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1. 发明申请

US20060116404A1 CAI-based systems and methods for the localized treatment of ocular and other diseases 审中-公开
标题翻译：基于CAI的系统和方法，用于局部治疗眼部和其他疾病
公开(公告)号：US20060116404A1
公开(公告)日：2006-06-01
申请号：US11235795
申请日：2005-09-26
申请人： Gary Robinson , Gideon Shapiro , Alan Franklin , Simona Jurczyk
发明人： Gary Robinson , Gideon Shapiro , Alan Franklin , Simona Jurczyk
IPC分类号： A61K31/4192
CPC分类号： A61K31/4192 , A61K9/0048 , A61K31/7088 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/38 , A61K47/44 , A61K47/6951
摘要： The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases. Formulations of CAI compounds of the subject invention include CAI free base and CAI prodrug microcrystallines, microparticles, emulsions, and the like. The subject invention further provides methods for treating non-life threatening diseases using the CAI compounds of the invention (i.e., novel delivery systems and combination therapies), that are effective and are associated with little or no adverse side effects.
摘要翻译：本发明提供了CAI化合物及其制剂，以及它们用于局部治疗非危及生命的疾病的方法。本发明的CAI化合物的制剂包括CAI游离碱和CAI前药微晶，微粒，乳液等。本发明还提供了使用本发明的CAI化合物（即，新型递送系统和组合疗法）治疗非危及生命的疾病的方法，所述方法是有效的且与很少或没有不良副作用相关。

2. 发明申请

US20110274748A1 CAI-Based Systems and Methods for the Localized Treatment of Ocular and Other Diseases 有权
标题翻译：用于局部治疗眼部和其他疾病的基于CAI的系统和方法
公开(公告)号：US20110274748A1
公开(公告)日：2011-11-10
申请号：US13181847
申请日：2011-07-13
申请人： Gary Robinson , Gideon Shapiro , Alan J. Franklin , Simona Jurczyk
发明人： Gary Robinson , Gideon Shapiro , Alan J. Franklin , Simona Jurczyk
IPC分类号： A61K9/127 , A61K31/4192 , A61M37/00 , A61K31/7088 , A61N1/30 , A61K9/14 , A61K39/395
CPC分类号： A61K31/4192 , A61K9/0048 , A61K31/7088 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/38 , A61K47/44 , A61K47/6951
摘要： The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases. Formulations of CAI compounds of the subject invention include CAI free base and CAI prodrug microcrystallines, microparticles, emulsions, and the like. The subject invention further provides methods for treating non-life threatening diseases using the CAI compounds of the invention (i.e., novel delivery systems and combination therapies) that are effective and are associated with little or no adverse side effects.
摘要翻译：本发明提供了CAI化合物及其制剂，以及它们用于局部治疗非危及生命的疾病的方法。本发明的CAI化合物的制剂包括CAI游离碱和CAI前药微晶，微粒，乳液等。本发明进一步提供了使用本发明的CAI化合物（即，新型递送系统和组合疗法）治疗非危及生命的疾病的方法，所述CAI化合物是有效的且与很少或没有不良副作用有关。

3. 发明授权

US08614235B2 CAI-based systems and methods for the localized treatment of ocular and other diseases 有权
标题翻译：基于CAI的系统和方法，用于局部治疗眼部和其他疾病
公开(公告)号：US08614235B2
公开(公告)日：2013-12-24
申请号：US13181847
申请日：2011-07-13
申请人： Gary Robinson , Gideon Shapiro , Alan J. Franklin , Simona Jurczyk
发明人： Gary Robinson , Gideon Shapiro , Alan J. Franklin , Simona Jurczyk
IPC分类号： A61K31/41
CPC分类号： A61K31/4192 , A61K9/0048 , A61K31/7088 , A61K39/3955 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/38 , A61K47/44 , A61K47/6951
摘要： The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases. Formulations of CAI compounds of the subject invention include CAI free base and CAI prodrug microcrystallines, microparticles, emulsions, and the like. The subject invention further provides methods for treating non-life threatening diseases using the CAI compounds of the invention (i.e., novel delivery systems and combination therapies) that are effective and are associated with little or no adverse side effects.
摘要翻译：本发明提供了CAI化合物及其制剂，以及它们用于局部治疗非危及生命的疾病的方法。本发明的CAI化合物的制剂包括CAI游离碱和CAI前药微晶，微粒，乳液等。本发明进一步提供了使用本发明的CAI化合物（即，新型递送系统和组合疗法）治疗非危及生命的疾病的方法，所述CAI化合物是有效的且与很少或没有不良副作用有关。

