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    • 7. 发明授权
    • Modulation of prion expression
    • 调节朊病毒表达
    • US08669102B2
    • 2014-03-11
    • US13059058
    • 2009-08-14
    • C. Frank BennettGene HungSusan M. FreierKenneth W. Dobie
    • C. Frank BennettGene HungSusan M. FreierKenneth W. Dobie
    • C12N15/85C07H21/04C07H21/02
    • A61K31/7125
    • Disclosed herein are compounds and methods for decreasing PrP and preventing, ameliorating, or treating a prion disease or conformational neurodegenerative disorder, in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to PrP include Creutzfeldt-Jakob disease (CJD); variant Creutzfeldt-Jakob Disease (vCJD); Gerstmann-Straussler-Scheinker syndrome; fatal familial insomnia; kuru; Bovine Spongiform Encephalopathy (BSE), e.g. “mad cow disease”; Chronic Wasting Disease (CWD); scrapie; transmissible mink encephalopathy; feline spongiform encephalopathy; ungulate spongiform encephalopathy; Alzheimer's disease; Parkinson's disease; Huntington's disease; and Amyotrophic Lateral Sclerosis (ALS).
    • 本文公开了在有需要的个体中减少PrP并预防,改善或治疗朊病毒疾病或构象神经变性疾病的化合物和方法。 通过施用针对PrP的反义化合物可以改善的疾病状况的实例包括克雅氏病(CJD); 变异克雅氏病(vCJD); Gerstmann-Straussler-Scheinker综合征; 致命性家族性失眠; 库鲁 牛海绵状脑病(BSE),例如。 “疯牛病”; 慢性疾病(CWD); scrap子 传染性貂脑病 猫海绵状脑病; 有蹄型海绵状脑病 阿尔茨海默氏病; 帕金森病 亨廷顿氏病 和肌萎缩性侧索硬化(ALS)。