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1. 发明授权

US11426610B2 Neuromodulation techniques for perturbation of physiological systems 有权
公开(公告)号：US11426610B2
公开(公告)日：2022-08-30
申请号：US16399692
申请日：2019-04-30
申请人： General Electric Company
发明人： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
IPC分类号： A61N7/00 , A61N1/05 , A61N1/36
摘要： Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

2. 发明申请

US20220126121A1 NEUROMODULATION ENERGY APPLICATION TECHNIQUES 有权
公开(公告)号：US20220126121A1
公开(公告)日：2022-04-28
申请号：US17572383
申请日：2022-01-10
申请人： General Electric Company
发明人： Christopher Michael Puleo , Yang Zhao , Kirk Dennis Wallace , Ying Fan , Jeffrey Michael Ashe , David Andrew Shoudy
IPC分类号： A61N7/00 , A61B90/00 , A61B8/00
摘要： Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

3. 发明申请

US20210170203A1 MULTI-BEAM NEUROMODULATION TECHNIQUES 有权
公开(公告)号：US20210170203A1
公开(公告)日：2021-06-10
申请号：US16709717
申请日：2019-12-10
申请人： General Electric Company
发明人： John Frederick Graf , Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , David Andrew Shoudy
IPC分类号： A61N7/00
摘要： The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

4. 发明申请

US20190015008A1 SYSTEMS AND METHODS FOR SHIELDED AND ADJUSTABLE MEDICAL MONITORING DEVICES 审中-公开
公开(公告)号：US20190015008A1
公开(公告)日：2019-01-17
申请号：US16027057
申请日：2018-07-03
申请人： General Electric Company
发明人： Azar Alizadeh , Andrew A. Burns , Matthew Jeremiah Misner , Ralf Lenigk , Jeffrey Michael Ashe , Obi Aghogho , Nancy Cecelia Stoffel , Juha Virtanen , Otto Pekander , Timo Toivanen , Robert Santala
IPC分类号： A61B5/0408 , A61B5/00
摘要： A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module.

5. 发明申请

US20170172451A1 SYSTEM AND METHOD FOR ENHANCED ELECTRICAL IMPEDANCE TOMOGRAPHY 审中-公开
公开(公告)号：US20170172451A1
公开(公告)日：2017-06-22
申请号：US14970589
申请日：2015-12-16
申请人： General Electric Company
发明人： Gregory Boverman , David Michael Davenport , Jeffrey Michael Ashe , Bruce Courtney Campbell Amm
IPC分类号： A61B5/053 , A61B5/00 , G06T11/00
CPC分类号： A61B5/0536 , A61B5/7221 , A61B2576/00 , G06T11/003
摘要： A method includes applying a plurality of currents to a plurality of electrodes disposed on a surface surrounding an anatomical region in a subject. Further, the method includes measuring a plurality of voltages generated in response to the plurality of currents. The method also includes selecting a coarse-scale basis corresponding to a response function associated with the plurality of electrodes. Moreover, the method includes determining simultaneously an internal admittivity corresponding to the anatomical region and a contact impedance corresponding to the plurality of electrodes based on the plurality of voltages and the coarse-scale basis. The method also includes reconstructing the diagnostic image based on the internal admittivity.

6. 发明申请

US20170105648A1 DETECTION OF PHYSIOLOGICAL CHANGES IN IMPEDANCE MONITORING 审中-公开
公开(公告)号：US20170105648A1
公开(公告)日：2017-04-20
申请号：US14918306
申请日：2015-10-20
申请人： GENERAL ELECTRIC COMPANY
发明人： Gregory Boverman , Tzu-Jen Kao , Bruce Courtney Campbell Amm , Jeffrey Michael Ashe , David Michael Davenport
IPC分类号： A61B5/053
摘要： Implementations are disclosed for monitoring a state or change in state of a physiological parameter based on measured impedance data. In certain implementations, no images are reconstructed from the impedance data. In certain implementations, a metric (e.g., distinguishability, likelihood ratios, and so forth) may be computed and compared to reference metrics or thresholds, such as for changes over time or in comparison to a standard to determine the presence or absence of a physiological state of interest or of a change in such state.