4. 发明授权

US08519117B2 Materials and methods for detection of nucleic acids 有权
标题翻译：用于检测核酸的材料和方法
公开(公告)号：US08519117B2
公开(公告)日：2013-08-27
申请号：US12751617
申请日：2010-03-31
申请人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Jennifer K. Grenier , Craig S. Richmond , Simona Jurczyk , Jerod L. Ptacin
发明人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Jennifer K. Grenier , Craig S. Richmond , Simona Jurczyk , Jerod L. Ptacin
IPC分类号： C07H21/04
CPC分类号： C12Q1/6853 , C12Q1/6823 , C12Q1/6827 , C12Q1/6832 , C12Q1/6834 , C12Q1/6858 , C12Q2600/156 , C12Q2565/1015 , C12Q2525/101 , C12Q2525/161
摘要： Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid by PCR using the first and second primers to generate an amplification product having a double-stranded region and a single-stranded region that comprises the non-natural base; contacting the sample with a reporter comprising a label and a non-natural base that is complementary to the non-natural base of the single-stranded region; annealing at least a portion of the reporter to the single-stranded region of the amplification product; and correlating a signal of the label with the presence of the target nucleic acid in the sample. The invention also provides corresponding kits for use in detecting target nucleic acids in a sample.
摘要翻译：描述了使用非天然碱的测定法。在一个实施方案中，所述方法包括使怀疑含有靶核酸的样品与聚合酶和第一和第二引物接触; 使用第一和第二引物通过PCR扩增靶核酸以产生具有双链区域和包含非天然碱基的单链区域的扩增产物; 使样品与包含与单链区域的非天然碱基互补的标记物和非天然碱基的报告子接触; 将至少一部分报告物退火至扩增产物的单链区域; 并将标记的信号与样品中靶核酸的存在相关联。本发明还提供用于检测样品中靶核酸的相应试剂盒。

5. 发明授权

US07189856B2 Non-peptide somatostatin receptor ligands 失效
标题翻译：非肽生长抑素受体配体
公开(公告)号：US07189856B2
公开(公告)日：2007-03-13
申请号：US10289924
申请日：2002-11-07
申请人： Gideon Shapiro , Michael G. Natchus , Mark A. Lockwood , Simona Jurczyk
发明人： Gideon Shapiro , Michael G. Natchus , Mark A. Lockwood , Simona Jurczyk
IPC分类号： C07D27/104 , A61K31/41
CPC分类号： C07D403/06
摘要： Non-peptide somatostatin receptor ligands with conformationally restricted side chains exhibiting high binding affinity toward somatostatin receptors are provided. The compounds exhibit a high selectivity and act as agonists at human subtype 2 somatostatin receptors. The compounds are long acting for advantageous use as medicaments in peripheral diseases where somatostatinergic therapy is indicated. Furthermore, many of the compounds are lipophilic and are particularly useful for treating central nervous system and ophthalmic diseases where penetration of the blood brain and blood retinal barriers is required. It is a further object to describe the preferred stereoisomers of these somatostatin agonists and processes for their preparation. Further objects will become apparent from reading the following description.
摘要翻译：提供了具有对生长抑素受体具有高结合亲和力的构象限制性侧链的非肽生长抑素受体配体。化合物表现出高选择性，并且作为人类2型生长抑素受体的激动剂。化合物长效作为有益用途，作为指示生长抑素治疗的外周疾病中的药物。此外，许多化合物是亲脂性的，并且特别可用于治疗中枢神经系统和需要渗透血脑屏障和血液视网膜屏障的眼科疾病。另一个目的是描述这些生长抑素激动剂的优选立体异构体及其制备方法。通过阅读以下描述，其他目的将变得显而易见。

