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1. 发明申请

US20050014746A1 Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-supressive agents 失效
标题翻译：芳基苯基杂环硫醚衍生物及其作为细胞粘附抑制性抗炎和免疫抑制剂的用途
公开(公告)号：US20050014746A1
公开(公告)日：2005-01-20
申请号：US10773332
申请日：2004-02-09
申请人： Gary Wang , Sheldon Wang , Robert Gentles
发明人： Gary Wang , Sheldon Wang , Robert Gentles
IPC分类号： C07D239/42 , A61K31/425 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61K31/54 , A61K31/551 , A61P9/10 , A61P29/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/74 , C07D263/48 , C07D265/30 , C07D277/20 , C07D277/42 , C07D279/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/04
CPC分类号： C07D239/42 , C07D263/48 , C07D277/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12
摘要： The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎性和免疫疾病的新型含杂环基的二芳基硫化物，包含这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。

2. 发明授权

US07129247B2 Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents 失效
公开(公告)号：US07129247B2
公开(公告)日：2006-10-31
申请号：US10773332
申请日：2004-02-09
申请人： Gary T. Wang , Sheldon Wang , Robert Gentles
发明人： Gary T. Wang , Sheldon Wang , Robert Gentles
IPC分类号： A61K31/4418 , C07D211/54
CPC分类号： C07D239/42 , C07D263/48 , C07D277/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12
摘要： The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

3. 发明授权

US06787542B2 Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents 失效
标题翻译：芳基苯基杂环硫醚衍生物及其作为细胞粘附抑制性抗炎和免疫抑制剂的用途
公开(公告)号：US06787542B2
公开(公告)日：2004-09-07
申请号：US09888840
申请日：2001-06-25
申请人： Gary T. Wang , Sheldon Wang , Robert Gentles
发明人： Gary T. Wang , Sheldon Wang , Robert Gentles
IPC分类号： C07D40114
CPC分类号： C07D239/42 , C07D263/48 , C07D277/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12
摘要： The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎性和免疫疾病的新型含杂环基的二芳基硫化物，包含这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。

4. 发明申请

US20060046983A1 Inhibitors of HCV replication 有权
公开(公告)号：US20060046983A1
公开(公告)日：2006-03-02
申请号：US11181639
申请日：2005-07-14
申请人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
发明人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
IPC分类号： A61K31/553 , A61K31/55 , A61K31/551 , A61K31/4745 , A61K31/407 , C07D491/04 , C07D487/04
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.

5. 发明申请

US20070078122A1 Indolobenzazepine HCV NS5B inhibitors 有权
标题翻译：吲哚扎嗪氮芥NS5B抑制剂
公开(公告)号：US20070078122A1
公开(公告)日：2007-04-05
申请号：US11516435
申请日：2006-09-06
申请人： Carl Bergstrom , John Bender , Robert Gentles , Piyasena Hewawasam , Thomas Hudyma , John Kadow , Scott Martin , Alicia Regueiro-Ren , Kap-Sun Yeung , Yong Tu , Katharine Grant-Young , Xiaofan Zheng
发明人： Carl Bergstrom , John Bender , Robert Gentles , Piyasena Hewawasam , Thomas Hudyma , John Kadow , Scott Martin , Alicia Regueiro-Ren , Kap-Sun Yeung , Yong Tu , Katharine Grant-Young , Xiaofan Zheng
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D491/14 , C07D487/04
摘要： The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I，II，III和IV的化合物和盐以及使用该化合物的组合物和方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

6. 发明申请

US20070060565A1 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors 有权
标题翻译：环丙基稠合吲哚并苯并氮平HCV NS5B抑制剂
公开(公告)号：US20070060565A1
公开(公告)日：2007-03-15
申请号：US11507731
申请日：2006-08-22
申请人： Nicholas Meanwell , Robert Gentles , Min Ding , John Bender , John Kadow , Piyasena Hewawasam , Thomas Hudyma , Xiaofan Zheng
发明人： Nicholas Meanwell , Robert Gentles , Min Ding , John Bender , John Kadow , Piyasena Hewawasam , Thomas Hudyma , Xiaofan Zheng
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

