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1. 发明授权

US06783853B2 Hetero-composite yarn, fabrics thereof and methods of making 失效
标题翻译：异腈复合纱，织物及其制造方法
公开(公告)号：US06783853B2
公开(公告)日：2004-08-31
申请号：US10256346
申请日：2002-09-27
申请人： Garret D. Figuly , Marc B. Goldfinger , Rakesh H. Mehta , H. Vaughn Samuelson , Anthony J. Soroka , Gregory P. Weeks
发明人： Garret D. Figuly , Marc B. Goldfinger , Rakesh H. Mehta , H. Vaughn Samuelson , Anthony J. Soroka , Gregory P. Weeks
IPC分类号： D01F800
CPC分类号： D02G1/18 , D01D5/253 , D01D5/30 , D01F8/04 , D01F8/06 , D01F8/12 , D01F8/14 , D01F8/16 , Y10T428/2913 , Y10T428/2924 , Y10T428/2929 , Y10T428/2931 , Y10T428/2973
摘要： A hetero-composite yarn useful in making garments comprises a combined biconstituent yarn and a companion yarn, wherein the biconstituent yarn comprises an axial core comprising a thermoplastic elastomeric polymer, and a plurality of wings attached to the core and comprising a thermoplastic, non-elastomeric polymer.
摘要翻译：可用于制造衣物的异型复合纱线包括组合的双成分纱线和伴随纱线，其中双成分纱线包括包含热塑性弹性体聚合物的轴向芯和连接到芯上的多个翼，并且包括热塑性非弹性体聚合物。

2. 发明授权

US06548166B2 Stretchable fibers of polymers, spinnerets useful to form the fibers, and articles produced therefrom 失效
公开(公告)号：US06548166B2
公开(公告)日：2003-04-15
申请号：US09966037
申请日：2001-09-28
申请人： Garret D. Figuly , Anthony J. Soroka , Marc B. Goldfinger , Rakesh H. Mehta , H. Vaughn Samuelson , Gregory P. Weeks
发明人： Garret D. Figuly , Anthony J. Soroka , Marc B. Goldfinger , Rakesh H. Mehta , H. Vaughn Samuelson , Gregory P. Weeks
IPC分类号： D01F800
CPC分类号： D01D5/30 , D01D5/253 , D01F8/04 , D01F8/12 , D01F8/14 , D01F8/16 , Y10T428/2913 , Y10T428/2924 , Y10T428/2929 , Y10T428/2931 , Y10T428/2973
摘要： A stretchable synthetic polymer fiber comprising an axial core formed from an elastomeric polymer, and two or more wings attached to the core and formed from a non-elastomeric polymer, wherein preferably at least one of the wings is mechanically locked with the axial core. The fibers can be used to form garments, such as hosiery. A spinneret pack for producing such fibers is also provided.

3. 发明申请

US20080004421A1 Tissue adhesives with modified elasticity 有权
标题翻译：具有改性弹性的组织粘合剂
公开(公告)号：US20080004421A1
公开(公告)日：2008-01-03
申请号：US11820834
申请日：2007-06-21
申请人： Henry Keith Chenault , Garret D. Figuly
发明人： Henry Keith Chenault , Garret D. Figuly
IPC分类号： C08G69/08
CPC分类号： C08G73/024 , C08L79/02
摘要： An embodiment of the invention is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether amine with a bifunctional crosslinker of the formula: X1—R—X2. Another embodiment is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether having at least three arms and three electrophilic endgroups with a primary diamine crosslinker of the formula: NH2—R2—NH2, followed by treating of the chain-extended product so as to convert the remaining electrophilic endgroups to amine endgroups. Crosslinking of the chain-extended polyamine products with an oxidized polysaccharide provides useful tissue adhesives with modified elasticity, that provides greater compliance to underlying tissue, and improved stability in aqueous environments.
摘要翻译：本发明的一个实施方案是通过包括使多臂聚醚胺与下式的双官能交联剂反应的方法制备的水溶性延伸链多胺产物：X 1 - / SUP>。另一个实施方案是通过包括使具有至少三个臂的多臂聚醚和三个亲电端基与下式的伯二胺交联剂反应的方法制备的水溶性延伸链多胺产物：NH 2 - 然后处理扩链产物，以便将剩余的亲电端基转化成胺端基。链延长的多胺产物与氧化多糖的交联提供了具有改进的弹性的有用的组织粘合剂，其提供对潜在组织的更大的依从性以及在水性环境中改善的稳定性。