6. 发明申请

US20090226926A1 MATERIALS AND METHODS FOR DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：用于检测核酸的材料和方法
公开(公告)号：US20090226926A1
公开(公告)日：2009-09-10
申请号：US12433991
申请日：2009-05-01
申请人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Jennifer K. Grenier , Craig S. Richmond , Simona Jurczyk , Jerod L. Ptacin
发明人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Jennifer K. Grenier , Craig S. Richmond , Simona Jurczyk , Jerod L. Ptacin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6823 , C12Q1/6827 , C12Q1/6832 , C12Q1/6834 , C12Q1/6858 , C12Q2600/156 , C12Q2565/1015 , C12Q2525/101 , C12Q2525/161
摘要： Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid by PCR using the first and second primers to generate an amplification product having a double-stranded region and a single-stranded region that comprises the non-natural base; contacting the sample with a reporter comprising a label and a non-natural base that is complementary to the non-natural base of the single-stranded region; annealing at least a portion of the reporter to the single-stranded region of the amplification product; and correlating a signal of the label with the presence of the target nucleic acid in the sample. The invention also provides corresponding kits for use in detecting target nucleic acids in a sample.
摘要翻译：描述了使用非天然碱的测定法。在一个实施方案中，所述方法包括使怀疑含有靶核酸的样品与聚合酶和第一和第二引物接触; 使用第一和第二引物通过PCR扩增靶核酸以产生具有双链区域和包含非天然碱基的单链区域的扩增产物; 使样品与包含与单链区域的非天然碱基互补的标记物和非天然碱基的报告子接触; 将至少一部分报告物退火至扩增产物的单链区域; 并将标记的信号与样品中靶核酸的存在相关联。本发明还提供用于检测样品中靶核酸的相应试剂盒。

7. 发明申请

US20070031885A1 Materials and methods for detection of nucleic acids 有权
标题翻译：用于检测核酸的材料和方法
公开(公告)号：US20070031885A1
公开(公告)日：2007-02-08
申请号：US11546631
申请日：2006-10-12
申请人： David Marshall , James Prudent , Christopher Sherrill , Gideon Shapiro , Jennifer Grenier , Craig Richmond , Simona Jurczyk , Jerod Ptacin
发明人： David Marshall , James Prudent , Christopher Sherrill , Gideon Shapiro , Jennifer Grenier , Craig Richmond , Simona Jurczyk , Jerod Ptacin
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6853 , C12Q1/6823 , C12Q1/6827 , C12Q1/6832 , C12Q1/6834 , C12Q1/6858 , C12Q2600/156 , C12Q2565/1015 , C12Q2525/101 , C12Q2525/161
摘要： Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid, if present in the sample, by PCR using the first and second primers to generate an amplification product having a double-stranded region and a single-stranded region that comprises the non-natural base; contacting the sample with a reporter comprising a label and a non-natural base that is complementary to the non-natural base of the single-stranded region; annealing at least a portion of the reporter to the single-stranded region of the amplification product; and correlating a signal of the label with the presence of the target nucleic acid in the sample. The invention also provides corresponding kits for use in detecting target nucleic acids in a sample.
摘要翻译：描述了使用非天然碱的测定法。在一个实施方案中，所述方法包括使怀疑含有靶核酸的样品与聚合酶和第一和第二引物接触; 如果存在于样品中，则使用第一和第二引物通过PCR扩增靶核酸以产生具有双链区域和包含非天然碱基的单链区域的扩增产物; 使样品与包含与单链区域的非天然碱基互补的标记物和非天然碱基的报告子接触; 将至少一部分报告物退火至扩增产物的单链区域; 并将标记的信号与样品中靶核酸的存在相关联。本发明还提供用于检测样品中靶核酸的相应试剂盒。