7. 发明申请

US20150157240A1 ELECTRICAL IMPEDANCE IMAGING SYSTEMS 审中-公开
标题翻译：电气阻抗成像系统
公开(公告)号：US20150157240A1
公开(公告)日：2015-06-11
申请号：US14098564
申请日：2013-12-06
申请人： General Electric Company
发明人： David Andrew Shoudy , Jeffrey Michael Ashe
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/0536 , A61B5/7225
摘要： An electrical channel having inbuilt current limiting is provided. The electrical channel includes an electrode current source. The electrode current source includes a voltage-to-current converter, a negative impedance converter, and at least one passive current limiting component. Further, the voltage-to-current converter is configured to receive an input voltage and output a corresponding output current. Moreover, the negative impedance converter is operatively coupled to the voltage-to-current converter, where the negative impedance converter is configured to cancel an output impedance of the voltage-to-current converter, a parasitic impedance, or both. Also, the passive current limiting component is configured to limit the output current to a load below a threshold value.
摘要翻译：提供具有内置电流限制的电通道。电通道包括电极电流源。电极电流源包括电压 - 电流转换器，负阻抗转换器和至少一个无源限流部件。此外，电压 - 电流转换器被配置为接收输入电压并输出相应的输出电流。此外，负阻抗变换器可操作地耦合到电压 - 电流转换器，其中负阻抗转换器被配置为消除电压 - 电流转换器的输出阻抗，寄生阻抗或两者。而且，无源限流部件被配置为将输出电流限制在低于阈值的负载上。

8. 发明授权

US11944490B2 Neuromodulation energy application techniques 有权
公开(公告)号：US11944490B2
公开(公告)日：2024-04-02
申请号：US16517289
申请日：2019-07-19
申请人： General Electric Company
发明人： Christopher Michael Puleo , Jeffrey Michael Ashe , David Andrew Shoudy , Victoria Eugenia Cotero , James Enrico Sabatini
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61B8/4236 , A61B8/4281 , A61N7/00 , A61N2007/0026
摘要： Techniques for accurate positioning of an energy application device for neuromodulation treatment protocols are provided. A neuromodulation positioning patch is applied to a patient's skin. The energy application device is coupled to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. The frame is also coupled to a removable dock for an imaging probe. When the frame is coupled to the removable dock the frame of the neuromodulation positioning patch, acquires image data through the opening to identify or verify the treatment position.

9. 发明公开

US20230414972A1 SYSTEMS AND METHODS OF ALIGNMENT CONTROL FOR NEUROMODULATION DELIVERY SYSTEM 审中-公开
公开(公告)号：US20230414972A1
公开(公告)日：2023-12-28
申请号：US17809311
申请日：2022-06-28
申请人： General Electric Company
发明人： David Andrew Shoudy , Weston Blaine Griffin , Radhika Madhavan , Jeffrey Michael Ashe
IPC分类号： A61N7/00 , A61B8/00 , A61B8/08
CPC分类号： A61N7/00 , A61B8/4245 , A61B8/54 , A61B8/085 , A61N2007/0026 , A61N2007/0095
摘要： The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, an alignment controller may be used to analyze images generated by an ultrasound transducer. The alignment controller may then send a communication to indicate the energy application device is positioned to provide therapy to the target region, or if the device needs to be repositioned. The alignment control of the energy application device provides guided repeatable targeting of the target anatomic region, even when in non-clinical settings.

10. 发明授权

US11633630B2 Noninvasive tissue displacement control and monitoring for neuromodulation 有权
公开(公告)号：US11633630B2
公开(公告)日：2023-04-25
申请号：US16750932
申请日：2020-01-23
申请人： General Electric Company
发明人： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
IPC分类号： A61N7/00 , A61B8/08
摘要： The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

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