4. 发明申请

US20070237956A1 Process for preparation of swellable and deformable microspheres 有权
标题翻译：可膨胀和可变形的微球的制备方法
公开(公告)号：US20070237956A1
公开(公告)日：2007-10-11
申请号：US11784066
申请日：2007-04-05
申请人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino
发明人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino
IPC分类号： B32B15/02
CPC分类号： C08F220/06 , A61K9/0034 , A61K9/1635 , C08F220/26 , C08F220/38 , C08F222/385 , Y10T428/2982 , C08F2/24
摘要： A process for producing microspheres was developed that provides microspheres with new combined properties of high density, low fracture, high swell capacity, rapid swell, and deformability following swell. The process is reliable and high yielding, and makes use of a low temperature azo initiator and a small molecule chlorinated solvent as the organic phase. The microsphere preparation made using the process is particularly useful in medical treatments such as embolization.
摘要翻译：开发了一种制备微球的方法，为微球提供了高密度，低断裂，高溶胀能力，膨胀后的快速膨胀和变形性的新组合特性。该方法可靠，产率高，利用低温偶氮引发剂和小分子氯化溶剂作为有机相。使用该方法制备的微球制剂在诸如栓塞的医学治疗中特别有用。

5. 发明申请

US20070237741A1 Medical treatment applications of swellable and deformable microspheres 有权
标题翻译：可溶胀和可变形的微球的医疗应用
公开(公告)号：US20070237741A1
公开(公告)日：2007-10-11
申请号：US11732909
申请日：2007-04-05
申请人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino , Sujata K. Bhatia , Elazer R. Edelman , Tarek Michael Shazly , Michael Jordan Feldstein
发明人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino , Sujata K. Bhatia , Elazer R. Edelman , Tarek Michael Shazly , Michael Jordan Feldstein
IPC分类号： A61K8/72 , C08J9/32 , A61K9/00 , A61K31/785
CPC分类号： A61K9/16 , A61K9/1635 , A61K9/1652 , A61K9/1682 , A61K31/785 , A61L15/24 , A61L15/44
摘要： A method for medical treatment was developed in which microspheres with novel properties are administered in a mammal. The microspheres are made using a novel process that results in microspheres with new combined properties of high density, low fracture, high swell capacity, rapid swell, and deformability following swell. These microspheres may be administered for void filling, tissue bulking, non-vasculature occlusion, body fluid absorption, and delivery of medications.
摘要翻译：开发了一种治疗方法，其中在哺乳动物中施用具有新特性的微球。使用新颖的方法制备微球，其导致具有高密度，低断裂，高溶胀能力，膨胀膨胀和膨胀后的变形性的新组合性质的微球。这些微球可以用于空隙填充，组织膨胀，非脉管闭塞，体液吸收和药物的递送。

6. 发明授权

US5633344A Crosslinked polymeric ammonium salts 失效
标题翻译：交联聚合铵盐
公开(公告)号：US5633344A
公开(公告)日：1997-05-27
申请号：US381876
申请日：1995-02-17
申请人： Garret D. Figuly
发明人： Garret D. Figuly
IPC分类号： A61K31/785 , A61K31/787 , A61P9/10 , C08G59/14 , C08G59/50 , C08G73/00 , C08G73/02 , C08G83/00 , C08G61/00 , A61K31/74
CPC分类号： C08G73/0226 , A61K31/787 , Y10S514/964
摘要： Disclosed are novel crosslinked polymeric ammonium salts wherein in said salt: about 25% or more of the groups which link ammonium nitrogen atoms are group Y wherein Y is an n-alkylene groups or alkyl substituted n-alkylene group, wherein said n-alkylene group has 7 to about 20 carbon atoms; zero to about 75% of groups which links ammonium nitrogen atoms are group Z wherein Z is a hydrocarbylene radical containing 2 or more carbon atoms, said hydrocarbylene radical optionally containing one or more hydroxyl, ether, amino, thioether, keto, or silyl groups or heterocyclic rings; and about 25% or more of the ammonium atoms are secondary ammonium atoms.
摘要翻译： PCT No.PCT / US93 / 07647 Sec。 371日期：1995年2月17日 102（e）1995年2月17日PCT PCT 1993年8月18日PCT公布。出版物WO94 / 04596 日期1994年3月3日公开是新型交联聚合铵盐，其中在所述盐中：连接铵氮原子的基团中约25％或更多为Y基团，其中Y为正亚烷基或烷基取代的正亚烷基，其中所述正亚烷基具有7至约20个碳原子; 0至约75％的连接铵氮原子的基团是基团Z，其中Z是含有2个或更多个碳原子的亚烃基，所述烃基任选地含有一个或多个羟基，醚，氨基，硫醚，酮基或甲硅烷基，或杂环约25％以上的铵原子为仲铵原子。