8. 发明申请

US20060252091A1 Materials and methods for detection of nucleic acids 有权
公开(公告)号：US20060252091A1
公开(公告)日：2006-11-09
申请号：US11486841
申请日：2006-07-14
申请人： David Marshall , James Prudent , Christopher Sherrill , Gideon Shapiro , Jennifer Grenier , Craig Richmond , Simona Jurczyk , Jerod Ptacin
发明人： David Marshall , James Prudent , Christopher Sherrill , Gideon Shapiro , Jennifer Grenier , Craig Richmond , Simona Jurczyk , Jerod Ptacin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6823 , C12Q1/6827 , C12Q1/6832 , C12Q1/6834 , C12Q1/6858 , C12Q2600/156 , C12Q2565/1015 , C12Q2525/101 , C12Q2525/161
摘要： Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid, if present in the sample, by PCR using the first and second primers to generate an amplification product having a double-stranded region and a single-stranded region that comprises the non-natural base; contacting the sample with a reporter comprising a label and a non-natural base that is complementary to the non-natural base of the single-stranded region; annealing at least a portion of the reporter to the single-stranded region of the amplification product; and correlating a signal of the label with the presence of the target nucleic acid in the sample. The invention also provides corresponding kits for use in detecting target nucleic acids in a sample.

9. 发明授权

US07541147B2 Materials and methods for detection of nucleic acids 有权
公开(公告)号：US07541147B2
公开(公告)日：2009-06-02
申请号：US11546631
申请日：2006-10-12
申请人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Simona Jurczyk , Jerod L. Ptacin
发明人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Simona Jurczyk , Jerod L. Ptacin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6823 , C12Q1/6827 , C12Q1/6832 , C12Q1/6834 , C12Q1/6858 , C12Q2600/156 , C12Q2565/1015 , C12Q2525/101 , C12Q2525/161
摘要： Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid, if present in the sample, by PCR using the first and second primers to generate an amplification product having a double-stranded region and a single-stranded region that comprises the non-natural base; contacting the sample with a reporter comprising a label and a non-natural base that is complementary to the non-natural base of the single-stranded region; annealing at least a portion of the reporter to the single-stranded region of the amplification product; and correlating a signal of the label with the presence of the target nucleic acid in the sample. The invention also provides corresponding kits for use in detecting target nucleic acids in a sample.

10. 发明授权

US07422850B2 Materials and methods for detection of nucleic acids 有权
标题翻译：用于检测核酸的材料和方法
公开(公告)号：US07422850B2
公开(公告)日：2008-09-09
申请号：US09861292
申请日：2001-05-18
申请人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Jennifer K. Grenier , Craig S. Richmond , Simona Jurczyk , Jerod L. Ptacin
发明人： David J. Marshall , James R. Prudent , Christopher B. Sherrill , Gideon Shapiro , Jennifer K. Grenier , Craig S. Richmond , Simona Jurczyk , Jerod L. Ptacin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6823 , C12Q1/6827 , C12Q1/6832 , C12Q1/6834 , C12Q1/6858 , C12Q2600/156 , C12Q2565/1015 , C12Q2525/101 , C12Q2525/161
摘要： Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid, if present in the sample, by PCR using the first and second primers to generate an amplification product having a double-stranded region and a single-stranded region that comprises the non-natural base; contacting the sample with a reporter comprising a label and a non-natural base that is complementary to the non-natural base of the single-stranded region; annealing at least a portion of the reporter to the single-stranded region of the amplification product; cleaving, after annealing, at least a portion of the reporter to release at least one reporter fragment; and correlating the release of the at least one reporter fragment with the presence of the target nucleic acid in the sample. The invention also provides corresponding kits for use in detecting target nucleic acids in a sample. Alternatively, the reporter can be incorporated into the amplification product rather than annealing and then cleaving.
摘要翻译：描述了使用非天然碱的测定法。在一个实施方案中，所述方法包括使怀疑含有靶核酸的样品与聚合酶和第一和第二引物接触; 如果存在于样品中，则使用第一和第二引物通过PCR扩增靶核酸以产生具有双链区域和包含非天然碱基的单链区域的扩增产物; 使样品与包含与单链区域的非天然碱基互补的标记物和非天然碱基的报告子接触; 将至少一部分报告物退火至扩增产物的单链区域; 在退火后切割至少一部分报告物以释放至少一个报道片段; 并将至少一个报道片段的释放与样品中靶核酸的存在相关联。本发明还提供用于检测样品中靶核酸的相应试剂盒。或者，可以将报道子并入扩增产物，而不是退火然后裂解。

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