constant pressure within the chamber. Supporting electronics are provided including means for compensating for the asymmetric motion of the transducer.
摘要翻译：公开了用于医疗诊断的超声波扫描器。扫描器包括上头组件和下驱动组件。上部头部组件包括填充有液体声学耦合剂的流体室。振荡换能器通过非对称运动被驱动，该联动装置偏离中心连接到流体腔内的飞轮。在上部组件中设置有可膨胀的气囊，其与流体室流体连通。将扫描器的膜引导件施加到液膜进入膀胱。一旦外部压力被去除，气囊被偏压使得其被压缩，从而迫使流体返回到流体室并且保持腔室内的大致恒定的压力。提供了支持电子设备，包括用于补偿换能器的非对称运动的装置。

2. 发明申请

US20080146903A1 DISPLAY AND PROBE HAVING A REMOVABLE CONNECTIONS 审中-公开
标题翻译：显示和探头有一个可拆卸的连接
公开(公告)号：US20080146903A1
公开(公告)日：2008-06-19
申请号：US12027898
申请日：2008-02-07
申请人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
发明人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
IPC分类号： A61B5/1459
CPC分类号： A61B5/14542 , A61B5/01 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/6852 , A61B2562/227
摘要： An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.
摘要翻译：一种用于患有携带血液的血管以确定血液特征的患者的装置。该装置包括显示模块和探针，其具有适于插入病人容器中的远端，并具有耦合到显示模块的近端。探头包括远端末端的传感器，用于当探针设置在血液中时向显示模块提供电信号。探针可以具有抗血栓形成表面处理，用于当设置在血液中时抑制血液成分对探针的粘附。

3. 发明申请

US20080125635A1 PROBE WITH GAS PERMEABLE MATERIAL SURROUNDING A GAS SENSOR ASSEMBLY 审中-公开
标题翻译：探测气体渗透材料探测气体传感器总成
公开(公告)号：US20080125635A1
公开(公告)日：2008-05-29
申请号：US12027915
申请日：2008-02-07
申请人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
发明人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
IPC分类号： A61B5/145
CPC分类号： A61B5/14542 , A61B5/01 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/6852 , A61B2562/227
摘要： An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.
摘要翻译：一种用于患有携带血液的血管以确定血液特征的患者的装置。该装置包括显示模块和探针，其具有适于插入病人容器中的远端，并具有耦合到显示模块的近端。探头包括远端末端的传感器，用于当探针设置在血液中时向显示模块提供电信号。探针可以具有抗血栓形成表面处理，用于当设置在血液中时抑制血液成分对探针的粘附。

4. 发明授权

US06767327B1 Method of measuring blood pressure and velocity proximally and distally of a stenosis 有权
标题翻译：测量血压和速度近端和远端狭窄的方法
公开(公告)号：US06767327B1
公开(公告)日：2004-07-27
申请号：US09644111
申请日：2000-08-21
申请人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
发明人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
IPC分类号： A61B500
CPC分类号： G01L19/141 , A61B5/0215 , A61B5/6851 , A61B8/06 , A61B8/12 , A61M25/09 , A61M25/10 , A61M2025/0002 , A61M2025/09008 , A61M2025/09083 , G01L9/0054 , G01L19/0084 , G01L19/147 , G01L19/149
摘要： A method of measuring blood pressure and velocity proximally and distally of a stenosis in a vessel carrying blood includes the steps of providing a guide wire having both a pressure sensor and a velocity sensor disposed on a distal region of the guide wire, introducing the guide wire into the vessel, advancing the guide wire to position the pressure sensor and the velocity sensor proximally and distally of the stenosis, and measuring the blood pressure and velocity proximally and distally of the stenosis with the pressure sensor and the velocity sensor.
摘要翻译：一种在携带血液的容器中向近端和远端测量血压和速度的方法，包括提供具有设置在导丝的远侧区域上的压力传感器和速度传感器两者的导丝的步骤，将引导线进入容器，推进导丝以将压力传感器和速度传感器定位在近端和远端的狭窄处，并用压力传感器和速度传感器测量近端和远端狭窄的血压和速度。