7. 发明授权

US4810770A Elastomers 失效
标题翻译：弹性体
公开(公告)号：US4810770A
公开(公告)日：1989-03-07
申请号：US109764
申请日：1987-10-23
申请人： Robin N. Greene , Garret D. Figuly
发明人： Robin N. Greene , Garret D. Figuly
IPC分类号： C08G63/685 , C08G69/26 , C08G69/44 , C08G73/14 , C08G73/16
CPC分类号： C08G73/16 , C08G63/685 , C08G69/26 , C08G69/44 , C08G73/14
摘要： Elastomers are prepared from high molecular weight relatively rigid difunctional compounds and low molecular weight compounds selected from diacids, diols, diamines, hydroxyacids, hydroxyamines and aminoacids.
摘要翻译：弹性体由高分子量相对刚性的二官能化合物和选自二酸，二醇，二胺，羟基酸，羟胺和氨基酸的低分子量化合物制备。

8. 发明授权

US07960498B2 Tissue adhesives with modified elasticity 有权
标题翻译：具有改性弹性的组织粘合剂
公开(公告)号：US07960498B2
公开(公告)日：2011-06-14
申请号：US11820834
申请日：2007-06-21
申请人： Henry Keith Chenault , Garret D. Figuly
发明人： Henry Keith Chenault , Garret D. Figuly
IPC分类号： C08G73/02 , C08G69/08
CPC分类号： C08G73/024 , C08L79/02
摘要： An embodiment of the invention is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether amine with a bifunctional crosslinker of the formula: X1—R—X2. Another embodiment is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether having at least three arms and three electrophilic endgroups with a primary diamine crosslinker of the formula: NH2—R2—NH2, followed by treating of the chain-extended product so as to convert the remaining electrophilic endgroups to amine endgroups. Crosslinking of the chain-extended polyamine products with an oxidized polysaccharide provides useful tissue adhesives with modified elasticity, that provides greater compliance to underlying tissue, and improved stability in aqueous environments.
摘要翻译：本发明的一个实施方案是通过包括使多臂聚醚胺与下式的双功能交联剂反应的方法制备的水溶性延伸链多胺产物：X1-R-X2。另一个实施方案是通过包括使具有至少三个臂的多臂聚醚和三个亲电端基与下式的二胺交联剂：NH2-R2-NH2反应的方法制备的水溶性延伸链多胺产物，链延长产物，以便将剩余的亲电端基转化为胺端基。链延长的多胺产物与氧化多糖的交联提供了具有改进的弹性的有用的组织粘合剂，其提供对潜在组织的更大的依从性以及在水性环境中改善的稳定性。

9. 发明授权

US07887846B2 Process for preparation of swellable and degradable microspheres 有权
标题翻译：可溶胀和可降解微球的制备方法
公开(公告)号：US07887846B2
公开(公告)日：2011-02-15
申请号：US12221560
申请日：2008-08-04
申请人： Garret D. Figuly
发明人： Garret D. Figuly
IPC分类号： A61K9/14 , A61K51/02 , C08F2/44
CPC分类号： A61K9/0019 , A61K9/1635 , A61K9/1676 , A61K9/1694 , A61K31/74 , Y10S514/849
摘要： A process for producing microspheres was developed that provides microspheres that are swellable and degradable. The process is reliable and high yielding, and makes use of a low temperature azo initiator, a small molecule chlorinated solvent as the organic phase, and a heat treatment step, and is carried out in absence of a crosslinking agent. The microsphere preparation made using the process is particularly useful as a degradable embolic material.
摘要翻译：开发了一种制备微球的方法，其提供了可膨胀和可降解的微球。该方法是可靠的和高产率的，并且使用低温偶氮引发剂，小分子氯化溶剂作为有机相和热处理步骤，并且在不存在交联剂的情况下进行。使用该方法制备的微球制剂作为可降解的栓塞材料是特别有用的。

10. 发明授权

US07794755B2 Process for preparation of swellable and deformable microspheres 有权
标题翻译：可膨胀和可变形的微球的制备方法
公开(公告)号：US07794755B2
公开(公告)日：2010-09-14
申请号：US11784066
申请日：2007-04-05
申请人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino
发明人： Garret D. Figuly , Surbhi Mahajan , Rinaldo S. Schiffino
IPC分类号： A61K9/14 , A61K9/16 , A61K51/02 , C08F2/20 , C08F2/44
CPC分类号： C08F220/06 , A61K9/0034 , A61K9/1635 , C08F220/26 , C08F220/38 , C08F222/385 , Y10T428/2982 , C08F2/24
摘要： A process for producing microspheres was developed that provides microspheres with new combined properties of high density, low fracture, high swell capacity, rapid swell, and deformability following swell. The process is reliable and high yielding, and makes use of a low temperature azo initiator and a small molecule chlorinated solvent as the organic phase. The microsphere preparation made using the process is particularly useful in medical treatments such as embolization.
摘要翻译：开发了一种制备微球的方法，为微球提供了高密度，低断裂，高溶胀能力，膨胀后的快速膨胀和变形性的新组合特性。该方法可靠，产率高，利用低温偶氮引发剂和小分子氯化溶剂作为有机相。使用该方法制备的微球制剂在诸如栓塞的医学治疗中特别有用。

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