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1. 发明授权

US08314097B2 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US08314097B2
公开(公告)日：2012-11-20
申请号：US11508445
申请日：2006-08-23
申请人： Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人： Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号： A61K31/535 , A61K31/445 , A61K31/415 , A61P9/00 , C07D413/00 , C07D211/32 , C07D235/02 , C07D487/10 , C07D403/00
CPC分类号： C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后，冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。最后，本发明还提供药物组合物。

2. 发明申请

US20120277215A1 Organic Compounds 审中-公开
标题翻译：有机化合物
公开(公告)号：US20120277215A1
公开(公告)日：2012-11-01
申请号：US13540113
申请日：2012-07-02
申请人： Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人： Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/454 , C07D487/20 , C07D471/04 , A61K31/437 , A61K31/55 , A61P9/12 , A61P9/04 , A61P13/12 , A61P9/10 , A61P3/00 , A61P3/04 , A61P9/00 , A61P29/00 , A61P19/10 , A61P35/00 , A61P15/08 , A61K31/4188
CPC分类号： C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后，冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。最后，本发明还提供药物组合物。

3. 发明授权

US09278969B2 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US09278969B2
公开(公告)日：2016-03-08
申请号：US14459567
申请日：2014-08-14
申请人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04 , C07D487/04 , A61K31/4188 , A61K31/454 , A61K31/5377 , A61K45/06 , A61K31/55
CPC分类号： C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后，冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。最后，本发明还提供药物组合物。

4. 发明申请

US20140357621A1 Organic Compounds 有权
标题翻译：有机化合物
公开(公告)号：US20140357621A1
公开(公告)日：2014-12-04
申请号：US14459567
申请日：2014-08-14
申请人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号： C07D471/04 , A61K31/55 , A61K45/06 , A61K31/437 , C07D487/04 , A61K31/4188
CPC分类号： C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后，冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。最后，本发明还提供药物组合物。

5. 发明授权

US08835646B2 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US08835646B2
公开(公告)日：2014-09-16
申请号：US13927514
申请日：2013-06-26
申请人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号： A61K31/4188 , C07D487/04 , A61K31/5377 , A61K45/06 , C07D471/04 , A61K31/454
CPC分类号： C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后，冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。最后，本发明还提供药物组合物。

6. 发明申请

US20130287789A1 Organic Compounds 有权
标题翻译：有机化合物
公开(公告)号：US20130287789A1
公开(公告)日：2013-10-31
申请号：US13927514
申请日：2013-06-26
申请人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人： Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号： C07D487/04 , A61K31/454 , A61K31/5377 , A61K31/4188 , A61K45/06
CPC分类号： C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后，冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。最后，本发明还提供药物组合物。

7. 发明申请

US20070049616A1 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US20070049616A1
公开(公告)日：2007-03-01
申请号：US11508445
申请日：2006-08-23
申请人： Gary Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人： Gary Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号： A61K31/4745 , A61K31/4188 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后，冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。最后，本发明还提供药物组合物。

8. 发明授权

US08501732B2 Aminomethyl quinolone compounds 有权
标题翻译：氨甲基喹诺酮化合物
公开(公告)号：US08501732B2
公开(公告)日：2013-08-06
申请号：US13546039
申请日：2012-07-11
申请人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
发明人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5375 , A61K31/5377 , A61K31/4427 , A61K31/435 , A61K31/47 , C07D243/08 , C07D401/02 , C07D413/02 , C07D413/14 , C07D471/00 , C07D215/00
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要翻译：本发明涉及JNK抑制剂和用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。本申请公开了如下式I所述的JNK抑制剂：其中变量如本文所定义。本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。

9. 发明授权

US08188090B2 Naphthylacetic acids 失效
标题翻译：萘乙酸
公开(公告)号：US08188090B2
公开(公告)日：2012-05-29
申请号：US12614497
申请日：2009-11-09
申请人： Fariborz Firooznia , Tai-An Lin , Sung-Sau So , Baoxia Wang , HongYing Yun
发明人： Fariborz Firooznia , Tai-An Lin , Sung-Sau So , Baoxia Wang , HongYing Yun
IPC分类号： A61K31/445 , A61K31/4965 , A01N43/40 , C07D241/04 , C07D295/00 , C07D205/00
CPC分类号： C07D295/192 , C07D213/74 , C07D239/42 , C07D295/18 , C07D401/12 , C07D487/10
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q and R1-R3 are defined in the detailed description and claims. The invention is also concerned with the compounds of formula Z: and pharmaceutically acceptable salts and esters thereof, wherein R1-R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I and Z as well as pharmaceutical compositions containing such compounds. The compounds of formula I and Z are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 3在详细描述和权利要求书中定义。本发明还涉及式Z化合物及其药学上可接受的盐和酯，其中R1-R3在详细描述和权利要求书中定义。此外，本发明涉及制备和使用式I和Z化合物的方法以及含有这些化合物的药物组合物。式I和Z的化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症如哮喘。

10. 发明授权

US08153644B2 Diacylglycerol acyltransferase inhibitors 有权
标题翻译：二酰基甘油酰基转移酶抑制剂
公开(公告)号：US08153644B2
公开(公告)日：2012-04-10
申请号：US12113295
申请日：2008-05-01
申请人： David Robert Bolin , Adrian Wai-Hing Cheung , Fariborz Firooznia , Matthew Michael Hamilton , Lee Aopstle McDermott , Yimin Qian , Jenny Tan , Weiya Yun
发明人： David Robert Bolin , Adrian Wai-Hing Cheung , Fariborz Firooznia , Matthew Michael Hamilton , Lee Aopstle McDermott , Yimin Qian , Jenny Tan , Weiya Yun
IPC分类号： A61K31/506 , A61K31/4525 , A61K31/443 , A61K31/421 , C07D239/34 , C07D239/42 , C07D211/22 , C07D413/14 , C07D263/34
CPC分类号： C07D263/34 , C07D231/14 , C07D249/06 , C07D277/56 , C07D307/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
摘要翻译：本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。

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