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1. 发明授权

US07734342B2 Techniques for positioning therapy delivery elements within a spinal cord or brain 有权
标题翻译：用于在脊髓或脑内定位治疗递送元件的技术
公开(公告)号：US07734342B2
公开(公告)日：2010-06-08
申请号：US11669758
申请日：2007-01-31
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

2. 发明授权

US07191018B2 Techniques for positioning therapy delivery elements within a spinal cord or brain 失效
标题翻译：用于在脊髓或脑内定位治疗递送元件的技术
公开(公告)号：US07191018B2
公开(公告)日：2007-03-13
申请号：US10881239
申请日：2004-06-30
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as_electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。治疗递送元件此后可以用位置控制机构和/或位置控制器原位调整以改善期望的治疗，例如电刺激和/或药物输注到精确的靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

3. 发明授权

US08600495B2 Techniques for positioning therapy delivery elements within a spinal cord or brain 有权
标题翻译：用于在脊髓或脑内定位治疗递送元件的技术
公开(公告)号：US08600495B2
公开(公告)日：2013-12-03
申请号：US12794363
申请日：2010-06-04
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

4. 发明授权

US06319241B1 Techniques for positioning therapy delivery elements within a spinal cord or a brain 失效
公开(公告)号：US06319241B1
公开(公告)日：2001-11-20
申请号：US09303145
申请日：1999-04-30
申请人： Gary W. King , Frans Gielen , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Gary W. King , Frans Gielen , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61M3100
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： The present invention addresses the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. The present invention discloses techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment therapy. The present invention also discloses techniques for non-invasively positioning and re-positioning therapy delivery elements after implant to provide electrical stimulation and/or drug infusion to a precise target. A position control mechanism and/or a position controller are provided for adjusting in situ the position of the therapy delivery elements relative to the targeted tissue of interest. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system may be provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

5. 发明申请

US20100241179A1 Techniques for Positioning Therapy Delivery Elements within a Spinal Cord or Brain 有权
标题翻译：在脊髓或脑内定位治疗传递元件的技术
公开(公告)号：US20100241179A1
公开(公告)日：2010-09-23
申请号：US12794363
申请日：2010-06-04
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/05 , A61N1/375 , A61M39/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

6. 发明授权

US06795737B2 Techniques for positioning therapy delivery elements within a spinal cord or a brain 失效
标题翻译：将治疗递送元件定位在脊髓或脑内的技术
公开(公告)号：US06795737B2
公开(公告)日：2004-09-21
申请号：US09934001
申请日：2001-08-21
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N118
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment therapy, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。治疗递送元件此后可以用位置控制机构和/或位置控制器原位调整以改善期望的治疗疗法，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

7. 发明申请

US20070123954A1 Techniques for positioning therapy delivery elements within a spinal cord or brain 有权
标题翻译：在脊髓或脑中定位治疗递送元件的技术
公开(公告)号：US20070123954A1
公开(公告)日：2007-05-31
申请号：US11669758
申请日：2007-01-31
申请人： Frans Gielen , Gary King , Daryle Petersen , Mark Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary King , Daryle Petersen , Mark Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

8. 发明申请

US20050049650A1 Method for treating obsessive-compulsive disorder with electrical stimulation of the brain internal capsule 有权
标题翻译：用电刺激脑内胶囊治疗强迫症的方法
公开(公告)号：US20050049650A1
公开(公告)日：2005-03-03
申请号：US10888807
申请日：2004-07-09
申请人： Bart Nuttin , Frans Gielen , Paul Cosyns , Jan Gybels , Bjorn Meyerson , Per Mindus
发明人： Bart Nuttin , Frans Gielen , Paul Cosyns , Jan Gybels , Bjorn Meyerson , Per Mindus
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36082 , A61N1/36096 , A61N1/36153 , A61N1/36171
摘要： A method for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder, comprising applying chronic electrical stimulation to at least a portion of the patient's anterior limb of the internal capsule under conditions effective to provide the patient with at least a partial relief from obsession and/or compulsion and/or anxiety and/or depression, by means of an electrical signal generator and at least an implantable electrode having a proximal end coupled to the said signal generator and a stimulation end capable of applying said chronic electrical stimulation, wherein the distance between the two outer contacts of the electrode corresponds to the depth of the internal capsule. A method is disclosed for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder. The method comprises applying electrical stimulation to at least a portion of the patient's anterior limb of the internal capsule or its surrounding structures including but not limited to the head of the caudate nucleus, putamen and nucleus accumbens. The electrical stimulation is applied by means of an electrical signal generator and at least an implantable electrode having a proximal end coupled to the signal generator and a stimulation end capable of applying electrical stimulation to the tissue.
摘要翻译：一种用于治疗痴迷症，强迫症，焦虑症或抑郁症症状的患者的方法，包括在有效地向患者提供至少一个或多个患者的条件下，在患者的内部胶囊的前肢的至少一部分上施加慢性电刺激通过电信号发生器和至少具有耦合到所述信号发生器的近端的至少可植入电极以及能够施加所述慢性电气的刺激端来部分缓解由于痴迷和/或强迫和/或焦虑和/或抑郁刺激，其中电极的两个外部触头之间的距离对应于内部胶囊的深度。公开了一种治疗痴迷症，强迫症，焦虑症或抑郁症患者的方法。该方法包括对内囊或其周围结构的患者前肢的至少一部分施加电刺激，包括但不限于尾状核，壳核和伏隔核的头部。电刺激通过电信号发生器和至少一个具有耦合到信号发生器的近端的可植入电极和能够对组织施加电刺激的刺激端施加。

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