5. 发明授权

US5163445A Apparatus, system and method for measuring spatial average velocity and/or volumetric flow of blood in a vessel and screw joint for use therewith 失效
标题翻译：用于测量血管中血液的空间平均速度和/或体积流量的装置，系统和方法的联合结构
公开(公告)号：US5163445A
公开(公告)日：1992-11-17
申请号：US759413
申请日：1991-09-13
申请人： Jeffrey J. Christian , Paul D. Corl , Jerome Segal , Ronald G. Williams , Wayne C. Haase
发明人： Jeffrey J. Christian , Paul D. Corl , Jerome Segal , Ronald G. Williams , Wayne C. Haase
IPC分类号： A61B8/06 , G01F1/66
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61M25/09 , G01F1/663 , A61M2025/09175
摘要： System for measuring a characteristic of flow of liquid in a vessel of a patient comprising a transducer positioned in a vessel in a patient for supplying ultrasonic energy. The transducer produces a substantially uniform beam which encompasses the vessel. The transducer receives ultrasonic energy back scattered from the red blood cells and provides an electrical output signal. A first moment detector is provided which receives the electrical output from the transducer and provides a first moment signal. Normalization is provided to the output of the first moment detector to provide an electrical output representing a characteristic of the flow of the liquid in the vessel.
摘要翻译：用于测量患者容器中液体流动特性的系统，包括位于病人容器中的换能器，用于提供超声能量。换能器产生包围血管的基本均匀的束。传感器接收从红细胞反向散射的超声能量，并提供电输出信号。提供了第一时刻检测器，其接收来自换能器的电输出并提供第一力矩信号。将标准化提供给第一力矩检测器的输出，以提供表示容器中液体流动的特性的电输出。

6. 发明授权

US4325257A Real-time digital, synthetic-focus, acoustic imaging system 失效
标题翻译：实时数字，合成焦点，声学成像系统
公开(公告)号：US4325257A
公开(公告)日：1982-04-20
申请号：US122880
申请日：1980-02-20
申请人： Gordon S. Kino , Paul D. Corl , Peter M. Grant
发明人： Gordon S. Kino , Paul D. Corl , Peter M. Grant
IPC分类号： G01N29/26 , G01S7/52 , G01S15/89 , G10K11/34 , G01N29/00
CPC分类号： G01N29/262 , G01S15/8918 , G01S7/52046 , G10K11/341
摘要： The invention involves a digital synthetic-focus, acoustic imaging system which is operative in real time and includes one or more electro-acoustic transducers arranged to receive broadband pulses from a pulse generator for excitation of acoustic pulses which are directed into the region under observation. Signals reflected from an object or discontinuity in the region are received by the same transducers, and after inverse filtering and nonlinear amplification are converted to digital signals. These digital signals are stored in separate high speed random access memory units for storage, but are subsequently time-equalized through use of a programmed focus memory unit prior to delivery to a digital adder and thence through a digital-to-analog converter for ultimate intensity modulation on a raster scanned display unit which provides the real time image.
摘要翻译：本发明涉及一种实时操作的数字合成焦点声学成像系统，并且包括一个或多个电声换能器，其布置成从脉冲发生器接收宽带脉冲，用于激发被引导到观察区域内的声脉冲。从该物体反射的信号或该区域的不连续性由相同的换能器接收，并且在逆滤波和非线性放大转换成数字信号之后。这些数字信号存储在用于存储的单独的高速随机存取存储器单元中，然后在递送到数字加法器之前通过使用编程的聚焦存储器单元随后进行时间均衡，并且然后通过数模转换器实现极限强度在提供实时图像的光栅扫描显示单元上进行调制。

7. 发明授权

US07630747B2 Apparatus for ascertaining blood characteristics and probe for use therewith 失效
标题翻译：用于确定血液特性的装置和与其一起使用的探针
公开(公告)号：US07630747B2
公开(公告)日：2009-12-08
申请号：US10658926
申请日：2003-09-09
申请人： Paul D. Corl , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
发明人： Paul D. Corl , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
IPC分类号： A61B5/05
CPC分类号： A61B5/14542 , A61B5/01 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/6852 , A61B2562/227
摘要： An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.
摘要翻译：一种用于患有携带血液的血管以确定血液特征的患者的装置。该装置包括显示模块和探针，其具有适于插入病人容器中的远端，并具有耦合到显示模块的近端。探头包括远端末端的传感器，用于当探针设置在血液中时向显示模块提供电信号。探针可以具有抗血栓形成表面处理，用于当设置在血液中时抑制血液成分对探针的粘附。

