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1. 发明申请

US20150174089A1 SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS 审中-公开
标题翻译：作为NEPRILYSIN抑制剂的取代的氨基嘌呤衍生物
公开(公告)号：US20150174089A1
公开(公告)日：2015-06-25
申请号：US14635311
申请日：2015-03-02
申请人： Gary Mark COPPOLA , Yuki IWAKI , Rajeshri KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Muneto MOGI , Robert SUN
发明人： Gary Mark COPPOLA , Yuki IWAKI , Rajeshri KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Muneto MOGI , Robert SUN
IPC分类号： A61K31/194 , A61K45/06 , C07C235/82 , C07C235/74
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

2. 发明申请

US20140296240A1 SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS 审中-公开
标题翻译：取代的氨基酸衍生物作为NEPRILYSIN抑制剂
公开(公告)号：US20140296240A1
公开(公告)日：2014-10-02
申请号：US14306429
申请日：2014-06-17
申请人： Gary Mark COPPOLA , Yuki IWAKI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Muneto MOGI , Robert SUN
发明人： Gary Mark COPPOLA , Yuki IWAKI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Muneto MOGI , Robert SUN
IPC分类号： C07D317/34 , A61K31/216 , A61K31/357 , C07D295/15 , A61K31/5375 , A61K45/06 , A61K31/505 , C07D239/34 , C07D213/82 , A61K31/44 , C07D309/32 , A61K31/351 , C07C235/78 , C07D239/28
CPC分类号： C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I'化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，B 1，X和n如本文所定义。本发明还涉及制备本发明化合物及其治疗用途的方法。本发明还提供药理活性剂和药物组合物的组合。

3. 发明申请

US20120122764A1 SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP 有权
标题翻译：取代的碳水化合物乙酸衍生物作为NEP
公开(公告)号：US20120122764A1
公开(公告)日：2012-05-17
申请号：US13293560
申请日：2011-11-10
申请人： Rajeshri Ganesh KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Qian LIU , Muneto MOGI , Nikolaus SCHIERING , Robert SUN
发明人： Rajeshri Ganesh KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Qian LIU , Muneto MOGI , Nikolaus SCHIERING , Robert SUN
IPC分类号： A61K38/05 , C07D295/195 , C07C235/82 , C07D213/56 , C07D257/04 , C07D471/04 , A61K31/216 , A61K31/194 , A61K31/4418 , A61K31/41 , A61K31/437 , A61P9/12 , A61P3/10 , A61P3/04 , A61P9/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P1/16 , A61P9/06 , A61P5/42 , A61P27/06 , A61P15/00 , A61P11/06 , A61P29/00 , A61P35/02 , A61P25/08 , A61P25/24 , A61P25/18 , A61P1/00 , A61P3/00 , C07D207/16
CPC分类号： C07C233/52 , C07C233/63 , C07C237/22 , C07C2601/08 , C07D207/16 , C07D213/55 , C07D257/04 , C07D295/185 , C07D307/52 , C07D471/04
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.
摘要翻译：本发明提供式I化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，B，X，m和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供了本发明化合物的药物组合物，以及药理活性剂和本发明化合物的组合。

4. 发明申请

US20140051672A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS 有权
标题翻译：用于治疗SMN缺陷相关病症的1,4-取代吡嗪类化合物及其方法
公开(公告)号：US20140051672A1
公开(公告)日：2014-02-20
申请号：US13960917
申请日：2013-08-07
申请人： Atwood Kim CHEUNG , Donovan Noel CHIN , Natalie DALES , Aleem FAZAL , Timothy Brian HURLEY , John KERRIGAN , Gary O'BRIEN , Lei SHU , Robert SUN , Moo Je SUNG
发明人： Atwood Kim CHEUNG , Donovan Noel CHIN , Natalie DALES , Aleem FAZAL , Timothy Brian HURLEY , John KERRIGAN , Gary O'BRIEN , Lei SHU , Robert SUN , Moo Je SUNG
IPC分类号： C07D401/12 , A61K45/06 , C07D409/14 , C07D401/14 , A61K31/502 , C07D413/14 , C07D417/14 , A61K31/5377 , C07D403/12 , A61K31/551 , C07D471/08 , C07D471/10 , C07D471/04 , C07D403/14 , C07D403/10 , C07D487/10 , C07D487/04 , C07D237/20 , C07D401/04 , C07D405/14 , A61K31/506 , A61K31/501
CPC分类号： A61K31/501 , A61K31/41 , A61K31/427 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/06 , C07D237/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐; 制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

5. 发明申请

US20140213570A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS 审中-公开
公开(公告)号：US20140213570A1
公开(公告)日：2014-07-31
申请号：US14242282
申请日：2014-04-01
申请人： Atwood Kim CHEUNG , Donovan Noel CHIN , Natalie DALES , Aleem FAZAL , Timothy HURLEY , John KERRIGAN , Gary O'BRIEN , Lei SHU , Robert SUN , Moo Je SUNG
发明人： Atwood Kim CHEUNG , Donovan Noel CHIN , Natalie DALES , Aleem FAZAL , Timothy HURLEY , John KERRIGAN , Gary O'BRIEN , Lei SHU , Robert SUN , Moo Je SUNG
IPC分类号： C07D401/14 , A61K31/5377 , C07D487/04 , A61K31/501 , C07D401/12 , C07D471/10 , C07D471/04 , C07D413/14 , C07D417/14 , C07D403/12 , C07D403/14 , C07D487/10 , A61K31/551 , C07D409/14
CPC分类号： A61K31/501 , A61K31/41 , A61K31/427 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/06 , C07D237/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

6. 发明申请

US20110088755A1 MOBILE SOLAR POWER GENERATOR 审中-公开
标题翻译：移动太阳能发电机
公开(公告)号：US20110088755A1
公开(公告)日：2011-04-21
申请号：US12580020
申请日：2009-10-15
申请人： Robert SUN
发明人： Robert SUN
IPC分类号： H01L31/058
CPC分类号： H02S10/10 , F24S10/90 , F24S60/00 , Y02E10/40
摘要： A mobile solar power generator is disclosed. The mobile solar power generator includes a plurality of solar energy collecting plates, a thermoelectric conversion unit, and a power distribution unit. The solar energy collecting plates are disposed at a top and/or a lateral side of the thermoelectric conversion unit for collecting thermal energy provided by the sun. The thermoelectric conversion unit is adapted for utilizing the collected thermal energy to vaporize a liquid into a vapor, and generating electric power with the vapor. The liquid has a relatively low boiling point. The power distribution unit is coupled to the thermoelectric conversion unit, for providing the electric power generated by the thermoelectric conversion unit to drive an external electric appliance.
摘要翻译：公开了一种移动式太阳能发电机。移动太阳能发电机包括多个太阳能收集板，热电转换单元和配电单元。太阳能收集板设置在热电转换单元的顶部和/或侧面，用于收集由太阳提供的热能。热电转换单元适于利用所收集的热能将液体蒸发成蒸汽，并且与蒸汽产生电力。液体沸点相对较低。电力分配单元耦合到热电转换单元，用于提供由热电转换单元产生的电力来驱动外部电器。

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