7. 发明申请

US20060166964A1 Inhibitors of HCV replication 有权
标题翻译： HCV复制抑制剂
公开(公告)号：US20060166964A1
公开(公告)日：2006-07-27
申请号：US11347765
申请日：2006-02-03
申请人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
发明人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
IPC分类号： A61K31/553 , A61K31/551 , A61K31/55 , C07D487/02 , C07D491/02
CPC分类号： C07D471/04 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/13 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D498/14 , C07D513/14 , A61K2300/00
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
摘要翻译：描述式I的吲哚化合物。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。还描述了包含化合物的不同形式和组合物以及制备化合物的方法。

8. 发明申请

US20070184024A1 Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors 有权
标题翻译：环丙基稠合吲哚扎嗪氮芥HCV NS5B抑制剂
公开(公告)号：US20070184024A1
公开(公告)日：2007-08-09
申请号：US11684710
申请日：2007-03-12
申请人： Nicholas Meanwell , Robert Gentles , Min Ding , John Bender , John Kadow , Piyasena Hewawasam , Thomas Hudyma , Xiaofan Zheng
发明人： Nicholas Meanwell , Robert Gentles , Min Ding , John Bender , John Kadow , Piyasena Hewawasam , Thomas Hudyma , Xiaofan Zheng
IPC分类号： A61K31/55 , A61K38/19 , C07D209/56 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

9. 发明授权

US5327771A Loading probe for use in testing transducers 失效
标题翻译：加载用于测试传感器的探头
公开(公告)号：US5327771A
公开(公告)日：1994-07-12
申请号：US904396
申请日：1992-06-25
申请人： Robert Gentles
发明人： Robert Gentles
IPC分类号： G01H3/00 , H01L41/22
CPC分类号： G01H3/005
摘要： A loading probe for use in testing transducers includes an elongated body capable of simulating the normal acoustic impedance presented to a transducer to be tested by the medium in which the transducer is to operate. The main body of the loading probe has a tube made from a rigid material, and a rod having an elongated convergent portion extending into the interior of the tube so as to define a cavity which has a varying cross section. The cavity houses a core of material having a close match of acoustic impedance with the material of the tube and rod but a higher acoustic loss factor. The cavity is sealed. The active end of the loading probe carries a piezoelectric element having a planar form, and a protective end cap is bonded to the active end of the loading probe to enclose the piezoelectric element.
摘要翻译：用于测试换能器的加载探针包括细长体，其能够模拟通过传感器要操作的介质测试的换能器所呈现的正常声阻抗。装载探针的主体具有由刚性材料制成的管，以及具有延伸到管内部的细长会聚部分的杆，以限定具有变化横截面的腔。空腔容纳材料芯，其声阻抗与管和杆的材料紧密匹配，但是具有较高的声学损耗因子。空腔密封。负载探针的活动端承载具有平面形式的压电元件，并且保护端盖接合到负载探针的有效端以封闭压电元件。

10. 发明授权

US4959992A Piezo-electric transducer test apparatus 失效
标题翻译：压电换能器测试仪
公开(公告)号：US4959992A
公开(公告)日：1990-10-02
申请号：US338952
申请日：1989-04-17
申请人： Robert Gentles
发明人： Robert Gentles
IPC分类号： G01H3/00
CPC分类号： G01H3/005
摘要： An acoustic loading rod for use in testing transducers which are intended for use in a liquid medium. The rod comprises an elongated body (10) capable of simulating the normal acoustic impedance presented to a transducer to be tested by the medium in which the transducer is to operate, the rod (10) having a bore (30) in its main body portion containing a core of material having a close match of acoustic impedance with the material of the rod but a higher acoustic loss factor. Active piezo-electric transducer (22) is mounted between the ends of the rod.

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