8. 发明申请

US20080125633A1 PROBE AND DISPLAY HAVING A GAS SENSOR ASSEMBLY AND SURFACE TREATMENT 审中-公开
标题翻译：具有气体传感器组件和表面处理的探测和显示
公开(公告)号：US20080125633A1
公开(公告)日：2008-05-29
申请号：US12027933
申请日：2008-02-07
申请人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
发明人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
IPC分类号： A61B5/145
CPC分类号： A61B5/14542 , A61B5/01 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/6852 , A61B2562/227
摘要： An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.
摘要翻译：一种用于患有携带血液的血管以确定血液特征的患者的装置。该装置包括显示模块和探针，其具有适于插入病人容器中的远端，并具有耦合到显示模块的近端。探头包括远端末端的传感器，用于当探针设置在血液中时向显示模块提供电信号。探针可以具有抗血栓形成表面处理，用于当设置在血液中时抑制血液成分对探针的粘附。

9. 发明授权

US07097620B2 Guidewire with pressure and temperature sensing capabilities 有权
公开(公告)号：US07097620B2
公开(公告)日：2006-08-29
申请号：US10247391
申请日：2002-09-19
申请人： Paul D. Corl , Robert Z. Obara , John E Ortiz
发明人： Paul D. Corl , Robert Z. Obara , John E Ortiz
IPC分类号： A61B5/00
CPC分类号： G01L19/141 , A61B5/0215 , A61B5/6851 , A61B8/06 , A61B8/12 , A61M25/09 , A61M25/10 , A61M2025/0002 , A61M2025/09008 , A61M2025/09083 , G01L9/0054 , G01L19/0084 , G01L19/147 , G01L19/149
摘要： A guide wire having pressure sensing capabilities for measuring the pressure of liquid in a vessel comprising a flexible elongate member and having proximal and distal extremities and having an outside diameter of 0.018″ or less. The distal extremity of said flexible elongate member is adapted to be disposed in the liquid in said vessel. A housing is carried by the flexible elongate member and has a diameter substantially the same as the diameter of the flexible elongate member. The housing has a space therein with a pressure sensor mounted in the space in the housing. The pressure sensor has a diaphragm that is sensitive to changes of pressure in the liquid in the vessel. The diaphragm is rectangular in shape and is bordered by a rim surrounding the well. A backing plate is formed of an insulating material bonded to the crystal and serves to reinforce the rim of the crystal of semiconductor material. The backing plate has a cavity therein underlying the diaphragm and is in substantial registration with the diaphragm. The cavity serves to provide a pressure reference.

10. 发明授权

US06755853B2 Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts 失效
标题翻译：用于抑制血管瘘和移植物增生的方法和试剂盒
公开(公告)号：US06755853B2
公开(公告)日：2004-06-29
申请号：US10010411
申请日：2001-12-05
申请人： John R. McKenzie , Robert F. Zuk , Axel F. Brisken , Paul D. Corl
发明人： John R. McKenzie , Robert F. Zuk , Axel F. Brisken , Paul D. Corl
IPC分类号： A61F206
CPC分类号： A61F2/02 , A61F2/06
摘要： A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.
摘要翻译：用于抑制血管瘘或血管移植物的吻合接合处的增生的方法包括以机械指数将吻合接头暴露于振动能量并足以抑制增生的时间。描述的试剂盒包括适于执行方法的导管或探针以及阐述方法的使用说明书。所述方法和试剂盒特别适用于治疗形成的吻合口以提供用于血液透析，血液滤过等的血管通路。方法和试剂盒也适用于治疗其它血管移植物，例如在心脏旁路移植手术期间形成的血管移植物，血管修复等。

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